Details for: SLC25A10

Gene ID: 1468

Symbol: SLC25A10

Ensembl ID: ENSG00000183048

Description: solute carrier family 25 member 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.5421
    Cell Significance Index: -6.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5034
    Cell Significance Index: 32.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4838
    Cell Significance Index: 77.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2897
    Cell Significance Index: 58.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.2290
    Cell Significance Index: 18.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2208
    Cell Significance Index: 73.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1916
    Cell Significance Index: 129.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0306
    Cell Significance Index: 167.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8951
    Cell Significance Index: 25.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8322
    Cell Significance Index: 96.9800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.7037
    Cell Significance Index: -1.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6802
    Cell Significance Index: 9.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6644
    Cell Significance Index: 599.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6176
    Cell Significance Index: 19.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6083
    Cell Significance Index: 42.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4453
    Cell Significance Index: 20.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4079
    Cell Significance Index: 40.3500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.3997
    Cell Significance Index: 5.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3804
    Cell Significance Index: 46.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3399
    Cell Significance Index: 3.1300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3181
    Cell Significance Index: 4.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3038
    Cell Significance Index: 165.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3000
    Cell Significance Index: 54.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2582
    Cell Significance Index: 51.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2190
    Cell Significance Index: 41.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1971
    Cell Significance Index: 13.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1893
    Cell Significance Index: 5.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1845
    Cell Significance Index: 3.9300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.1755
    Cell Significance Index: 1.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1562
    Cell Significance Index: 5.4900
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.1390
    Cell Significance Index: 1.0100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.1350
    Cell Significance Index: 1.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1216
    Cell Significance Index: 53.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1199
    Cell Significance Index: 15.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1172
    Cell Significance Index: 2.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1073
    Cell Significance Index: 2.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0786
    Cell Significance Index: 28.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0722
    Cell Significance Index: 12.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0708
    Cell Significance Index: 2.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0700
    Cell Significance Index: 5.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0668
    Cell Significance Index: 13.4000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0660
    Cell Significance Index: 0.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0597
    Cell Significance Index: 3.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0550
    Cell Significance Index: 0.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0542
    Cell Significance Index: 1.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0333
    Cell Significance Index: 0.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0292
    Cell Significance Index: 4.0200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0117
    Cell Significance Index: 0.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0079
    Cell Significance Index: 0.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0034
    Cell Significance Index: 2.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0004
    Cell Significance Index: -0.0500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0010
    Cell Significance Index: -1.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0018
    Cell Significance Index: -2.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0024
    Cell Significance Index: -1.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0034
    Cell Significance Index: -4.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0053
    Cell Significance Index: -3.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0069
    Cell Significance Index: -3.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0083
    Cell Significance Index: -5.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0085
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0104
    Cell Significance Index: -1.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0136
    Cell Significance Index: -6.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0147
    Cell Significance Index: -0.7400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0170
    Cell Significance Index: -0.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0209
    Cell Significance Index: -2.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0258
    Cell Significance Index: -0.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0266
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0297
    Cell Significance Index: -6.2600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0303
    Cell Significance Index: -0.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0331
    Cell Significance Index: -4.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0342
    Cell Significance Index: -2.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0360
    Cell Significance Index: -2.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0469
    Cell Significance Index: -2.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0532
    Cell Significance Index: -3.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0535
    Cell Significance Index: -4.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0554
    Cell Significance Index: -5.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0668
    Cell Significance Index: -3.7500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0670
    Cell Significance Index: -0.9600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0681
    Cell Significance Index: -1.4200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0702
    Cell Significance Index: -1.0000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0706
    Cell Significance Index: -1.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0739
    Cell Significance Index: -4.5400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0800
    Cell Significance Index: -0.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0802
    Cell Significance Index: -2.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0805
    Cell Significance Index: -1.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0827
    Cell Significance Index: -5.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0863
    Cell Significance Index: -1.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0939
    Cell Significance Index: -3.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0944
    Cell Significance Index: -4.1800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0976
    Cell Significance Index: -1.4400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1016
    Cell Significance Index: -1.4100
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.1113
    Cell Significance Index: -0.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1114
    Cell Significance Index: -4.2200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1144
    Cell Significance Index: -4.6900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1177
    Cell Significance Index: -3.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1184
    Cell Significance Index: -3.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1197
    Cell Significance Index: -2.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1207
    Cell Significance Index: -4.4300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1248
    Cell Significance Index: -1.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The SLC25A10 protein exhibits a unique combination of transport activities, including: 1. **Antiporter activity**: The ability to transport ions and compounds in exchange for other ions or molecules. 2. **Dicarboxylic acid transport**: The ability to transport dicarboxylic acids, such as malate and oxaloacetate, across cell membranes. 3. **Gluconeogenesis and glucose metabolism**: The ability to regulate glucose metabolism and gluconeogenesis, a process by which cells generate glucose from non-carbohydrate sources. 4. **Lipid transport**: The ability to transport lipids and other small molecules across cell membranes. 5. **Organic anion transporters**: The ability to transport a wide range of organic anions, including amino acids, glutathione, and bilirubin. **Pathways and Functions** The SLC25A10 protein is involved in various cellular pathways, including: 1. **Mitochondrial inner membrane transport**: The ability to regulate the transport of ions and compounds across the mitochondrial inner membrane, which is essential for energy production and cellular metabolism. 2. **Gluconeogenesis**: The ability to regulate glucose metabolism and gluconeogenesis, which is crucial for maintaining blood glucose levels and energy homeostasis. 3. **Lipid metabolism**: The ability to regulate lipid metabolism, including the transport of lipids and other small molecules across cell membranes. 4. **Immune cell function**: The ability to regulate immune cell function, including the transport of ions and compounds that are essential for immune cell activation and function. **Clinical Significance** Dysregulation of the SLC25A10 gene has been implicated in various diseases and disorders, including: 1. **Metabolic disorders**: Mutations in the SLC25A10 gene have been associated with metabolic disorders, such as diabetes and metabolic syndrome. 2. **Kidney disease**: The SLC25A10 protein plays a crucial role in kidney function, and dysregulation of the gene has been implicated in kidney disease. 3. **Immune system disorders**: The SLC25A10 protein is expressed in immune cells, and dysregulation of the gene has been implicated in immune system disorders, such as autoimmune diseases and immunodeficiency disorders. In conclusion, the SLC25A10 gene plays a critical role in maintaining cellular homeostasis and regulating various physiological processes, including gluconeogenesis, lipid metabolism, and immune cell function. Dysregulation of the gene has been implicated in various diseases and disorders, highlighting the importance of further research into the function and regulation of the SLC25A10 protein.

