Genular: Defining Cellular Identity and Function

Details for: Glud1

Gene ID: 14661

Symbol: Glud1

Ensembl ID: ENSMUSG00000021794

Description: glutamate dehydrogenase 1

Associated with

Glutamate and glutamine metabolism
(R-MMU-8964539)
Metabolism
(R-MMU-1430728)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Metabolism of proteins
(R-MMU-392499)
Mitochondrial biogenesis
(R-MMU-1592230)
Mitochondrial protein degradation
(R-MMU-9837999)
Organelle biogenesis and maintenance
(R-MMU-1852241)
Transcriptional activation of mitochondrial biogenesis
(R-MMU-2151201)
Adp binding
(GO:0043531)
Amino acid metabolic process
(GO:0006520)
Atp binding
(GO:0005524)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum
(GO:0005783)
Enzyme binding
(GO:0019899)
Glutamate catabolic process
(GO:0006538)
Glutamate dehydrogenase (nad+) activity
(GO:0004352)
Glutamate dehydrogenase [nad(p)+] activity
(GO:0004353)
Glutamine metabolic process
(GO:0006541)
Gtp binding
(GO:0005525)
Leucine binding
(GO:0070728)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Nad+ binding
(GO:0070403)
Nucleotide binding
(GO:0000166)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on the ch-nh2 group of donors, nad or nadp as acceptor
(GO:0016639)
Positive regulation of insulin secretion
(GO:0032024)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Response to aluminum ion
(GO:0010044)
Tricarboxylic acid metabolic process
(GO:0072350)

Other Information

Proteins

Glutamate dehydrogenase 1, mitochondrial
Q3TSQ7_MOUSE

Genular Protein ID: 1969309777

Symbol: DHE3_MOUSE

Name: Glutamate dehydrogenase 1, mitochondrial

UniProtKB Accession Codes:

P26443 Q8C273

Database IDs:

Citations:

PubMed ID: 1711373

Title: Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA.

PubMed ID: 1711373

DOI: 10.1016/0167-4781(91)90017-g

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959573

Title: SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.

PubMed ID: 16959573

DOI: 10.1016/j.cell.2006.06.057

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20670938

Title: Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.

PubMed ID: 20670938

DOI: 10.1074/jbc.m110.123638

PubMed ID: 23663782

Title: The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.

PubMed ID: 23663782

DOI: 10.1016/j.cell.2013.04.023

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

Sequence Information:

Length: 558
Mass: 61337
Checksum: 92738AA5A133838A
Sequence:

MYRRLGEALL LSRAGPAALG SAAADSAALL GWARGQPSAA PQPGLTPVAR RHYSEAAADR 
EDDPNFFKMV EGFFDRGASI VEDKLVEDLK TRESEEQKRN RVRGILRIIK PCNHVLSLSF 
PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG 
GAKAGVKINP KNYTDNELEK ITRRFTMELA KKGFIGPGID VPAPDMSTGE REMSWIADTY 
ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGFG 
DKTFVVQGFG NVGLHSMRYL HRFGAKCVGV GESDGSIWNP DGIDPKELED FKLQHGSILG 
FPKAKVYEGS ILEADCDILI PAASEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER 
NIMVIPDLYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLMSV QESLERKFGK 
HGGTIPVVPT AEFQDRISGA SEKDIVHSGL AYTMERSARQ IMRTAMKYNL GLDLRTAAYV 
NAIEKVFKVY NEAGVTFT

Genular Protein ID: 4152384551

Symbol: Q3TSQ7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TSQ7

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 326
Mass: 35824
Checksum: 9CD283444EFF5405
Sequence:

MSWIADTYAS TIGHYDINAH ACVTGKPISQ GGIHGRISAT GRGVFHGIEN FINEASYMSI 
LGMTPGFGDK TFVVQGFGNV GLHSMRYLHR FGAKCVGVGE SDGSIWNPDG IDPKELEDFK 
LQHGSILGFP KAKVYEGSIL EADCDILIPA ASEKQLTKSN APRVKAKIIA EGANGPTTPE 
ADKIFLERNI MVIPDLYLNA GGVTVSYFEW LKNLNHVSYG RLTFKYERDS NYHLLMSVQE 
SLERKFGKHG GTIPVVPTAE FQDRISGASE KDIVHSGLAY TMERSARQIM RTAMKYNLGL 
DLRTAAYVNA IEKVFKVYNE AGVTFT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Glud1

Associated with

Other Information

Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA. PubMed ID: 1711373

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. PubMed ID: 16959573

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. PubMed ID: 20670938

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. PubMed ID: 23663782

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073