Details for: CSRP1

Gene ID: 1465

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CSRP1

Ensembl ID: ENSG00000159176

Description: cysteine and glycine rich protein 1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • enteric smooth muscle cell CL0002504
    CSI 52.35
    rCSI 74.71%
    PRS 76.02
  • myoepithelial cell CL0000185
    CSI 44.26
    rCSI 100%
    PRS 80.42
  • fibroblast of lung CL0002553
    CSI 37.36
    rCSI 34.77%
    PRS 75.27
  • myofibroblast cell CL0000186
    CSI 37.24
    rCSI 51.58%
    PRS 72.87
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 33.35
    rCSI 63.05%
    PRS 87.29
  • alveolar type 1 fibroblast cell CL4028004
    CSI 31.29
    rCSI 34.27%
    PRS 77.13
  • smooth muscle cell CL0000192
    CSI 28.59
    rCSI 68.18%
    PRS 73.06
  • perivascular cell CL4033054
    CSI 28.44
    rCSI 38.88%
    PRS 79.46
  • bronchus fibroblast of lung CL2000093
    CSI 23.02
    rCSI 18.71%
    PRS 74.41
  • epithelial cell of lower respiratory tract CL0002632
    CSI 21.13
    rCSI 16.38%
    PRS 77.93
  • microcirculation associated smooth muscle cell CL0008035
    CSI 20.62
    rCSI 59.7%
    PRS 74.95
  • fallopian tube secretory epithelial cell CL4030006
    CSI 18.25
    rCSI 17.57%
    PRS 74.04
  • pancreatic ductal cell CL0002079
    CSI 17.79
    rCSI 34.6%
    PRS 77.7
  • basal cell of prostate epithelium CL0002341
    CSI 17.21
    rCSI 49.8%
    PRS 82.82
  • podocyte CL0000653
    CSI 17.01
    rCSI 75.61%
    PRS 74.93
  • tracheobronchial smooth muscle cell CL0019019
    CSI 15.84
    rCSI 27.94%
    PRS 80.87
  • vascular associated smooth muscle cell CL0000359
    CSI 15.44
    rCSI 50.09%
    PRS 73.12
  • stromal cell of ovary CL0002132
    CSI 13.88
    rCSI 38.13%
    PRS 83.15
  • ciliated cell CL0000064
    CSI 13.83
    rCSI 22.41%
    PRS 70.13
  • enterocyte CL0000584
    CSI 13.43
    rCSI 21.66%
    PRS 74.97
  • mammary gland epithelial cell CL0002327
    CSI 13.3
    rCSI 46.67%
    PRS 84.01
  • group 3 innate lymphoid cell CL0001071
    CSI 13.18
    rCSI 9.9%
    PRS 80.79
  • luminal epithelial cell of mammary gland CL0002326
    CSI 12.75
    rCSI 23.17%
    PRS 86.16
  • extravillous trophoblast CL0008036
    CSI 10.7
    rCSI 13.24%
    PRS 72.06
  • respiratory basal cell CL0002633
    CSI 10.52
    rCSI 10.89%
    PRS 79.47
  • smooth muscle cell of the pulmonary artery CL0002591
    CSI 9.56
    rCSI 73.29%
    PRS 77.74
  • pulmonary artery endothelial cell CL1001568
    CSI 9.03
    rCSI 12.29%
    PRS 84.37
  • uterine smooth muscle cell CL0002601
    CSI 8.9
    rCSI 58.52%
    PRS 84.93
  • lung macrophage CL1001603
    CSI 8.74
    rCSI 19.51%
    PRS 82.35
  • plasmablast CL0000980
    CSI 8.7
    rCSI 6.85%
    PRS 80.72
  • mesangial cell CL0000650
    CSI 8.7
    rCSI 35.47%
    PRS 84.71
  • pancreatic A cell CL0000171
    CSI 8.45
    rCSI 8.85%
    PRS 77.89
  • mononuclear phagocyte CL0000113
    CSI 8.41
    rCSI 18.5%
    PRS 78.77
  • stromal cell CL0000499
    CSI 8.39
    rCSI 23.62%
    PRS 69.87
  • pulmonary capillary endothelial cell CL4028001
    CSI 8.13
    rCSI 15.5%
    PRS 85.76
  • secretory cell CL0000151
    CSI 7.99
    rCSI 8.34%
    PRS 74.41
  • blood vessel endothelial cell CL0000071
    CSI 7.91
    rCSI 16.4%
    PRS 71.58
  • blood vessel smooth muscle cell CL0019018
    CSI 7.85
    rCSI 63.84%
    PRS 68.15
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 7.75
    rCSI 7%
    PRS 72.35
  • chondrocyte CL0000138
    CSI 7.36
    rCSI 11.7%
    PRS 67.16
  • melanocyte CL0000148
    CSI 7.28
    rCSI 5.39%
    PRS 67.51
  • pancreatic acinar cell CL0002064
    CSI 7.24
    rCSI 9.63%
