Details for: VCAN

Gene ID: 1462

Symbol: VCAN

Ensembl ID: ENSG00000038427

Description: versican

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 421.3887
    Cell Significance Index: -65.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 263.2436
    Cell Significance Index: -66.7700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 171.7694
    Cell Significance Index: -70.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 136.1511
    Cell Significance Index: -64.2800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 133.2654
    Cell Significance Index: -54.1400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 120.5128
    Cell Significance Index: -61.9900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 57.0101
    Cell Significance Index: -54.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.1730
    Cell Significance Index: -65.5600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.5279
    Cell Significance Index: -65.2200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 9.1720
    Cell Significance Index: 56.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.9440
    Cell Significance Index: 109.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.3924
    Cell Significance Index: 91.9400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.9415
    Cell Significance Index: 31.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.3998
    Cell Significance Index: 134.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.1687
    Cell Significance Index: 133.3000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.1614
    Cell Significance Index: 27.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.8881
    Cell Significance Index: 65.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.7910
    Cell Significance Index: 51.3400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.7542
    Cell Significance Index: 19.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6896
    Cell Significance Index: 196.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6064
    Cell Significance Index: 318.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.5454
    Cell Significance Index: 23.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5094
    Cell Significance Index: 193.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8956
    Cell Significance Index: 17.4800
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.8581
    Cell Significance Index: 4.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.5648
    Cell Significance Index: 16.6400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5637
    Cell Significance Index: 8.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5535
    Cell Significance Index: 14.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3120
    Cell Significance Index: 111.9100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2804
    Cell Significance Index: 1.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1989
    Cell Significance Index: 4.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1681
    Cell Significance Index: 91.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1016
    Cell Significance Index: 1.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0668
    Cell Significance Index: 9.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0203
    Cell Significance Index: -14.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0324
    Cell Significance Index: -60.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0412
    Cell Significance Index: -25.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0452
    Cell Significance Index: -33.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0571
    Cell Significance Index: -105.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0645
    Cell Significance Index: -40.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0668
    Cell Significance Index: -102.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0755
    Cell Significance Index: -33.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0781
    Cell Significance Index: -106.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0787
    Cell Significance Index: -57.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0847
    Cell Significance Index: -64.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1014
    Cell Significance Index: -57.1700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1086
    Cell Significance Index: -0.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1550
    Cell Significance Index: -70.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1940
    Cell Significance Index: -55.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2218
    Cell Significance Index: -46.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2460
    Cell Significance Index: -49.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2545
    Cell Significance Index: -26.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2814
    Cell Significance Index: -50.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2992
    Cell Significance Index: -51.0900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3106
    Cell Significance Index: -6.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3516
    Cell Significance Index: -23.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3542
    Cell Significance Index: -51.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3825
    Cell Significance Index: -29.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4312
    Cell Significance Index: -49.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.4489
    Cell Significance Index: -55.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4687
    Cell Significance Index: -60.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4883
    Cell Significance Index: -13.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5393
    Cell Significance Index: -63.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5534
    Cell Significance Index: -63.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6557
    Cell Significance Index: -68.2700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.7073
    Cell Significance Index: -9.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7667
    Cell Significance Index: -49.4700
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.8046
    Cell Significance Index: -5.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8178
    Cell Significance Index: -42.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8200
    Cell Significance Index: -61.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.9463
    Cell Significance Index: -44.4800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.0480
    Cell Significance Index: -20.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0788
    Cell Significance Index: -30.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0898
    Cell Significance Index: -66.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2578
    Cell Significance Index: -41.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.3631
    Cell Significance Index: -15.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.3867
    Cell Significance Index: -72.8100
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -1.4646
    Cell Significance Index: -9.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.4830
    Cell Significance Index: -77.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.4905
    Cell Significance Index: -65.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.6756
    Cell Significance Index: -43.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.7436
    Cell Significance Index: -66.0300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.7663
    Cell Significance Index: -30.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.7830
    Cell Significance Index: -47.7000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.8514
    Cell Significance Index: -25.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.9238
    Cell Significance Index: -70.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.9317
    Cell Significance Index: -51.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.9953
    Cell Significance Index: -93.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.0085
    Cell Significance Index: -70.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -2.0415
    Cell Significance Index: -65.0200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -2.0657
    Cell Significance Index: -26.9600
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -2.0681
    Cell Significance Index: -12.1400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -2.1002
    Cell Significance Index: -20.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -2.1090
    Cell Significance Index: -46.1800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -2.1213
    Cell Significance Index: -18.0300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -2.1504
    Cell Significance Index: -35.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -2.1850
    Cell Significance Index: -64.1700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -2.2467
    Cell Significance Index: -54.4200
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: -2.2507
    Cell Significance Index: -12.9100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -2.2778
    Cell Significance Index: -33.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** VCAN is a large, negatively charged glycosaminoglycan (GAG) that consists of a core protein (CSPG2) covalently attached to a tetrasaccharide linker sequence. This structure allows VCAN to bind to various ligands, including hyaluronic acid, dermatan sulfate, and chondroitin sulfate. The core protein of VCAN is composed of 47 repeats of the sequence Gly-Gly-X-X-Ser-Gly-Gly, which confers its unique properties and functions. **Pathways and Functions:** VCAN is involved in numerous signaling pathways, including: 1. **Cell Adhesion and Migration:** VCAN interacts with integrins, chemokines, and growth factors, facilitating cell adhesion, migration, and proliferation. 2. **Central Nervous System Development:** VCAN is essential for the development of the central nervous system, particularly in the formation of the perineuronal net and photoreceptor outer segments. 3. **Extracellular Matrix Organization:** VCAN contributes to the organization and structure of the ECM, influencing tissue development and remodeling. 4. **Glycosaminoglycan Metabolism:** VCAN is involved in the biosynthesis and degradation of glycosaminoglycans, such as chondroitin sulfate and dermatan sulfate. VCAN also interacts with various receptors, including CD44, CD166, and L1CAM, which modulate its functions and signaling pathways. **Clinical Significance:** VCAN has been implicated in various diseases and disorders, including: 1. **Neurological Disorders:** VCAN is associated with neurodevelopmental disorders, such as autism spectrum disorder, and neurodegenerative diseases, like Alzheimer's disease and amyotrophic lateral sclerosis. 2. **Cancer:** VCAN is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with tumor progression and metastasis. 3. **Cardiovascular Diseases:** VCAN is involved in the development of cardiovascular diseases, such as atherosclerosis and cardiac fibrosis. 4. **Musculoskeletal Disorders:** VCAN is associated with musculoskeletal disorders, including osteoarthritis and muscular dystrophy. In conclusion, VCAN is a multifunctional proteoglycan that plays a critical role in various biological processes, including cell adhesion, recognition, and migration. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the mechanisms and therapeutic potential of VCAN in immunology and disease.

