Details for: VCAN

Gene ID: 1462

Symbol: VCAN

Ensembl ID: ENSG00000038427

Description: versican

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 4.88
    Marker Score: 2760
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.06
    Marker Score: 226855
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.95
    Marker Score: 2642
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.48
    Marker Score: 4786
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.45
    Marker Score: 5316
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.18
    Marker Score: 41922
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.14
    Marker Score: 1358
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.08
    Marker Score: 1789
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.99
    Marker Score: 7445
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.79
    Marker Score: 31403
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.61
    Marker Score: 11261
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.55
    Marker Score: 29634
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.54
    Marker Score: 6241
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.54
    Marker Score: 1092
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.5
    Marker Score: 14805.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.41
    Marker Score: 42856
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.36
    Marker Score: 2923
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 2.32
    Marker Score: 2365
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.31
    Marker Score: 9582
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 2.29
    Marker Score: 1184
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.28
    Marker Score: 4447
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.28
    Marker Score: 14822
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.26
    Marker Score: 2418
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.26
    Marker Score: 4345
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.23
    Marker Score: 5837
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.22
    Marker Score: 2086
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.2
    Marker Score: 4592
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.19
    Marker Score: 1225
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.1
    Marker Score: 2398
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.08
    Marker Score: 70855
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.03
    Marker Score: 574
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.98
    Marker Score: 7658
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.98
    Marker Score: 6624
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.91
    Marker Score: 1062
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.8
    Marker Score: 1557
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.76
    Marker Score: 10716
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.76
    Marker Score: 648
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.74
    Marker Score: 1162
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.72
    Marker Score: 1829
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.7
    Marker Score: 818
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.66
    Marker Score: 691
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.64
    Marker Score: 1974
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.62
    Marker Score: 1069
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.55
    Marker Score: 33099
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.5
    Marker Score: 3052
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.48
    Marker Score: 1822
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167296
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.45
    Marker Score: 558
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.39
    Marker Score: 327
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.39
    Marker Score: 871
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.38
    Marker Score: 3252
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.38
    Marker Score: 1333
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.37
    Marker Score: 500
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.31
    Marker Score: 339
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.3
    Marker Score: 1689.5
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.27
    Marker Score: 803
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.23
    Marker Score: 1895
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.2
    Marker Score: 417
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.17
    Marker Score: 285
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.16
    Marker Score: 266
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.15
    Marker Score: 730
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.14
    Marker Score: 282
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.14
    Marker Score: 284
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.14
    Marker Score: 586
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.13
    Marker Score: 284
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.13
    Marker Score: 392
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.12
    Marker Score: 251
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 1.11
    Marker Score: 314
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.1
    Marker Score: 1206
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 1.08
    Marker Score: 321
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.06
    Marker Score: 35842
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.04
    Marker Score: 685
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.04
    Marker Score: 593
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.04
    Marker Score: 2507
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.03
    Marker Score: 5429
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.01
    Marker Score: 6098
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.01
    Marker Score: 15856
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71733
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47961
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.99
    Marker Score: 545
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.98
    Marker Score: 838
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.96
    Marker Score: 516
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.96
    Marker Score: 801.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.95
    Marker Score: 14279
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.93
    Marker Score: 23906
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.93
    Marker Score: 943
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.92
    Marker Score: 701
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5193
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.9
    Marker Score: 3753
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.9
    Marker Score: 233
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.9
    Marker Score: 301
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.89
    Marker Score: 2173
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.88
    Marker Score: 197
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.87
    Marker Score: 1084
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 655
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1378