    PRS 80.61
  • alternatively activated macrophage CL0000890
    CSI 6.98
    rCSI 8.77%
    PRS 84.82
  • goblet cell CL0000160
    CSI 6.89
    rCSI 6.51%
    PRS 73.83
  • enteroglial cell CL4040002
    CSI 6.62
    rCSI 34.81%
    PRS 76.94
  • alveolar macrophage CL0000583
    CSI 6.49
    rCSI 10.7%
    PRS 79.28
  • neural crest cell CL0011012
    CSI 6.32
    rCSI 5%
    PRS 62.29
  • hematopoietic stem cell CL0000037
    CSI 6.31
    rCSI 4.2%
    PRS 77.62
  • M cell of gut CL0000682
    CSI 6.3
    rCSI 6.7%
    PRS 81.22
  • intestine goblet cell CL0019031
    CSI 6.21
    rCSI 5.51%
    PRS 72.58
  • adipocyte CL0000136
    CSI 6.2
    rCSI 7.97%
    PRS 65.05
  • smooth muscle cell of prostate CL1000487
    CSI 6.13
    rCSI 36.01%
    PRS 83
  • intermediate monocyte CL0002393
    CSI 6.08
    rCSI 9.17%
    PRS 79.94
  • syncytiotrophoblast cell CL0000525
    CSI 5.94
    rCSI 17.1%
    PRS 82.99
  • CD4-positive helper T cell CL0000492
    CSI 5.87
    rCSI 4.44%
    PRS 87.28
  • renal interstitial pericyte CL1001318
    CSI 5.81
    rCSI 16.02%
    PRS 69.36
  • Bergmann glial cell CL0000644
    CSI 5.79
    rCSI 7.92%
    PRS 66.45
  • glial cell CL0000125
    CSI 5.66
    rCSI 21.53%
    PRS 64.95
  • pancreatic D cell CL0000173
    CSI 5.52
    rCSI 5.43%
    PRS 77.3
  • epithelial cell CL0000066
    CSI 5.48
    rCSI 8.41%
    PRS 65.62
  • lung neuroendocrine cell CL1000223
    CSI 5.46
    rCSI 8.08%
    PRS 79.32
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 5.41
    rCSI 15.51%
    PRS 91.75
  • Schwann cell CL0002573
    CSI 5.33
    rCSI 15.14%
    PRS 70.89
  • promyelocyte CL0000836
    CSI 5.32
    rCSI 7.67%
    PRS 81.7
  • colon epithelial cell CL0011108
    CSI 5.29
    rCSI 5.55%
    PRS 71.8
  • dendritic cell, human CL0001056
    CSI 5.04
    rCSI 7.74%
    PRS 83.81
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 5.02
    rCSI 3.82%
    PRS 87.36
  • bronchiolar smooth muscle cell CL4033017
    CSI 5.01
    rCSI 75.13%
    PRS 85.35
  • enteroendocrine cell CL0000164
    CSI 4.57
    rCSI 6.25%
    PRS 75.11
  • colonocyte CL1000347
    CSI 4.54
    rCSI 6.51%
    PRS 76.44
  • stem cell CL0000034
    CSI 4.43
    rCSI 4.27%
    PRS 66.97
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 4.32
    rCSI 4.24%
    PRS 88.74
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 4.27
    rCSI 3.07%
    PRS 87.84
  • elicited macrophage CL0000861
    CSI 4.23
    rCSI 3.89%
    PRS 83.11
  • skin fibroblast CL0002620
    CSI 4.09
    rCSI 3.52%
    PRS 76.91
  • mature astrocyte CL0002627
    CSI 4.08
    rCSI 17.33%
    PRS 66.51
  • hepatocyte CL0000182
    CSI 3.98
    rCSI 7.12%
    PRS 73.89
  • T follicular helper cell CL0002038
    CSI 3.68
    rCSI 2.76%
    PRS 87.93
  • type B pancreatic cell CL0000169
    CSI 3.64
    rCSI 8.06%
    PRS 73.57
  • interstitial cell of Cajal CL0002088
    CSI 3.64
    rCSI 4.63%
    PRS 80.14
  • lung pericyte CL0009089
    CSI 3.51
    rCSI 9.27%
    PRS 82.3
  • type EC enteroendocrine cell CL0000577
    CSI 3.51
    rCSI 12.45%
    PRS 80.31
  • hepatic stellate cell CL0000632
    CSI 3.45
    rCSI 12.91%
    PRS 66.6
  • keratinocyte CL0000312
    CSI 3.29
    rCSI 2.75%
    PRS 77.8
  • epithelial cell of lung CL0000082
    CSI 3.26
    rCSI 2.7%
    PRS 75.08
  • ciliated epithelial cell CL0000067
    CSI 3.21
    rCSI 2.82%
    PRS 63.11
  • ionocyte CL0005006
    CSI 3.18
    rCSI 3.41%
    PRS 75.37
  • myeloid leukocyte CL0000766
    CSI 3.16
    rCSI 2.91%
    PRS 76.32
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 3.12
    rCSI 4.09%
    PRS 86.41
  • midzonal region hepatocyte CL0019028
