Details for: CSPG4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: embryonic stem cell (CL0002322)
Fold Change: 27.2122
Cell Significance Index: -11.2100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.5874
Cell Significance Index: -10.2100 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.4849
Cell Significance Index: 3.0000 - Cell Name: perivascular cell (CL4033054)
Fold Change: 0.4700
Cell Significance Index: 2.1700 - Cell Name: preosteoblast (CL0007010)
Fold Change: 0.4672
Cell Significance Index: 4.2400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4093
Cell Significance Index: 26.4100 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.3538
Cell Significance Index: 1.5400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.1758
Cell Significance Index: 4.5200 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.1702
Cell Significance Index: 1.4300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1682
Cell Significance Index: 74.3700 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0863
Cell Significance Index: 1.3400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.0631
Cell Significance Index: 1.5400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0571
Cell Significance Index: 4.3800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0559
Cell Significance Index: 0.9400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0447
Cell Significance Index: 16.0300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0232
Cell Significance Index: 10.5500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0200
Cell Significance Index: 37.6000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0147
Cell Significance Index: 1.8900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0084
Cell Significance Index: 5.8300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0002
Cell Significance Index: -0.3500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0039
Cell Significance Index: -7.2600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0060
Cell Significance Index: -8.2000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0085
Cell Significance Index: -5.4100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0121
Cell Significance Index: -2.4400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0130
Cell Significance Index: -2.5800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0131
Cell Significance Index: -9.5700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0136
Cell Significance Index: -10.0800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0142
Cell Significance Index: -10.7600 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0162
Cell Significance Index: -8.8700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0179
Cell Significance Index: -10.1100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0184
Cell Significance Index: -5.3100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0221
Cell Significance Index: -2.3000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0313
Cell Significance Index: -4.5500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0335
Cell Significance Index: -6.0300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0420
Cell Significance Index: -5.7700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0506
Cell Significance Index: -10.6600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0535
Cell Significance Index: -6.2400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0538
Cell Significance Index: -9.1800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0597
Cell Significance Index: -7.3400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0646
Cell Significance Index: -6.6000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0691
Cell Significance Index: -8.9300 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0803
Cell Significance Index: -1.1500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0864
Cell Significance Index: -6.1100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0922
Cell Significance Index: -10.5600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1186
Cell Significance Index: -6.0000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1228
Cell Significance Index: -2.5700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1230
Cell Significance Index: -3.5300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1308
Cell Significance Index: -9.7500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1322