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Other Information

**Key characteristics:** - Versican is a large protein with a molecular weight of approximately 160 kDa. - It is a transmembrane protein with a unique structure consisting of four tandem copies of a type III transmembrane domain. - Versican is a key component of the extracellular matrix (ECM) and plays a crucial role in cell adhesion, migration, and signaling. **Pathways and functions:** - Versican is involved in the synthesis of glycosaminoglycans (GAGs), a family of proteins that provide structural support and elasticity to the ECM. - It is required for the assembly of proteoglycans, which are important for cell adhesion, migration, and signaling. - Versican also plays a role in the degradation of chondroitin sulfate, a component of GAGs, and in the biosynthesis of dermatan sulfate, another important GAG. - It is involved in the regulation of insulin-like growth factor (IGF) transport and uptake by insulin-like growth factor binding proteins (IGFBs). **Clinical significance:** - Mutations in the VCAN gene have been linked to several diseases, including: - Edwards-Danlos syndrome, an inherited disorder characterized by intellectual disability, cardiac malformations, and skeletal abnormalities. - Marfan syndrome, a genetic disorder characterized by connective tissue abnormalities, cardiovascular disease, and eye problems. - Heterozygous mutations in VCAN have been associated with a condition called pseudo-Marfan syndrome, which is characterized by growth retardation, heart defects, and skeletal abnormalities. - Targeting the VCAN gene has been investigated as a therapeutic strategy for these diseases.

Genular Protein ID: 3881967781

Symbol: CSPG2_HUMAN

Name: Versican core protein

UniProtKB Accession Codes:

P13611 P20754 Q13010 Q13189 Q15123 Q9UCL9 Q9UNW5

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 6 CPTAC 2 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 25 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 1 PIR 1 PRINTS 1 PRO 1 PROSITE 11 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 13 RefSeq 4 SAM 1 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2583089

Title: Multiple domains of the large fibroblast proteoglycan, versican.

PubMed ID: 2583089

DOI: 10.1002/j.1460-2075.1989.tb08447.x

PubMed ID: 7806529

Title: A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican.

PubMed ID: 7806529

DOI: 10.1016/s0021-9258(20)30089-2

PubMed ID: 7528742

Title: Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter.

PubMed ID: 7528742

DOI: 10.1016/s0021-9258(20)30090-9

PubMed ID: 7876137

Title: Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissues.

PubMed ID: 7876137

DOI: 10.1074/jbc.270.8.3914

PubMed ID: 7921538

Title: Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry.

PubMed ID: 7921538

DOI: 10.1016/0945-053x(94)90185-6

PubMed ID: 1478664

Title: Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14).

PubMed ID: 1478664

DOI: 10.1016/s0888-7543(05)80103-x

PubMed ID: 2820964

Title: A fibroblast chondroitin sulfate proteoglycan core protein contains lectin-like and growth factor-like sequences.

PubMed ID: 2820964

DOI: 10.1016/s0021-9258(18)45176-9

PubMed ID: 10397680

Title: Versican/PG-M isoforms in vascular smooth muscle cells.

PubMed ID: 10397680

DOI: 10.1161/01.atv.19.7.1630

PubMed ID: 1429726

Title: Isolation of a large aggregating proteoglycan from human brain.

PubMed ID: 1429726

DOI: 10.1016/s0021-9258(18)35919-2

PubMed ID: 2466833

Title: Isolation and partial characterization of a glial hyaluronate-binding protein.

PubMed ID: 2466833

DOI: 10.1016/s0021-9258(18)83646-8

PubMed ID: 2469524

Title: Structural similarity of hyaluronate binding proteins in brain and cartilage.

PubMed ID: 2469524

DOI: 10.1016/0361-9230(89)90129-9

PubMed ID: 8627343

Title: Differential expression of versican isoforms in brain tumors.

PubMed ID: 8627343

DOI: 10.1097/00005072-199605000-00005

PubMed ID: 16043844

Title: Identification of a novel splice site mutation of the CSPG2 gene in a Japanese family with Wagner syndrome.

PubMed ID: 16043844

DOI: 10.1167/iovs.05-0057

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22739342

Title: Novel VCAN mutations and evidence for unbalanced alternative splicing in the pathogenesis of Wagner syndrome.

PubMed ID: 22739342

DOI: 10.1038/ejhg.2012.137

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 29777959

Title: Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix.

PubMed ID: 29777959

DOI: 10.1016/j.actbio.2018.05.023

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 36213313

Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.

