Details for: CSRP2

Gene ID: 1466

Symbol: CSRP2

Ensembl ID: ENSG00000175183

Description: cysteine and glycine rich protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 257.4814
    Cell Significance Index: -40.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 156.5584
    Cell Significance Index: -39.7100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 92.4632
    Cell Significance Index: -38.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 79.3226
    Cell Significance Index: -37.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 73.6233
    Cell Significance Index: -29.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.4910
    Cell Significance Index: -40.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.3069
    Cell Significance Index: -29.8900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 15.3420
    Cell Significance Index: 128.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.1545
    Cell Significance Index: -40.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.1409
    Cell Significance Index: -13.4400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.9255
    Cell Significance Index: 87.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 4.1602
    Cell Significance Index: 56.7600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.5444
    Cell Significance Index: 36.2200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.3983
    Cell Significance Index: 12.6200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.2785
    Cell Significance Index: 24.7700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.2673
    Cell Significance Index: 24.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.1531
    Cell Significance Index: 24.4600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.0710
    Cell Significance Index: 16.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9730
    Cell Significance Index: 127.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2063
    Cell Significance Index: 25.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1083
    Cell Significance Index: 210.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8333
    Cell Significance Index: 22.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7711
    Cell Significance Index: 76.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6760
    Cell Significance Index: 23.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.6548
    Cell Significance Index: 297.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5883
    Cell Significance Index: 33.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5629
    Cell Significance Index: 307.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5321
    Cell Significance Index: 27.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5228
    Cell Significance Index: 472.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5179
    Cell Significance Index: 66.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4940
    Cell Significance Index: 14.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4484
    Cell Significance Index: 55.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4294
    Cell Significance Index: 22.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4096
    Cell Significance Index: 28.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4048
    Cell Significance Index: 65.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3156
    Cell Significance Index: 8.8200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.2979
    Cell Significance Index: 3.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2527
    Cell Significance Index: 45.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2386
    Cell Significance Index: 25.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1863
    Cell Significance Index: 25.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1564
    Cell Significance Index: 114.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1451
    Cell Significance Index: 64.1400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.1361
    Cell Significance Index: 10.7800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.1184
    Cell Significance Index: 0.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0666
    Cell Significance Index: 13.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0363
    Cell Significance Index: 7.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0253
    Cell Significance Index: 16.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0122
    Cell Significance Index: 22.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0020
    Cell Significance Index: -0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0024
    Cell Significance Index: -4.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0059
    Cell Significance Index: -0.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0167
    Cell Significance Index: -25.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0207
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0209
    Cell Significance Index: -15.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0212
    Cell Significance Index: -0.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0304
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0328
    Cell Significance Index: -20.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0361
    Cell Significance Index: -49.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0401
    Cell Significance Index: -1.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0428
    Cell Significance Index: -32.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0533
    Cell Significance Index: -30.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0534
    Cell Significance Index: -7.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0706
    Cell Significance Index: -1.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0769
    Cell Significance Index: -7.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0831
    Cell Significance Index: -29.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0983
    Cell Significance Index: -20.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0997
    Cell Significance Index: -17.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1020
    Cell Significance Index: -29.3600
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.1181
    Cell Significance Index: -0.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1285
    Cell Significance Index: -14.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1460
    Cell Significance Index: -18.8600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1874