Cell Significance Index: -6.8900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1507
Cell Significance Index: -10.1300 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.1517
Cell Significance Index: -1.9100 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: -0.1663
Cell Significance Index: -1.2500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1672
Cell Significance Index: -8.6900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1695
Cell Significance Index: -9.5100 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1775
Cell Significance Index: -4.3000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1783
Cell Significance Index: -8.3800 - Cell Name: mural cell (CL0008034)
Fold Change: -0.2238
Cell Significance Index: -2.7300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2375
Cell Significance Index: -8.3200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2376
Cell Significance Index: -10.5100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2403
Cell Significance Index: -6.4400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2424
Cell Significance Index: -11.3000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2532
Cell Significance Index: -8.8000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2569
Cell Significance Index: -7.1800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2709
Cell Significance Index: -4.0000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2760
Cell Significance Index: -10.4500 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.2819
Cell Significance Index: -3.0700 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2988
Cell Significance Index: -10.9700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3002
Cell Significance Index: -9.5600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3033
Cell Significance Index: -9.9300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3172
Cell Significance Index: -8.4900 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.3227
Cell Significance Index: -5.1200 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.3244
Cell Significance Index: -8.0900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3262
Cell Significance Index: -8.7100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3266
Cell Significance Index: -9.6200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.3355
Cell Significance Index: -11.7900 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.3379
Cell Significance Index: -4.4100 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.3407
Cell Significance Index: -8.5100 - Cell Name: precursor cell (CL0011115)
Fold Change: -0.3468
Cell Significance Index: -2.6300 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3529
Cell Significance Index: -9.2800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3564
Cell Significance Index: -10.1700 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.3636
Cell Significance Index: -9.0700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3663
Cell Significance Index: -7.1500 - Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.3700
Cell Significance Index: -5.9700 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: -0.3708
Cell Significance Index: -3.9000 - Cell Name: melanocyte (CL0000148)
Fold Change: -0.3725
Cell Significance Index: -3.4900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3817
Cell Significance Index: -10.3900 - Cell Name: pro-B cell (CL0000826)
Fold Change: -0.3892
Cell Significance Index: -4.1900 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.3968
Cell Significance Index: -8.0800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.4012
Cell Significance Index: -11.5600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4036
Cell Significance Index: -10.3100 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.4039
Cell Significance Index: -10.2900 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.4174
Cell Significance Index: -13.2000 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.4224
Cell Significance Index: -9.2500 - Cell Name: ependymal cell (CL0000065)
Fold Change: -0.4239
Cell Significance Index: -5.0000 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.4279
Cell Significance Index: -5.4800 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.4331
Cell Significance Index: -17.7400 - Cell Name: fast muscle cell (CL0000190)
Fold Change: -0.4367
Cell Significance Index: -5.7200 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.4478