PubMed ID: 36213313

DOI: 10.1007/s42485-022-00092-3

Sequence Information:

  • Length: 3396
  • Mass: 372820
  • Checksum: D174A1BBB8304FEC
  • Sequence:
    • MFINIKSILW MCSTLIVTHA LHKVKVGKSP PVRGSLSGKV SLPCHFSTMP TLPPSYNTSE 
FLRIKWSKIE VDKNGKDLKE TTVLVAQNGN IKIGQDYKGR VSVPTHPEAV GDASLTVVKL 
LASDAGLYRC DVMYGIEDTQ DTVSLTVDGV VFHYRAATSR YTLNFEAAQK ACLDVGAVIA 
TPEQLFAAYE DGFEQCDAGW LADQTVRYPI RAPRVGCYGD KMGKAGVRTY GFRSPQETYD 
VYCYVDHLDG DVFHLTVPSK FTFEEAAKEC ENQDARLATV GELQAAWRNG FDQCDYGWLS 
DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTGFPPPDSR FDAYCFKPKE ATTIDLSILA 
ETASPSLSKE PQMVSDRTTP IIPLVDELPV IPTEFPPVGN IVSFEQKATV QPQAITDSLA 
TKLPTPTGST KKPWDMDDYS PSASGPLGKL DISEIKEEVL QSTTGVSHYA TDSWDGVVED 
KQTQESVTQI EQIEVGPLVT SMEILKHIPS KEFPVTETPL VTARMILESK TEKKMVSTVS 
ELVTTGHYGF TLGEEDDEDR TLTVGSDEST LIFDQIPEVI TVSKTSEDTI HTHLEDLESV 
SASTTVSPLI MPDNNGSSMD DWEERQTSGR ITEEFLGKYL STTPFPSQHR TEIELFPYSG 
DKILVEGIST VIYPSLQTEM THRRERTETL IPEMRTDTYT DEIQEEITKS PFMGKTEEEV 
FSGMKLSTSL SEPIHVTESS VEMTKSFDFP TLITKLSAEP TEVRDMEEDF TATPGTTKYD 
ENITTVLLAH GTLSVEAATV SKWSWDEDNT TSKPLESTEP SASSKLPPAL LTTVGMNGKD 
KDIPSFTEDG ADEFTLIPDS TQKQLEEVTD EDIAAHGKFT IRFQPTTSTG IAEKSTLRDS 
TTEEKVPPIT STEGQVYATM EGSALGEVED VDLSKPVSTV PQFAHTSEVE GLAFVSYSST 
QEPTTYVDSS HTIPLSVIPK TDWGVLVPSV PSEDEVLGEP SQDILVIDQT RLEATISPET 
MRTTKITEGT TQEEFPWKEQ TAEKPVPALS STAWTPKEAV TPLDEQEGDG SAYTVSEDEL 
LTGSERVPVL ETTPVGKIDH SVSYPPGAVT EHKVKTDEVV TLTPRIGPKV SLSPGPEQKY 
ETEGSSTTGF TSSLSPFSTH ITQLMEETTT EKTSLEDIDL GSGLFEKPKA TELIEFSTIK 
VTVPSDITTA FSSVDRLHTT SAFKPSSAIT KKPPLIDREP GEETTSDMVI IGESTSHVPP 
TTLEDIVAKE TETDIDREYF TTSSPPATQP TRPPTVEDKE AFGPQALSTP QPPASTKFHP 
DINVYIIEVR ENKTGRMSDL SVIGHPIDSE SKEDEPCSEE TDPVHDLMAE ILPEFPDIIE 
IDLYHSEENE EEEEECANAT DVTTTPSVQY INGKHLVTTV PKDPEAAEAR RGQFESVAPS 
QNFSDSSESD THPFVIAKTE LSTAVQPNES TETTESLEVT WKPETYPETS EHFSGGEPDV 
FPTVPFHEEF ESGTAKKGAE SVTERDTEVG HQAHEHTEPV SLFPEESSGE IAIDQESQKI 
AFARATEVTF GEEVEKSTSV TYTPTIVPSS ASAYVSEEEA VTLIGNPWPD DLLSTKESWV 
