Gene NCAN - ENSG00000130287 | NCBI Gene ID: 1463

Details for: NCAN

Gene ID: 1463

Symbol: NCAN

Ensembl ID: ENSG00000130287

Description: neurocan

Associated with

A tetrasaccharide linker sequence is required for gag synthesis
(R-HSA-1971475)
Axon guidance
(R-HSA-422475)
Chondroitin sulfate/dermatan sulfate metabolism
(R-HSA-1793185)
Chondroitin sulfate biosynthesis
(R-HSA-2022870)
Cs/ds degradation
(R-HSA-2024101)
Defective b3galt6 causes edsp2 and semdjl1
(R-HSA-4420332)
Defective b3gat3 causes jdssdhd
(R-HSA-3560801)
Defective b4galt7 causes eds, progeroid type
(R-HSA-3560783)
Defective chst3 causes sedcjd
(R-HSA-3595172)
Defective chst14 causes eds, musculocontractural type
(R-HSA-3595174)
Defective chsy1 causes tpbs
(R-HSA-3595177)
Dermatan sulfate biosynthesis
(R-HSA-2022923)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases associated with glycosaminoglycan metabolism
(R-HSA-3560782)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Ecm proteoglycans
(R-HSA-3000178)
Extracellular matrix organization
(R-HSA-1474244)
Glycosaminoglycan metabolism
(R-HSA-1630316)
Heparan sulfate/heparin (hs-gag) metabolism
(R-HSA-1638091)
L1cam interactions
(R-HSA-373760)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Ncam1 interactions
(R-HSA-419037)
Ncam signaling for neurite out-growth
(R-HSA-375165)
Nervous system development
(R-HSA-9675108)
Calcium ion binding
(GO:0005509)
Carbohydrate binding
(GO:0030246)
Cell adhesion
(GO:0007155)
Central nervous system development
(GO:0007417)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glial cell differentiation
(GO:0010001)
Golgi lumen
(GO:0005796)
Hyaluronic acid binding
(GO:0005540)
Lysosomal lumen
(GO:0043202)
Perineuronal net
(GO:0072534)
Positive regulation of neuroblast proliferation
(GO:0002052)
Skeletal system development
(GO:0001501)
Synapse
(GO:0045202)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mature astrocyte (CL0002627)
Fold Change: 2.41
Marker Score: 1586
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.32
Marker Score: 49475
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.48
Marker Score: 50035
Cell Name: astrocyte (CL0000127)
Fold Change: 1.34
Marker Score: 1162
Cell Name: erythrocyte (CL0000232)
Fold Change: 1.33
Marker Score: 739
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 1.24
Marker Score: 722
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 1.23
Marker Score: 6471
Cell Name: neuron (CL0000540)
Fold Change: 1.22
Marker Score: 4966
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.2
Marker Score: 1845
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.17
Marker Score: 71738
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.1
Marker Score: 8458
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.05
Marker Score: 402
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.02
Marker Score: 38621
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71811
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48033
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: goblet cell (CL0000160)
Fold Change: 0.97
Marker Score: 6470
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2426
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.95
Marker Score: 8973
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5349
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2743
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.88
Marker Score: 3394
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.88
Marker Score: 1814
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5284
Cell Name: stellate neuron (CL0000122)
Fold Change: 0.85
Marker Score: 4556
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.82
Marker Score: 367
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1267
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.78
Marker Score: 3229
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 399
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.75
Marker Score: 27656
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.73
Marker Score: 14527
Cell Name: granule cell (CL0000120)
Fold Change: 0.72
Marker Score: 5397
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.71
Marker Score: 1194
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.71
Marker Score: 396
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.7
Marker Score: 6679
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.68
Marker Score: 7013
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.67
Marker Score: 834
Cell Name: macroglial cell (CL0000126)
Fold Change: 0.66
Marker Score: 1523
Cell Name: glial cell (CL0000125)
Fold Change: 0.65
Marker Score: 712
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 0.64
Marker Score: 2158
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.64
Marker Score: 262
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.63
Marker Score: 5415
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.63
Marker Score: 9422
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.62
Marker Score: 493
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.58
Marker Score: 2260
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.55
Marker Score: 1043
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.54
Marker Score: 864
Cell Name: ganglion interneuron (CL0000397)
Fold Change: 0.53
Marker Score: 161
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.53
Marker Score: 2449
Cell Name: mast cell (CL0000097)
Fold Change: 0.49
Marker Score: 287
Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.47
Marker Score: 225
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.46
Marker Score: 567
Cell Name: macrophage (CL0000235)
Fold Change: 0.45
Marker Score: 505
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.45
Marker Score: 451
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.43
Marker Score: 1782
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.41
Marker Score: 142
Cell Name: plasma cell (CL0000786)
Fold Change: 0.4
Marker Score: 443
Cell Name: B cell (CL0000236)
Fold Change: 0.38
Marker Score: 364
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.38
Marker Score: 764
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.36
Marker Score: 5657
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.34
Marker Score: 126
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.34
Marker Score: 95
Cell Name: interneuron (CL0000099)
Fold Change: 0.33
Marker Score: 151
Cell Name: microglial cell (CL0000129)
Fold Change: 0.32
Marker Score: 576
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.31
Marker Score: 161
Cell Name: T cell (CL0000084)
Fold Change: 0.3
Marker Score: 521
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.28
Marker Score: 672.5
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.26
Marker Score: 82
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.26
Marker Score: 731
Cell Name: melanocyte (CL0000148)
Fold Change: 0.25
Marker Score: 101
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.25
Marker Score: 582
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.24
Marker Score: 145
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.24
Marker Score: 144
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.23
Marker Score: 157
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.22
Marker Score: 2248
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.21
Marker Score: 117
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.19
Marker Score: 91
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.19
Marker Score: 141
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.19
Marker Score: 41
Cell Name: pericyte (CL0000669)
Fold Change: 0.19
Marker Score: 109
Cell Name: stromal cell (CL0000499)
Fold Change: 0.19
Marker Score: 217
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.18
Marker Score: 67
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.18
Marker Score: 44
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.18
Marker Score: 64
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.17
Marker Score: 56
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.16
Marker Score: 158
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.16
Marker Score: 55
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.16
Marker Score: 41
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.16
Marker Score: 144
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 0.15
Marker Score: 44
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.15
Marker Score: 141
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.15
Marker Score: 99
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.15
Marker Score: 43
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.15
Marker Score: 57
Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.15
Marker Score: 44
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.15
Marker Score: 37
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.14
Marker Score: 41.5
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.14
Marker Score: 43
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.14
Marker Score: 36

