Details for: ADRA1B

Gene ID: 147

Symbol: ADRA1B

Ensembl ID: ENSG00000170214

Description: adrenoceptor alpha 1B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 5.14
    Marker Score: 4931
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 4.94
    Marker Score: 2739
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 4.47
    Marker Score: 14304
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 2.82
    Marker Score: 23846
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1507
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.16
    Marker Score: 16586
  • Cell Name: interneuron (CL0000099)
    Fold Change: 2.08
    Marker Score: 951.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.03
    Marker Score: 77184
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.75
    Marker Score: 1959
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.65
    Marker Score: 937
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168043
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.37
    Marker Score: 3914
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 853
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.23
    Marker Score: 5139
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.18
    Marker Score: 11259
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.13
    Marker Score: 593
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7463
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.11
    Marker Score: 9540
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.1
    Marker Score: 2598
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.1
    Marker Score: 1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.04
    Marker Score: 16209
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71810.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48035
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.97
    Marker Score: 1847
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.87
    Marker Score: 664
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.83
    Marker Score: 5001
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.81
    Marker Score: 3311
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.79
    Marker Score: 1525
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1601
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3286.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.77
    Marker Score: 956
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1194
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.72
    Marker Score: 2565
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.67
    Marker Score: 41204
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.63
    Marker Score: 386
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.63
    Marker Score: 9430
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 402.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.6
    Marker Score: 250
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 455
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.57
    Marker Score: 206
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.56
    Marker Score: 867
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.55
    Marker Score: 207
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.55
    Marker Score: 246
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5
    Marker Score: 301
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.49
    Marker Score: 285
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.47
    Marker Score: 122
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.47
    Marker Score: 1814
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.46
    Marker Score: 9814
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.44
    Marker Score: 194
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.44
    Marker Score: 243
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.43
    Marker Score: 296
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 204
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.42
    Marker Score: 232
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.39
    Marker Score: 191
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.3
    Marker Score: 177
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.3
    Marker Score: 281
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.29
    Marker Score: 90
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.29
    Marker Score: 2967
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.29
    Marker Score: 111
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.28
    Marker Score: 309
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.28
    Marker Score: 134
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.26
    Marker Score: 126
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.25
    Marker Score: 75
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.25
    Marker Score: 251
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.25
    Marker Score: 79
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.24
    Marker Score: 207
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.24
    Marker Score: 63
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.22
    Marker Score: 199
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.21
    Marker Score: 4248
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.21
    Marker Score: 440.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.21
    Marker Score: 72.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.21
    Marker Score: 220
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 111
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.2
    Marker Score: 83
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.2
    Marker Score: 218

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Other Information

**Key characteristics:** - ADRA1B is a member of the alpha-1 adrenergic receptor family, which are G protein-coupled receptors that are involved in a wide range of physiological responses, including vasoconstriction, heart rate, and blood pressure regulation. - It is expressed in various cell types, including retinal horizontal cells, erythrocytes, amacrine cells, retinal bipolar neurons, conventional dendritic cells, and various interneurons. - The protein is a G protein-coupled receptor, meaning that it is a transmembrane protein that when activated by a specific ligand, it initiates a signaling cascade that involves the activation of downstream signaling pathways. **Pathways and functions:** - ADRA1B is involved in the regulation of the adrenoceptor-mediated G protein-coupled receptor signaling pathway. - It is a key regulator of vasoconstriction, as it is expressed in retinal cells and is involved in the regulation of blood flow to the retina. - ADRA1B also plays a role in regulating heart rate, as it is expressed in cardiac cells and is involved in the regulation of cardiac output. - It also regulates blood pressure by influencing the release of calcium ions from vascular smooth muscle cells. **Clinical significance:** - Mutations in the ADRA1B gene have been linked to certain eye diseases, including retinitis pigmentosa and age-related macular degeneration. - ADRA1B is a potential therapeutic target for diseases that are characterized by abnormal blood flow or cardiovascular dysfunction. **Additional information:** - The ADRA1B gene is located on chromosome 15q21.1. - It is a highly conserved gene, with a similar gene found in mammals, birds, and fish. - ADRA1B is a well-studied gene, and there are a number of drugs that target it for medical purposes.

Genular Protein ID: 3379519419

Symbol: ADA1B_HUMAN

Name: Alpha-1B adrenergic receptor

UniProtKB Accession Codes:

P35368 B0LPE1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 95 DrugCentral 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1328250

Title: Genomic organization and expression of the human alpha 1B-adrenergic receptor.

PubMed ID: 1328250

DOI: 10.1016/s0021-9258(19)36703-1

PubMed ID: 8183249

Title: The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.

PubMed ID: 8183249

PubMed ID: 7815325

Title: Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.

PubMed ID: 7815325

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18802028

Title: Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes.

PubMed ID: 18802028

DOI: 10.1161/circresaha.108.176024

PubMed ID: 22120526

Title: Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes.

PubMed ID: 22120526

DOI: 10.1016/j.cellsig.2011.11.014

PubMed ID: 24567387

Title: MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors.

PubMed ID: 24567387

DOI: 10.1073/pnas.1315359111

Sequence Information:

  • Length: 520
  • Mass: 56836
  • Checksum: F081A23D2F943F7F
  • Sequence:
    • MNPDLDTGHN TSAPAHWGEL KNANFTGPNQ TSSNSTLPQL DITRAISVGL VLGAFILFAI 
VGNILVILSV ACNRHLRTPT NYFIVNLAMA DLLLSFTVLP FSAALEVLGY WVLGRIFCDI 
WAAVDVLCCT ASILSLCAIS IDRYIGVRYS LQYPTLVTRR KAILALLSVW VLSTVISIGP 
LLGWKEPAPN DDKECGVTEE PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG 
VMKEMSNSKE LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV 
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC SSKEFKRAFV 
RILGCQCRGR GRRRRRRRRR LGGCAYTYRP WTRGGSLERS QSRKDSLDDS GSCLSGSQRT 
LPSASPSPGY LGRGAPPPVE LCAFPEWKAP GALLSLPAPE PPGRRGRHDS GPLFTFKLLT 
EPESPGTDGG ASNGGCEAAA DVANGQPGFK SNMPLAPGQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.