EATPRQVVEL SGSSSIPITE GSGEAEEDED TMFTMVTDLS QRNTTDTLIT LDTSRIITES 
FFEVPATTIY PVSEQPSAKV VPTKFVSETD TSEWISSTTV EEKKRKEEEG TTGTASTFEV 
YSSTQRSDQL ILPFELESPN VATSSDSGTR KSFMSLTTPT QSEREMTDST PVFTETNTLE 
NLGAQTTEHS SIHQPGVQEG LTTLPRSPAS VFMEQGSGEA AADPETTTVS SFSLNVEYAI 
QAEKEVAGTL SPHVETTFST EPTGLVLSTV MDRVVAENIT QTSREIVISE RLGEPNYGAE 
IRGFSTGFPL EEDFSGDFRE YSTVSHPIAK EETVMMEGSG DAAFRDTQTS PSTVPTSVHI 
SHISDSEGPS STMVSTSAFP WEEFTSSAEG SGEQLVTVSS SVVPVLPSAV QKFSGTASSI 
IDEGLGEVGT VNEIDRRSTI LPTAEVEGTK APVEKEEVKV SGTVSTNFPQ TIEPAKLWSR 
QEVNPVRQEI ESETTSEEQI QEEKSFESPQ NSPATEQTIF DSQTFTETEL KTTDYSVLTT 
KKTYSDDKEM KEEDTSLVNM STPDPDANGL ESYTTLPEAT EKSHFFLATA LVTESIPAEH 
VVTDSPIKKE ESTKHFPKGM RPTIQESDTE LLFSGLGSGE EVLPTLPTES VNFTEVEQIN 
NTLYPHTSQV ESTSSDKIED FNRMENVAKE VGPLVSQTDI FEGSGSVTST TLIEILSDTG 
AEGPTVAPLP FSTDIGHPQN QTVRWAEEIQ TSRPQTITEQ DSNKNSSTAE INETTTSSTD 
FLARAYGFEM AKEFVTSAPK PSDLYYEPSG EGSGEVDIVD SFHTSATTQA TRQESSTTFV 
SDGSLEKHPE VPSAKAVTAD GFPTVSVMLP LHSEQNKSSP DPTSTLSNTV SYERSTDGSF 
QDRFREFEDS TLKPNRKKPT ENIIIDLDKE DKDLILTITE STILEILPEL TSDKNTIIDI 
DHTKPVYEDI LGMQTDIDTE VPSEPHDSND ESNDDSTQVQ EIYEAAVNLS LTEETFEGSA 
DVLASYTQAT HDESMTYEDR SQLDHMGFHF TTGIPAPSTE TELDVLLPTA TSLPIPRKSA 
TVIPEIEGIK AEAKALDDMF ESSTLSDGQA IADQSEIIPT LGQFERTQEE YEDKKHAGPS 
FQPEFSSGAE EALVDHTPYL SIATTHLMDQ SVTEVPDVME GSNPPYYTDT TLAVSTFAKL 
SSQTPSSPLT IYSGSEASGH TEIPQPSALP GIDVGSSVMS PQDSFKEIHV NIEATFKPSS 
EEYLHITEPP SLSPDTKLEP SEDDGKPELL EEMEASPTEL IAVEGTEILQ DFQNKTDGQV 
SGEAIKMFPT IKTPEAGTVI TTADEIELEG ATQWPHSTSA SATYGVEAGV VPWLSPQTSE 
RPTLSSSPEI NPETQAALIR GQDSTIAASE QQVAARILDS NDQATVNPVE FNTEVATPPF 
SLLETSNETD FLIGINEESV EGTAIYLPGP DRCKMNPCLN GGTCYPTETS YVCTCVPGYS 
GDQCELDFDE CHSNPCRNGA TCVDGFNTFR CLCLPSYVGA LCEQDTETCD YGWHKFQGQC 
YKYFAHRRTW DAAERECRLQ GAHLTSILSH EEQMFVNRVG HDYQWIGLND KMFEHDFRWT 
DGSTLQYENW RPNQPDSFFS AGEDCVVIIW HENGQWNDVP CNYHLTYTCK KGTVACGQPP 
VVENAKTFGK MKPRYEINSL IRYHCKDGFI QRHLPTIRCL GNGRWAIPKI TCMNPSAYQR 
TYSMKYFKNS SSAKDNSINT SKHDHRWSRR WQESRR