    CSI 3.06
    rCSI 7.18%
    PRS 75.82
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.97
    rCSI 4.21%
    PRS 70.95
  • basal cell CL0000646
    CSI 2.88
    rCSI 3.85%
    PRS 73.59
  • mesenchymal cell CL0008019
    CSI 2.85
    rCSI 7.24%
    PRS 68.13
  • mesenchymal stem cell CL0000134
    CSI 2.85
    rCSI 31.18%
    PRS 82.17
  • respiratory suprabasal cell CL4033048
    CSI 2.85
    rCSI 3.65%
    PRS 78.35
  • pancreatic stellate cell CL0002410
    CSI 2.79
    rCSI 16.24%
    PRS 80.23
  • club cell CL0000158
    CSI 2.78
    rCSI 4.07%
    PRS 69.4
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.76
    rCSI 6.2%
    PRS 56.69
  • pulmonary ionocyte CL0017000
    CSI 2.73
    rCSI 3.32%
    PRS 81.58
  • lung secretory cell CL1000272
    CSI 2.67
    rCSI 6.6%
    PRS 73.72
  • cytotoxic T cell CL0000910
    CSI 0.3
    rCSI 1.4%
    PRS 80.5%
  • megakaryocyte progenitor cell CL0000553
    CSI 0.3
    rCSI 4.7%
    PRS 93.5%
  • vasa recta descending limb cell CL1001285
    CSI 0.4
    rCSI 2.9%
    PRS 85.6%
  • luminal cell of prostate epithelium CL0002340
    CSI 0.5
    rCSI 2.5%
    PRS 83.4%
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.5
    rCSI 3.3%
    PRS 83.3%
  • tracheobronchial serous cell CL0019001
    CSI 0.5
    rCSI 2.3%
    PRS 83.5%
  • hair follicular keratinocyte CL2000092
    CSI 0.6
    rCSI 10.1%
    PRS 87.5%
  • P/D1 enteroendocrine cell CL0002268
    CSI 0.7
    rCSI 3.8%
    PRS 84.6%
  • endothelial cell of placenta CL0009092
    CSI 0.8
    rCSI 4.1%
    PRS 83.6%
  • parietal epithelial cell CL1000452
    CSI 0.8
    rCSI 2.2%
    PRS 65.6%
  • endocardial cell CL0002350
    CSI 0.9
    rCSI 4.1%
    PRS 71.7%
  • colon goblet cell CL0009039
    CSI 0.9
    rCSI 2.2%
    PRS 81.5%
  • transit amplifying cell CL0009010
    CSI 0.9
    rCSI 1.4%
    PRS 84.6%
  • acinar cell of salivary gland CL0002623
    CSI 1.0
    rCSI 22.8%
    PRS 88.5%
  • promonocyte CL0000559
    CSI 1.0
    rCSI 1.7%
    PRS 81.9%
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 1.0
    rCSI 1.2%
    PRS 82.9%
  • lung microvascular endothelial cell CL2000016
    CSI 1.0
    rCSI 19.7%
    PRS 84.9%
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 1.1
    rCSI 1.9%
    PRS 88.9%
  • foveolar cell of stomach CL0002179
    CSI 1.1
    rCSI 2.4%
    PRS 82.2%
  • enteroendocrine cell of small intestine CL0009006
    CSI 1.2
    rCSI 2.5%
    PRS 84.1%
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 1.3
    rCSI 2.5%
    PRS 88.0%
  • intestinal tuft cell CL0019032
    CSI 1.3
    rCSI 2.0%
    PRS 78.8%
  • mucous neck cell CL0000651
    CSI 1.3
    rCSI 1.9%
    PRS 82.9%
  • stratified epithelial cell CL0000079
    CSI 1.4
    rCSI 8.4%
    PRS 85.7%
  • forebrain radial glial cell CL0013000
    CSI 1.4
    rCSI 4.6%
    PRS 77.6%
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.4
    rCSI 1.8%
    PRS 53.9%
  • common myeloid progenitor CL0000049
    CSI 1.5
    rCSI 1.2%
    PRS 76.9%
  • pancreatic PP cell CL0002275
    CSI 1.5
    rCSI 5.9%
    PRS 83.5%
  • respiratory hillock cell CL4030023
    CSI 1.5
    rCSI 2.7%
    PRS 84.7%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.5
    rCSI 3.8%
    PRS 69.6%
  • multi-ciliated epithelial cell CL0005012
    CSI 1.5
    rCSI 1.5%
    PRS 68.3%
  • contractile cell CL0000183
    CSI 1.6
    rCSI 4.6%
    PRS 73.5%
  • neural progenitor cell CL0011020
    CSI 1.6
    rCSI 6.9%
    PRS 63.2%
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.6
    rCSI 1.2%
    PRS 77.0%
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 1.6
    rCSI 8.1%
    PRS 86.8%
  • placental villous trophoblast CL2000060
