Genular: Defining Cellular Identity and Function

Details for: Gnaq

Gene ID: 14682

Symbol: Gnaq

Ensembl ID: ENSMUSG00000024639

Description: guanine nucleotide binding protein, alpha q polypeptide

Associated with

Acetylcholine regulates insulin secretion
(R-MMU-399997)
Adp signalling through p2y purinoceptor 1
(R-MMU-418592)
Chaperonin-mediated protein folding
(R-MMU-390466)
Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding
(R-MMU-6814122)
Fatty acids bound to gpr40 (ffar1) regulate insulin secretion
(R-MMU-434316)
Free fatty acids regulate insulin secretion
(R-MMU-400451)
G-protein activation
(R-MMU-202040)
G-protein mediated events
(R-MMU-112040)
G alpha (i) signalling events
(R-MMU-418594)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Hemostasis
(R-MMU-109582)
Integration of energy metabolism
(R-MMU-163685)
Metabolism
(R-MMU-1430728)
Metabolism of proteins
(R-MMU-392499)
Opioid signalling
(R-MMU-111885)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Plc beta mediated events
(R-MMU-112043)
Protein folding
(R-MMU-391251)
Regulation of insulin secretion
(R-MMU-422356)
Signal amplification
(R-MMU-392518)
Signaling by gpcr
(R-MMU-372790)
Thrombin signalling through proteinase activated receptors (pars)
(R-MMU-456926)
Thromboxane signalling through tp receptor
(R-MMU-428930)
Action potential
(GO:0001508)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Alkylglycerophosphoethanolamine phosphodiesterase activity
(GO:0047391)
Caveola
(GO:0005901)
Cell body
(GO:0044297)
Cranial skeletal system development
(GO:1904888)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Developmental pigmentation
(GO:0048066)
Embryonic digit morphogenesis
(GO:0042733)
Endothelin receptor signaling pathway
(GO:0086100)
Enzyme regulator activity
(GO:0030234)
Forebrain neuron development
(GO:0021884)
G-protein beta/gamma-subunit complex binding
(GO:0031683)
Glutamate receptor signaling pathway
(GO:0007215)
Golgi apparatus
(GO:0005794)
G protein-coupled receptor binding
(GO:0001664)
G protein-coupled receptor signaling pathway
(GO:0007186)
G protein activity
(GO:0003925)
Gtpase activator activity
(GO:0005096)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Guanyl nucleotide binding
(GO:0019001)
Heart development
(GO:0007507)
Heterotrimeric g-protein complex
(GO:0005834)
Ion channel modulating, g protein-coupled receptor signaling pathway
(GO:0099105)
Ligand-gated ion channel signaling pathway
(GO:1990806)
Maternal behavior
(GO:0042711)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of potassium ion transport
(GO:0043267)
Negative regulation of protein kinase activity
(GO:0006469)
Neuron remodeling
(GO:0016322)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phospholipase c-activating dopamine receptor signaling pathway
(GO:0060158)
Phospholipase c-activating g protein-coupled acetylcholine receptor signaling pathway
(GO:0007207)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Post-embryonic development
(GO:0009791)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein stabilization
(GO:0050821)
Regulation of blood pressure
(GO:0008217)
Regulation of canonical wnt signaling pathway
(GO:0060828)
Regulation of melanocyte differentiation
(GO:0045634)
Regulation of platelet activation
(GO:0010543)
Signal transduction
(GO:0007165)
Skeletal system development
(GO:0001501)

Other Information

Proteins

Guanine nucleotide-binding protein G(q) subunit alpha

Genular Protein ID: 2445957846

Symbol: GNAQ_MOUSE

Name: Guanine nucleotide-binding protein G(q) subunit alpha

UniProtKB Accession Codes:

P21279 Q6PFF5

Database IDs:

Citations:

PubMed ID: 2123549

Title: G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.

PubMed ID: 2123549

DOI: 10.1073/pnas.87.23.9113

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9296496

Title: Defective platelet activation in G alpha(q)-deficient mice.

PubMed ID: 9296496

DOI: 10.1038/38284

PubMed ID: 9391157

Title: Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Galphaq.

PubMed ID: 9391157

DOI: 10.1073/pnas.94.25.14089

PubMed ID: 9687499

Title: Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice.

PubMed ID: 9687499

DOI: 10.1093/emboj/17.15.4304

PubMed ID: 8227063

Title: Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha.

PubMed ID: 8227063

DOI: 10.1016/s0021-9258(19)74563-3

PubMed ID: 17938235

Title: Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes.

PubMed ID: 17938235

DOI: 10.1084/jem.20071267

PubMed ID: 18802028

Title: Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes.

PubMed ID: 18802028

DOI: 10.1161/circresaha.108.176024

PubMed ID: 19001095

Title: Identification of G protein alpha subunit-palmitoylating enzyme.

PubMed ID: 19001095

DOI: 10.1128/mcb.01144-08

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20624888

Title: G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity.

PubMed ID: 20624888

DOI: 10.1084/jem.20092735

PubMed ID: 23022564

Title: Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling.

PubMed ID: 23022564

DOI: 10.1016/j.febslet.2012.09.027

PubMed ID: 23994616

Title: A novel Galphas-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor.

PubMed ID: 23994616

DOI: 10.1016/j.bbamcr.2013.08.009

Sequence Information:

Length: 359
Mass: 42158
Checksum: 3BCBA4EE7DADADBF
Sequence:

MTLESIMACC LSEEAKEARR INDEIERQLR RDKRDARREL KLLLLGTGES GKSTFIKQMR 
IIHGSGYSDE DKRGFTKLVY QNIFTAMQAM IRAMDTLKIP YKYEHNKAHA QLVREVDVEK 
VSAFENPYVD AIKSLWNDPG IQECYDRRRE YQLSDSTKYY LNDLDRVADP SYLPTQQDVL 
RVRVPTTGII EYPFDLQSVI FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV 
ESDNENRMEE SKALFRTIIT YPWFQNSSVI LFLNKKDLLE EKIMYSHLVD YFPEYDGPQR 
DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ LNLKEYNLV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gnaq

Associated with

Other Information

G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates. PubMed ID: 2123549

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Defective platelet activation in G alpha(q)-deficient mice. PubMed ID: 9296496

Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Galphaq. PubMed ID: 9391157

Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice. PubMed ID: 9687499

Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha. PubMed ID: 8227063

Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes. PubMed ID: 17938235

Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes. PubMed ID: 18802028

Identification of G protein alpha subunit-palmitoylating enzyme. PubMed ID: 19001095

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity. PubMed ID: 20624888

Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling. PubMed ID: 23022564

A novel Galphas-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor. PubMed ID: 23994616