Details for: CSRP1

Gene ID: 1465

Symbol: CSRP1

Ensembl ID: ENSG00000159176

Description: cysteine and glycine rich protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 277.4756
    Cell Significance Index: -43.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 158.0566
    Cell Significance Index: -40.0900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 91.6257
    Cell Significance Index: -37.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 86.7923
    Cell Significance Index: -35.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 85.4651
    Cell Significance Index: -40.3500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 75.6048
    Cell Significance Index: -38.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.0466
    Cell Significance Index: -35.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.3111
    Cell Significance Index: -44.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.0242
    Cell Significance Index: -34.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.5153
    Cell Significance Index: -45.4400
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 11.1117
    Cell Significance Index: 58.4700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 10.7229
    Cell Significance Index: 66.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.7055
    Cell Significance Index: -29.8100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.1142
    Cell Significance Index: -15.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.7448
    Cell Significance Index: 74.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.5809
    Cell Significance Index: 333.4400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.0165
    Cell Significance Index: 35.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.9629
    Cell Significance Index: 92.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.9475
    Cell Significance Index: 267.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5148
    Cell Significance Index: 112.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4424
    Cell Significance Index: 67.2500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.4039
    Cell Significance Index: 8.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3354
    Cell Significance Index: 80.1700
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.3185
    Cell Significance Index: 6.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2179
    Cell Significance Index: 538.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0084
    Cell Significance Index: 71.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0029
    Cell Significance Index: 26.7800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9254
    Cell Significance Index: 21.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8601
    Cell Significance Index: 11.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7692
    Cell Significance Index: 22.0500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.7405
    Cell Significance Index: 6.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7371
    Cell Significance Index: 50.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6331
    Cell Significance Index: 345.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5721
    Cell Significance Index: 70.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5687
    Cell Significance Index: 102.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5022
    Cell Significance Index: 26.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4064
    Cell Significance Index: 52.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3651
    Cell Significance Index: 7.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3058
    Cell Significance Index: 8.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2660
    Cell Significance Index: 31.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2429
    Cell Significance Index: 8.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1893
    Cell Significance Index: 32.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1496
    Cell Significance Index: 67.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1310
    Cell Significance Index: 246.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1281
    Cell Significance Index: 24.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1168
    Cell Significance Index: 19.0000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0800
    Cell Significance Index: 0.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0784
    Cell Significance Index: 15.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0489
    Cell Significance Index: 1.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0271
    Cell Significance Index: 1.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0179
    Cell Significance Index: 0.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0154
    Cell Significance Index: 0.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0000
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0225
    Cell Significance Index: -14.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0249
    Cell Significance Index: -45.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0265
    Cell Significance Index: -19.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0278
    Cell Significance Index: -17.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0285
    Cell Significance Index: -2.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0346
    Cell Significance Index: -53.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0353
    Cell Significance Index: -2.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0404
    Cell Significance Index: -8.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0406
    Cell Significance Index: -4.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0414
    Cell Significance Index: -56.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0433
    Cell Significance Index: -24.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0677
    Cell Significance Index: -24.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0737
    Cell Significance Index: -3.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0882
    Cell Significance Index: -18.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1022
    Cell Significance Index: -11.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1044
    Cell Significance Index: -10.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1130
    Cell Significance Index: -13.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1245
    Cell Significance Index: -35.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1590
    Cell Significance Index: -2.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1603
    Cell Significance Index: -18.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2004
    Cell Significance Index: -1.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2122
    Cell Significance Index: -5.9300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2304
    Cell Significance Index: -11.6500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2401
    Cell Significance Index: -4.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2462
    Cell Significance Index: -35.7900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2943
    Cell Significance Index: -4.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2986
    Cell Significance Index: -6.2500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3116
    Cell Significance Index: -3.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3130
    Cell Significance Index: -6.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4206
    Cell Significance Index: -33.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4368
    Cell Significance Index: -17.9000
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.4579
    Cell Significance Index: -3.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4739
    Cell Significance Index: -29.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4952
    Cell Significance Index: -13.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5616
    Cell Significance Index: -43.0900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5686
    Cell Significance Index: -8.5200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.5729
    Cell Significance Index: -3.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6118
    Cell Significance Index: -41.1400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6190
    Cell Significance Index: -3.7400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6356
    Cell Significance Index: -10.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6737
    Cell Significance Index: -35.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6767
    Cell Significance Index: -41.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6778
    Cell Significance Index: -18.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6925
    Cell Significance Index: -43.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7418
    Cell Significance Index: -23.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7934
    Cell Significance Index: -20.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Properties**: CSRP1's unique amino acid sequence is characterized by a high content of cysteine and glycine residues, which contribute to its stability and interaction capabilities. 2. **Cellular Expression**: CSRP1 is expressed in a variety of cell types, including uterine smooth muscle cells, smooth muscle cells of the large intestine, and mammary gland epithelial cells, highlighting its role in maintaining tissue homeostasis. 3. **Protein-Protein Interactions**: CSRP1 interacts with various proteins, including actin, tropomyosin, and actinin, to regulate actin cytoskeleton organization and cell adhesion. 4. **Signaling Pathways**: CSRP1 is involved in signaling pathways that respond to cellular stimuli, metal ions, and RNA binding, further emphasizing its multifaceted role in cellular regulation. **Pathways and Functions:** CSRP1 is implicated in various cellular processes, including: 1. **Actinin Binding**: CSRP1 interacts with actinin to regulate actin cytoskeleton organization, which is crucial for cell motility, adhesion, and tissue structure. 2. **Cellular Responses to Stimuli**: CSRP1 is involved in signaling pathways that respond to cellular stimuli, such as metal ions and RNA binding, to regulate cellular responses. 3. **Muscle Tissue Development**: CSRP1 plays a role in muscle tissue development, particularly in the organization of the sarcomere and the structural constituent of the muscle. 4. **Platelet Aggregation**: CSRP1 interacts with platelet proteins to regulate platelet aggregation, which is essential for blood clotting. 5. **Zinc Ion Binding**: CSRP1 binds to zinc ions, which are essential for various cellular processes, including protein function and cell signaling. **Clinical Significance:** The dysregulation of CSRP1 has been implicated in various diseases, including: 1. **Muscle Disorders**: Mutations in CSRP1 have been linked to muscle disorders, such as muscular dystrophy and hypertrophic cardiomyopathy. 2. **Cancer**: CSRP1 has been identified as a potential oncogene, contributing to cancer progression and metastasis. 3. **Neurological Disorders**: CSRP1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation contributes to neuronal dysfunction. In conclusion, CSRP1 is a multifaceted protein that plays a crucial role in various cellular processes, including actin cytoskeleton organization, cell adhesion, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functional and clinical significance of CSRP1.

