Genular: Defining Cellular Identity and Function

Details for: Rack1

Gene ID: 14694

Symbol: Rack1

Ensembl ID: ENSMUSG00000020372

Description: receptor for activated C kinase 1

Associated with

Death receptor signaling
(R-MMU-73887)
Regulation of tnfr1 signaling
(R-MMU-5357905)
Signal transduction
(R-MMU-162582)
Tnfr1-induced nf-kappa-b signaling pathway
(R-MMU-5357956)
Tnfr1-mediated ceramide production
(R-MMU-5626978)
Tnf signaling
(R-MMU-75893)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Apoptotic process
(GO:0006915)
Bh3 domain binding
(GO:0051434)
Cell body
(GO:0044297)
Cell cycle
(GO:0007049)
Cell projection
(GO:0042995)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to growth factor stimulus
(GO:0071363)
Cyclin binding
(GO:0030332)
Cysteine-type endopeptidase activator activity involved in apoptotic process
(GO:0008656)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Enzyme binding
(GO:0019899)
Gastrulation
(GO:0007369)
Intracellular signal transduction
(GO:0035556)
Ion channel inhibitor activity
(GO:0008200)
Ire1-rack1-pp2a complex
(GO:1990630)
Membrane
(GO:0016020)
Midbody
(GO:0030496)
Mitochondrion
(GO:0005739)
Multicellular organism development
(GO:0007275)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
(GO:1903751)
Negative regulation of peptidyl-serine phosphorylation
(GO:0033137)
Negative regulation of phagocytosis
(GO:0050765)
Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051898)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Negative regulation of translation
(GO:0017148)
Neuronal cell body
(GO:0043025)
Neuron projection
(GO:0043005)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Phagocytic cup
(GO:0001891)
Pigmentation
(GO:0043473)
Plasma membrane
(GO:0005886)
Positive regulation of amide metabolic process
(GO:0034250)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cellular metabolic process
(GO:0031325)
Positive regulation of cyclic-nucleotide phosphodiesterase activity
(GO:0051343)
Positive regulation of golgi to plasma membrane protein transport
(GO:0042998)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of intrinsic apoptotic signaling pathway
(GO:2001244)
Positive regulation of lipid metabolic process
(GO:0045834)
Positive regulation of mitochondrial depolarization
(GO:0051901)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase c binding
(GO:0005080)
Protein localization
(GO:0008104)
Protein phosphatase binding
(GO:0019903)
Protein tyrosine kinase inhibitor activity
(GO:0030292)
Protein ubiquitination
(GO:0016567)
Receptor tyrosine kinase binding
(GO:0030971)
Regulation of cell cycle
(GO:0051726)
Regulation of membrane lipid metabolic process
(GO:1905038)
Regulation of protein localization to plasma membrane
(GO:1903076)
Regulation of translation
(GO:0006417)
Rescue of stalled ribosome
(GO:0072344)
Rhythmic process
(GO:0048511)
Ribonucleoprotein complex
(GO:1990904)
Ribosome
(GO:0005840)
Ribosome binding
(GO:0043022)
Sh2 domain binding
(GO:0042169)
Signaling adaptor activity
(GO:0035591)
Signaling receptor activity
(GO:0038023)
Small ribosomal subunit
(GO:0015935)
Translation
(GO:0006412)
Translation regulator activity
(GO:0045182)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)

Other Information

Proteins

12-3

Genular Protein ID: 770584101

Symbol: RACK1_MOUSE

Name: 12-3

UniProtKB Accession Codes:

P68040 P25388 P99049 Q3THP0 Q3THY7 Q3TKQ0 Q3TW88 Q5NCC5 Q5NCC6 Q9CSQ0 Q9ERM6

Database IDs:

Citations:

PubMed ID: 7968370

Title: Cloning and expression of a neural differentiation-associated gene, p205, in the embryonal carcinoma cell line P19 and in the developing mouse.

PubMed ID: 7968370

DOI: 10.1016/0169-328x(94)90144-9

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16414032

Title: Localization of the scaffolding protein RACK1 in the developing and adult mouse brain.

PubMed ID: 16414032

DOI: 10.1016/j.brainres.2005.11.018

PubMed ID: 18258429

Title: RACK1 inhibits TRPM6 activity via phosphorylation of the fused alpha-kinase domain.

PubMed ID: 18258429

DOI: 10.1016/j.cub.2007.12.058

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20093473

Title: Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock.

PubMed ID: 20093473

DOI: 10.1126/science.1180067

PubMed ID: 21262816

Title: Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity.

PubMed ID: 21262816

DOI: 10.1073/pnas.1013170108

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 33505023

Title: AIM2 in regulatory T cells restrains autoimmune diseases.

PubMed ID: 33505023

DOI: 10.1038/s41586-021-03231-w

PubMed ID: 36517592

Title: A male germ-cell-specific ribosome controls male fertility.

PubMed ID: 36517592

DOI: 10.1038/s41586-022-05508-0

Sequence Information:

Length: 317
Mass: 35077
Checksum: 257F91E369ED2044
Sequence:

MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR 
GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSSDNRQI 
VSGSRDKTIK LWNTLGVCKY TVQDESHSEW VSCVRFSPNS SNPIIVSCGW DKLVKVWNLA 
NCKLKTNHIG HTGYLNTVTV SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDIINALC 
FSPNRYWLCA ATGPSIKIWD LEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA 
GYTDNLVRVW QVTIGTR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rack1

Associated with

Other Information

Cloning and expression of a neural differentiation-associated gene, p205, in the embryonal carcinoma cell line P19 and in the developing mouse. PubMed ID: 7968370

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Localization of the scaffolding protein RACK1 in the developing and adult mouse brain. PubMed ID: 16414032

RACK1 inhibits TRPM6 activity via phosphorylation of the fused alpha-kinase domain. PubMed ID: 18258429

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock. PubMed ID: 20093473

Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity. PubMed ID: 21262816

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

AIM2 in regulatory T cells restrains autoimmune diseases. PubMed ID: 33505023

A male germ-cell-specific ribosome controls male fertility. PubMed ID: 36517592