Genular: Defining Cellular Identity and Function

Details for: Gnb5

Gene ID: 14697

Symbol: Gnb5

Ensembl ID: ENSMUSG00000032192

Description: guanine nucleotide binding protein (G protein), beta 5

Associated with

Activation of gabab receptors
(R-MMU-991365)
Activation of g protein gated potassium channels
(R-MMU-1296041)
Activation of kainate receptors upon glutamate binding
(R-MMU-451326)
Adp signalling through p2y purinoceptor 1
(R-MMU-418592)
Adp signalling through p2y purinoceptor 12
(R-MMU-392170)
Adrenaline,noradrenaline inhibits insulin secretion
(R-MMU-400042)
Aquaporin-mediated transport
(R-MMU-445717)
Beta-catenin independent wnt signaling
(R-MMU-3858494)
Ca2+ pathway
(R-MMU-4086398)
Chaperonin-mediated protein folding
(R-MMU-390466)
Class b/2 (secretin family receptors)
(R-MMU-373080)
Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding
(R-MMU-6814122)
Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
G-protein activation
(R-MMU-202040)
G-protein beta:gamma signalling
(R-MMU-397795)
Gaba b receptor activation
(R-MMU-977444)
Gaba receptor activation
(R-MMU-977443)
G alpha (12/13) signalling events
(R-MMU-416482)
G alpha (i) signalling events
(R-MMU-418594)
G alpha (q) signalling events
(R-MMU-416476)
G alpha (s) signalling events
(R-MMU-418555)
G alpha (z) signalling events
(R-MMU-418597)
G beta:gamma signalling through btk
(R-MMU-8964315)
G beta:gamma signalling through cdc42
(R-MMU-8964616)
G beta:gamma signalling through pi3kgamma
(R-MMU-392451)
G beta:gamma signalling through plc beta
(R-MMU-418217)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-MMU-381676)
Glucagon-type ligand receptors
(R-MMU-420092)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Gper1 signaling
(R-MMU-9634597)
G protein gated potassium channels
(R-MMU-1296059)
Hemostasis
(R-MMU-109582)
Inactivation, recovery and regulation of the phototransduction cascade
(R-MMU-2514859)
Inhibition of voltage gated ca2+ channels via gbeta/gamma subunits
(R-MMU-997272)
Integration of energy metabolism
(R-MMU-163685)
Inwardly rectifying k+ channels
(R-MMU-1296065)
Metabolism
(R-MMU-1430728)
Metabolism of proteins
(R-MMU-392499)
Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Opioid signalling
(R-MMU-111885)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet homeostasis
(R-MMU-418346)
Potassium channels
(R-MMU-1296071)
Presynaptic function of kainate receptors
(R-MMU-500657)
Prostacyclin signalling through prostacyclin receptor
(R-MMU-392851)
Protein folding
(R-MMU-391251)
Regulation of insulin secretion
(R-MMU-422356)
Sensory perception
(R-MMU-9709957)
Signal amplification
(R-MMU-392518)
Signaling by gpcr
(R-MMU-372790)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by wnt
(R-MMU-195721)
The phototransduction cascade
(R-MMU-2514856)
Thrombin signalling through proteinase activated receptors (pars)
(R-MMU-456926)
Thromboxane signalling through tp receptor
(R-MMU-428930)
Transmission across chemical synapses
(R-MMU-112315)
Transport of small molecules
(R-MMU-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-MMU-432040)
Visual phototransduction
(R-MMU-2187338)
Cell body
(GO:0044297)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dark adaptation
(GO:1990603)
Dopamine receptor signaling pathway
(GO:0007212)
G-protein gamma-subunit binding
(GO:0031682)
G protein-coupled receptor signaling pathway
(GO:0007186)
Gtpase activating protein binding
(GO:0032794)
Gtpase activator activity
(GO:0005096)
Heterotrimeric g-protein complex
(GO:0005834)
Light adaption
(GO:0036367)
Membrane
(GO:0016020)
Myelin sheath
(GO:0043209)
Negative regulation of voltage-gated calcium channel activity
(GO:1901386)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of gtpase activity
(GO:0043547)
Presynapse
(GO:0098793)
Protein-containing complex
(GO:0032991)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Signaling receptor complex adaptor activity
(GO:0030159)
Signal transduction
(GO:0007165)

Other Information

Proteins

Guanine nucleotide-binding protein subunit beta-5
Q3UG14_MOUSE

Genular Protein ID: 3427869334

Symbol: GNB5_MOUSE

Name: Guanine nucleotide-binding protein subunit beta-5

UniProtKB Accession Codes:

P62881 O35354 P54314 Q91WB3

Database IDs:

Citations:

PubMed ID: 8071339

Title: A fifth member of the mammalian G-protein beta-subunit family. Expression in brain and activation of the beta 2 isotype of phospholipase C.

