Details for: CST2

Gene ID: 1470

Symbol: CST2

Ensembl ID: ENSG00000170369

Description: cystatin SA

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 6.38
    Marker Score: 3536
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.93
    Marker Score: 2231
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.62
    Marker Score: 1381
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.65
    Marker Score: 690
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.51
    Marker Score: 3437
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.33
    Marker Score: 1489
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.26
    Marker Score: 1198
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.16
    Marker Score: 767
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7490
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5357
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1364
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.82
    Marker Score: 1547
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 495
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.6
    Marker Score: 1211
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.5
    Marker Score: 232
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.49
    Marker Score: 7601
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.38
    Marker Score: 294
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.33
    Marker Score: 197
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 134
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.29
    Marker Score: 401
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.24
    Marker Score: 116
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 388.5
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.23
    Marker Score: 148
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.21
    Marker Score: 364
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.19
    Marker Score: 181
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.17
    Marker Score: 72
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.16
    Marker Score: 202
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.16
    Marker Score: 39
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.16
    Marker Score: 174
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.16
    Marker Score: 39
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.15
    Marker Score: 145
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.14
    Marker Score: 35
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.12
    Marker Score: 57
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 23
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.1
    Marker Score: 161
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.1
    Marker Score: 104
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1
    Marker Score: 1702
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.09
    Marker Score: 169
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 80
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.08
    Marker Score: 173
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.08
    Marker Score: 127
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.08
    Marker Score: 198
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.07
    Marker Score: 48
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.07
    Marker Score: 106
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.06
    Marker Score: 198
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.06
    Marker Score: 397
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.06
    Marker Score: 173
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 58
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: fibrocyte (CL0000135)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.05
    Marker Score: 95
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.04
    Marker Score: 106
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 24.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.04
    Marker Score: 226
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.04
    Marker Score: 98
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.04
    Marker Score: 46
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.03
    Marker Score: 35
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.03
    Marker Score: 55
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.03
    Marker Score: 67
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.02
    Marker Score: 25

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Other Information

**Key characteristics:** * Gene name: CST2 * Ensembl ID: ENSG00000170369 * Protein: CYTT_HUMAN (Cystatin-SA) * Pathway: Cysteine-type endopeptidase inhibitor activity * Ontology: Ctoplasm * Function: Negative regulation of cysteine-type endopeptidase activity **Pathways and functions:** * The CST2 gene encodes a protein that acts as a cysteine-type endopeptidase inhibitor. * This protein is expressed in a variety of cell types, including erythrocyte, megakaryocyte, hematopoietic stem cell, megakaryocyte-erythroid progenitor cell, acinar cell of salivary gland, plasma cell, B cell, precursor B cell, goblet cell, and absorptive cell. * The protein inhibits the activity of cysteine-type endopeptidases, which are enzymes that break down proteins. * This inhibition helps to maintain the stability and function of other proteins involved in taste sensation. * In the context of taste sensation, the CST2 protein is thought to be involved in the detection of chemical stimuli that trigger the sensation of bitter taste. **Clinical significance:** * Mutations in the CST2 gene have been linked to a number of human diseases, including laryngeal cancer, esophageal cancer, and chronic pain. * These mutations can lead to the loss of CST2 protein function, which can result in the abnormal perception of taste. * As a result, individuals with CST2 mutations may experience bitter taste, which can be a symptom of these diseases. * Therefore, CST2 is a promising target for the treatment of taste disorders associated with cancer and chronic pain.

Genular Protein ID: 3961827958

Symbol: CYTT_HUMAN

Name: Cystatin-SA

UniProtKB Accession Codes:

P09228 Q9UCQ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3446578

Title: Human cysteine-proteinase inhibitors: nucleotide sequence analysis of three members of the cystatin gene family.

PubMed ID: 3446578

DOI: 10.1016/0378-1119(87)90196-x

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1778989

Title: Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S.

PubMed ID: 1778989

DOI: 10.1093/oxfordjournals.jbchem.a123634

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 3436950

Title: Characterization and amino acid sequence of a new acidic cysteine proteinase inhibitor (cystatin SA) structurally closely related to cystatin S, from human whole saliva.

PubMed ID: 3436950

DOI: 10.1093/oxfordjournals.jbchem.a122107

PubMed ID: 3202964

Title: Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes.

PubMed ID: 3202964

PubMed ID: 11879580

Title: Expression of type 2 cystatin genes CST1-CST5 in adult human tissues and the developing submandibular gland.

PubMed ID: 11879580

DOI: 10.1089/10445490252810311

PubMed ID: 20189825

Title: Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry.

PubMed ID: 20189825

DOI: 10.1016/j.jasms.2010.01.025

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

Sequence Information:

  • Length: 141
  • Mass: 16445
  • Checksum: EB54915B1B977AA2
  • Sequence:
    • MAWPLCTLLL LLATQAVALA WSPQEEDRII EGGIYDADLN DERVQRALHF VISEYNKATE 
DEYYRRLLRV LRAREQIVGG VNYFFDIEVG RTICTKSQPN LDTCAFHEQP ELQKKQLCSF 
QIYEVPWEDR MSLVNSRCQE A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.