Genular Protein ID: 3533282208

Symbol: Q59FG9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FG9

Database IDs:

ARBA 16 BioGRID-ORCS 1 CDD 6 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 4 Genevisible 1 GenomeRNAi 1 InterPro 17 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 16 PROSITE-ProRule 3 PeptideAtlas 1 Pfam 5 PharmGKB 1 RefSeq 1 SAM 1 SMART 6 SUPFAM 4

Sequence Information:

  • Length: 3410
  • Mass: 374369
  • Checksum: 37872E30DF626185
  • Sequence:
    • IFPPNCNKPP SKAKMFINIK SILWMCSTLI VTHALHKVKV GKSPPVRGSL SGKVSLPCHF 
STMPTLPPSY NTSEFLRIKW SKIEVDKNGK DLKETTVLVA QNGNIKIGQD YKGRVSVPTH 
PEAVGDASLT VVKLLASDAG LYRCDVMYGI EDTQDTVSLT VDGVVFHYRA ATSRYTLNFE 
AAQKACLDVG AVIATPEQLF AAYEDGFEQC DAGWLADQTV RYPIRAPRVG CYGDKMGKAG 
VRTYGFRSPQ ETYDVYCYVD HLDGDVFHLT VPSKFTFEEA AKECENQDAR LATVGELQAA 
WRNGFDQCDY GWLSDASVRH PVTVARAQCG GGLLGVRTLY RFENQTGFPP PDSRFDAYCF 
KPKEATTIDL SILAETASPS LSKEPQMVSD RTTPIIPLVD ELPVIPTEFP PVGNIVSFEQ 
KATVQPQAIT DSLATKLPTP TGSTKKPWDM DDYSPSASGP LGKLDISEIK EEVLQSTTGV 
SHYATDSWDG VVEDKQTQES VTQIEQIEVG PLVTSMEILK HIPSKEFPVT ETPLVTARMI 
LESKTEKKMV STVSELVTTG HYGFTLGEED DEDRTLTVGS DESTLIFDQI PEVITVSKTS 
EDTIHTHLED LESVSASTTV SPLIMPDNNG SSMDDWEERQ TSGRITEEFL GKYLSTTPFP 
SQHRTEIELF PYSGDKILVE GISTVIYPSL QTEMTHRRER TETLIPEMRT DTYTDEIQEE 
ITKSPFMGKT EEEVFSGMKL STSLSEPIHV TESSVEMTKS FDFPTLITKL SAEPTEVRDM 
EEDFTATPGT TKYDENITTV LLAHGTLSVE AATVSKWSWD EDNTTSKPLE STEPSASSKL 
PPALLTTVGM NGKDKDIPSF TEDGADEFTL IPDSTQKQLE EVTDEDIAAH GKFTIRFQPT 
TSTGIAEKST LRDSTTEEKV PPITSTEGQV YATMEGSALG EVEDVDLSKP VSTVPQFAHT 
SEVEGLAFVS YSSTQEPTTY VDSSHTIPLS VIPKTDWGVL VPSVPSEDEV LGEPSQDILV 
IDQTRLEATI SPETMRTTKI TEGTTQEEFP WKEQTAEKPV PALSSTAWTP KEAVTPLDEQ 
EGDGSAYTVS EDELLTGSER VPVLETTPVG KIDHSVSYPP GAVTEHKVKT DEVVTLTPRI 
GPKVSLSPGP EQKYETEGSS TTGFTSSLSP FSTHITQLME ETTTEKTSLE DIDLGSGLFE 
KPKATELIEF STIKVTVPSD ITTAFSSVDR LHTTSAFKPS SAITKKPPLI DREPGEETTS 
DMVIIGESTS HVPPTTLEDI VAKETETDID REYFTTSSPP ATQPTRPPTV EDKEAFGPQA 
LSTPQPPAST KFHPDINVYI IEVRENKTGR MSDLSVIGHP IDSESKEDEP CSEETDPVHD 
LMAEILPEFP DIIEIDLYHS EENEEEEEEC ANATDVTTTP SVQYINGKHL VTTVPKDPEA 
AEARRGQFES VAPSQNFSDS SESDTHPFVI AKTELSTAVQ PNESTETTES LEVTWKPETY 