    CSI 1.7
    rCSI 2.6%
    PRS 73.6%
  • endothelial cell of uterus CL0009095
    CSI 1.7
    rCSI 12.5%
    PRS 85.1%
  • squamous epithelial cell CL0000076
    CSI 1.7
    rCSI 4.1%
    PRS 76.1%
  • peripheral nervous system neuron CL2000032
    CSI 1.8
    rCSI 2.4%
    PRS 66.0%
  • cerebral cortex endothelial cell CL1001602
    CSI 1.8
    rCSI 3.1%
    PRS 65.4%
  • epithelial cell of urethra CL1000296
    CSI 1.8
    rCSI 45.9%
    PRS 84.6%
  • mesodermal cell CL0000222
    CSI 1.8
    rCSI 2.2%
    PRS 72.7%
  • erythroid progenitor cell CL0000038
    CSI 1.9
    rCSI 10.6%
    PRS 81.2%
  • pulmonary alveolar type 1 cell CL0002062
    CSI 1.9
    rCSI 10.7%
    PRS 71.9%
  • alveolar adventitial fibroblast CL4028006
    CSI 1.9
    rCSI 2.9%
    PRS 76.4%
  • lung ciliated cell CL1000271
    CSI 1.9
    rCSI 2.2%
    PRS 66.2%
  • kidney connecting tubule epithelial cell CL1000768
    CSI 2.0
    rCSI 5.0%
    PRS 64.5%
  • glandular epithelial cell CL0000150
    CSI 2.0
    rCSI 5.2%
    PRS 88.3%
  • granulocyte monocyte progenitor cell CL0000557
    CSI 2.1
    rCSI 1.8%
    PRS 79.1%
  • class switched memory B cell CL0000972
    CSI 2.1
    rCSI 1.5%
    PRS 87.9%
  • intestinal epithelial cell CL0002563
    CSI 2.1
    rCSI 2.2%
    PRS 72.5%
  • duct epithelial cell CL0000068
    CSI 2.1
    rCSI 3.1%
    PRS 79.7%
  • vascular leptomeningeal cell CL4023051
    CSI 2.1
    rCSI 3.7%
    PRS 67.5%
  • granulocyte CL0000094
    CSI 2.1
    rCSI 3.3%
    PRS 82.9%
  • acinar cell CL0000622
    CSI 2.2
    rCSI 3.2%
    PRS 84.7%
  • adventitial cell CL0002503
    CSI 2.2
    rCSI 5.2%
    PRS 79.8%
  • kidney interstitial cell CL1000500
    CSI 2.2
    rCSI 36.0%
    PRS 81.1%
  • mucus secreting cell CL0000319
    CSI 2.3
    rCSI 3.6%
    PRS 83.9%
  • Langerhans cell CL0000453
    CSI 2.3
    rCSI 3.5%
    PRS 87.3%
  • activated type II NK T cell CL0000931
    CSI 2.3
    rCSI 2.6%
    PRS 88.9%
  • retinal blood vessel endothelial cell CL0002585
    CSI 2.4
    rCSI 3.8%
    PRS 78.3%
  • tuft cell of colon CL0009041
    CSI 2.4
    rCSI 5.6%
    PRS 82.4%
  • transit amplifying cell of colon CL0009011
    CSI 2.4
    rCSI 2.9%
    PRS 76.7%
  • cardiac neuron CL0010022
    CSI 2.4
    rCSI 7.8%
    PRS 71.6%
  • tendon cell CL0000388
    CSI 2.5
    rCSI 6.4%
    PRS 84.0%
  • megakaryocyte CL0000556
    CSI 2.5
    rCSI 10.9%
    PRS 82.1%
  • lung secretory cell CL1000272
    CSI 2.7
    rCSI 6.6%
    PRS 73.7%
  • pulmonary ionocyte CL0017000
    CSI 2.7
    rCSI 3.3%
    PRS 81.6%
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.8
    rCSI 6.2%
    PRS 56.7%
  • club cell CL0000158
    CSI 2.8
    rCSI 4.1%
    PRS 69.4%
  • pancreatic stellate cell CL0002410
    CSI 2.8
    rCSI 16.2%
    PRS 80.2%
  • respiratory suprabasal cell CL4033048
    CSI 2.9
    rCSI 3.7%
    PRS 78.4%
  • mesenchymal stem cell CL0000134
    CSI 2.9
    rCSI 31.2%
    PRS 82.2%
  • mesenchymal cell CL0008019
    CSI 2.9
    rCSI 7.2%
    PRS 68.1%
  • basal cell CL0000646
    CSI 2.9
    rCSI 3.9%
    PRS 73.6%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 3.0
    rCSI 4.2%
    PRS 71.0%
  • midzonal region hepatocyte CL0019028
    CSI 3.1
    rCSI 7.2%
    PRS 75.8%
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 3.1
    rCSI 4.1%
    PRS 86.4%
  • myeloid leukocyte CL0000766
    CSI 3.2
    rCSI 2.9%
    PRS 76.3%
  • ionocyte CL0005006
    CSI 3.2
    rCSI 3.4%
    PRS 75.4%
  • ciliated epithelial cell CL0000067
    CSI 3.2
    rCSI 2.8%
    PRS 63.1%
  • epithelial cell of lung CL0000082
    CSI 3.3
    rCSI 2.7%
    PRS 75.1%
  • keratinocyte CL0000312
    CSI 3.3
