Genular: Defining Cellular Identity and Function

Details for: Gli3

Gene ID: 14634

Symbol: Gli3

Ensembl ID: ENSMUSG00000021318

Description: GLI-Kruppel family member GLI3

Associated with

Gli3 is processed to gli3r by the proteasome
(R-MMU-5610785)
Hedgehog 'off' state
(R-MMU-5610787)
Hedgehog 'on' state
(R-MMU-5632684)
Signaling by hedgehog
(R-MMU-5358351)
Signal transduction
(R-MMU-162582)
Anterior/posterior pattern specification
(GO:0009952)
Apoptotic process
(GO:0006915)
Axon guidance
(GO:0007411)
Beta-catenin binding
(GO:0008013)
Brain development
(GO:0007420)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Camera-type eye development
(GO:0043010)
Cell population proliferation
(GO:0008283)
Central nervous system development
(GO:0007417)
Cerebral cortex radial glia-guided migration
(GO:0021801)
Chondrocyte differentiation
(GO:0002062)
Chromatin binding
(GO:0003682)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Dorsal/ventral pattern formation
(GO:0009953)
Embryonic digit morphogenesis
(GO:0042733)
Embryonic limb morphogenesis
(GO:0030326)
Forebrain development
(GO:0030900)
Forebrain dorsal/ventral pattern formation
(GO:0021798)
Forebrain radial glial cell differentiation
(GO:0021861)
Gene expression
(GO:0010467)
Heart development
(GO:0007507)
Hindgut morphogenesis
(GO:0007442)
Hippocampus development
(GO:0021766)
Histone acetyltransferase binding
(GO:0035035)
Histone deacetylase binding
(GO:0042826)
In utero embryonic development
(GO:0001701)
Kidney development
(GO:0001822)
Lateral ganglionic eminence cell proliferation
(GO:0022018)
Layer formation in cerebral cortex
(GO:0021819)
Limb morphogenesis
(GO:0035108)
Lung development
(GO:0030324)
Mammary gland development
(GO:0030879)
Mediator complex binding
(GO:0036033)
Melanocyte differentiation
(GO:0030318)
Metal ion binding
(GO:0046872)
Metanephros development
(GO:0001656)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of chondrocyte differentiation
(GO:0032331)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative thymic t cell selection
(GO:0045060)
Neural tube development
(GO:0021915)
Neuroblast proliferation
(GO:0007405)
Neuron differentiation
(GO:0030182)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Optic nerve morphogenesis
(GO:0021631)
Osteoblast differentiation
(GO:0001649)
Pallium development
(GO:0021543)
Pattern specification process
(GO:0007389)
Positive regulation of chondrocyte differentiation
(GO:0032332)
Positive regulation of neuroblast proliferation
(GO:0002052)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of protein import into nucleus
(GO:0042307)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Protein processing
(GO:0016485)
Proximal/distal pattern formation
(GO:0009954)
Regulation of apoptotic process
(GO:0042981)
Regulation of cell differentiation
(GO:0045595)
Regulation of cell population proliferation
(GO:0042127)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of smoothened signaling pathway
(GO:0008589)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Smoothened signaling pathway
(GO:0007224)
Smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
(GO:0021776)
Smoothened signaling pathway involved in ventral spinal cord interneuron specification
(GO:0021775)
Spinal cord dorsal/ventral patterning
(GO:0021513)
Spinal cord motor neuron differentiation
(GO:0021522)
Subpallium development
(GO:0021544)
T cell differentiation in thymus
(GO:0033077)
Telencephalon development
(GO:0021537)
Tongue development
(GO:0043586)
Tube development
(GO:0035295)

Other Information

Proteins

Transcriptional activator GLI3
Q3TYX7_MOUSE

Genular Protein ID: 2139489988

Symbol: GLI3_MOUSE

Name: Transcriptional activator GLI3

UniProtKB Accession Codes:

Q61602

Database IDs:

Citations:

PubMed ID: 8688459

Title: Cloning and sequence analysis of the murine Gli3 cDNA.

