Genular: Defining Cellular Identity and Function

Details for: Glrb

Gene ID: 14658

Symbol: Glrb

Ensembl ID: ENSMUSG00000028020

Description: glycine receptor, beta subunit

Associated with

Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Transmission across chemical synapses
(R-MMU-112315)
Acrosome reaction
(GO:0007340)
Adult walking behavior
(GO:0007628)
Cell projection
(GO:0042995)
Chemical synaptic transmission
(GO:0007268)
Chemical synaptic transmission, postsynaptic
(GO:0099565)
Chloride channel activity
(GO:0005254)
Chloride channel complex
(GO:0034707)
Chloride transmembrane transport
(GO:1902476)
Chloride transport
(GO:0006821)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Endoplasmic reticulum
(GO:0005783)
Excitatory extracellular ligand-gated monoatomic ion channel activity
(GO:0005231)
External side of plasma membrane
(GO:0009897)
Extracellular ligand-gated monoatomic ion channel activity
(GO:0005230)
Extracellularly glycine-gated chloride channel activity
(GO:0016934)
Extracellularly glycine-gated ion channel activity
(GO:0016933)
Gaba-ergic synapse
(GO:0098982)
Gamma-aminobutyric acid receptor clustering
(GO:0097112)
Glycine-gated chloride channel complex
(GO:0016935)
Glycine binding
(GO:0016594)
Glycinergic synapse
(GO:0098690)
Membrane
(GO:0016020)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Nervous system development
(GO:0007399)
Nervous system process
(GO:0050877)
Neuromuscular process
(GO:0050905)
Neuron projection
(GO:0043005)
Neuropeptide signaling pathway
(GO:0007218)
Neurotransmitter receptor activity
(GO:0030594)
Plasma membrane
(GO:0005886)
Postsynaptic membrane
(GO:0045211)
Postsynaptic specialization
(GO:0099572)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Regulation of membrane potential
(GO:0042391)
Regulation of postsynaptic membrane potential
(GO:0060078)
Righting reflex
(GO:0060013)
Startle response
(GO:0001964)
Synapse
(GO:0045202)
Synaptic transmission, glycinergic
(GO:0060012)
Transmembrane signaling receptor activity
(GO:0004888)
Transmembrane transporter complex
(GO:1902495)
Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
(GO:1904315)
Visual perception
(GO:0007601)

Other Information

Proteins

Glycine receptor subunit beta
A1KR23_MOUSE

Genular Protein ID: 1872743376

Symbol: GLRB_MOUSE

Name: Glycine receptor subunit beta

UniProtKB Accession Codes:

P48168 Q5U5X3

Database IDs:

Citations:

PubMed ID: 7920630

Title: Glycine receptor beta-subunit gene mutation in spastic mouse associated with LINE-1 element insertion.

PubMed ID: 7920630

DOI: 10.1038/ng0694-136

PubMed ID: 7946325

Title: The spastic mouse: aberrant splicing of glycine receptor beta subunit mRNA caused by intronic insertion of L1 element.

PubMed ID: 7946325

DOI: 10.1016/0896-6273(94)90265-8

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12809985

Title: Spinal inhibitory synaptic transmission in the glycine receptor mouse mutant spastic.

PubMed ID: 12809985

DOI: 10.1016/s0304-3940(03)00499-3

PubMed ID: 16672662

Title: Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator.

PubMed ID: 16672662

DOI: 10.1523/jneurosci.3991-05.2006

PubMed ID: 19723286

Title: Splice-specific roles of glycine receptor alpha3 in the hippocampus.

PubMed ID: 19723286

DOI: 10.1111/j.1460-9568.2009.06903.x

PubMed ID: 22592841

Title: Distribution of the glycine receptor beta-subunit in the mouse CNS as revealed by a novel monoclonal antibody.