Cell Significance Index: -8.9300 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.4561
Cell Significance Index: -8.0600 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4666
Cell Significance Index: -10.0800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 667298284
Symbol: CSPG4_HUMAN
Name: Chondroitin sulfate proteoglycan 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8790396
Title: Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan.
PubMed ID: 8790396
PubMed ID: 15210734
Title: Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms.
PubMed ID: 15210734
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 9488735
Title: A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion.
PubMed ID: 9488735
PubMed ID: 10587647
Title: Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.
PubMed ID: 10587647
DOI: 10.1038/70302
PubMed ID: 11278606
Title: Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen.
PubMed ID: 11278606
PubMed ID: 12220645
Title: A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family.
PubMed ID: 12220645
PubMed ID: 15181153
Title: NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin.
PubMed ID: 15181153
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 25547119
Title: Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B.
PubMed ID: 25547119
DOI: 10.1038/cr.2014.169
PubMed ID: 27680706
Title: Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.
PubMed ID: 27680706
DOI: 10.1038/nature19799
PubMed ID: 31233493
Title: Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B.
PubMed ID: 31233493
PubMed ID: 32337544
Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.
PubMed ID: 32337544
PubMed ID: 36213313
Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.
PubMed ID: 36213313
Sequence Information:
- Length: 2322
- Mass: 250537
- Checksum: 0B4F39AFC5ADD3CA
- Sequence:
MQSGPRPPLP APGLALALTL TMLARLASAA SFFGENHLEV PVATALTDID LQLQFSTSQP EALLLLAAGP ADHLLLQLYS GRLQVRLVLG QEELRLQTPA ETLLSDSIPH TVVLTVVEGW ATLSVDGFLN ASSAVPGAPL EVPYGLFVGG TGTLGLPYLR GTSRPLRGCL HAATLNGRSL LRPLTPDVHE GCAEEFSASD DVALGFSGPH SLAAFPAWGT QDEGTLEFTL TTQSRQAPLA FQAGGRRGDF IYVDIFEGHL RAVVEKGQGT VLLHNSVPVA DGQPHEVSVH INAHRLEISV DQYPTHTSNR GVLSYLEPRG SLLLGGLDAE ASRHLQEHRL GLTPEATNAS LLGCMEDLSV NGQRRGLREA LLTRNMAAGC RLEEEEYEDD AYGHYEAFST LAPEAWPAME LPEPCVPEPG LPPVFANFTQ LLTISPLVVA EGGTAWLEWR HVQPTLDLME AELRKSQVLF SVTRGARHGE LELDIPGAQA RKMFTLLDVV NRKARFIHDG SEDTSDQLVL EVSVTARVPM PSCLRRGQTY LLPIQVNPVN DPPHIIFPHG SLMVILEHTQ KPLGPEVFQA YDPDSACEGL TFQVLGTSSG LPVERRDQPG EPATEFSCRE LEAGSLVYVH RGGPAQDLTF RVSDGLQASP PATLKVVAIR PAIQIHRSTG LRLAQGSAMP ILPANLSVET NAVGQDVSVL FRVTGALQFG ELQKQGAGGV EGAEWWATQA FHQRDVEQGR VRYLSTDPQH HAYDTVENLA LEVQVGQEIL SNLSFPVTIQ RATVWMLRLE PLHTQNTQQE TLTTAHLEAT LEEAGPSPPT FHYEVVQAPR KGNLQLQGTR LSDGQGFTQD DIQAGRVTYG ATARASEAVE DTFRFRVTAP PYFSPLYTFP IHIGGDPDAP VLTNVLLVVP EGGEGVLSAD HLFVKSLNSA SYLYEVMERP RHGRLAWRGT QDKTTMVTSF TNEDLLRGRL VYQHDDSETT EDDIPFVATR QGESSGDMAW EEVRGVFRVA IQPVNDHAPV QTISRIFHVA RGGRRLLTTD DVAFSDADSG FADAQLVLTR KDLLFGSIVA VDEPTRPIYR FTQEDLRKRR VLFVHSGADR GWIQLQVSDG QHQATALLEV QASEPYLRVA NGSSLVVPQG GQGTIDTAVL HLDTNLDIRS GDEVHYHVTA GPRWGQLVRA GQPATAFSQQ DLLDGAVLYS HNGSLSPRDT MAFSVEAGPV HTDATLQVTI ALEGPLAPLK LVRHKKIYVF QGEAAEIRRD QLEAAQEAVP PADIVFSVKS PPSAGYLVMV SRGALADEPP SLDPVQSFSQ EAVDTGRVLY LHSRPEAWSD AFSLDVASGL GAPLEGVLVE LEVLPAAIPL EAQNFSVPEG GSLTLAPPLL RVSGPYFPTL LGLSLQVLEP PQHGALQKED GPQARTLSAF SWRMVEEQLI RYVHDGSETL TDSFVLMANA SEMDRQSHPV AFTVTVLPVN DQPPILTTNT GLQMWEGATA PIPAEALRST DGDSGSEDLV YTIEQPSNGR VVLRGAPGTE VRSFTQAQLD GGLVLFSHRG TLDGGFRFRL SDGEHTSPGH FFRVTAQKQV LLSLKGSQTL TVCPGSVQPL SSQTLRASSS AGTDPQLLLY RVVRGPQLGR LFHAQQDSTG EALVNFTQAE VYAGNILYEH EMPPEPFWEA HDTLELQLSS PPARDVAATL AVAVSFEAAC PQRPSHLWKN KGLWVPEGQR ARITVAALDA SNLLASVPSP QRSEHDVLFQ VTQFPSRGQL LVSEEPLHAG QPHFLQSQLA AGQLVYAHGG GGTQQDGFHF RAHLQGPAGA SVAGPQTSEA FAITVRDVNE RPPQPQASVP LRLTRGSRAP ISRAQLSVVD PDSAPGEIEY EVQRAPHNGF LSLVGGGLGP VTRFTQADVD SGRLAFVANG SSVAGIFQLS MSDGASPPLP MSLAVDILPS AIEVQLRAPL EVPQALGRSS LSQQQLRVVS DREEPEAAYR LIQGPQYGHL LVGGRPTSAF SQFQIDQGEV VFAFTNFSSS HDHFRVLALA RGVNASAVVN VTVRALLHVW AGGPWPQGAT LRLDPTVLDA GELANRTGSV PRFRLLEGPR HGRVVRVPRA RTEPGGSQLV EQFTQQDLED GRLGLEVGRP EGRAPGPAGD SLTLELWAQG VPPAVASLDF ATEPYNAARP YSVALLSVPE AARTEAGKPE SSTPTGEPGP MASSPEPAVA KGGFLSFLEA NMFSVIIPMC LVLLLLALIL PLLFYLRKRN KTGKHDVQVL TAKPRNGLAG DTETFRKVEP GQAIPLTAVP GQGPPPGGQP DPELLQFCRT PNPALKNGQY WV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.