PubMed ID: 8688459

DOI: 10.1016/0167-4781(96)00079-6

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 1983115

Title: Evidence for allelism of the recessive insertional mutation add and the dominant mouse mutation extra-toes (Xt).

PubMed ID: 1983115

DOI: 10.1242/dev.110.4.1153

PubMed ID: 10051311

Title: The mouse mutation Pdn (Polydactyly Nagoya) is caused by the integration of a retrotransposon into the Gli3 gene.

PubMed ID: 10051311

DOI: 10.1007/s003359900973

PubMed ID: 10693759

Title: Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.

PubMed ID: 10693759

DOI: 10.1016/s0092-8674(00)80678-9

PubMed ID: 11053430

Title: Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins.

PubMed ID: 11053430

DOI: 10.1074/jbc.m004430200

PubMed ID: 17400206

Title: The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning.

PubMed ID: 17400206

DOI: 10.1016/j.ydbio.2007.02.029

PubMed ID: 19592253

Title: The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.

PubMed ID: 19592253

DOI: 10.1016/j.cub.2009.06.046

PubMed ID: 19389374

Title: Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3.

PubMed ID: 19389374

DOI: 10.1016/j.ydbio.2009.01.012

PubMed ID: 19549984

Title: The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling.

PubMed ID: 19549984

DOI: 10.1126/scisignal.2000405

PubMed ID: 20360384

Title: The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins.

PubMed ID: 20360384

DOI: 10.1101/gad.1902910

PubMed ID: 23955340

Title: Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis.

PubMed ID: 23955340

DOI: 10.1074/jbc.m113.492066

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 29263200

Title: WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.

PubMed ID: 29263200

DOI: 10.15252/embr.201744632

Sequence Information:

Length: 1583
Mass: 171655
Checksum: 37ECC0C3ACF26C24
Sequence:

MEAQAHSSTA TERKKAENSI GKCPTRTDVS EKAVASSTTS NEDESPGQIY HRERRNAITM 
QPQSVQGLNK ISEEPSTSSD ERASLIKKEI HGSLPHLAEP SLPYRGTVFA MDPRNGYMEP 
HYHPPHLFPA FHPPVPIDAR HHEGRYHYDP SPIPPLHVPS ALSSSPTYPD LPFIRISPHR 
NPTAASESPF SPPHPYINPY MDYIRSLHSS PSLSMISAAR GLSPTDAPHA GVSPAEYYHQ 
MALLTGQRSP YADILPSAAT AGAGAIHMEY LHAMDSTRFP SPRLSARPSR KRTLSISPLS 
DHSFDLQTMI RTSPNSLVTI LNNSRSSSSA SGSYGHLSAS AISPALSFTY PSAPVSLHMH 
QQILSRQQSL GSAFGHSPPL IHPAPTFPTQ RPIPGIPTVL NPVQVSSGPS ESSQSKPTSE 
SAVSSTGDPM HNKRSKIKPD EDLPSPGSRG QQEQPEGTTL VKEEADKDES KQEPEVIYET 
NCHWEGCTRE FDTQDQLVHH INNDHIHGEK KEFVCRWLDC SREQKPFKAQ YMLVVHMRRH 
TGEKPHKCTF EGCTKAYSRL ENLKTHLRSH TGEKPYVCEH EGCNKAFSNA SDRAKHQNRT 
HSNEKPYVCK IPGCTKRYTD PSSLRKHVKT VHGPEAHVTK KQRGDMHPRP PPPRDSGSHS 
QSRSPGRPTQ GAFGEQKELS NTTSKREECL QVKTVKAEKP MTSQPSPGGQ SSCSSQQSPI 
SNYSNSGLEL PLTDGGSVAD LSAIDETPIM DSTISTATTA LALQARRNPA GTKWMEHIKL 
ERLKQVNGMF PRLNPILPSK APAVSPLIGN GTQSNNNYSS GGPGTLLPSR SDLSGVDFTV 
LNTLNRRDSN TSTISSAYLS SRRSSGISPC FSSRRSSEAS QAEGRPQNVS VADSYDPIST 
DASRRSSEAS QGDGLPSLLS LTPVQQYRLK AKYAAATGGP PPTPLPHMER LSLKTKMALL 
GEGRDSGVTL PPVHPPRRCS DGGGHTYRGR HLMPHDALAN SVRRASDPVR TVSENMSLAR 
VQRFSSLNSF NPPNLPPSVE KRSLVLQNYT RQESSQPRYF QASPCPPSIT ENVALEALTM 
DADANLNDED LLPDDVVQYL NSQNQTGYGQ QLQSGISEDS KVAHEPEDLD LAGLPDSHVG 
QEYPALEQPC SEGSKTDLPI QWNEVSSGTS DLSSSKLKCG QQRPSAQQPR GFGLYNNMVV 
HPHNLWKVGT GPAGGYQTLG ENSSTYNGPE HFAIHSGDGL GTNGNTFHEQ PFKTQQYGSQ 
LNRQPLTSSA LDHACGTGIQ GSKLKGNSLQ ENGGLLDFSL SVAPNELAGN TVNGMQTQDQ 
MGQGYIAHQL LSGSMQHQGP SRPGQQVLGQ VGATSHINIY QGTESCLPGT QDNSSQPSSM 
AAIRGYQPCA SYGGNRRQAM PRGNLTLQQG QLSDMSQSSR VNSIKMEAQG QSQQLCSTVQ 
NYSGQFYDQT MGFSQQDRKA GSFSLSDANC LLQGNGTENS ELLSPGANQV TSTVDSFESH 
DLEGVQIDFD AIIDDGDHTS LMSGALSPSI IQNLSHSSSR LTTPRASLPF PSLSMGTTNM 
AIGDMSSLLT SLAEESKFLA VMQ

