Gclc | ENSMUSG00000032350 | NCBI 14629

Details for: Gclc

Gene ID: 14629

Symbol: Gclc

Ensembl ID: ENSMUSG00000032350

Description: glutamate-cysteine ligase, catalytic subunit

Associated with

Biological oxidations
(R-MMU-211859)
Glutathione conjugation
(R-MMU-156590)
Glutathione synthesis and recycling
(R-MMU-174403)
Metabolism
(R-MMU-1430728)
Phase ii - conjugation of compounds
(R-MMU-156580)
Adp binding
(GO:0043531)
Atp binding
(GO:0005524)
Blood vessel diameter maintenance
(GO:0097746)
Catalytic activity
(GO:0003824)
Cell redox homeostasis
(GO:0045454)
Cysteine metabolic process
(GO:0006534)
Cytosol
(GO:0005829)
Glutamate-cysteine ligase activity
(GO:0004357)
Glutamate-cysteine ligase complex
(GO:0017109)
Glutamate binding
(GO:0016595)
Glutamate metabolic process
(GO:0006536)
Glutathione biosynthetic process
(GO:0006750)
Glutathione metabolic process
(GO:0006749)
L-ascorbic acid metabolic process
(GO:0019852)
Ligase activity
(GO:0016874)
Magnesium ion binding
(GO:0000287)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of extrinsic apoptotic signaling pathway
(GO:2001237)
Negative regulation of hepatic stellate cell activation
(GO:2000490)
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
(GO:1901029)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of protein ubiquitination
(GO:0031397)
Nucleotide binding
(GO:0000166)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Regulation of mitochondrial depolarization
(GO:0051900)
Response to arsenic-containing substance
(GO:0046685)
Response to heat
(GO:0009408)
Response to hormone
(GO:0009725)
Response to nitrosative stress
(GO:0051409)
Response to oxidative stress
(GO:0006979)
Response to xenobiotic stimulus
(GO:0009410)

Other Information

Proteins

GCS heavy chain
Q3UNA7_MOUSE

Genular Protein ID: 1140993290

Symbol: GSH1_MOUSE

Name: GCS heavy chain

UniProtKB Accession Codes:

P97494 O09166 Q8VCS5

Database IDs:

Citations:

PubMed ID: 9223101

Title: Cloning/brain localization of mouse glutamylcysteine synthetase heavy chain mRNA.

PubMed ID: 9223101

DOI: 10.1097/00001756-199705260-00049

PubMed ID: 9224945

Title: Molecular cloning and sequencing of the cDNA encoding the catalytic subunit of mouse glutamate-cysteine ligase.

PubMed ID: 9224945

DOI: 10.1016/s0167-4781(97)00058-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16608839

Title: Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption.

PubMed ID: 16608839

DOI: 10.1074/jbc.m601876200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 637
Mass: 72571
Checksum: 8A176CD1DE49094C
Sequence:

MGLLSQGSPL SWEETQRHAD HVRRHGILQF LHIYHAVKDR HKDVLKWGDE VEYMLVSFDH 
ENRKVQLLLN GGDVLETLQE KGERTNPNHP TLWRPEYGSY MIEGTPGQPY GGTMSEFNTV 
EANMRKRRKE ATSVLGEHQA LCTITSFPRL GCPGFTLPEH RPNPEEGGAS KSLFFPDEAI 
NKHPRFGTLT RNIRHRRGEK VVINVPIFKD KNTPSPFVET FPEDAEASKA SQPDHIYMDA 
MGFGMGNCCL QVTFQACSIS EARYLYDQLA TICPIVMALS AASPFYRGYV SDIDCRWGVI 
SASVDDRTRE ERGLEPLKNN RFRISKSRYD SIDSYLSKCG EKYNDIDLTI DKEIYEQLLE 
EGIDHLLAQH VAHLFIRDPL TLFEEKIHLD DANESDHFEN IQSTNWQTMR FKPPPPNSDI 
GWRVEFRPME VQLTDFENSA YVVFVVLLTR VILSYKLDFL IPLSKVDENM KVAQKRDAVL 
QGMFYFRKDI CKGGNAVVDG CSKAQSSSEP AAEEYTLMSI DTIINGKEGV FPGLIPILNS 
YLENMEVDVD TRCSILNYLK LIKKRASGEL MTVARWMREF IANHPDYKQD SVITDEINYS 
LIWKCNQIAD ELCECPELLG SGFRKAKYSG GKSDPSA

Genular Protein ID: 2510107509

Symbol: Q3UNA7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UNA7

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 637
Mass: 72585
Checksum: 2F3E970B79669D79
Sequence:

MGLLSQGSPL SWEETQRHAD HVRRHGILQF LHIYHAVKDR HKDVLKWGDE VEYMLVSFDH 
ENRKVQLLLN GGDVLKTLQE KGERTNPNHP TLWRPEYGSY MIEGTPGQPY GGTMSEFNTV 
EANMRKRRKE ATSVLGEHQA LCTITSFPRL GCPGFTLPEH RPNPEEGGAS KSLFFPDEAI 
NKHPRFGTLT RNIRHRRGEK VVINVPIFKD KNTPSPFVET FPEDAEASKA SQPDHIYMDA 
MGFGMGNCCL QVTFQACSIS EARYLYDQLA TICPIVMALS AASPFYRGYV SDIDCRWGVI 
SASVDDRTRE ERGPEPLKNN RFRISKSRYD SIDSYLSKCG EKYNDIDLTI DKEIYEQLLE 
EGIDHLLAQH VAHLFIRDPL TLFEEKIHLD DANESDHFEN IQSTNWQTMR FKPPPPNSDI 
GWRVEFRPME VQLTDFENSA YVVFVVLLTR VILSYKLDFL IQLSKVDENM KVAQKRDAVL 
QGMFYFRKDI CKGGNAVVDG CSKAQSSSEP AAEEYTLMSI DTIINGKEGV FPGLIPILNS 
YLENMEVDVD TRCSILNYLK LIKKRASGEL MTVARWMREF IANHPDYKQD SVITDEINYS 
LIWKCNQIAD ELCECPELLG SGFRKAKYSG GKSDPSA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gclc

Associated with

Other Information

Cloning/brain localization of mouse glutamylcysteine synthetase heavy chain mRNA. PubMed ID: 9223101

Molecular cloning and sequencing of the cDNA encoding the catalytic subunit of mouse glutamate-cysteine ligase. PubMed ID: 9224945

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. PubMed ID: 16608839

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073