Details for: CST1

Gene ID: 1469

Symbol: CST1

Ensembl ID: ENSG00000170373

Description: cystatin SN

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 65.0387
    Cell Significance Index: 362.0100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 55.1854
    Cell Significance Index: 1150.9300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 16.9152
    Cell Significance Index: 218.5400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 15.6674
    Cell Significance Index: 248.5600
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.7466
    Cell Significance Index: 22.0000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.6728
    Cell Significance Index: 11.5000
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 0.6168
    Cell Significance Index: 0.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5342
    Cell Significance Index: 106.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3011
    Cell Significance Index: 15.6400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0947
    Cell Significance Index: 1.5600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0217
    Cell Significance Index: 0.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0204
    Cell Significance Index: 9.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0120
    Cell Significance Index: 1.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0101
    Cell Significance Index: 0.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0064
    Cell Significance Index: 0.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0202
    Cell Significance Index: -14.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0204
    Cell Significance Index: -3.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0270
    Cell Significance Index: -15.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0285
    Cell Significance Index: -15.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0454
    Cell Significance Index: -5.5800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0460
    Cell Significance Index: -0.4300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0707
    Cell Significance Index: -1.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0784
    Cell Significance Index: -10.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0820
    Cell Significance Index: -9.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0855
    Cell Significance Index: -18.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1046
    Cell Significance Index: -17.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1147
    Cell Significance Index: -23.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1228
    Cell Significance Index: -2.5700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2073
    Cell Significance Index: -2.8200
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2122
    Cell Significance Index: -2.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2228
    Cell Significance Index: -14.9800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2614
    Cell Significance Index: -2.8400
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.2649
    Cell Significance Index: -2.5700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2669
    Cell Significance Index: -4.1300
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.2810
    Cell Significance Index: -2.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2889
    Cell Significance Index: -16.2100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.3149
    Cell Significance Index: -2.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3459
    Cell Significance Index: -12.0200
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.3676
    Cell Significance Index: -2.9200
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.3724
    Cell Significance Index: -2.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3727
    Cell Significance Index: -9.3000
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.3769
    Cell Significance Index: -2.3700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4025
    Cell Significance Index: -6.7700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.4196
    Cell Significance Index: -2.5700
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.4327
    Cell Significance Index: -2.5400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4390
    Cell Significance Index: -5.6800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4399
    Cell Significance Index: -3.3900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4476
    Cell Significance Index: -5.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4527
    Cell Significance Index: -28.5400
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.4575
    Cell Significance Index: -5.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4669
    Cell Significance Index: -17.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4786
    Cell Significance Index: -12.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4930
    Cell Significance Index: -13.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5032
    Cell Significance Index: -14.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5180
    Cell Significance Index: -13.6200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.5451
    Cell Significance Index: -10.8700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.5694
    Cell Significance Index: -7.9000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6272
    Cell Significance Index: -15.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6283
    Cell Significance Index: -18.0100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.6358
    Cell Significance Index: -6.5800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.6706
    Cell Significance Index: -11.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6794
    Cell Significance Index: -11.3700
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.6806
    Cell Significance Index: -8.6200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.6848
    Cell Significance Index: -6.9900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.7290
    Cell Significance Index: -5.8000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.7631
    Cell Significance Index: -9.0100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.7691
    Cell Significance Index: -9.6600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.7740
    Cell Significance Index: -9.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7873
    Cell Significance Index: -7.2500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.8240
    Cell Significance Index: -16.1100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.8337
    Cell Significance Index: -8.6000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.8532
    Cell Significance Index: -21.3100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.8677
    Cell Significance Index: -9.6500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.8693
    Cell Significance Index: -9.1700
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -0.8740
    Cell Significance Index: -8.5800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.8772
    Cell Significance Index: -12.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8887
    Cell Significance Index: -24.1900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.8921
    Cell Significance Index: -11.8600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.9030
    Cell Significance Index: -13.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9059
    Cell Significance Index: -20.9300
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.9160
    Cell Significance Index: -8.0600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.9374
    Cell Significance Index: -11.8600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.9394
    Cell Significance Index: -10.2400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.9399
    Cell Significance Index: -9.7300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.9558
    Cell Significance Index: -11.9400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.9640
    Cell Significance Index: -9.5100
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.9691
    Cell Significance Index: -9.9000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.9718
    Cell Significance Index: -11.0400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.9742
    Cell Significance Index: -12.7400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.9846
    Cell Significance Index: -13.1300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.9879
    Cell Significance Index: -9.9800
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.9884
    Cell Significance Index: -9.6700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.9986
    Cell Significance Index: -11.8700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -1.0071
    Cell Significance Index: -12.2500
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -1.0108
    Cell Significance Index: -9.2500
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -1.0182
    Cell Significance Index: -11.0400
  • Cell Name: B cell (CL0000236)
    Fold Change: -1.0231
    Cell Significance Index: -12.0900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -1.0251
    Cell Significance Index: -12.9900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -1.0488
    Cell Significance Index: -13.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CST1 is a small cysteine-rich protein that belongs to the cystatin family, which is characterized by its ability to inhibit cysteine-type endopeptidases. The protein is encoded by the CST1 gene, which is located on chromosome 21q22.3. CST1 is a member of the cysteine proteinase inhibitor (CPI) family, which plays a crucial role in regulating the activity of various cysteine-type endopeptidases. The protein is highly conserved across species, suggesting its importance in maintaining cellular homeostasis. **Pathways and Functions:** The pathways and functions of CST1 are multifaceted, and it is involved in various physiological processes. Some of the key pathways and functions of CST1 include: 1. **Negative regulation of cysteine-type endopeptidase activity:** CST1 inhibits the activity of cysteine-type endopeptidases, such as cathepsins and granzymes, which are involved in protein degradation and apoptosis. 2. **Detection of chemical stimulus involved in sensory perception of bitter taste:** CST1 is expressed in the taste buds of the tongue and plays a role in detecting bitter taste compounds. 3. **Protein binding:** CST1 binds to various proteins, including cysteine-type endopeptidases, and regulates their activity. 4. **Cytoplasmic localization:** CST1 is localized to the cytoplasm, where it can interact with cysteine-type endopeptidases and regulate their activity. **Clinical Significance:** CST1 has been implicated in various diseases and disorders, including: 1. **Immunological disorders:** CST1 has been shown to play a role in regulating immune responses, and its dysregulation has been implicated in diseases such as rheumatoid arthritis and multiple sclerosis. 2. **Neurological disorders:** CST1 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it may play a role in regulating protein degradation and apoptosis. 3. **Cancer:** CST1 has been shown to be overexpressed in various types of cancer, including breast cancer and lung cancer, where it may play a role in regulating tumor growth and metastasis. In conclusion, CST1 is a multifunctional protein that plays a crucial role in regulating cysteine-type endopeptidase activity, detecting chemical stimuli involved in sensory perception of bitter taste, and modulating immune responses. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of CST1 in maintaining cellular homeostasis and overall health.