    rCSI 2.8%
    PRS 77.8%
  • hepatic stellate cell CL0000632
    CSI 3.5
    rCSI 12.9%
    PRS 66.6%
  • type EC enteroendocrine cell CL0000577
    CSI 3.5
    rCSI 12.5%
    PRS 80.3%
  • lung pericyte CL0009089
    CSI 3.5
    rCSI 9.3%
    PRS 82.3%
  • interstitial cell of Cajal CL0002088
    CSI 3.6
    rCSI 4.6%
    PRS 80.1%
  • type B pancreatic cell CL0000169
    CSI 3.6
    rCSI 8.1%
    PRS 73.6%
  • T follicular helper cell CL0002038
    CSI 3.7
    rCSI 2.8%
    PRS 87.9%
  • hepatocyte CL0000182
    CSI 4.0
    rCSI 7.1%
    PRS 73.9%
  • mature astrocyte CL0002627
    CSI 4.1
    rCSI 17.3%
    PRS 66.5%
  • skin fibroblast CL0002620
    CSI 4.1
    rCSI 3.5%
    PRS 76.9%
  • elicited macrophage CL0000861
    CSI 4.2
    rCSI 3.9%
    PRS 83.1%
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 4.3
    rCSI 3.1%
    PRS 87.8%
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 4.3
    rCSI 4.2%
    PRS 88.7%
  • stem cell CL0000034
    CSI 4.4
    rCSI 4.3%
    PRS 67.0%
  • colonocyte CL1000347
    CSI 4.5
    rCSI 6.5%
    PRS 76.4%
  • enteroendocrine cell CL0000164
    CSI 4.6
    rCSI 6.3%
    PRS 75.1%
  • bronchiolar smooth muscle cell CL4033017
    CSI 5.0
    rCSI 75.1%
    PRS 85.4%
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 5.0
    rCSI 3.8%
    PRS 87.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CSRP1](/details-gene/1465) (Cysteine and Glycine Rich Protein 1) is a protein-coding gene located on chromosome 1q32.1. It encodes a member of the LIM/double-finger protein family, characterized by a distinctive zinc-finger motif ([Link](https://doi.org/10.1093/nar/18.13.3871)). Functionally, [CSRP1](/details-gene/1465) is implicated as a structural protein involved in cytoskeletal organization and muscle development. Expression data indicates that **Overall**, [CSRP1](/details-gene/1465) is most significant in cells associated with contractility and structural support, such as `[enteric smooth muscle cell](/details-cell/CL0002504)`, `[myoepithelial cell](/details-cell/CL0000185)`, and various fibroblast populations. Its role appears to be tied to the organization of the sarcomere and focal adhesions, consistent with its function as a structural constituent of muscle and its ability to bind actin-associated proteins. ## Cellular Roles and Expression Landscape The expression profile of [CSRP1](/details-gene/1465) highlights its fundamental role in mesenchymal and myoepithelial cell lineages. **Overall**, the gene shows the highest significance in `[enteric smooth muscle cell](/details-cell/CL0002504)` (CSI: 52.35), `[myoepithelial cell](/details-cell/CL0000185)` (CSI: 44.26), and `[smooth muscle cell](/details-cell/CL0000192)` (CSI: 28.59), establishing it as a key marker for cells with contractile properties. Beyond muscle, [CSRP1](/details-gene/1465) is also a prominent marker in various stromal and structural cell types. It is highly significant in `[fibroblast of lung](/details-cell/CL0002553)` (CSI: 37.36), `[myofibroblast cell](/details-cell/CL0000186)` (CSI: 37.24), `[alveolar type 1 fibroblast cell](/details-cell/CL4028004)` (CSI: 31.29), and `[perivascular cell](/details-cell/CL4033054)` (CSI: 28.44). This pattern suggests a broad role in maintaining tissue architecture, mediating cell adhesion, and contributing to the extracellular matrix environment. Its expression is coordinately induced with c-myc in response to serum, suggesting a potential role in cellular proliferation and differentiation in these contexts ([Link](https://doi.org/10.1016/s0021-9258(19)50405-7)). ## Pathways and Molecular Function The molecular functions of [CSRP1](/details-gene/1465) are