Details for: ADRA1B

Gene ID: 147

Symbol: ADRA1B

Ensembl ID: ENSG00000170214

Description: adrenoceptor alpha 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.0089
    Cell Significance Index: 59.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.4247
    Cell Significance Index: 95.8000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.0708
    Cell Significance Index: 15.8100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7815
    Cell Significance Index: 18.9300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7486
    Cell Significance Index: 14.6100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.6492
    Cell Significance Index: 8.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5041
    Cell Significance Index: 101.1200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.4935
    Cell Significance Index: 6.4000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.4560
    Cell Significance Index: 7.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3379
    Cell Significance Index: 121.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3210
    Cell Significance Index: 46.6600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2396
    Cell Significance Index: 3.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1993
    Cell Significance Index: 10.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1869
    Cell Significance Index: 11.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1666
    Cell Significance Index: 115.2500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1187
    Cell Significance Index: 2.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1059
    Cell Significance Index: 8.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0886
    Cell Significance Index: 1.9400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0662
    Cell Significance Index: 1.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0525
    Cell Significance Index: 1.2600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0338
    Cell Significance Index: 0.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0144
    Cell Significance Index: 2.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0095
    Cell Significance Index: 6.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0026
    Cell Significance Index: -4.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0043
    Cell Significance Index: -5.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0047
    Cell Significance Index: -8.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0057
    Cell Significance Index: -8.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0064
    Cell Significance Index: -4.7500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0095
    Cell Significance Index: -0.0900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0095
    Cell Significance Index: -0.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0128
    Cell Significance Index: -9.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0129
    Cell Significance Index: -9.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0150
    Cell Significance Index: -8.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0166
    Cell Significance Index: -9.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0182
    Cell Significance Index: -8.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0280
    Cell Significance Index: -8.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0424
    Cell Significance Index: -8.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0439
    Cell Significance Index: -7.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0514
    Cell Significance Index: -8.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0587
    Cell Significance Index: -8.0600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0620
    Cell Significance Index: -1.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0647
    Cell Significance Index: -2.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0713
    Cell Significance Index: -2.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0720
    Cell Significance Index: -8.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0807
    Cell Significance Index: -8.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0817
    Cell Significance Index: -1.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0839
    Cell Significance Index: -9.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0930
    Cell Significance Index: -9.6800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.1065
    Cell Significance Index: -1.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1067
    Cell Significance Index: -2.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1199
    Cell Significance Index: -4.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1295
    Cell Significance Index: -5.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1508
    Cell Significance Index: -8.4600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1530
    Cell Significance Index: -1.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1592
    Cell Significance Index: -4.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1612
    Cell Significance Index: -4.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1698
    Cell Significance Index: -2.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1839
    Cell Significance Index: -8.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1879
    Cell Significance Index: -8.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1986
    Cell Significance Index: -9.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1996
    Cell Significance Index: -7.5600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2151
    Cell Significance Index: -2.5100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2219
    Cell Significance Index: -2.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2229
    Cell Significance Index: -4.7300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2274
    Cell Significance Index: -3.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2286
    Cell Significance Index: -4.5200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2290
    Cell Significance Index: -3.9600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2368
    Cell Significance Index: -2.5800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2517
    Cell Significance Index: -3.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2564
    Cell Significance Index: -9.0100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2588
    Cell Significance Index: -2.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2634
    Cell Significance Index: -7.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2638
    Cell Significance Index: -6.7800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2639
    Cell Significance Index: -3.6600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2641
    Cell Significance Index: -5.6500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2663
    Cell Significance Index: -5.3100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2770
    Cell Significance Index: -8.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2920
    Cell Significance Index: -8.3700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2931
    Cell Significance Index: -10.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3009
    Cell Significance Index: -8.1900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3058
    Cell Significance Index: -7.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3101
    Cell Significance Index: -8.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3109
    Cell Significance Index: -4.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3251
    Cell Significance Index: -8.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3328
    Cell Significance Index: -8.7500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3341
    Cell Significance Index: -4.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3387
    Cell Significance Index: -9.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3389
    Cell Significance Index: -9.0800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3447
    Cell Significance Index: -4.4200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3522
    Cell Significance Index: -7.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3640
    Cell Significance Index: -9.1000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3689
    Cell Significance Index: -9.2000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3704
    Cell Significance Index: -9.2500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3742
    Cell Significance Index: -9.1300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3767
    Cell Significance Index: -5.0800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3797
    Cell Significance Index: -4.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3851
    Cell Significance Index: -8.0600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3858
    Cell Significance Index: -7.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3874
    Cell Significance Index: -8.9500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3940
    Cell Significance Index: -4.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G Protein-Coupled Receptor (GPCR) Structure:** The alpha-1B adrenergic receptor is a transmembrane receptor that spans the plasma membrane, with seven transmembrane domains and three intracellular loops. 2. **Agonist and Antagonist Binding:** The receptor is activated by the endogenous agonists epinephrine and norepinephrine, which bind to specific binding sites on the receptor. Antagonists, such as prazosin, can block receptor activation. 3. **Signaling Pathways:** The alpha-1B adrenergic receptor activates adenylate cyclase, leading to the production of cAMP, which in turn activates various downstream signaling pathways, including the MAPK cascade and the regulation of cardiac muscle contraction. 4. **Cellular Expression:** The ADRA1B gene is highly expressed in various cell types, including immune cells (e.g., plasma cells, megakaryocytes), neurons (e.g., retinal bipolar neurons, amacrine cells), and cardiac muscle cells. **Pathways and Functions:** 1. **Adenylate Cyclase-Activating Adrenergic Receptor Signaling Pathway:** The alpha-1B adrenergic receptor activates adenylate cyclase, leading to the production of cAMP, which regulates various cellular processes, including cardiac muscle contraction and immune response. 2. **Adenylate Cyclase-Modulating G Protein-Coupled Receptor Signaling Pathway:** The alpha-1B adrenergic receptor modulates the activity of adenylate cyclase, influencing the production of cAMP and subsequent signaling pathways. 3. **Cardiovascular Regulation:** The alpha-1B adrenergic receptor plays a crucial role in regulating cardiac muscle contraction, heart rate, and blood pressure. 4. **Immune Response:** The alpha-1B adrenergic receptor is involved in regulating immune cell function, including the activation of plasma cells and the regulation of immune responses. **Clinical Significance:** 1. **Hypertension:** The alpha-1B adrenergic receptor is a target for antihypertensive therapy, as its activation contributes to vasoconstriction and increased blood pressure. 2. **Cardiac Arrhythmias:** The alpha-1B adrenergic receptor plays a role in regulating cardiac muscle contraction and heart rate, making it a potential target for the treatment of cardiac arrhythmias. 3. **Neurological Disorders:** The alpha-1B adrenergic receptor is involved in neurotransmission and has been implicated in various neurological disorders, including Parkinson's disease and multiple sclerosis. 4. **Cancer:** The alpha-1B adrenergic receptor has been shown to play a role in cancer progression and metastasis, making it a potential target for cancer therapy. In conclusion, the alpha-1B adrenergic receptor gene plays a crucial role in various physiological processes, including cardiovascular regulation, immune response, and neurotransmission. Understanding the mechanisms of action and clinical significance of this receptor is essential for the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 3379519419