Hover over a box to see details here...

**Key characteristics:** - NCAN is a type I transmembrane protein with a molecular weight of approximately 150 kDa. - It is a glycoprotein with a unique structure consisting of four tandem repeats of a repeating unit. - Each repeat contains an N-terminal CUB domain that is responsible for binding to ECM proteins and an C-terminal FERM domain that is involved in protein-protein interactions. - NCAN is a transmembrane protein that is expressed in a variety of cell types, including astrocytes, neurons, and endothelial cells. **Pathways and functions:** - NCAN is involved in the assembly of the ECM, where it forms homodimers or heterodimers with other ECM proteins. - It is also involved in cell migration, adhesion, and signaling. - NCAN is a key regulator of neuronal survival, migration, and differentiation. - It is involved in the development and maintenance of the CNS, and its dysfunction has been linked to a number of neurological diseases. **Clinical significance:** - Mutations in the NCAN gene have been linked to a number of neurological diseases, including Alzheimer's disease, multiple sclerosis, and autism. - These mutations can affect the structure or function of NCAN, leading to the formation of abnormal ECMs that can promote inflammation and neuronal death. - Targeting NCAN has been explored as a therapeutic strategy for these diseases, but it has not been successful so far.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Neurocan core protein
Q4LE67_HUMAN

Genular Protein ID: 932628623

Symbol: NCAN_HUMAN

Name: Neurocan core protein

UniProtKB Accession Codes:

O14594 Q9UPK6

Database IDs:

Citations:

PubMed ID: 9795216

Title: Characterization of the human neurocan gene, CSPG3.