Genular Protein ID: 3881967781

Symbol: CSPG2_HUMAN

Name: Versican core protein

UniProtKB Accession Codes:

P13611 P20754 Q13010 Q13189 Q15123 Q9UCL9 Q9UNW5

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 6 CPTAC 2 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 26 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 18 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 11 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 13 RefSeq 4 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2583089

Title: Multiple domains of the large fibroblast proteoglycan, versican.

PubMed ID: 2583089

DOI: 10.1002/j.1460-2075.1989.tb08447.x

PubMed ID: 7806529

Title: A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican.

PubMed ID: 7806529

DOI: 10.1016/s0021-9258(20)30089-2

PubMed ID: 7528742

Title: Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter.

PubMed ID: 7528742

DOI: 10.1016/s0021-9258(20)30090-9

PubMed ID: 7876137

Title: Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissues.

PubMed ID: 7876137

DOI: 10.1074/jbc.270.8.3914

PubMed ID: 7921538

Title: Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry.

PubMed ID: 7921538

DOI: 10.1016/0945-053x(94)90185-6

PubMed ID: 1478664

Title: Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14).

PubMed ID: 1478664

DOI: 10.1016/s0888-7543(05)80103-x

PubMed ID: 2820964

Title: A fibroblast chondroitin sulfate proteoglycan core protein contains lectin-like and growth factor-like sequences.

PubMed ID: 2820964

DOI: 10.1016/s0021-9258(18)45176-9

PubMed ID: 10397680

Title: Versican/PG-M isoforms in vascular smooth muscle cells.