PubMed ID: 8071339

DOI: 10.1016/s0021-9258(17)31768-4

PubMed ID: 8910430

Title: A novel form of the G protein beta subunit Gbeta5 is specifically expressed in the vertebrate retina.

PubMed ID: 8910430

DOI: 10.1074/jbc.271.45.28154

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12119397

Title: R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1.

PubMed ID: 12119397

DOI: 10.1073/pnas.152094799

PubMed ID: 16908407

Title: RGS expression rate-limits recovery of rod photoresponses.

PubMed ID: 16908407

DOI: 10.1016/j.neuron.2006.07.010

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 18204463

Title: Crystal structure of the multifunctional Gbeta5-RGS9 complex.

PubMed ID: 18204463

DOI: 10.1038/nsmb.1377

PubMed ID: 31311860

Title: The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex.

PubMed ID: 31311860

DOI: 10.1074/jbc.ra119.007533

PubMed ID: 34793198

Title: Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gbeta5 signaling complex.

PubMed ID: 34793198

DOI: 10.1126/science.abl4732

Sequence Information:

Length: 395
Mass: 43565
Checksum: 972A41AAEC4CB3F8
Sequence:

MCDQTFLVNV FGSCDKCFKQ RALRPVFKKS QQLNYCSTCA EIMATDGLHE NETLASLKSE 
AESLKGKLEE ERAKLHDVEL HQVAERVEAL GQFVMKTRRT LKGHGNKVLC MDWCKDKRRI 
VSSSQDGKVI VWDSFTTNKE HAVTMPCTWV MACAYAPSGC AIACGGLDNK CSVYPLTFDK 
NENMAAKKKS VAMHTNYLSA CSFTNSDMQI LTASGDGTCA LWDVESGQLL QSFHGHGADV 
LCLDLAPSET GNTFVSGGCD KKAMVWDMRS GQCVQAFETH ESDVNSVRYY PSGDAFASGS 
DDATCRLYDL RADREVAIYS KESIIFGASS VDFSLSGRLL FAGYNDYTIN VWDVLKGSRV 
SILFGHENRV STLRVSPDGT AFCSGSWDHT LRVWA

Genular Protein ID: 2486222278

Symbol: Q3UG14_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UG14

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 353
Mass: 38732
Checksum: 30FCF51C125A024D
Sequence:

MATDGLHENE TLASLKSEAE SLKGKLEEER AKLHDVELHQ VAERVEALGQ FVMKTRRTLK 
GHGNKVLCMD WCKDKRRIVS SSQDGKVIVW DSFTTNKEHA VTMPCTWVMA CAYAPSGCAI 
ACGGLDNKCS VYPLTFDKNE NMAAKKKSVA MHTNYLSACS FTNSDMQILT ASGDGTCALW 
DVESGQLLQS FHGHGADVLC LDLAPSETGN TFVSGGCDKK AMVWDMRSGQ CVQAFETHES 
DVNSVRYYPS GDAFASGSDD ATCRLYDLRA DREVAIYSKE SIIFGASSVD FSLSGRLLFA 
GYNDYTINVW DVLKGSRVSI LFGHENRVST LRVSPDGTAF CSGSWDHTLR VWA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gnb5

Associated with

Other Information

A fifth member of the mammalian G-protein beta-subunit family. Expression in brain and activation of the beta 2 isotype of phospholipase C. PubMed ID: 8071339

A novel form of the G protein beta subunit Gbeta5 is specifically expressed in the vertebrate retina. PubMed ID: 8910430

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1. PubMed ID: 12119397

RGS expression rate-limits recovery of rod photoresponses. PubMed ID: 16908407

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Crystal structure of the multifunctional Gbeta5-RGS9 complex. PubMed ID: 18204463

The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex. PubMed ID: 31311860

Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gbeta5 signaling complex. PubMed ID: 34793198

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073