PubMed ID: 9795216

DOI: 10.1016/s0378-1119(98)00455-7

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

Sequence Information:

Length: 1321
Mass: 143093
Checksum: 22E21FFA24CE9FB2
Sequence:

MGAPFVWALG LLMLQMLLFV AGEQGTQDIT DASERGLHMQ KLGSGSVQAA LAELVALPCL 
FTLQPRPSAA RDAPRIKWTK VRTASGQRQD LPILVAKDNV VRVAKSWQGR VSLPSYPRRR 
ANATLLLGPL RASDSGLYRC QVVRGIEDEQ DLVPLEVTGV VFHYRSARDR YALTFAEAQE 
ACRLSSAIIA APRHLQAAFE DGFDNCDAGW LSDRTVRYPI TQSRPGCYGD RSSLPGVRSY 
GRRNPQELYD VYCFARELGG EVFYVGPARR LTLAGARAQC RRQGAALASV GQLHLAWHEG 
LDQCDPGWLA DGSVRYPIQT PRRRCGGPAP GVRTVYRFAN RTGFPSPAER FDAYCFRAHH 
PTSQHGDLET PSSGDEGEIL SAEGPPVREL EPTLEEEEVV TPDFQEPLVS SGEEETLILE 
EKQESQQTLS PTPGDPMLAS WPTGEVWLST VAPSPSDMGA GTAASSHTEV APTDPMPRRR 
GRFKGLNGRY FQQQEPEPGL QGGMEASAQP PTSEAAVNQM EPPLAMAVTE MLGSGQSRSP 
WADLTNEVDM PGAGSAGGKS SPEPWLWPPT MVPPSISGHS RAPVLELEKA EGPSARPATP 
DLFWSPLEAT VSAPSPAPWE AFPVATSPDL PMMAMLRGPK EWMLPHPTPI STEANRVEAH 
GEATATAPPS PAAETKVYSL PLSLTPTGQG GEAMPTTPES PRADFRETGE TSPAQVNKAE 
HSSSSPWPSV NRNVAVGFVP TETATEPTGL RGIPGSESGV FDTAESPTSG LQATVDEVQD 
PWPSVYSKGL DASSPSAPLG SPGVFLVPKV TPNLEPWVAT DEGPTVNPMD STVTPAPSDA 
SGIWEPGSQV FEEAESTTLS PQVALDTSIV TPLTTLEQGD KVGVPAMSTL GSSSSQPHPE 
PEDQVETQGT SGASVPPHQS SPLGKPAVPP GTPTAASVGE SASVSSGEPT VPWDPSSTLL 
PVTLGIEDFE LEVLAGSPGV ESFWEEVASG EEPALPGTPM NAGAEEVHSD PCENNPCLHG 
GTCNANGTMY GCSCDQGFAG ENCEIDIDDC LCSPCENGGT CIDEVNGFVC LCLPSYGGSF 
CEKDTEGCDR GWHKFQGHCY RYFAHRRAWE DAEKDCRRRS GHLTSVHSPE EHSFINSFGH 
ENTWIGLNDR IVERDFQWTD NTGLQFENWR ENQPDNFFAG GEDCVVMVAH ESGRWNDVPC 
NYNLPYVCKK GTVLCGPPPA VENASLIGAR KAKYNVHATV RYQCNEGFAQ HHVATIRCRS 
NGKWDRPQIV CTKPRRSHRM RRHHHHHQHH HQHHHHKSRK ERRKHKKHPT EDWEKDEGNF 
C