PubMed ID: 10397680

DOI: 10.1161/01.atv.19.7.1630

PubMed ID: 1429726

Title: Isolation of a large aggregating proteoglycan from human brain.

PubMed ID: 1429726

DOI: 10.1016/s0021-9258(18)35919-2

PubMed ID: 2466833

Title: Isolation and partial characterization of a glial hyaluronate-binding protein.

PubMed ID: 2466833

DOI: 10.1016/s0021-9258(18)83646-8

PubMed ID: 2469524

Title: Structural similarity of hyaluronate binding proteins in brain and cartilage.

PubMed ID: 2469524

DOI: 10.1016/0361-9230(89)90129-9

PubMed ID: 8627343

Title: Differential expression of versican isoforms in brain tumors.

PubMed ID: 8627343

DOI: 10.1097/00005072-199605000-00005

PubMed ID: 16043844

Title: Identification of a novel splice site mutation of the CSPG2 gene in a Japanese family with Wagner syndrome.

PubMed ID: 16043844

DOI: 10.1167/iovs.05-0057

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22739342

Title: Novel VCAN mutations and evidence for unbalanced alternative splicing in the pathogenesis of Wagner syndrome.

PubMed ID: 22739342

DOI: 10.1038/ejhg.2012.137

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 29777959

Title: Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix.

PubMed ID: 29777959

DOI: 10.1016/j.actbio.2018.05.023

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 36213313

Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.

PubMed ID: 36213313

DOI: 10.1007/s42485-022-00092-3

Sequence Information:

  • Length: 3396
  • Mass: 372820
  • Checksum: D174A1BBB8304FEC
  • Sequence:
    • MFINIKSILW MCSTLIVTHA LHKVKVGKSP PVRGSLSGKV SLPCHFSTMP TLPPSYNTSE 
FLRIKWSKIE VDKNGKDLKE TTVLVAQNGN IKIGQDYKGR VSVPTHPEAV GDASLTVVKL 
LASDAGLYRC DVMYGIEDTQ DTVSLTVDGV VFHYRAATSR YTLNFEAAQK ACLDVGAVIA 
TPEQLFAAYE DGFEQCDAGW LADQTVRYPI RAPRVGCYGD KMGKAGVRTY GFRSPQETYD 
VYCYVDHLDG DVFHLTVPSK FTFEEAAKEC ENQDARLATV GELQAAWRNG FDQCDYGWLS 
DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTGFPPPDSR FDAYCFKPKE ATTIDLSILA 
ETASPSLSKE PQMVSDRTTP IIPLVDELPV IPTEFPPVGN IVSFEQKATV QPQAITDSLA 
TKLPTPTGST KKPWDMDDYS PSASGPLGKL DISEIKEEVL QSTTGVSHYA TDSWDGVVED 
KQTQESVTQI EQIEVGPLVT SMEILKHIPS KEFPVTETPL VTARMILESK TEKKMVSTVS 
ELVTTGHYGF TLGEEDDEDR TLTVGSDEST LIFDQIPEVI TVSKTSEDTI HTHLEDLESV 
SASTTVSPLI MPDNNGSSMD DWEERQTSGR ITEEFLGKYL STTPFPSQHR TEIELFPYSG 
DKILVEGIST VIYPSLQTEM THRRERTETL IPEMRTDTYT DEIQEEITKS PFMGKTEEEV 
FSGMKLSTSL SEPIHVTESS VEMTKSFDFP TLITKLSAEP TEVRDMEEDF TATPGTTKYD 
ENITTVLLAH GTLSVEAATV SKWSWDEDNT TSKPLESTEP SASSKLPPAL LTTVGMNGKD 
KDIPSFTEDG ADEFTLIPDS TQKQLEEVTD EDIAAHGKFT IRFQPTTSTG IAEKSTLRDS 
TTEEKVPPIT STEGQVYATM EGSALGEVED VDLSKPVSTV PQFAHTSEVE GLAFVSYSST 
QEPTTYVDSS HTIPLSVIPK TDWGVLVPSV PSEDEVLGEP SQDILVIDQT RLEATISPET 
MRTTKITEGT TQEEFPWKEQ TAEKPVPALS STAWTPKEAV TPLDEQEGDG SAYTVSEDEL 
LTGSERVPVL ETTPVGKIDH SVSYPPGAVT EHKVKTDEVV TLTPRIGPKV SLSPGPEQKY 
ETEGSSTTGF TSSLSPFSTH ITQLMEETTT EKTSLEDIDL GSGLFEKPKA TELIEFSTIK 
VTVPSDITTA FSSVDRLHTT SAFKPSSAIT KKPPLIDREP GEETTSDMVI IGESTSHVPP 
TTLEDIVAKE TETDIDREYF TTSSPPATQP TRPPTVEDKE AFGPQALSTP QPPASTKFHP 
DINVYIIEVR ENKTGRMSDL SVIGHPIDSE SKEDEPCSEE TDPVHDLMAE ILPEFPDIIE 
IDLYHSEENE EEEEECANAT DVTTTPSVQY INGKHLVTTV PKDPEAAEAR RGQFESVAPS 
QNFSDSSESD THPFVIAKTE LSTAVQPNES TETTESLEVT WKPETYPETS EHFSGGEPDV 
FPTVPFHEEF ESGTAKKGAE SVTERDTEVG HQAHEHTEPV SLFPEESSGE IAIDQESQKI 
AFARATEVTF GEEVEKSTSV TYTPTIVPSS ASAYVSEEEA VTLIGNPWPD DLLSTKESWV 
EATPRQVVEL SGSSSIPITE GSGEAEEDED TMFTMVTDLS QRNTTDTLIT LDTSRIITES 