Genular Protein ID: 3858872589

Symbol: CSRP1_HUMAN

Name: Cysteine and glycine-rich protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2115670

Title: Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif.

PubMed ID: 2115670

DOI: 10.1093/nar/18.13.3871

PubMed ID: 1374386

Title: Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc.

PubMed ID: 1374386

DOI: 10.1016/s0021-9258(19)50405-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26924529

Title: Mutations in subunits of the activating signal cointegrator 1 complex are associated with prenatal spinal muscular atrophy and congenital bone fractures.

PubMed ID: 26924529

DOI: 10.1016/j.ajhg.2016.01.006

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 193
  • Mass: 20567
  • Checksum: AC6970255D68D69A
  • Sequence:
  • MPNWGGGKKC GVCQKTVYFA EEVQCEGNSF HKSCFLCMVC KKNLDSTTVA VHGEEIYCKS 
    CYGKKYGPKG YGYGQGAGTL STDKGESLGI KHEEAPGHRP TTNPNASKFA QKIGGSERCP 
    RCSQAVYAAE KVIGAGKSWH KACFRCAKCG KGLESTTLAD KDGEIYCKGC YAKNFGPKGF 
    GFGQGAGALV HSE

Genular Protein ID: 698947783

Symbol: B4DY28_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 187
  • Mass: 20042
  • Checksum: 7EA5F53F50578B05
  • Sequence:
  • MPNWGGGKKC GVCQKTVYFA EEVQCEGNSF HKSCFLCMVC KKNLDSTTVA VHGEEIYCKS 
    CYGKKYGPKG YGYGQGAGTL STDKGESLGI KHEEAPGHRP TTNPNASKFA QKIGGSERCP 
    RCSQAVYAAE KSWHKACFRC AKCGKGLEST TLADKDGEIY CKGCYAKNFG PKGFGFGQGA 
    GALVHSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.