Genular Protein ID: 1210393860

Symbol: Q4LE67_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4LE67

Database IDs:

Sequence Information:

Length: 1335
Mass: 144643
Checksum: 4560E9CE87A699A7
Sequence:

RPPRDASELG ARSRMGAPFV WALGLLMLQM LLFVAGEQGT QDITDASERG LHMQKLGSGS 
VQAALAELVA LPCLFTLQPR PSAARDAPRI KWTKVRTASG QRQDLPILVA KDNVVRVAKS 
WQGRVSLPSY PRRRANATLL LGPLRASDSG LYRCQVVRGI EDEQDLVPLE VTGVVFHYRS 
ARDRYALTFA EAQEACRLSS AIIAAPRHLQ AAFEDGFDNC DAGWLSDRTV RYPITQSRPG 
CYGDRSSLPG VRSYGRRNPQ ELYDVYCFAR ELGGEVFYVG PARRLTLAGA RAQCRRQGAA 
LASVGQLHLA WHEGLDQCDP GWLADGSVRY PIQTPRRRCG GPAPGVRTVY RFANRTGFPS 
PAERFDAYCF RAHHPTSQHG DLETPSSGDE GEILSAEGPP VRELEPTLEE EEVVTPDFQE 
PLVSSGEEET LILEEKQESQ QTLSPTPGDP MLASWPTGEV WLSTVAPSPS DMGAGTAASS 
HTEVAPTDPM PRRRGRFKGL NGRYFQQQEP EPGLQGGMEA SAQPPTSEAA VNQMEPPLAM 
AVTEMLGSGQ SRSPWADLTN EVDMPGAGSA GGKSSPEPWL WPPTMVPPSI SGHSRAPVLE 
LEKAEGPSAR PATPDLFWSP LEATVSAPSP APWEAFPVAT SPDLPMMAML RGPKEWMLPH 
PTPISTEANR VEAHGEATAT APPSPAAETK VYSLPLSLTP TGQGGEAMPT TPESPRADFR 
ETGETSPAQV NKAEHSSSSP WPSVNRNVAV GFVPTETATE PTGLRGIPGS ESGVFDTAES 
PTSGLQATVD EVQDPWPSVY SKGLDASSPS APLGSPGVFL VPKVTPNLEP WVATDEGPTV 
NPMDSTVTPA PSDASGIWEP GSQVFEEAES TTLSPQVALD TSIVTPLTTL EQGDKVGVPA 
MSTLGSSSSQ PHPEPEDQVE TQGTSGASVP PHQSSPLGKP AVPPGTPTAA SVGESASVSS 
GEPTVPWDPS STLLPVTLGI EDFELEVLAG SPGVESFWEE VASGEEPALP GTPMNAGAEE 
VHSDPCENNP CLHGGTCNAN GTMYGCSCDQ GFAGENCEID IDDCLCSPCE NGGTCIDEVN 
GFVCLCLPSY GGSFCEKDTE GCDRGWHKFQ GHCYRYFAHR RAWEDAEKDC RRRSGHLTSV 
HSPEEHSFIN SFGHENTWIG LNDRIVERDF QWTDNTGLQF ENWRENQPDN FFAGGEDCVV 
MVAHESGRWN DVPCNYNLPY VCKKGTVLCG PPPAVENASL IGARKAKYNV HATVRYQCNE 
GFAQHHVATI RCRSNGKWDR PQIVCTKPRR SHRMRRHHHH HQHHHQHHHH KSRKERRKHK 
KHPTEDWEKD EGNFC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: NCAN

Associated with

Cells (max top 100)

Other Information

Characterization of the human neurocan gene, CSPG3. PubMed ID: 9795216

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. PubMed ID: 23234360

Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans. PubMed ID: 25326458

Database document:

PubMed ID: 9795216

PubMed ID: 15057824

PubMed ID: 23234360

PubMed ID: 25326458