FFEVPATTIY PVSEQPSAKV VPTKFVSETD TSEWISSTTV EEKKRKEEEG TTGTASTFEV 
YSSTQRSDQL ILPFELESPN VATSSDSGTR KSFMSLTTPT QSEREMTDST PVFTETNTLE 
NLGAQTTEHS SIHQPGVQEG LTTLPRSPAS VFMEQGSGEA AADPETTTVS SFSLNVEYAI 
QAEKEVAGTL SPHVETTFST EPTGLVLSTV MDRVVAENIT QTSREIVISE RLGEPNYGAE 
IRGFSTGFPL EEDFSGDFRE YSTVSHPIAK EETVMMEGSG DAAFRDTQTS PSTVPTSVHI 
SHISDSEGPS STMVSTSAFP WEEFTSSAEG SGEQLVTVSS SVVPVLPSAV QKFSGTASSI 
IDEGLGEVGT VNEIDRRSTI LPTAEVEGTK APVEKEEVKV SGTVSTNFPQ TIEPAKLWSR 
QEVNPVRQEI ESETTSEEQI QEEKSFESPQ NSPATEQTIF DSQTFTETEL KTTDYSVLTT 
KKTYSDDKEM KEEDTSLVNM STPDPDANGL ESYTTLPEAT EKSHFFLATA LVTESIPAEH 
VVTDSPIKKE ESTKHFPKGM RPTIQESDTE LLFSGLGSGE EVLPTLPTES VNFTEVEQIN 
NTLYPHTSQV ESTSSDKIED FNRMENVAKE VGPLVSQTDI FEGSGSVTST TLIEILSDTG 
AEGPTVAPLP FSTDIGHPQN QTVRWAEEIQ TSRPQTITEQ DSNKNSSTAE INETTTSSTD 
FLARAYGFEM AKEFVTSAPK PSDLYYEPSG EGSGEVDIVD SFHTSATTQA TRQESSTTFV 
SDGSLEKHPE VPSAKAVTAD GFPTVSVMLP LHSEQNKSSP DPTSTLSNTV SYERSTDGSF 
QDRFREFEDS TLKPNRKKPT ENIIIDLDKE DKDLILTITE STILEILPEL TSDKNTIIDI 
DHTKPVYEDI LGMQTDIDTE VPSEPHDSND ESNDDSTQVQ EIYEAAVNLS LTEETFEGSA 
DVLASYTQAT HDESMTYEDR SQLDHMGFHF TTGIPAPSTE TELDVLLPTA TSLPIPRKSA 
TVIPEIEGIK AEAKALDDMF ESSTLSDGQA IADQSEIIPT LGQFERTQEE YEDKKHAGPS 
FQPEFSSGAE EALVDHTPYL SIATTHLMDQ SVTEVPDVME GSNPPYYTDT TLAVSTFAKL 
SSQTPSSPLT IYSGSEASGH TEIPQPSALP GIDVGSSVMS PQDSFKEIHV NIEATFKPSS 
EEYLHITEPP SLSPDTKLEP SEDDGKPELL EEMEASPTEL IAVEGTEILQ DFQNKTDGQV 
SGEAIKMFPT IKTPEAGTVI TTADEIELEG ATQWPHSTSA SATYGVEAGV VPWLSPQTSE 
RPTLSSSPEI NPETQAALIR GQDSTIAASE QQVAARILDS NDQATVNPVE FNTEVATPPF 
SLLETSNETD FLIGINEESV EGTAIYLPGP DRCKMNPCLN GGTCYPTETS YVCTCVPGYS 
GDQCELDFDE CHSNPCRNGA TCVDGFNTFR CLCLPSYVGA LCEQDTETCD YGWHKFQGQC 
YKYFAHRRTW DAAERECRLQ GAHLTSILSH EEQMFVNRVG HDYQWIGLND KMFEHDFRWT 
DGSTLQYENW RPNQPDSFFS AGEDCVVIIW HENGQWNDVP CNYHLTYTCK KGTVACGQPP 
VVENAKTFGK MKPRYEINSL IRYHCKDGFI QRHLPTIRCL GNGRWAIPKI TCMNPSAYQR 
TYSMKYFKNS SSAKDNSINT SKHDHRWSRR WQESRR

