Genular: Defining Cellular Identity and Function

Details for: Gli1

Gene ID: 14632

Symbol: Gli1

Ensembl ID: ENSMUSG00000025407

Description: GLI-Kruppel family member GLI1

Associated with

Degradation of gli1 by the proteasome
(R-MMU-5610780)
Hedgehog 'off' state
(R-MMU-5610787)
Hedgehog 'on' state
(R-MMU-5632684)
Signaling by hedgehog
(R-MMU-5358351)
Axoneme
(GO:0005930)
Cell differentiation
(GO:0030154)
Cerebellar cortex morphogenesis
(GO:0021696)
Chromatin binding
(GO:0003682)
Cilium
(GO:0005929)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Dorsal/ventral pattern formation
(GO:0009953)
Epidermal cell differentiation
(GO:0009913)
Gli-sufu complex
(GO:1990788)
Liver regeneration
(GO:0097421)
Lung development
(GO:0030324)
Metal ion binding
(GO:0046872)
Microtubule binding
(GO:0008017)
Multicellular organism development
(GO:0007275)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Notochord regression
(GO:0060032)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Osteoblast differentiation
(GO:0001649)
Pituitary gland development
(GO:0021983)
Positive regulation of cardiac muscle cell proliferation
(GO:0060045)
Positive regulation of cell cycle g1/s phase transition
(GO:1902808)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna replication
(GO:0045740)
Positive regulation of smoothened signaling pathway
(GO:0045880)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Proximal/distal pattern formation
(GO:0009954)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of hepatocyte proliferation
(GO:2000345)
Regulation of osteoblast differentiation
(GO:0045667)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to wounding
(GO:0009611)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Signal transduction
(GO:0007165)
Smoothened signaling pathway
(GO:0007224)
Spermatogenesis
(GO:0007283)
Transcription cis-regulatory region binding
(GO:0000976)
Ventral midline development
(GO:0007418)

Other Information

Proteins

Zinc finger protein GLI1

Genular Protein ID: 1541739700

Symbol: GLI1_MOUSE

Name: Zinc finger protein GLI1

UniProtKB Accession Codes:

P47806 G5E857 Q9QYK1

Database IDs:

Citations:

PubMed ID: 9524201

Title: Characterization of the promoter region and genomic organization of GLI, a member of the Sonic hedgehog-Patched signaling pathway.

PubMed ID: 9524201

DOI: 10.1016/s0378-1119(97)00668-9

PubMed ID: 10433919

Title: Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling.

PubMed ID: 10433919

DOI: 10.1242/dev.126.17.3915

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 8364225

Title: gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development.

PubMed ID: 8364225

DOI: 10.1002/aja.1001960203

PubMed ID: 19592253

Title: The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.

PubMed ID: 19592253

DOI: 10.1016/j.cub.2009.06.046

Sequence Information:

Length: 1111
Mass: 118560
Checksum: 8A83B254DCBB9BDC
Sequence:

MFNPMTPPQV NSYSEPCCLR PLHSQGVPSM GTEGLSGLPF CHQANFMSGS QGYGAARETS 
SCTEGSLFPP PPPPRSSVKL TKKRALSISP LSDASLDLQT VIRTSPSSLV AFINSRCTSP 
GGSYGHLSIG TMSPSLGFPP QMSHQKGTSP PYGVQPCVPH DSTRGSMMLH PQSRGPRATC 
QLKSELDMMV GKCPEDPLEG DMSSPNSTGT QDHLLGMLDG REDLEREEKP EPESVYETDC 
RWDGCSQEFD SQEQLVHHIN SEHIHGERKE FVCHWGGCSR ELRPFKAQYM LVVHMRRHTG 
EKPHKCTFEG CRKSYSRLEN LKTHLRSHTG EKPYMCEQEG CSKAFSNASD RAKHQNRTHS 
NEKPYVCKLP GCTKRYTDPS SLRKHVKTVH GPDAHVTKRH RGDGPLPRAQ PLSTVEPKRE 
REGGSGREES RLTVPESAMP QQSPGAQSSC SSDHSPAGSA ANTDSGVEMA GNAGGSTEDL 
SSLDEGPCVS ATGLSTLRRL ENLRLDQLHQ LRPIGSRGLK LPSLTHAGAP VSRRLGPPVS 
LDRRSSSSSS MSSAYTVSRR SSLASPFPPG TPPENGASSL PGLTPAQHYM LRARYASARG 
SGTPPTAAHS LDRMGGLSVP PWRSRTEYPG YNPNAGVTRR ASDPARAADH PAPARVQRFK 
SLGCVHTPPS VATGRNFDPH HPTSVYSPQP PSITENVAMD TRGLQEEPEV GTSVMGNGLN 
PYMDFSSTDT LGYGGPEGTA AEPYEARGPG SLPLGPGPPT NYGPGHCAQQ VSYPDPTPEN 
WGEFPSHAGV YPSNKAPGAA YSQCPRLEHY GQVQVKPEQG CPVGSDSTGL APCLNAHPSE 
GSPGPQPLFS HHPQLPQPQY PQSGPYPQPP HGYLSTEPRL GLNFNPSSSH STGQLKAQLV 
CNYVQSQQEL LWEGRNRGGL PNQELPYQSP KFLGGSQVSQ SPAKTPAAAA AAYGSGFAPA 
SANHKSGSYP APSPCHETFT VGVNRPSHRP AAPPRLLPPL SPCYGPLKVG DTNPSCGHPE 
VGRLGAGPAL YPPPEGQVCN ALDSLDLDNT QLDFVAILDE AQGLSPPLSH EQGDSSKNTP 
SPSGPPNMAV GNMSVLLGSL PGETQFLNSS A

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gli1

Associated with

Other Information

Characterization of the promoter region and genomic organization of GLI, a member of the Sonic hedgehog-Patched signaling pathway. PubMed ID: 9524201

Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. PubMed ID: 10433919

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303