PubMed ID: 22592841

DOI: 10.1002/cne.23139

Sequence Information:

Length: 496
Mass: 55951
Checksum: 554840A6DE9DE7BE
Sequence:

MKFSLAISFF ILMSLLFEDA CAKEKSSKKG KGKKKQYLCP SQQSPEDLAR VPPNSTSNIL 
NRLLVSYDPR IRPNFKGIPV DVVVNIFINS FGSIQETTMD YRVNIFLRQK WNDPRLKLPS 
DFRGSDALTV DPTMYKCLWK PDLFFANEKS ANFHDVTQEN ILLFIFRDGD VLVSMRLSIT 
LSCPLDLTLF PMDTQRCKMQ LESFGYTTDD LRFIWQSGDP VQLEKIALPQ FDIKKEDIEY 
GNCTKYYKGT GYYTCVEVIF TLRRQVGFYM MGVYAPTLLI VVLSWLSFWI NPDASAARVP 
LGIFSVLSLA SECTTLAAEL PKVSYVKALD VWLIACLLFG FASLVEYAVV QVMLNNPKRV 
EAEKARIAKA EQADGKGGNA AKKNTVNGTG TPVHISTLQV GETRCKKVCT SKSDLRSNDF 
SIVGSLPRDF ELSNYDCYGK PIEVNNGLGK PQAKNKKPPP AKPVIPTAAK RIDLYARALF 
PFCFLFFNVI YWSIYL

Genular Protein ID: 135779252

Symbol: A1KR23_MOUSE

Name: N/A

UniProtKB Accession Codes:

A1KR23

Database IDs:

Citations:

PubMed ID: 17145751

Title: A novel glycine receptor beta subunit splice variant predicts an unorthodox transmembrane topology. Assembly into heteromeric receptor complexes.

PubMed ID: 17145751

DOI: 10.1074/jbc.M608941200

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 445
Mass: 50140
Checksum: 7299E97C49A31875
Sequence:

MKFSLAISFF ILMSLLFEDA CAKEKSSKKG KGKKKQYLCP SQQSPEDLAR VPPNSTSNIL 
NRLLVSYDPR IRPNFKGIPV DVVVNIFINS FGSIQETTMD YRVNIFLRQK WNDPRLKLPS 
DFRGSDALTV DPTMYKCLWK PDLFFANEKS ANFHDVTQEN ILLFIFRDGD VLVSMRLSIT 
LSCPLDLTLF PMDTQRCKMQ LESFGYTTDD LRFIWQSGDP VQLEKIALPQ FDIKKEDIEY 
GNCTKYYKGT GIFSVLSLAS ECTTLAAELP KVSYVKALDV WLIACLLFGF ASLVEYAVVQ 
VMLNNPKRVE AEKARIAKAE QADGKGGNAA KKNTVNGTGT PVHISTLQVG ETRCKKVCTS 
KSDLRSNDFS IVGSLPRDFE LSNYDCYGKP IEVNNGLGKP QAKNKKPPPA KPVIPTAAKR 
IDLYARALFP FCFLFFNVIY WSIYL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Glrb

Associated with

Other Information

Glycine receptor beta-subunit gene mutation in spastic mouse associated with LINE-1 element insertion. PubMed ID: 7920630

The spastic mouse: aberrant splicing of glycine receptor beta subunit mRNA caused by intronic insertion of L1 element. PubMed ID: 7946325

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Spinal inhibitory synaptic transmission in the glycine receptor mouse mutant spastic. PubMed ID: 12809985

Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator. PubMed ID: 16672662

Splice-specific roles of glycine receptor alpha3 in the hippocampus. PubMed ID: 19723286

Distribution of the glycine receptor beta-subunit in the mouse CNS as revealed by a novel monoclonal antibody. PubMed ID: 22592841

A novel glycine receptor beta subunit splice variant predicts an unorthodox transmembrane topology. Assembly into heteromeric receptor complexes. PubMed ID: 17145751

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303