Genular Protein ID: 3393375864

Symbol: CYTN_HUMAN

Name: Cystatin-SN

UniProtKB Accession Codes:

P01037 Q96LE6 Q9UCQ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3446578

Title: Human cysteine-proteinase inhibitors: nucleotide sequence analysis of three members of the cystatin gene family.

PubMed ID: 3446578

DOI: 10.1016/0378-1119(87)90196-x

PubMed ID: 2837486

Title: Purification, molecular cloning, and sequencing of salivary cystatin SA-1.

PubMed ID: 2837486

DOI: 10.1016/s0021-9258(19)76552-1

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3202964

Title: Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes.

PubMed ID: 3202964

PubMed ID: 1778989

Title: Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S.

PubMed ID: 1778989

DOI: 10.1093/oxfordjournals.jbchem.a123634

PubMed ID: 11788998

Title: Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting.

PubMed ID: 11788998

DOI: 10.1002/1615-9861(200201)2:1<112::aid-prot112>3.3.co;2-e

PubMed ID: 3514272

Title: Characterization of a new cysteine proteinase inhibitor of human saliva, cystatin SN, which is immunologically related to cystatin S.

PubMed ID: 3514272

DOI: 10.1016/0014-5793(86)81201-7

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

PubMed ID: 20189825

Title: Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry.

PubMed ID: 20189825

DOI: 10.1016/j.jasms.2010.01.025

Sequence Information:

  • Length: 141
  • Mass: 16388
  • Checksum: 9F9934704D6C077D
  • Sequence:
    • MAQYLSTLLL LLATLAVALA WSPKEEDRII PGGIYNADLN DEWVQRALHF AISEYNKATK 
DDYYRRPLRV LRARQQTVGG VNYFFDVEVG RTICTKSQPN LDTCAFHEQP ELQKKQLCSF 
EIYEVPWENR RSLVKSRCQE S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.