Details for: CST1

Gene ID: 1469

Symbol: CST1

Ensembl ID: ENSG00000170373

Description: cystatin SN

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162074
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3170
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.72
    Marker Score: 4865
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.33
    Marker Score: 1489
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.08
    Marker Score: 7191
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.06
    Marker Score: 2012
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.91
    Marker Score: 1254
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.91
    Marker Score: 479
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.88
    Marker Score: 5361
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.83
    Marker Score: 1425
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.78
    Marker Score: 739
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.73
    Marker Score: 421
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.7
    Marker Score: 1715
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 492
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.62
    Marker Score: 1254
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.58
    Marker Score: 835
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.49
    Marker Score: 7705
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.38
    Marker Score: 160
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.35
    Marker Score: 80
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.33
    Marker Score: 187
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.29
    Marker Score: 177
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.29
    Marker Score: 111
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.29
    Marker Score: 70
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.29
    Marker Score: 461
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.27
    Marker Score: 274
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.26
    Marker Score: 124
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.26
    Marker Score: 133
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.26
    Marker Score: 169
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 93
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.19
    Marker Score: 1422
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.18
    Marker Score: 335
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.14
    Marker Score: 40
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 113
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.12
    Marker Score: 182
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.12
    Marker Score: 56
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.12
    Marker Score: 47
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.12
    Marker Score: 58
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.12
    Marker Score: 26
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.11
    Marker Score: 179
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.09
    Marker Score: 100
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.09
    Marker Score: 19
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 90.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.09
    Marker Score: 26
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.09
    Marker Score: 555
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.08
    Marker Score: 244
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.08
    Marker Score: 157
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.07
    Marker Score: 901
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.06
    Marker Score: 79
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.06
    Marker Score: 140
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.06
    Marker Score: 52
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 69
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.05
    Marker Score: 169
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.05
    Marker Score: 28

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Other Information

**Key characteristics:** * It is a cysteine-type endopeptidase inhibitor. * It is a protein of the cystatin family, which are involved in the regulation of cysteine proteases. * It is expressed in high levels in neurons, suggesting a role in synaptic plasticity and neuronal communication. * It is also expressed in immune cells, including dendritic cells and macrophages, indicating a potential role in immune regulation. **Pathways and functions:** * Cystatin SN inhibits the activity of cysteine-type endopeptidase, which is a protein that breaks down cystatins, proteins that are involved in maintaining the structure of cell membranes. * By inhibiting cysteine-type endopeptidase, cystatin SN allows cystatins to exert their effects, such as regulating cell adhesion and migration. * It also plays a role in the detection of chemical stimuli involved in sensory perception of bitter taste. **Clinical significance:** * Mutations in the CST1 gene have been linked to a rare neurological disorder called cystinuria, which is characterized by the abnormal transport of cystatins into the brain. * In this disorder, the excessive cystatin levels are thought to contribute to the neuronal damage and synaptic dysfunction that underlies the symptoms. * Therefore, CST1 is an important target for the treatment of cystinuria. **Additional notes:** * CST1 is a highly conserved protein, with similar genes found in other mammals. * It is a well-characterized protein that has been extensively studied in both human and animal models. * It is a promising target for the development of novel therapies for neurological disorders associated with cystatins.

Genular Protein ID: 3393375864

Symbol: CYTN_HUMAN

Name: Cystatin-SN

UniProtKB Accession Codes:

P01037 Q96LE6 Q9UCQ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 2 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3446578

Title: Human cysteine-proteinase inhibitors: nucleotide sequence analysis of three members of the cystatin gene family.

PubMed ID: 3446578

DOI: 10.1016/0378-1119(87)90196-x

PubMed ID: 2837486

Title: Purification, molecular cloning, and sequencing of salivary cystatin SA-1.

PubMed ID: 2837486

DOI: 10.1016/s0021-9258(19)76552-1

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3202964

Title: Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes.

PubMed ID: 3202964

PubMed ID: 1778989

Title: Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S.

PubMed ID: 1778989

DOI: 10.1093/oxfordjournals.jbchem.a123634

PubMed ID: 11788998

Title: Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting.

PubMed ID: 11788998

DOI: 10.1002/1615-9861(200201)2:1<112::aid-prot112>3.3.co;2-e

PubMed ID: 3514272

Title: Characterization of a new cysteine proteinase inhibitor of human saliva, cystatin SN, which is immunologically related to cystatin S.

PubMed ID: 3514272

DOI: 10.1016/0014-5793(86)81201-7

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

PubMed ID: 20189825

Title: Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry.

PubMed ID: 20189825

DOI: 10.1016/j.jasms.2010.01.025

Sequence Information:

  • Length: 141
  • Mass: 16388
  • Checksum: 9F9934704D6C077D
  • Sequence:
    • MAQYLSTLLL LLATLAVALA WSPKEEDRII PGGIYNADLN DEWVQRALHF AISEYNKATK 
DDYYRRPLRV LRARQQTVGG VNYFFDVEVG RTICTKSQPN LDTCAFHEQP ELQKKQLCSF 
EIYEVPWENR RSLVKSRCQE S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.