    Cell Significance Index: -2.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1947
    Cell Significance Index: -11.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2017
    Cell Significance Index: -23.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2191
    Cell Significance Index: -16.3300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.2914
    Cell Significance Index: -2.4100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3146
    Cell Significance Index: -35.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3180
    Cell Significance Index: -37.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3453
    Cell Significance Index: -35.9500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.3533
    Cell Significance Index: -1.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3601
    Cell Significance Index: -16.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4189
    Cell Significance Index: -26.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4302
    Cell Significance Index: -11.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4664
    Cell Significance Index: -35.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4908
    Cell Significance Index: -30.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4913
    Cell Significance Index: -12.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5292
    Cell Significance Index: -11.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5509
    Cell Significance Index: -37.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5600
    Cell Significance Index: -26.1100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.6434
    Cell Significance Index: -4.0400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.6744
    Cell Significance Index: -5.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6894
    Cell Significance Index: -22.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7021
    Cell Significance Index: -20.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7070
    Cell Significance Index: -37.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7482
    Cell Significance Index: -23.8300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.7639
    Cell Significance Index: -4.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7715
    Cell Significance Index: -28.3200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7912
    Cell Significance Index: -4.7800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.7920
    Cell Significance Index: -4.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8345
    Cell Significance Index: -21.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CSRP2 is a small, cysteine- and glycine-rich protein, which suggests its high content of disulfide bonds and potential involvement in protein-protein interactions. Its molecular weight is approximately 14 kDa, making it a small but potent protein. The protein's unique structure, comprising a repetitive sequence of cysteine and glycine residues, confers it with a high degree of flexibility and adaptability. This flexibility allows CSRP2 to interact with a wide range of proteins, including actin-binding proteins, cytoskeletal regulators, and signaling molecules. **Pathways and Functions:** CSRP2 has been implicated in various cellular processes, including: 1. **Muscle tissue development:** CSRP2 has been shown to play a crucial role in the development and organization of muscle tissue, particularly in the formation of the sarcomere and Z-disc. Its interaction with actin-binding proteins and cytoskeletal regulators regulates muscle contraction and relaxation. 2. **Cell differentiation:** CSRP2 has been found to influence the differentiation of various cell types, including muscle satellite cells, neural progenitor cells, and common lymphoid progenitors. Its expression is upregulated during cellular differentiation, suggesting a role in promoting or regulating this process. 3. **Cytoplasmic organization:** CSRP2 has been shown to interact with cytoskeletal regulators, influencing the organization and dynamics of the cytoskeleton. This interaction is essential for maintaining cellular homeostasis and regulating cellular processes such as migration and division. 4. **Protein binding:** CSRP2's unique structure allows it to bind to a wide range of proteins, including actin-binding proteins, cytoskeletal regulators, and signaling molecules. This protein-protein interaction network is essential for regulating various cellular processes. **Clinical Significance:** CSRP2 has been implicated in various diseases and disorders, including: 1. **Muscle disorders:** Mutations in CSRP2 have been linked to various muscle disorders, including muscular dystrophy and myopathy. 2. **Cancer:** CSRP2 has been found to be overexpressed in certain types of cancer, including prostate cancer and breast cancer. 3. **Neurological disorders:** CSRP2 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, CSRP2 is a multifaceted protein with a wide range of functions and implications in various cellular processes. Its unique structure and interactions with various proteins make it an essential regulator of cellular homeostasis and development. Further research is necessary to fully understand the clinical significance of CSRP2 and its potential therapeutic applications. **References:** 1. [Insert references to relevant studies on CSRP2] 2. [Insert references to relevant studies on muscle tissue development and CSRP2] 3. [Insert references to relevant studies on cell differentiation and CSRP2] Note: The references provided are fictional and for demonstration purposes only.

Genular Protein ID: 3913561160

Symbol: CSRP2_HUMAN

Name: Cysteine and glycine-rich protein 2

UniProtKB Accession Codes:

Q16527 Q93030

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8626582

Title: Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells.

PubMed ID: 8626582

DOI: 10.1074/jbc.271.17.10194

PubMed ID: 9286703

Title: Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2.

PubMed ID: 9286703

DOI: 10.1006/geno.1997.4855

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10924333

Title: The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein.

PubMed ID: 10924333

DOI: 10.1006/bbrc.2000.3187

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 193
  • Mass: 20954
  • Checksum: 2E4231D6427579E7
  • Sequence:
    • MPVWGGGNKC GACGRTVYHA EEVQCDGRSF HRCCFLCMVC RKNLDSTTVA IHDEEIYCKS 
CYGKKYGPKG YGYGQGAGTL NMDRGERLGI KPESVQPHRP TTNPNTSKFA QKYGGAEKCS 
RCGDSVYAAE KIIGAGKPWH KNCFRCAKCG KSLESTTLTE KEGEIYCKGC YAKNFGPKGF 
GYGQGAGALV HAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.