Genular Protein ID: 1680537261

Symbol: Q6MZK8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6MZK8

Database IDs:

ARBA 10 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 11 Gene3D 3 InterPro 12 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 11 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SMART 4 SUPFAM 3

Sequence Information:

  • Length: 2060
  • Mass: 226423
  • Checksum: D33CB7F70465D02E
  • Sequence:
    • MSDLSVIGHP IDSESKEDEP CSEETDPVHD LMAEILPEFP DIIEIDLYHS EENEEEEEEC 
ANATDVTTTP SVQYINGKHL VTTVPKDPEA AEARRGQFES VAPSQNFSDS SESDTHPFVI 
AKTELSTAVQ PNESTETTES LEVTWKPETY PETSEHFSGG EPDVFPTVPF HEEFESGTAR 
KGAESVTERD TEVGHQAHEH TEPVSLFPEE SSGEIAIDQE SQKIAFARAT EVTFGEEVEK 
STSVTYTPTI VPSSASAYVS EEEAVTLIGN PWPDDLLSTK ESWVEATPRQ VVELSGSSSI 
PITEGSGEAE EDEDTMFTMV TDLSQRNTTD TLITLDTSRI ITESFFEVPA TTIYPVSEQP 
SAKVVPTKFV SETDTSEWIS STTVEEKKRK EEEGTTGTAS TFEVYSSTQR SDQLILPFEL 
ESPNVATSSD SGTRKSFMSL TTPTRSEREM TDSTPVFTET NTLENLGAQT TEHSSIHQPG 
VQEGLTTLPH SPASVFMEQG SGEAAADPET TTVSSFSLNV EYAIQAEKEV AGTLSPHVET 
TFSTEPTGLV LSTVMDRVVA ENITQTSREI AISERLGEPN YGAEIRGFST GFPLEEDFSG 
DFREYSTVSH PIAKEETVMM EGSGDAAFRD TQTSPSTVPT SVHISHISDS EGPSSTMVST 
SAFPWEEFTS SAEGSGEQLV TVSSSVVPVL PSAVQKFSGT ASSIIDEGLG EVGTVNEIDR 
RSTILPTAEV EGTKAPVEKE EVKVSGTVST NFPQTIEPAK LWSRQEVNPV RQEIESETTS 
EEQIQEEKSF ESPQNSPATE QTIFDSQTFT ETELKTTDYS VLTTKKTYSD DKEMKEEDTS 
LVNMSTPDPD ANGLESYTTL PEATEKSHFF LATALVTESI PAEHVVTDSP IKKEESTKHF 
PKGMRPTIQE SDTELLFSGL GSGEEVLPTL PTESVNFTEV EQINNTLYPH TSQVESTSSD 
KIEDYNRMEN VAKEVGPLVS QTDIFEGSGS VTSTTLIEIL SDTGAEGPTV APLPFSTDIG 
HPQNQTVRWA EEIQTSRPQT ITEQDSNKNS STAEINETTT SSTDFLARAY GFEMAKEFVT 
SAPKPSDLYY EPSGEGSGEV DIVDSFHTSA TTQATRQESS TTFVSDGSLE KHPEVPSAKA 
VTADGFPTVS VMLPLHSEQN KSSPDPTSTL SNTVSYERST DGSFQDRFRE FEDSTLKPNR 
KKPTENIIID LDKEDKDLIL TITESTILEI LPELTSDKNT IIDIDHTKPV YEDILGMQTD 
IDTEVPSEPH DSNDESNDDS TQVQEIYEAA VNLSLTEETF EGSADVLASY TQATHDESMT 
YEDRSQLDHM GFHFTTGIPA PSTETELDVL LPTATSLPIP RKSATVIPEI EGIKAEAKAL 
DDMFESSTLS DGQAIADQSE IIPTLGQFER TQEEYEDKKH AGPSFQPEFS SGAEEALVDH 
TPYLSIATTH LMDQSVTEVP DVMEGSNPPY YTDTTLAVST FAKLSSQTPS SPLTIYSGSE 
ASGHTEIPQP SALPGIDVGS SVMSPQDSFK EIHVNIEATF KPSSEEYLHI TEPPSLSPDT 
KLEPSEDDGK PELLEEMEAS PTELIAVEGT EILQDFQNKT YGQVSGEAIK MFPTIKTPEA 
GTVITTADEI ELEGATQWPH STSASATYGV EAGVVPWLSP QTSERPTLSS SPEINPETQA 
ALIRGQDSTI AASEQQVAAR ILDSNDQATV NPVEFNTEVA TPPFSLLETS NETDFLIGIN 
EESVEGTAIY LPGPDRCKMN PCLNGGTCYP TETSYVCTCV PGYSGDQCEL DFDECHSNPC 
RNGATCVDGF NTFRCLCLPS YVGALCEQDT ETCDYGWHKF QGQCYKYFAH RRTWDAAERE 
CRLQGAHLTS ILSHEEQMFV NRVGHDYQWI GLNDKMFEHD FRWTDGSTLQ YENWRPNQPD 
SFFSAGEDCV VIIWHENGQW NDVPCNYHLT YTCKKGTVAC GQPPVVENAK TFGKMKPRYE 
INSLIRYHCK DGFIQRHLPT IRCLGNGRWA IPKITCMNPS AYQRTYSMKY FKNSSSAKDN 
SINTSKHDHR WSRRWQESRR

Genular Protein ID: 1572071638

Symbol: Q86W61_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86W61

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 2 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 354
  • Mass: 39265
  • Checksum: 1EC99C686837C793
  • Sequence:
    • MFINIKSILW MCSTLIVTHA LHKVKVGKSP PVRGSLSGKV SLPCHFSTMP TLPPSYNTSE 
FLRIKWSKIE VDKNGKDLKE TTVLVAQNGN IKIGQDYKGR VSVPTHPEAV GDASLTVVKL 
LASDAGLYRC DVMYGIEDTQ DTVSLTVDGV VFHYRAATSR YTLNFEAAQK ACLDVGAVIA 
TPEQLFAAYE DGFEQCDAGW LADQTVRYPI RAPRVGCYGD KMGKAGVRTY GFRSPQETYD 
VYCYVDHLDG DVFHLTVPSK FTFEEAAKEC ENQDARLATV GELQAAWRNG FDQCDYGWLS 
DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTGFPPPDSR FDAYCFKRKC LIPF

Genular Protein ID: 3533282208

Symbol: Q59FG9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FG9

Database IDs:

ARBA 20 BioGRID-ORCS 1 CDD 6 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 14 Gene3D 4 InterPro 18 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 16 PROSITE-ProRule 3 PeptideAtlas 1 Pfam 5 PharmGKB 1 RefSeq 1 SAM 1 SMART 6 SUPFAM 4

Sequence Information:

  • Length: 3410
  • Mass: 374369
  • Checksum: 37872E30DF626185
  • Sequence:
    • IFPPNCNKPP SKAKMFINIK SILWMCSTLI VTHALHKVKV GKSPPVRGSL SGKVSLPCHF 
STMPTLPPSY NTSEFLRIKW SKIEVDKNGK DLKETTVLVA QNGNIKIGQD YKGRVSVPTH 
PEAVGDASLT VVKLLASDAG LYRCDVMYGI EDTQDTVSLT VDGVVFHYRA ATSRYTLNFE 
AAQKACLDVG AVIATPEQLF AAYEDGFEQC DAGWLADQTV RYPIRAPRVG CYGDKMGKAG 
VRTYGFRSPQ ETYDVYCYVD HLDGDVFHLT VPSKFTFEEA AKECENQDAR LATVGELQAA 
WRNGFDQCDY GWLSDASVRH PVTVARAQCG GGLLGVRTLY RFENQTGFPP PDSRFDAYCF 
KPKEATTIDL SILAETASPS LSKEPQMVSD RTTPIIPLVD ELPVIPTEFP PVGNIVSFEQ 
KATVQPQAIT DSLATKLPTP TGSTKKPWDM DDYSPSASGP LGKLDISEIK EEVLQSTTGV 
SHYATDSWDG VVEDKQTQES VTQIEQIEVG PLVTSMEILK HIPSKEFPVT ETPLVTARMI 
LESKTEKKMV STVSELVTTG HYGFTLGEED DEDRTLTVGS DESTLIFDQI PEVITVSKTS 
EDTIHTHLED LESVSASTTV SPLIMPDNNG SSMDDWEERQ TSGRITEEFL GKYLSTTPFP 
SQHRTEIELF PYSGDKILVE GISTVIYPSL QTEMTHRRER TETLIPEMRT DTYTDEIQEE 
ITKSPFMGKT EEEVFSGMKL STSLSEPIHV TESSVEMTKS FDFPTLITKL SAEPTEVRDM 
EEDFTATPGT TKYDENITTV LLAHGTLSVE AATVSKWSWD EDNTTSKPLE STEPSASSKL 
PPALLTTVGM NGKDKDIPSF TEDGADEFTL IPDSTQKQLE EVTDEDIAAH GKFTIRFQPT 
TSTGIAEKST LRDSTTEEKV PPITSTEGQV YATMEGSALG EVEDVDLSKP VSTVPQFAHT 
SEVEGLAFVS YSSTQEPTTY VDSSHTIPLS VIPKTDWGVL VPSVPSEDEV LGEPSQDILV 
IDQTRLEATI SPETMRTTKI TEGTTQEEFP WKEQTAEKPV PALSSTAWTP KEAVTPLDEQ 
EGDGSAYTVS EDELLTGSER VPVLETTPVG KIDHSVSYPP GAVTEHKVKT DEVVTLTPRI 
GPKVSLSPGP EQKYETEGSS TTGFTSSLSP FSTHITQLME ETTTEKTSLE DIDLGSGLFE 
KPKATELIEF STIKVTVPSD ITTAFSSVDR LHTTSAFKPS SAITKKPPLI DREPGEETTS 
DMVIIGESTS HVPPTTLEDI VAKETETDID REYFTTSSPP ATQPTRPPTV EDKEAFGPQA 
LSTPQPPAST KFHPDINVYI IEVRENKTGR MSDLSVIGHP IDSESKEDEP CSEETDPVHD 
LMAEILPEFP DIIEIDLYHS EENEEEEEEC ANATDVTTTP SVQYINGKHL VTTVPKDPEA 
AEARRGQFES VAPSQNFSDS SESDTHPFVI AKTELSTAVQ PNESTETTES LEVTWKPETY 
PETSEHFSGG EPDVFPTVPF HEEFESGTAK KGAESVTERD TEVGHQAHEH TEPVSLFPEE 
SSGEIAIDQE SQKIAFARAT EVTFGEEVEK STSVTYTPTI VPSSASAYVS EEEAVTLIGN 
PWPDDLLSTK ESWVEATPRQ VVELSGSSSI PITEGSGEAE EDEDTMFTMV TDLSQRNTTD 