Genular Protein ID: 678193718

Symbol: DIC_HUMAN

Name: Solute carrier family 25 member 10

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10585886

Title: Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family.

PubMed ID: 10585886

DOI: 10.1042/bj3440953

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 29211846

Title: SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency.

PubMed ID: 29211846

DOI: 10.1093/hmg/ddx419

Sequence Information:

  • Length: 287
  • Mass: 31282
  • Checksum: 32BE9920C7CD8ADF
  • Sequence:
  • MAAEARVSRW YFGGLASCGA ACCTHPLDLL KVHLQTQQEV KLRMTGMALR VVRTDGILAL 
    YSGLSASLCR QMTYSLTRFA IYETVRDRVA KGSQGPLPFH EKVLLGSVSG LAGGFVGTPA 
    DLVNVRMQND VKLPQGQRRN YAHALDGLYR VAREEGLRRL FSGATMASSR GALVTVGQLS 
    CYDQAKQLVL STGYLSDNIF THFVASFIAG GCATFLCQPL DVLKTRLMNS KGEYQGVFHC 
    AVETAKLGPL AFYKGLVPAG IRLIPHTVLT FVFLEQLRKN FGIKVPS

Genular Protein ID: 3780892583

Symbol: A0A0S2Z3G3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 296
  • Mass: 32145
  • Checksum: A8B1484218C4125C
  • Sequence:
  • MAAEARVSRW YFGGLASCGA ACCTHPLDLL KVHLQTQQEV KLRMTGMALR VVRTDGILAL 
    YSGLSASLCR QMTYSLTRFA IYETVRDRVA KGSQGPLPFH EKVLLGSVSG LAGGFVGTPA 
    DLVNVRMQND VKLPQGQRRN YAHALDGLYR VAREEGLRRL FSGATMASSR GALVTVGQLS 
    CYDQAKQLVL STGYLSDNIF THFVASFIAA AGDEPPPQGG CATFLCQPLD VLKTRLMNSK 
    GEYQGVFHCA VETAKLGPLA FYKGLVPAGI RLIPHTVLTF VFLEQLRKNF GIKVPS

Genular Protein ID: 356266415

Symbol: F6RGN5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 406
  • Mass: 43611
  • Checksum: 71BE8D17CFFCFC6C
  • Sequence:
  • MAAEARVSRW YFGGLASCGA ACCTHPLDLL KVHLQTQQEV KLRMTGMALR VVRTDGILAL 
    YSGLSASLCR QMTYSLTRFA IYETVRDRVA KGSQGPLPFH EKVLLGSVSG LAGGFVGTPA 
    DLVNVRMQND VKLPQGQRRN YAHALDGLYR VAREEGLRRL FSGATMASSR GALVTVGQLY 
    CRWMCHVPVP APGCAEDSPD ELQGGVSGRF PLRRGDSEAR ASGLLQGPRP SWHPPHPPHR 
    AHFCVSGTAT QKLWHQSAIL TSRGNGWAAR PDTLGSSKES QAQHLLLGPR PPWPWPPVLR 
    SRPLLSPHLL AELLLASSPL SCSCTTPALA TRLSRLGTAW PCPSPAGSSS GEQGLPEADF 
    SPLLGQGRGI IPASCPRCPK QHLPALSIED LGGRVWVQPG CCSPKC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.