tightly linked to cytoskeletal architecture and cellular mechanics. Gene Ontology annotations classify it as a `[Structural constituent of muscle](/details-ontology/GO:0008307)` involved in biological processes such as `[Muscle tissue development](/details-ontology/GO:0060537)` and `[Sarcomere organization](/details-ontology/GO:0045214)`. This is further supported by its localization to the `[Z disc](/details-ontology/GO:0030018)` and `[Focal adhesion](/details-ontology/GO:0005925)`, critical sites for force transmission and cell-matrix interactions. At the molecular level, [CSRP1](/details-gene/1465) functions through protein-protein interactions, including `[Actinin binding](/details-ontology/GO:0042805)` and general `[protein binding](/details-ontology/GO:0005515)`. These interactions are central to its role in linking the actin cytoskeleton to adhesion complexes. Its involvement in Reactome pathways like `[Cellular responses to stimuli](/details-pathway/R-HSA-8953897)` and `[Response to metal ions](/details-pathway/R-HSA-5660526)` (related to its zinc-binding motif) suggests it acts as a signaling scaffold, translating external mechanical or chemical cues into changes in cell structure and behavior. Additionally, its annotation for `[Platelet aggregation](/details-ontology/GO:0070527)` points to a potential role in hemostasis and wound healing. ## Research Directions The specific and high expression of [CSRP1](/details-gene/1465) in myofibroblasts and smooth muscle cells suggests it could be a key player in pathological processes involving tissue remodeling, such as fibrosis and vascular disease. **Proposed Hypotheses:** 1. Given its high significance in `[myofibroblast cell](/details-cell/CL0000186)` and its role in focal adhesions, [CSRP1](/details-gene/1465) may be a critical mediator of fibroblast-to-myofibroblast differentiation, a hallmark of progressive fibrotic diseases like idiopathic pulmonary fibrosis (IPF) or liver cirrhosis. 2. Based on its expression in `[perivascular cell](/details-cell/CL4033054)` and `[smooth muscle cell](/details-cell/CL0000192)`, and its link to `[Platelet aggregation](/details-ontology/GO:0070527)`, [CSRP1](/details-gene/1465) could regulate vascular smooth muscle cell proliferation and migration during neointima formation following vascular injury. **Experimental Approach:** To test the hypothesis regarding its role in fibrosis, a compelling experiment would involve a loss-of-function study in a murine model of lung fibrosis. CRISPR-Cas9-mediated or conditional knockout of [CSRP1](/details-gene/1465) in fibroblasts could be performed. Following induction of fibrosis (e.g., via bleomycin administration), lung tissue would be analyzed. A reduction in collagen deposition (assessed by Masson's trichrome staining and hydroxyproline assays) and decreased expression of myofibroblast markers (e.g., alpha-smooth muscle actin) in knockout animals compared to wild-type controls would provide strong evidence for its pro-fibrotic role. **Therapeutic Potential:** The involvement of [CSRP1](/details-gene/1465) in myofibroblast activation makes it a plausible therapeutic target for anti-fibrotic therapies. As an intracellular scaffolding protein, targeting it would likely require the development of small molecule inhibitors or nucleic acid-based therapies (e.g., siRNA, ASOs) designed to disrupt its key protein-protein interactions or reduce its expression. **Inhibition** of [CSRP1](/details-gene/1465) function could potentially attenuate the progression of fibrosis in organs like the lung, liver, and kidney, representing a novel strategy to combat these debilitating diseases.

