Details for: SLC25A10

Gene ID: 1468

Symbol: SLC25A10

Ensembl ID: ENSG00000183048

Description: solute carrier family 25 member 10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.49
    Marker Score: 5156.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Marker Score: 17048
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.03
    Marker Score: 2087
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1
    Marker Score: 2356
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.99
    Marker Score: 2805
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.98
    Marker Score: 1226
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.96
    Marker Score: 1824
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1475
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5178
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.84
    Marker Score: 2974
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.83
    Marker Score: 3974
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.74
    Marker Score: 742.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 676
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.74
    Marker Score: 1089
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.73
    Marker Score: 1727
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 288
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.68
    Marker Score: 1559
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2765.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.66
    Marker Score: 396
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.66
    Marker Score: 5679
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.65
    Marker Score: 4135
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.63
    Marker Score: 238
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.58
    Marker Score: 1306
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.57
    Marker Score: 281
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 362
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.56
    Marker Score: 135
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.55
    Marker Score: 371
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.55
    Marker Score: 137
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.55
    Marker Score: 371
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.52
    Marker Score: 1102
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.52
    Marker Score: 4075
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.52
    Marker Score: 17945
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.52
    Marker Score: 2032
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.5
    Marker Score: 2173
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.5
    Marker Score: 1576
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 234
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.48
    Marker Score: 736
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.46
    Marker Score: 450.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.45
    Marker Score: 430
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.44
    Marker Score: 1085.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.43
    Marker Score: 444
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.43
    Marker Score: 679
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.42
    Marker Score: 382
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.41
    Marker Score: 2225
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.4
    Marker Score: 354
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.39
    Marker Score: 164
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.38
    Marker Score: 253
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.38
    Marker Score: 110
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.38
    Marker Score: 2437
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 364
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.36
    Marker Score: 381
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.36
    Marker Score: 343
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 157
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.35
    Marker Score: 163
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.34
    Marker Score: 342
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.34
    Marker Score: 256
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.34
    Marker Score: 146
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.34
    Marker Score: 73
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.32
    Marker Score: 158
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.32
    Marker Score: 122
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.32
    Marker Score: 157
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.32
    Marker Score: 150
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.32
    Marker Score: 337
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.31
    Marker Score: 143
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.31
    Marker Score: 212.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.31
    Marker Score: 99
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.31
    Marker Score: 2669
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.31
    Marker Score: 153
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.31
    Marker Score: 213
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.31
    Marker Score: 639
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.3
    Marker Score: 93
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.29
    Marker Score: 245
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.29
    Marker Score: 84
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.29
    Marker Score: 481
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.28
    Marker Score: 479
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.28
    Marker Score: 766
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.28
    Marker Score: 203
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.27
    Marker Score: 300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.27
    Marker Score: 725
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.26
    Marker Score: 109
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.26
    Marker Score: 98
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.26
    Marker Score: 151
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.25
    Marker Score: 237
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.25
    Marker Score: 59
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.25
    Marker Score: 399
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.25
    Marker Score: 1649
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 139
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.24
    Marker Score: 461
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.24
    Marker Score: 259

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Other Information

**Key characteristics:** - SLC25A10 is a multi-functional protein that performs various transport functions. - It is involved in the degradation of cysteine and homocysteine, the regulation of the dicarboxylic acid (DCA) cycle, gluconeogenesis, glucose metabolism, and other cellular processes. - It also plays a role in the transport of inorganic cations, amino acids, and small molecules. **Pathways and functions:** - The SLC25A10 gene is involved in the degradation of various substrates, including cysteine, homocysteine, and other molecules involved in the metabolism of amino acids, carbohydrates, and other cellular components. - It also regulates the flux of metabolites through the TCA cycle, the DCA cycle, and other metabolic pathways. - Additionally, it is involved in the transport of inorganic cations, amino acids, and small molecules, including glucose, potassium, and hydrogen ions. **Clinical significance:** - Mutations in the SLC25A10 gene have been linked to several human diseases, including kidney diseases, cardiovascular diseases, and diabetes. - Studies of SLC25A10 function and regulation have implications for understanding and developing therapeutic strategies for these diseases. **Additional notes:** - The SLC25A10 gene is also involved in the regulation of bile acid metabolism. - It is a highly conserved protein with homologs in other species. - The expression of SLC25A10 is regulated by various factors, including hormones, cytokines, and genetic variants.