Genular Protein ID: 4162529024

Symbol: Q3TYX7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TYX7

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 535
Mass: 58238
Checksum: 83BFE56B42F152C7
Sequence:

MEAQAHSSTA TERKKAENSI GKCPTRTDVS EKAVASSTTS NEDESPGQIY HRERRNAITM 
QPQSVQGLNK ISEEPSTSSD ERASLIKKEI HGSLPHLAEP SLPYRGTVFA MDPRNGYMEP 
HYHPPHLFPA FHPPVPIDAR HHEGRYHYDP SPIPPLHVPS ALSSSPTYPD LPFIRISPHR 
NPTAASESPF SPPHPYINPY MDYIRSLHSS PSLSMISAAR GLSPTDAPHA GVSPAEYYHQ 
MALLTGQRSP YADILPSAAT AGAGAIHMEY LHAMDSTRFP SPRLSARPSR KRTLSISPLS 
DHSFDLQTMI RTSPNSLVTI LNNSRSSSSA SGSYGHLSAS AISPALSFTY PSAPVSLHMH 
QQILSRQQSL GSAFGHSPPL IHPAPTFPTQ RPIPGIPTVL NPVQVSSGPS ESSQSKPTSE 
SAVSSTGDPM HNKRSKIKPD EDLPSPGSRG QQEQPEGTTL VKEEADKDES KQEPEVIYET 
NCHWEGCTRE FDTQDQLVHV SGCCVGTDAA SQISDLCRRA AALTLRGVKF LSWQH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gli3

Associated with

Other Information

Cloning and sequence analysis of the murine Gli3 cDNA. PubMed ID: 8688459

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Evidence for allelism of the recessive insertional mutation add and the dominant mouse mutation extra-toes (Xt). PubMed ID: 1983115

The mouse mutation Pdn (Polydactyly Nagoya) is caused by the integration of a retrotransposon into the Gli3 gene. PubMed ID: 10051311

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. PubMed ID: 10693759

Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. PubMed ID: 11053430

The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. PubMed ID: 17400206

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. PubMed ID: 19592253

Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3. PubMed ID: 19389374

The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling. PubMed ID: 19549984

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. PubMed ID: 20360384

Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. PubMed ID: 23955340

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome. PubMed ID: 29263200

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073