Genular Protein ID: 3858872589

Symbol: CSRP1_HUMAN

Name: Cysteine and glycine-rich protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2115670

Title: Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif.

PubMed ID: 2115670

DOI: 10.1093/nar/18.13.3871

PubMed ID: 1374386

Title: Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc.

PubMed ID: 1374386

DOI: 10.1016/s0021-9258(19)50405-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26924529

Title: Mutations in subunits of the activating signal cointegrator 1 complex are associated with prenatal spinal muscular atrophy and congenital bone fractures.

PubMed ID: 26924529

DOI: 10.1016/j.ajhg.2016.01.006

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 193
  • Mass: 20567
  • Checksum: AC6970255D68D69A
  • Sequence:
  • MPNWGGGKKC GVCQKTVYFA EEVQCEGNSF HKSCFLCMVC KKNLDSTTVA VHGEEIYCKS 
    CYGKKYGPKG YGYGQGAGTL STDKGESLGI KHEEAPGHRP TTNPNASKFA QKIGGSERCP 
    RCSQAVYAAE KVIGAGKSWH KACFRCAKCG KGLESTTLAD KDGEIYCKGC YAKNFGPKGF 
    GFGQGAGALV HSE

Genular Protein ID: 698947783

Symbol: B4DY28_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 187
  • Mass: 20042
  • Checksum: 7EA5F53F50578B05
  • Sequence:
  • MPNWGGGKKC GVCQKTVYFA EEVQCEGNSF HKSCFLCMVC KKNLDSTTVA VHGEEIYCKS 
    CYGKKYGPKG YGYGQGAGTL STDKGESLGI KHEEAPGHRP TTNPNASKFA QKIGGSERCP 
    RCSQAVYAAE KSWHKACFRC AKCGKGLEST TLADKDGEIY CKGCYAKNFG PKGFGFGQGA 
    GALVHSE