Genular: Defining Cellular Identity and Function

Details for: Glul

Gene ID: 14645

Symbol: Glul

Ensembl ID: ENSMUSG00000026473

Description: glutamate-ammonia ligase

Associated with

Astrocytic glutamate-glutamine uptake and metabolism
(R-MMU-210455)
Glutamate and glutamine metabolism
(R-MMU-8964539)
Metabolism
(R-MMU-1430728)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Neuronal system
(R-MMU-112316)
Neurotransmitter uptake and metabolism in glial cells
(R-MMU-112313)
Transmission across chemical synapses
(R-MMU-112315)
Ammonia assimilation cycle
(GO:0019676)
Angiogenesis
(GO:0001525)
Atp binding
(GO:0005524)
Axon terminus
(GO:0043679)
Catalytic activity
(GO:0003824)
Cell body
(GO:0044297)
Cell population proliferation
(GO:0008283)
Cell projection
(GO:0042995)
Cellular response to starvation
(GO:0009267)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dynein light chain binding
(GO:0045503)
Endoplasmic reticulum
(GO:0005783)
Glial cell projection
(GO:0097386)
Glutamate binding
(GO:0016595)
Glutamate metabolic process
(GO:0006536)
Glutamine biosynthetic process
(GO:0006542)
Glutamine synthetase activity
(GO:0004356)
Identical protein binding
(GO:0042802)
Intracellular membrane-bounded organelle
(GO:0043231)
Ligase activity
(GO:0016874)
Magnesium ion binding
(GO:0000287)
Manganese ion binding
(GO:0030145)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Myelin sheath
(GO:0043209)
Nickel cation binding
(GO:0016151)
Nitrogen compound metabolic process
(GO:0006807)
Nucleotide binding
(GO:0000166)
Perikaryon
(GO:0043204)
Plasma membrane
(GO:0005886)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Protein-containing complex
(GO:0032991)
Protein-cysteine s-palmitoyltransferase activity
(GO:0019706)
Protein binding
(GO:0005515)
Protein palmitoylation
(GO:0018345)
Regulation of endothelial cell migration
(GO:0010594)
Regulation of protein localization to nucleolus
(GO:1904749)
Regulation of sprouting angiogenesis
(GO:1903670)
Response to glucose
(GO:0009749)
Ribosome biogenesis
(GO:0042254)
Transferase activity
(GO:0016740)

Other Information

Proteins

GLNA_MOUSE

Genular Protein ID: 2136154491

Symbol: GLNA_MOUSE

Name: N/A

UniProtKB Accession Codes:

P15105 Q3TRK7 Q64432 Q91VC6

Database IDs:

Citations:

PubMed ID: 2475638

Title: Mouse glutamine synthetase is encoded by a single gene that can be expressed in a localized fashion.

PubMed ID: 2475638

DOI: 10.1016/0022-2836(89)90086-7

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16323283

Title: Molecular characterization and immunohistochemical localization of palmdelphin, a cytosolic isoform of the paralemmin protein family implicated in membrane dynamics.

PubMed ID: 16323283

DOI: 10.1016/j.ejcb.2005.07.002

PubMed ID: 17557305

Title: Glutamine synthetase is essential in early mouse embryogenesis.

PubMed ID: 17557305

DOI: 10.1002/dvdy.21185

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20107048

Title: Proteasomal degradation of glutamine synthetase regulates schwann cell differentiation.

PubMed ID: 20107048

DOI: 10.1523/jneurosci.3591-09.2010

PubMed ID: 25870278

Title: Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase.

PubMed ID: 25870278

DOI: 10.1073/pnas.1423968112

PubMed ID: 30158707

Title: Role of glutamine synthetase in angiogenesis beyond glutamine synthesis.

PubMed ID: 30158707

DOI: 10.1038/s41586-018-0466-7

Sequence Information:

Length: 373
Mass: 42120
Checksum: 1EC9CDC5D81DE63F
Sequence:

MATSASSHLN KGIKQMYMSL PQGEKVQAMY IWVDGTGEGL RCKTRTLDCE PKCVEELPEW 
NFDGSSTFQS EGSNSDMYLH PVAMFRDPFR KDPNKLVLCE VFKYNRKPAE TNLRHICKRI 
MDMVSNQHPW FGMEQEYTLM GTDGHPFGWP SNGFPGPQGP YYCGVGADKA YGRDIVEAHY 
RACLYAGVKI TGTNAEVMPA QWEFQIGPCE GIRMGDHLWI ARFILHRVCE DFGVIATFDP 
KPIPGNWNGA GCHTNFSTKA MREENGLKCI EEAIDKLSKR HQYHIRAYDP KGGLDNARRL 
TGFHETSNIN DFSAGVANRG ASIRIPRTVG QEKKGYFEDR RPSANCDPYA VTEAIVRTCL 
LNETGDEPFQ YKN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Glul

Associated with

Other Information

Mouse glutamine synthetase is encoded by a single gene that can be expressed in a localized fashion. PubMed ID: 2475638

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular characterization and immunohistochemical localization of palmdelphin, a cytosolic isoform of the paralemmin protein family implicated in membrane dynamics. PubMed ID: 16323283

Glutamine synthetase is essential in early mouse embryogenesis. PubMed ID: 17557305

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Proteasomal degradation of glutamine synthetase regulates schwann cell differentiation. PubMed ID: 20107048

Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase. PubMed ID: 25870278

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis. PubMed ID: 30158707