Genular: Defining Cellular Identity and Function

Details for: Slc6a9

Gene ID: 14664

Symbol: Slc6a9

Ensembl ID: ENSMUSG00000028542

Description: solute carrier family 6 (neurotransmitter transporter, glycine), member 9

Associated with

Na+/cl- dependent neurotransmitter transporters
(R-MMU-442660)
Slc-mediated transmembrane transport
(R-MMU-425407)
Transport of bile salts and organic acids, metal ions and amine compounds
(R-MMU-425366)
Transport of small molecules
(R-MMU-382551)
Amino acid:sodium symporter activity
(GO:0005283)
Amino acid transport
(GO:0006865)
Apical plasma membrane
(GO:0016324)
Asymmetric synapse
(GO:0032279)
Basal plasma membrane
(GO:0009925)
Basolateral plasma membrane
(GO:0016323)
Dense core granule
(GO:0031045)
Endosome
(GO:0005768)
Glycine:sodium symporter activity
(GO:0015375)
Glycine import across plasma membrane
(GO:1903804)
Glycine secretion, neurotransmission
(GO:0061537)
Glycine transmembrane transporter activity
(GO:0015187)
Glycine transport
(GO:0015816)
Hippocampal mossy fiber to ca3 synapse
(GO:0098686)
Lateral plasma membrane
(GO:0016328)
Membrane
(GO:0016020)
Negative regulation of nmda glutamate receptor activity
(GO:1904782)
Neurotransmitter transport
(GO:0006836)
Neurotransmitter uptake
(GO:0001504)
Parallel fiber to purkinje cell synapse
(GO:0098688)
Plasma membrane
(GO:0005886)
Positive regulation of heme biosynthetic process
(GO:0070455)
Positive regulation of hemoglobin biosynthetic process
(GO:0046985)
Postsynaptic density
(GO:0014069)
Postsynaptic membrane
(GO:0045211)
Presynaptic membrane
(GO:0042734)
Regulation of synaptic transmission, glycinergic
(GO:0060092)
Sodium ion transmembrane transport
(GO:0035725)
Symporter activity
(GO:0015293)
Synaptic transmission, glycinergic
(GO:0060012)
Synaptic vesicle membrane
(GO:0030672)

Other Information

Proteins

Sodium- and chloride-dependent glycine transporter 1

Genular Protein ID: 868770530

Symbol: SC6A9_MOUSE

Name: Sodium- and chloride-dependent glycine transporter 1

UniProtKB Accession Codes:

P28571 B1ASI9 Q8VC47

Database IDs:

Citations:

PubMed ID: 1618338

Title: Cloning and expression of a glycine transporter from mouse brain.

PubMed ID: 1618338

DOI: 10.1016/0014-5793(92)80875-h

PubMed ID: 7891186

Title: Gene structure and glial expression of the glycine transporter GlyT1 in embryonic and adult rodents.

PubMed ID: 7891186

DOI: 10.1523/jneurosci.15-03-02524.1995

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8226790

Title: Cloning and expression of a spinal cord- and brain-specific glycine transporter with novel structural features.

PubMed ID: 8226790

DOI: 10.1016/s0021-9258(18)41598-0

PubMed ID: 14622582

Title: Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition.

PubMed ID: 14622582

DOI: 10.1016/s0896-6273(03)00672-x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 27773429

Title: Loss of Glycine Transporter 1 Causes a Subtype of Glycine Encephalopathy with Arthrogryposis and Mildly Elevated Cerebrospinal Fluid Glycine.

PubMed ID: 27773429

DOI: 10.1016/j.ajhg.2016.09.004

Sequence Information:

Length: 692
Mass: 76544
Checksum: C4A78A6562DAB01E
Sequence:

MIGGDTRAAS AHPGMASAQG PVATPSPEQP FPGTTSVSLA RPVLRVWHGA HSSGLLPNLI 
AQHSPAMAQN GAVPSEATKK DQNLTRGNWG NQIEFVLTSV GYAVGLGNVW RFPYLCYRNG 
GGAFMFPYFI MLIFCGIPLF FMELSFGQFA SQGCLGVWRI SPMFKGVGYG MMVVSTYIGI 
YYNVVICIAF YYFFSSMTHV LPWAYCNNPW NTPDCAGVLD ASNLTNGSRP AALSGNLSHL 
FNYTLQRTSP SEEYWRLYVL KLSDDIGNFG EVRLPLLGCL GVSWVVVFLC LIRGVKSSGK 
VVYFTATFPY VVLTILFVRG VTLEGAFTGI MYYLTPQWDK ILEAKVWGDA ASQIFYSLGC 
AWGGLITMAS YNKFHNNCYR DSVIISITNC ATSVYAGFVI FSILGFMANH LGVDVSRVAD 
HGPGLAFVAY PEALTLLPIS PLWSLLFFFM LILLGLGTQF CLLETLVTAI VDEVGNEWIL 
QKKTYVTLGV AVAGFLLGIP LTSQAGIYWL LLMDNYAASF SLVVISCIMC VSIMYIYGHR 
NYFQDIQMML GFPPPLFFQI CWRFVSPAII FFILIFTVIQ YRPITYNHYQ YPGWAVAIGF 
LMALSSVICI PLYALFQLCR TDGDTLLQRL KNATKPSRDW GPALLEHRTG RYAPTTTPSP 
EDGFEVQPLH PDKAQIPIVG SNGSSRFQDS RI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc6a9

Associated with

Other Information

Cloning and expression of a glycine transporter from mouse brain. PubMed ID: 1618338

Gene structure and glial expression of the glycine transporter GlyT1 in embryonic and adult rodents. PubMed ID: 7891186

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning and expression of a spinal cord- and brain-specific glycine transporter with novel structural features. PubMed ID: 8226790

Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition. PubMed ID: 14622582

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Loss of Glycine Transporter 1 Causes a Subtype of Glycine Encephalopathy with Arthrogryposis and Mildly Elevated Cerebrospinal Fluid Glycine. PubMed ID: 27773429