PETSEHFSGG EPDVFPTVPF HEEFESGTAK KGAESVTERD TEVGHQAHEH TEPVSLFPEE 
SSGEIAIDQE SQKIAFARAT EVTFGEEVEK STSVTYTPTI VPSSASAYVS EEEAVTLIGN 
PWPDDLLSTK ESWVEATPRQ VVELSGSSSI PITEGSGEAE EDEDTMFTMV TDLSQRNTTD 
TLITLDTSRI ITESFFEVPA TTIYPVSEQP SAKVVPTKFV SETDTSEWIS STTVEEKKRK 
EEEGTTGTAS TFEVYSSTQR SDQLILPFEL ESPNVATSSD SGTRKSFMSL TTPTQSEREM 
TDSTPVFTET NTLENLGAQT TEHSSIHQPG VQEGLTTLPR SPASVFMEQG SGEAAADPET 
TTVSSFSLNV EYAIQAEKEV AGTLSPHVET TFSTEPTGLV LSTVMDRVVA ENITQTSREI 
VISERLGEPN YGAEIRGFST GFPLEEDFSG DFREYSTVSH PIAKEETVMM EGSGDAAFRD 
TQTSPSTVPT SVHISHISDS EGPSSTMVST SAFPWEEFTS SAEGSGEQLV TVSSSVVPVL 
PSAVQKFSGT ASSIIDEGLG EVGTVNEIDR RSTILPTAEV EGTKAPVEKE EVKVSGTVST 
NFPQTIEPAK LWSRQEVNPV RQEIESETTS EEQIQEEKSF ESPQNSPATE QTIFDSQTFT 
ETELKTTDYS VLTTKKTYSD DKEMKEEDTS LVNMSTPDPD ANGLESYTTL PEATEKSHFF 
LATALVTESI PAEHVVTDSP IKKEESTKHF PKGMRPTIQE SDTELLFSGL GSGEEVLPTL 
PTESVNFTEV EQINNTLYPH TSQVESTSSD KIEDFNRMEN VAKEVGPLVS QTDIFEGSGS 
VTSTTLIEIL SDTGAEGPTV APLPFSTDIG HPQNQTVRWA EEIQTSRPQT ITEQDSNKNS 
STAEINETTT SSTDFLARAY GFEMAKEFVT SAPKPSDLYY EPSGEGSGEV DIVDSFHTSA 
TTQATRQESS TTFVSDGSLE KHPEVPSAKA VTADGFPTVL VMLPLHSEQN KSSPDPTSTL 
SNTVSYERST DGSFQDRFRE FEDSTLKPNR KKPTENIIID LDKEDKDLIL TITESTILEI 
LPELTSDKNT IIDIDHTKPV YEDILGMQTD IDTEVPSEPH DSNDESNDDS TQVQEIYEAA 
VNLSLTEETF EGSADVLASY TQATHDESMT YEDRSQLDHM GFHFTTGIPA PSTETELDVL 
LPTATSLPIP RKSATVIPEI EGIKAEAKAL DDMFESSTLS DGQAIADQSE IIPTLGQFER 
TQEEYEDKKH AGPSFQPEFS SGAEEALVDH TPYLSIATTH LMDQSVTEVP DVMEGSNPPY 
YTDTTLAVST FAKLSSQTPS SPLTIYSGSE ASGHTEIPQP SALPGIDVGS SVMSPQDSFK 
EIHVNIEATF KPSSEEYLHI TEPPSLSPDT KLEPSEDDGK PELLEEMEAS PTELIAVEGT 
EILQDFQNKT DGQVSGEAIK MFPTIKTPEA GTVITTADEI ELEGATQWPH STSASATYGV 
EAGVVPWLSP QTSERPTLSS SPEINPETQA ALIRGQDSTI AASEQQVAAR ILDSNDQATV 
NPVEFNTEVA TPPFSLLETS NETDFLIGIN EESVEGTAIY LPGPDRCKMN PCLNGGTCYP 
TETSYVCTCV PGYSGDQCEL DFDECHSNPC RNGATCVDGF NTFRCLCLPS YVGALCEQDT 
ETCDYGWHKF QGQCYKYFAH RRTWDAAERE CRLQGAHLTS ILSHEEQMFV NRVGHDYQWI 
GLNDKMFEHD FRWTDGSTLQ YENWRPNQPD SFFSAGEDCV VIIWHENGQW NDVPCNYHLT 
YTCKKGTVAC GQPPVVENAK TFGKMKPRYE INSLIRYHCK DGFIQRHLPT IRCLGNGRWA 
IPKITCMNPS AYQRTYSMKY FKNSSSAKDN SINTSKHDHR WSRRWQESRR

