Genular: Defining Cellular Identity and Function

Details for: Gls

Gene ID: 14660

Symbol: Gls

Ensembl ID: ENSMUSG00000026103

Description: glutaminase

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Glutamate and glutamine metabolism
(R-MMU-8964539)
Glutamate neurotransmitter release cycle
(R-MMU-210500)
Metabolism
(R-MMU-1430728)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Neuronal system
(R-MMU-112316)
Neurotransmitter release cycle
(R-MMU-112310)
Rna polymerase ii transcription
(R-MMU-73857)
Tp53 regulates metabolic genes
(R-MMU-5628897)
Transcriptional regulation by tp53
(R-MMU-3700989)
Transmission across chemical synapses
(R-MMU-112315)
Chemical synaptic transmission
(GO:0007268)
Cytoplasm
(GO:0005737)
Glutamate biosynthetic process
(GO:0006537)
Glutaminase activity
(GO:0004359)
Glutamine catabolic process
(GO:0006543)
Glutamine metabolic process
(GO:0006541)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Intracellular glutamate homeostasis
(GO:0090461)
Mitochondrion
(GO:0005739)
Protein binding
(GO:0005515)
Protein homotetramerization
(GO:0051289)
Regulation of respiratory gaseous exchange by nervous system process
(GO:0002087)
Suckling behavior
(GO:0001967)
Synapse
(GO:0045202)

Other Information

Proteins

Glutaminase kidney isoform, mitochondrial

Genular Protein ID: 3555288812

Symbol: GLSK_MOUSE

Name: Glutaminase kidney isoform, mitochondrial

UniProtKB Accession Codes:

D3Z7P3 E9PUF0 Q69ZX9

Database IDs:

Citations:

PubMed ID: 15368895

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 15368895

DOI: 10.1093/dnares/11.3.205

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 16899818

Title: Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels.

PubMed ID: 16899818

DOI: 10.1242/jcs.03061

PubMed ID: 16641247

Title: Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth.

PubMed ID: 16641247

DOI: 10.1523/jneurosci.4241-05.2006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22373647

Title: Brain slices from glutaminase-deficient mice metabolize less glutamine: a cellular metabolomic study with carbon 13 NMR.

PubMed ID: 22373647

DOI: 10.1038/jcbfm.2012.22

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 22228304

Title: Mitochondrial localization and structure-based phosphate activation mechanism of glutaminase C with implications for cancer metabolism.

PubMed ID: 22228304

DOI: 10.1073/pnas.1112495109

PubMed ID: 23935106

Title: Active glutaminase C self-assembles into a supratetrameric oligomer that can be disrupted by an allosteric inhibitor.

PubMed ID: 23935106

DOI: 10.1074/jbc.m113.501346

PubMed ID: 27542409

Title: Mechanistic basis of glutaminase activation: a key enzyme that promotes glutamine metabolism in cancer cells.

PubMed ID: 27542409

DOI: 10.1074/jbc.m116.720268

Sequence Information:

Length: 674
Mass: 73964
Checksum: C46824C83E1D9639
Sequence:

MMRLRGSAML RELLLRPPAA VGAVLRRAQP LGTLCRRPRG GSRPTAGLVA AARLHPWWGG 
GGRAKGPGAG GLSSSPSEIL QELGKGGTPP QQQQQQQQQP GASPPAAPGP KDSPGETDAF 
GNSEGKEMVA AGDNKIKQGL LPSLEDLLFY TIAEGQEKIP VHKFITALKS TGLRTSDPRL 
KECMDMLRLT LQTTSDGVML DKDLFKKCVQ SNIVLLTQAF RRKFVIPDFM SFTSHIDELY 
ESAKKQSGGK VADYIPQLAK FSPDLWGVSV CTVDGQRHSI GDTKVPFCLQ SCVKPLKYAI 
AVNDLGTEYV HRYVGKEPSG LRFNKLFLNE DDKPHNPMVN AGAIVVTSLI KQGVNNAEKF 
DYVMQFLNKM AGNEYVGFSN ATFQSERESG DRNFAIGYYL KEKKCFPEGT DMVGILDFYF 
QLCSIEVTCE SASVMAATLA NGGFCPITGE RVLSPEAVRN TLSLMHSCGM YDFSGQFAFH 
VGLPAKSGVA GGILLVVPNV MGMMCWSPPL DKMGNSVKGI HFCHDLVSLC NFHNYDNLRH 
FAKKLDPRRE GGDQRVKSVI NLLFAAYTGD VSALRRFALS AMDMEQRDYD SRTALHVAAA 
EGHVEVVKFL LEACKVNPFP KDRWNNTPMD EALHFGHHDV FKILQEYQVQ YTPQGDSDDG 
KGNQTVHKNL DGLL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gls

Associated with

Other Information

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. PubMed ID: 15368895

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels. PubMed ID: 16899818

Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth. PubMed ID: 16641247

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Brain slices from glutaminase-deficient mice metabolize less glutamine: a cellular metabolomic study with carbon 13 NMR. PubMed ID: 22373647

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Mitochondrial localization and structure-based phosphate activation mechanism of glutaminase C with implications for cancer metabolism. PubMed ID: 22228304

Active glutaminase C self-assembles into a supratetrameric oligomer that can be disrupted by an allosteric inhibitor. PubMed ID: 23935106

Mechanistic basis of glutaminase activation: a key enzyme that promotes glutamine metabolism in cancer cells. PubMed ID: 27542409