TLITLDTSRI ITESFFEVPA TTIYPVSEQP SAKVVPTKFV SETDTSEWIS STTVEEKKRK 
EEEGTTGTAS TFEVYSSTQR SDQLILPFEL ESPNVATSSD SGTRKSFMSL TTPTQSEREM 
TDSTPVFTET NTLENLGAQT TEHSSIHQPG VQEGLTTLPR SPASVFMEQG SGEAAADPET 
TTVSSFSLNV EYAIQAEKEV AGTLSPHVET TFSTEPTGLV LSTVMDRVVA ENITQTSREI 
VISERLGEPN YGAEIRGFST GFPLEEDFSG DFREYSTVSH PIAKEETVMM EGSGDAAFRD 
TQTSPSTVPT SVHISHISDS EGPSSTMVST SAFPWEEFTS SAEGSGEQLV TVSSSVVPVL 
PSAVQKFSGT ASSIIDEGLG EVGTVNEIDR RSTILPTAEV EGTKAPVEKE EVKVSGTVST 
NFPQTIEPAK LWSRQEVNPV RQEIESETTS EEQIQEEKSF ESPQNSPATE QTIFDSQTFT 
ETELKTTDYS VLTTKKTYSD DKEMKEEDTS LVNMSTPDPD ANGLESYTTL PEATEKSHFF 
LATALVTESI PAEHVVTDSP IKKEESTKHF PKGMRPTIQE SDTELLFSGL GSGEEVLPTL 
PTESVNFTEV EQINNTLYPH TSQVESTSSD KIEDFNRMEN VAKEVGPLVS QTDIFEGSGS 
VTSTTLIEIL SDTGAEGPTV APLPFSTDIG HPQNQTVRWA EEIQTSRPQT ITEQDSNKNS 
STAEINETTT SSTDFLARAY GFEMAKEFVT SAPKPSDLYY EPSGEGSGEV DIVDSFHTSA 
TTQATRQESS TTFVSDGSLE KHPEVPSAKA VTADGFPTVL VMLPLHSEQN KSSPDPTSTL 
SNTVSYERST DGSFQDRFRE FEDSTLKPNR KKPTENIIID LDKEDKDLIL TITESTILEI 
LPELTSDKNT IIDIDHTKPV YEDILGMQTD IDTEVPSEPH DSNDESNDDS TQVQEIYEAA 
VNLSLTEETF EGSADVLASY TQATHDESMT YEDRSQLDHM GFHFTTGIPA PSTETELDVL 
LPTATSLPIP RKSATVIPEI EGIKAEAKAL DDMFESSTLS DGQAIADQSE IIPTLGQFER 
TQEEYEDKKH AGPSFQPEFS SGAEEALVDH TPYLSIATTH LMDQSVTEVP DVMEGSNPPY 
YTDTTLAVST FAKLSSQTPS SPLTIYSGSE ASGHTEIPQP SALPGIDVGS SVMSPQDSFK 
EIHVNIEATF KPSSEEYLHI TEPPSLSPDT KLEPSEDDGK PELLEEMEAS PTELIAVEGT 
EILQDFQNKT DGQVSGEAIK MFPTIKTPEA GTVITTADEI ELEGATQWPH STSASATYGV 
EAGVVPWLSP QTSERPTLSS SPEINPETQA ALIRGQDSTI AASEQQVAAR ILDSNDQATV 
NPVEFNTEVA TPPFSLLETS NETDFLIGIN EESVEGTAIY LPGPDRCKMN PCLNGGTCYP 
TETSYVCTCV PGYSGDQCEL DFDECHSNPC RNGATCVDGF NTFRCLCLPS YVGALCEQDT 
ETCDYGWHKF QGQCYKYFAH RRTWDAAERE CRLQGAHLTS ILSHEEQMFV NRVGHDYQWI 
GLNDKMFEHD FRWTDGSTLQ YENWRPNQPD SFFSAGEDCV VIIWHENGQW NDVPCNYHLT 
YTCKKGTVAC GQPPVVENAK TFGKMKPRYE INSLIRYHCK DGFIQRHLPT IRCLGNGRWA 
IPKITCMNPS AYQRTYSMKY FKNSSSAKDN SINTSKHDHR WSRRWQESRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.