Genular Protein ID: 1572071638

Symbol: Q86W61_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86W61

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 8 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 1 Pfam 2 PharmGKB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 354
  • Mass: 39265
  • Checksum: 1EC99C686837C793
  • Sequence:
    • MFINIKSILW MCSTLIVTHA LHKVKVGKSP PVRGSLSGKV SLPCHFSTMP TLPPSYNTSE 
FLRIKWSKIE VDKNGKDLKE TTVLVAQNGN IKIGQDYKGR VSVPTHPEAV GDASLTVVKL 
LASDAGLYRC DVMYGIEDTQ DTVSLTVDGV VFHYRAATSR YTLNFEAAQK ACLDVGAVIA 
TPEQLFAAYE DGFEQCDAGW LADQTVRYPI RAPRVGCYGD KMGKAGVRTY GFRSPQETYD 
VYCYVDHLDG DVFHLTVPSK FTFEEAAKEC ENQDARLATV GELQAAWRNG FDQCDYGWLS 
DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTGFPPPDSR FDAYCFKRKC LIPF

Genular Protein ID: 1680537261

Symbol: Q6MZK8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6MZK8

Database IDs:

ARBA 7 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 11 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SMART 4 SUPFAM 3

Sequence Information:

  • Length: 2060
  • Mass: 226423
  • Checksum: D33CB7F70465D02E
  • Sequence:
    • MSDLSVIGHP IDSESKEDEP CSEETDPVHD LMAEILPEFP DIIEIDLYHS EENEEEEEEC 
ANATDVTTTP SVQYINGKHL VTTVPKDPEA AEARRGQFES VAPSQNFSDS SESDTHPFVI 
AKTELSTAVQ PNESTETTES LEVTWKPETY PETSEHFSGG EPDVFPTVPF HEEFESGTAR 
KGAESVTERD TEVGHQAHEH TEPVSLFPEE SSGEIAIDQE SQKIAFARAT EVTFGEEVEK 
STSVTYTPTI VPSSASAYVS EEEAVTLIGN PWPDDLLSTK ESWVEATPRQ VVELSGSSSI 
PITEGSGEAE EDEDTMFTMV TDLSQRNTTD TLITLDTSRI ITESFFEVPA TTIYPVSEQP 
SAKVVPTKFV SETDTSEWIS STTVEEKKRK EEEGTTGTAS TFEVYSSTQR SDQLILPFEL 
ESPNVATSSD SGTRKSFMSL TTPTRSEREM TDSTPVFTET NTLENLGAQT TEHSSIHQPG 
VQEGLTTLPH SPASVFMEQG SGEAAADPET TTVSSFSLNV EYAIQAEKEV AGTLSPHVET 
