Details for: CSRP2

Gene ID: 1466

Symbol: CSRP2

Ensembl ID: ENSG00000175183

Description: cysteine and glycine rich protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.54
    Marker Score: 3015
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.27
    Marker Score: 3490
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.94
    Marker Score: 2093
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.85
    Marker Score: 6262.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.66
    Marker Score: 2535.5
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 2.64
    Marker Score: 1801
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.6
    Marker Score: 4534
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.39
    Marker Score: 9252
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.2
    Marker Score: 918
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.17
    Marker Score: 4086
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.1
    Marker Score: 15610
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.05
    Marker Score: 8043
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.03
    Marker Score: 3323
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.97
    Marker Score: 2074
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.97
    Marker Score: 7284
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.91
    Marker Score: 629
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.82
    Marker Score: 18461
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.78
    Marker Score: 3727
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.77
    Marker Score: 519
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.68
    Marker Score: 1854.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.67
    Marker Score: 13033
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.66
    Marker Score: 469
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.65
    Marker Score: 468
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.62
    Marker Score: 2741
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.59
    Marker Score: 619
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.59
    Marker Score: 3745
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.58
    Marker Score: 1487
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.55
    Marker Score: 1642
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.55
    Marker Score: 1035
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.54
    Marker Score: 383
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.54
    Marker Score: 20279
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.53
    Marker Score: 723
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.53
    Marker Score: 383
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.53
    Marker Score: 891
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.51
    Marker Score: 627
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.47
    Marker Score: 363
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.43
    Marker Score: 495
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.42
    Marker Score: 333
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.41
    Marker Score: 405
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.4
    Marker Score: 1314
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.36
    Marker Score: 11683
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.35
    Marker Score: 3628
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.35
    Marker Score: 431
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.33
    Marker Score: 339
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.33
    Marker Score: 1840
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.32
    Marker Score: 1893
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.31
    Marker Score: 1929
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.3
    Marker Score: 6367
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.26
    Marker Score: 3070.5
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.2
    Marker Score: 645.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.19
    Marker Score: 930
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.18
    Marker Score: 448
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.18
    Marker Score: 284
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.18
    Marker Score: 1817.5
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.17
    Marker Score: 1054
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.16
    Marker Score: 39532
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.14
    Marker Score: 255
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.14
    Marker Score: 1215
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.1
    Marker Score: 2188
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.07
    Marker Score: 1325
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.04
    Marker Score: 335
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.04
    Marker Score: 1170
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.02
    Marker Score: 344.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.02
    Marker Score: 640
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1
    Marker Score: 550
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71770
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47994
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.98
    Marker Score: 1418
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.96
    Marker Score: 1237
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.95
    Marker Score: 964
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.94
    Marker Score: 1786.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.92
    Marker Score: 2515.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.92
    Marker Score: 31805
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.91
    Marker Score: 546
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14282
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.91
    Marker Score: 944
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.9
    Marker Score: 590
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.89
    Marker Score: 8466
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.89
    Marker Score: 234
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5267
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.87
    Marker Score: 1193
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.87
    Marker Score: 837
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4892
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.85
    Marker Score: 240
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.84
    Marker Score: 284
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.83
    Marker Score: 2786
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.82
    Marker Score: 1031.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 625
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.82
    Marker Score: 327
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.81
    Marker Score: 437
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.79
    Marker Score: 904
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.78
    Marker Score: 842
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.78
    Marker Score: 206
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.78
    Marker Score: 2760

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Other Information

**Key characteristics** - The protein is a cysteine and glycine-rich protein (CGRP). - It is a secreted protein that is expressed in high levels in skeletal muscle, cardiac muscle, and connective tissue. - It is a key component of the cytoskeleton, where it is involved in the organization of muscle fibers. - It is also involved in the regulation of cell signaling pathways, and it has been shown to play a role in cell differentiation and migration. **Pathways and functions** - CSRP2 is involved in cell differentiation by promoting the migration of skeletal muscle satellite stem cells to the developing embryo. - It is also involved in the regulation of cell survival and proliferation in muscle tissue. - It is involved in the maintenance of muscle structure and function by regulating the assembly and disassembly of muscle fibers. - CSRP2 is also involved in the regulation of cell signaling pathways, and it has been shown to play a role in cell differentiation and migration. **Clinical significance** - Mutations in the CSRP2 gene have been linked to a number of human diseases, including cancer, heart disease, and kidney disease. - These diseases are characterized by the abnormal growth and proliferation of cells, and CSRP2 is a key target for therapy in these diseases. - By targeting CSRP2, it is possible to inhibit the growth and proliferation of cancer cells and to treat heart disease and kidney disease.

Genular Protein ID: 3913561160

Symbol: CSRP2_HUMAN

Name: Cysteine and glycine-rich protein 2

UniProtKB Accession Codes:

Q16527 Q93030

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8626582

Title: Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells.

PubMed ID: 8626582

DOI: 10.1074/jbc.271.17.10194

PubMed ID: 9286703

Title: Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2.

PubMed ID: 9286703

DOI: 10.1006/geno.1997.4855

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10924333

Title: The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein.

PubMed ID: 10924333

DOI: 10.1006/bbrc.2000.3187

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 193
  • Mass: 20954
  • Checksum: 2E4231D6427579E7
  • Sequence:
    • MPVWGGGNKC GACGRTVYHA EEVQCDGRSF HRCCFLCMVC RKNLDSTTVA IHDEEIYCKS 
CYGKKYGPKG YGYGQGAGTL NMDRGERLGI KPESVQPHRP TTNPNTSKFA QKYGGAEKCS 
RCGDSVYAAE KIIGAGKPWH KNCFRCAKCG KSLESTTLTE KEGEIYCKGC YAKNFGPKGF 
GYGQGAGALV HAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.