Genular Protein ID: 678193718

Symbol: DIC_HUMAN

Name: Solute carrier family 25 member 10

UniProtKB Accession Codes:

Q9UBX3 Q542Z3 Q96BA1 Q96IP1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 16 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 8 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10585886

Title: Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family.

PubMed ID: 10585886

DOI: 10.1042/bj3440953

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 29211846

Title: SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency.

PubMed ID: 29211846

DOI: 10.1093/hmg/ddx419

Sequence Information:

  • Length: 287
  • Mass: 31282
  • Checksum: 32BE9920C7CD8ADF
  • Sequence:
    • MAAEARVSRW YFGGLASCGA ACCTHPLDLL KVHLQTQQEV KLRMTGMALR VVRTDGILAL 
YSGLSASLCR QMTYSLTRFA IYETVRDRVA KGSQGPLPFH EKVLLGSVSG LAGGFVGTPA 
DLVNVRMQND VKLPQGQRRN YAHALDGLYR VAREEGLRRL FSGATMASSR GALVTVGQLS 
CYDQAKQLVL STGYLSDNIF THFVASFIAG GCATFLCQPL DVLKTRLMNS KGEYQGVFHC 
AVETAKLGPL AFYKGLVPAG IRLIPHTVLT FVFLEQLRKN FGIKVPS

Genular Protein ID: 356266415

Symbol: F6RGN5_HUMAN

Name: N/A

UniProtKB Accession Codes:

F6RGN5

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 406
  • Mass: 43611
  • Checksum: 71BE8D17CFFCFC6C
  • Sequence:
    • MAAEARVSRW YFGGLASCGA ACCTHPLDLL KVHLQTQQEV KLRMTGMALR VVRTDGILAL 
YSGLSASLCR QMTYSLTRFA IYETVRDRVA KGSQGPLPFH EKVLLGSVSG LAGGFVGTPA 
DLVNVRMQND VKLPQGQRRN YAHALDGLYR VAREEGLRRL FSGATMASSR GALVTVGQLY 
CRWMCHVPVP APGCAEDSPD ELQGGVSGRF PLRRGDSEAR ASGLLQGPRP SWHPPHPPHR 
AHFCVSGTAT QKLWHQSAIL TSRGNGWAAR PDTLGSSKES QAQHLLLGPR PPWPWPPVLR 
SRPLLSPHLL AELLLASSPL SCSCTTPALA TRLSRLGTAW PCPSPAGSSS GEQGLPEADF 
SPLLGQGRGI IPASCPRCPK QHLPALSIED LGGRVWVQPG CCSPKC

Genular Protein ID: 3780892583

Symbol: A0A0S2Z3G3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3G3

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 3 Gene3D 1 GenomeRNAi 1 IntAct 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 Pfam 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 296
  • Mass: 32145
  • Checksum: A8B1484218C4125C
  • Sequence:
    • MAAEARVSRW YFGGLASCGA ACCTHPLDLL KVHLQTQQEV KLRMTGMALR VVRTDGILAL 
YSGLSASLCR QMTYSLTRFA IYETVRDRVA KGSQGPLPFH EKVLLGSVSG LAGGFVGTPA 
DLVNVRMQND VKLPQGQRRN YAHALDGLYR VAREEGLRRL FSGATMASSR GALVTVGQLS 
CYDQAKQLVL STGYLSDNIF THFVASFIAA AGDEPPPQGG CATFLCQPLD VLKTRLMNSK 
GEYQGVFHCA VETAKLGPLA FYKGLVPAGI RLIPHTVLTF VFLEQLRKNF GIKVPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.