TFSTEPTGLV LSTVMDRVVA ENITQTSREI AISERLGEPN YGAEIRGFST GFPLEEDFSG 
DFREYSTVSH PIAKEETVMM EGSGDAAFRD TQTSPSTVPT SVHISHISDS EGPSSTMVST 
SAFPWEEFTS SAEGSGEQLV TVSSSVVPVL PSAVQKFSGT ASSIIDEGLG EVGTVNEIDR 
RSTILPTAEV EGTKAPVEKE EVKVSGTVST NFPQTIEPAK LWSRQEVNPV RQEIESETTS 
EEQIQEEKSF ESPQNSPATE QTIFDSQTFT ETELKTTDYS VLTTKKTYSD DKEMKEEDTS 
LVNMSTPDPD ANGLESYTTL PEATEKSHFF LATALVTESI PAEHVVTDSP IKKEESTKHF 
PKGMRPTIQE SDTELLFSGL GSGEEVLPTL PTESVNFTEV EQINNTLYPH TSQVESTSSD 
KIEDYNRMEN VAKEVGPLVS QTDIFEGSGS VTSTTLIEIL SDTGAEGPTV APLPFSTDIG 
HPQNQTVRWA EEIQTSRPQT ITEQDSNKNS STAEINETTT SSTDFLARAY GFEMAKEFVT 
SAPKPSDLYY EPSGEGSGEV DIVDSFHTSA TTQATRQESS TTFVSDGSLE KHPEVPSAKA 
VTADGFPTVS VMLPLHSEQN KSSPDPTSTL SNTVSYERST DGSFQDRFRE FEDSTLKPNR 
KKPTENIIID LDKEDKDLIL TITESTILEI LPELTSDKNT IIDIDHTKPV YEDILGMQTD 
IDTEVPSEPH DSNDESNDDS TQVQEIYEAA VNLSLTEETF EGSADVLASY TQATHDESMT 
YEDRSQLDHM GFHFTTGIPA PSTETELDVL LPTATSLPIP RKSATVIPEI EGIKAEAKAL 
DDMFESSTLS DGQAIADQSE IIPTLGQFER TQEEYEDKKH AGPSFQPEFS SGAEEALVDH 
TPYLSIATTH LMDQSVTEVP DVMEGSNPPY YTDTTLAVST FAKLSSQTPS SPLTIYSGSE 
ASGHTEIPQP SALPGIDVGS SVMSPQDSFK EIHVNIEATF KPSSEEYLHI TEPPSLSPDT 
KLEPSEDDGK PELLEEMEAS PTELIAVEGT EILQDFQNKT YGQVSGEAIK MFPTIKTPEA 
GTVITTADEI ELEGATQWPH STSASATYGV EAGVVPWLSP QTSERPTLSS SPEINPETQA 
ALIRGQDSTI AASEQQVAAR ILDSNDQATV NPVEFNTEVA TPPFSLLETS NETDFLIGIN 
EESVEGTAIY LPGPDRCKMN PCLNGGTCYP TETSYVCTCV PGYSGDQCEL DFDECHSNPC 
RNGATCVDGF NTFRCLCLPS YVGALCEQDT ETCDYGWHKF QGQCYKYFAH RRTWDAAERE 
CRLQGAHLTS ILSHEEQMFV NRVGHDYQWI GLNDKMFEHD FRWTDGSTLQ YENWRPNQPD 
SFFSAGEDCV VIIWHENGQW NDVPCNYHLT YTCKKGTVAC GQPPVVENAK TFGKMKPRYE 
INSLIRYHCK DGFIQRHLPT IRCLGNGRWA IPKITCMNPS AYQRTYSMKY FKNSSSAKDN 
SINTSKHDHR WSRRWQESRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.