Details for: CSRP1

Gene ID: 1465

Symbol: CSRP1

Ensembl ID: ENSG00000159176

Description: cysteine and glycine rich protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.48
    Marker Score: 5832
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.9
    Marker Score: 1097.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.81
    Marker Score: 13805
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.61
    Marker Score: 4910
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.57
    Marker Score: 1830
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.55
    Marker Score: 2178
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.51
    Marker Score: 6119
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.44
    Marker Score: 1605.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.38
    Marker Score: 2265
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.32
    Marker Score: 825
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.32
    Marker Score: 10002
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.31
    Marker Score: 5437.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.3
    Marker Score: 49139
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.25
    Marker Score: 2774
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.23
    Marker Score: 5350
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.18
    Marker Score: 616
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.09
    Marker Score: 612
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.04
    Marker Score: 519
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.86
    Marker Score: 4872
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.86
    Marker Score: 1221
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.83
    Marker Score: 4018
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.81
    Marker Score: 573
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.79
    Marker Score: 2586.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.74
    Marker Score: 2396
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.74
    Marker Score: 6703
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.69
    Marker Score: 2997
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.68
    Marker Score: 1584
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.67
    Marker Score: 3802
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.66
    Marker Score: 4518
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.65
    Marker Score: 1431
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.63
    Marker Score: 680
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.63
    Marker Score: 2675
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.59
    Marker Score: 17897
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.58
    Marker Score: 10302
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.55
    Marker Score: 1096
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.55
    Marker Score: 497
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.53
    Marker Score: 617
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.49
    Marker Score: 2974
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.49
    Marker Score: 1793
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.47
    Marker Score: 756
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166621
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.44
    Marker Score: 3651
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.43
    Marker Score: 5609
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.41
    Marker Score: 1103
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.4
    Marker Score: 2155
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.39
    Marker Score: 47349
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.39
    Marker Score: 1494
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.39
    Marker Score: 3494
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.38
    Marker Score: 1959
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.37
    Marker Score: 755
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.36
    Marker Score: 1446
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.36
    Marker Score: 767
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.31
    Marker Score: 1033
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.3
    Marker Score: 684
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.3
    Marker Score: 2197
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.29
    Marker Score: 340
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.29
    Marker Score: 2044
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.28
    Marker Score: 1238
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.28
    Marker Score: 1156
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.27
    Marker Score: 739
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.24
    Marker Score: 899
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.24
    Marker Score: 2109
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.24
    Marker Score: 1286
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.24
    Marker Score: 1064
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.23
    Marker Score: 1810
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.23
    Marker Score: 895.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.21
    Marker Score: 18945
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.2
    Marker Score: 1601
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.2
    Marker Score: 1401
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.18
    Marker Score: 439
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.17
    Marker Score: 9156.5
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.17
    Marker Score: 736
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.16
    Marker Score: 29812.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.16
    Marker Score: 2230
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.15
    Marker Score: 1035
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.15
    Marker Score: 3617
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.14
    Marker Score: 262
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.12
    Marker Score: 2336
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.12
    Marker Score: 260
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.11
    Marker Score: 7105
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.11
    Marker Score: 4091.5
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.1
    Marker Score: 275
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.1
    Marker Score: 9504
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.1
    Marker Score: 5772.5
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.1
    Marker Score: 275
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.09
    Marker Score: 12719
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.09
    Marker Score: 1156
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.09
    Marker Score: 6617
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.08
    Marker Score: 6927
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.08
    Marker Score: 1098
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.08
    Marker Score: 1152
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.08
    Marker Score: 1388
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.07
    Marker Score: 14171
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.07
    Marker Score: 517
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.05
    Marker Score: 1115
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.05
    Marker Score: 702
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.04
    Marker Score: 36089
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.03
    Marker Score: 428
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.03
    Marker Score: 700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.03
    Marker Score: 473

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Other Information

**Key characteristics:** - It is a cysteine and glycine-rich protein. - It is highly expressed in smooth muscle cells, particularly in tissues such as the uterus, large intestine, and mammary gland. - It is also expressed in other cell types, including fibroblasts, renal interstitial cells, and myoepithelial cells. **Pathways and functions:** - CSRP1 is involved in the actinin binding pathway, which is essential for the organization and function of muscle tissues. - It is a key regulator of cellular responses to stimuli, including growth factor signaling and inflammation. - It is involved in the cytoplasm, extracellular exosome, focal adhesion, and platelet aggregation pathways. - It also plays a role in the regulation of muscle tissue development, maintenance, and regeneration. - CSRP1 is a key regulator of the development and function of the cardiovascular and skeletal muscle tissues. **Clinical significance:** - Mutations in the CSRP1 gene have been linked to various human diseases, including cancer and cardiovascular disease. - Studies of CSRP1 have implications for understanding muscle development, tissue repair, and cancer progression. - Targeting CSRP1 has been investigated as a potential therapeutic strategy for these diseases. **Additional information:** - The CSRP1 gene is also known as B4DY28. - It is a highly conserved protein, with similar sequences found in organisms from humans to flies. - It is a member of the cysteine and glycine-rich protein (CGRP) family of proteins.

Genular Protein ID: 3858872589

Symbol: CSRP1_HUMAN

Name: Cysteine and glycine-rich protein 1

UniProtKB Accession Codes:

P21291 A8K268 Q5U0J2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 10 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2115670

Title: Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif.

PubMed ID: 2115670

DOI: 10.1093/nar/18.13.3871

PubMed ID: 1374386

Title: Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc.

PubMed ID: 1374386

DOI: 10.1016/s0021-9258(19)50405-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26924529

Title: Mutations in subunits of the activating signal cointegrator 1 complex are associated with prenatal spinal muscular atrophy and congenital bone fractures.

PubMed ID: 26924529

DOI: 10.1016/j.ajhg.2016.01.006

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 193
  • Mass: 20567
  • Checksum: AC6970255D68D69A
  • Sequence:
    • MPNWGGGKKC GVCQKTVYFA EEVQCEGNSF HKSCFLCMVC KKNLDSTTVA VHGEEIYCKS 
CYGKKYGPKG YGYGQGAGTL STDKGESLGI KHEEAPGHRP TTNPNASKFA QKIGGSERCP 
RCSQAVYAAE KVIGAGKSWH KACFRCAKCG KGLESTTLAD KDGEIYCKGC YAKNFGPKGF 
GFGQGAGALV HSE

Genular Protein ID: 698947783

Symbol: B4DY28_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DY28

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 187
  • Mass: 20042
  • Checksum: 7EA5F53F50578B05
  • Sequence:
    • MPNWGGGKKC GVCQKTVYFA EEVQCEGNSF HKSCFLCMVC KKNLDSTTVA VHGEEIYCKS 
CYGKKYGPKG YGYGQGAGTL STDKGESLGI KHEEAPGHRP TTNPNASKFA QKIGGSERCP 
RCSQAVYAAE KSWHKACFRC AKCGKGLEST TLADKDGEIY CKGCYAKNFG PKGFGFGQGA 
GALVHSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.