Genular: Defining Cellular Identity and Function

Details for: Gna12

Gene ID: 14673

Symbol: Gna12

Ensembl ID: ENSMUSG00000000149

Description: guanine nucleotide binding protein, alpha 12

Associated with

G alpha (12/13) signalling events
(R-MMU-416482)
Gpcr downstream signalling
(R-MMU-388396)
Hemostasis
(R-MMU-109582)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Signaling by gpcr
(R-MMU-372790)
Thrombin signalling through proteinase activated receptors (pars)
(R-MMU-456926)
Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
(GO:0007188)
Brush border membrane
(GO:0031526)
Cell differentiation
(GO:0030154)
Cytoplasm
(GO:0005737)
D5 dopamine receptor binding
(GO:0031752)
Embryonic digit morphogenesis
(GO:0042733)
G-protein beta/gamma-subunit complex binding
(GO:0031683)
G protein-coupled receptor binding
(GO:0001664)
G protein-coupled receptor signaling pathway
(GO:0007186)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Guanyl nucleotide binding
(GO:0019001)
Heterotrimeric g-protein complex
(GO:0005834)
Intracellular signal transduction
(GO:0035556)
In utero embryonic development
(GO:0001701)
Lateral plasma membrane
(GO:0016328)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of vascular associated smooth muscle cell migration
(GO:1904753)
Negative regulation of vascular associated smooth muscle cell proliferation
(GO:1904706)
Neuronal cell body
(GO:0043025)
Neuron projection
(GO:0043005)
Nucleotide binding
(GO:0000166)
Plasma membrane
(GO:0005886)
Positive regulation of phosphoprotein phosphatase activity
(GO:0032516)
Protein phosphatase 2a binding
(GO:0051721)
Protein phosphatase regulator activity
(GO:0019888)
Regulation of blood pressure
(GO:0008217)
Regulation of cell shape
(GO:0008360)
Regulation of fibroblast migration
(GO:0010762)
Regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032434)
Regulation of tor signaling
(GO:0032006)
Rho protein signal transduction
(GO:0007266)
Signal transduction
(GO:0007165)

Other Information

Proteins

Guanine nucleotide-binding protein subunit alpha-12

Genular Protein ID: 1105903632

Symbol: GNA12_MOUSE

Name: Guanine nucleotide-binding protein subunit alpha-12

UniProtKB Accession Codes:

P27600

Database IDs:

Citations:

PubMed ID: 1905812

Title: G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits.

PubMed ID: 1905812

DOI: 10.1073/pnas.88.13.5582

PubMed ID: 2508088

Title: Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse.

PubMed ID: 2508088

DOI: 10.1073/pnas.86.19.7407

PubMed ID: 9485474

Title: Galpha12 requires acylation for its transforming activity.

PubMed ID: 9485474

DOI: 10.1021/bi972253j

PubMed ID: 15240885

Title: A role for Galpha12/Galpha13 in p120ctn regulation.

PubMed ID: 15240885

DOI: 10.1073/pnas.0401366101

PubMed ID: 19151758

Title: The gep oncogenes, Galpha(12) and Galpha(13), upregulate the transforming growth factor-beta1 gene.

PubMed ID: 19151758

DOI: 10.1038/onc.2008.488

PubMed ID: 21212405

Title: G(alpha)12/13 induction of CYR61 in association with arteriosclerotic intimal hyperplasia: effect of sphingosine-1-phosphate.

PubMed ID: 21212405

DOI: 10.1161/atvbaha.110.218552

PubMed ID: 22609986

Title: PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12.

PubMed ID: 22609986

DOI: 10.1038/ncb2507

PubMed ID: 16388592

Title: A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins.

PubMed ID: 16388592

DOI: 10.1021/bi051729t

Sequence Information:

Length: 379
Mass: 44095
Checksum: 647C524AD7A0B5E2
Sequence:

MSGVVRTLSR CLLPAEAGAR ERRAGAARDA EREARRRSRD IDALLARERR AVRRLVKILL 
LGAGESGKST FLKQMRIIHG REFDQKALLE FRDTIFDNIL KGSRVLVDAR DKLGIPWQHS 
ENEKHGMFLM AFENKAGLPV EPATFQLYVP ALSALWRDSG IREAFSRRSE FQLGESVKYF 
LDNLDRIGQL NYFPSKQDIL LARKATKGIV EHDFVIKKIP FKMVDVGGQR SQRQKWFQCF 
DGITSILFMV SSSEYDQVLM EDRRTNRLVE SMNIFETIVN NKLFFNVSII LFLNKMDLLV 
EKVKSVSIKK HFPDFKGDPH RLEDVQRYLV QCFDRKRRNR SKPLFHHFTT AIDTENIRFV 
FHAVKDTILQ ENLKDIMLQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gna12

Associated with

Other Information

G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits. PubMed ID: 1905812

Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. PubMed ID: 2508088

Galpha12 requires acylation for its transforming activity. PubMed ID: 9485474

A role for Galpha12/Galpha13 in p120ctn regulation. PubMed ID: 15240885

The gep oncogenes, Galpha(12) and Galpha(13), upregulate the transforming growth factor-beta1 gene. PubMed ID: 19151758

G(alpha)12/13 induction of CYR61 in association with arteriosclerotic intimal hyperplasia: effect of sphingosine-1-phosphate. PubMed ID: 21212405

PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12. PubMed ID: 22609986

A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins. PubMed ID: 16388592