Symbol: ADA1B_HUMAN

Name: Alpha-1B adrenergic receptor

UniProtKB Accession Codes:

P35368 B0LPE1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 95 DrugCentral 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1328250

Title: Genomic organization and expression of the human alpha 1B-adrenergic receptor.

PubMed ID: 1328250

DOI: 10.1016/s0021-9258(19)36703-1

PubMed ID: 8183249

Title: The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.

PubMed ID: 8183249

PubMed ID: 7815325

Title: Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.

PubMed ID: 7815325

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18802028

Title: Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes.

PubMed ID: 18802028

DOI: 10.1161/circresaha.108.176024

PubMed ID: 22120526

Title: Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes.

PubMed ID: 22120526

DOI: 10.1016/j.cellsig.2011.11.014

PubMed ID: 24567387

Title: MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors.

PubMed ID: 24567387

DOI: 10.1073/pnas.1315359111

Sequence Information:

  • Length: 520
  • Mass: 56836
  • Checksum: F081A23D2F943F7F
  • Sequence:
    • MNPDLDTGHN TSAPAHWGEL KNANFTGPNQ TSSNSTLPQL DITRAISVGL VLGAFILFAI 
VGNILVILSV ACNRHLRTPT NYFIVNLAMA DLLLSFTVLP FSAALEVLGY WVLGRIFCDI 
WAAVDVLCCT ASILSLCAIS IDRYIGVRYS LQYPTLVTRR KAILALLSVW VLSTVISIGP 
LLGWKEPAPN DDKECGVTEE PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG 
VMKEMSNSKE LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV 
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC SSKEFKRAFV 
RILGCQCRGR GRRRRRRRRR LGGCAYTYRP WTRGGSLERS QSRKDSLDDS GSCLSGSQRT 
LPSASPSPGY LGRGAPPPVE LCAFPEWKAP GALLSLPAPE PPGRRGRHDS GPLFTFKLLT 
EPESPGTDGG ASNGGCEAAA DVANGQPGFK SNMPLAPGQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.