CST3 | ENSG00000101439 | NCBI 1471

Details for: CST3

Gene ID: 1471

Symbol: CST3

Ensembl ID: ENSG00000101439

Description: cystatin C

Associated with

Amyloid fiber formation
(R-HSA-977225)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism of proteins
(R-HSA-392499)
Neutrophil degranulation
(R-HSA-6798695)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Amyloid-beta binding
(GO:0001540)
Cysteine-type endopeptidase inhibitor activity
(GO:0004869)
Cytoplasm
(GO:0005737)
Defense response
(GO:0006952)
Endopeptidase inhibitor activity
(GO:0004866)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Ficolin-1-rich granule lumen
(GO:1904813)
Golgi apparatus
(GO:0005794)
Identical protein binding
(GO:0042802)
Negative regulation of blood vessel remodeling
(GO:0060313)
Negative regulation of collagen catabolic process
(GO:0010711)
Negative regulation of cysteine-type endopeptidase activity
(GO:2000117)
Negative regulation of elastin catabolic process
(GO:0060311)
Negative regulation of extracellular matrix disassembly
(GO:0010716)
Negative regulation of peptidase activity
(GO:0010466)
Negative regulation of proteolysis
(GO:0045861)
Peptidase inhibitor activity
(GO:0030414)
Plasma membrane
(GO:0005886)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Regulation of tissue remodeling
(GO:0034103)
Supramolecular fiber organization
(GO:0097435)
Tertiary granule lumen
(GO:1904724)
Vesicle
(GO:0031982)

Other Information

Proteins

Cystatin-C

Genular Protein ID: 2360737090

Symbol: CYTC_HUMAN

Name: Cystatin-C

UniProtKB Accession Codes:

P01034 B2R5J9 D3DW42 Q6FGW9

Database IDs:

Citations:

PubMed ID: 3495457

Title: Molecular cloning and sequence analysis of cDNA coding for the precursor of the human cysteine proteinase inhibitor cystatin C.

PubMed ID: 3495457

DOI: 10.1016/0014-5793(87)80695-6

PubMed ID: 2764935

Title: The human cystatin C gene (CST3) is a member of the cystatin gene family which is localized on chromosome 20.

PubMed ID: 2764935

DOI: 10.1016/0006-291x(89)90818-8

PubMed ID: 2541223

Title: Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases.

PubMed ID: 2541223

DOI: 10.1084/jem.169.5.1771

PubMed ID: 2363674

Title: Structure and expression of the human cystatin C gene.

PubMed ID: 2363674

DOI: 10.1042/bj2680287

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6283552

Title: Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis.

PubMed ID: 6283552

DOI: 10.1073/pnas.79.9.3024

PubMed ID: 6365094

Title: Human cystatin, a new protein inhibitor of cysteine proteinases.

PubMed ID: 6365094

DOI: 10.1016/0006-291x(84)91073-8

PubMed ID: 6662498

Title: Protein inhibitors of cysteine proteinases. III. Amino-acid sequence of cystatin from chicken egg white.

PubMed ID: 6662498

DOI: 10.1515/bchm2.1983.364.2.1487

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 15274116

Title: Cystatin C as a potential cerebrospinal fluid marker for the diagnosis of Creutzfeldt-Jakob disease.

PubMed ID: 15274116

DOI: 10.1002/pmic.200300799

PubMed ID: 16635487

Title: A dual Golgi- and mitochondria-localised Ala25Ser precursor cystatin C: an additional tool for characterising intracellular mis-localisation leading to increased AMD susceptibility.

PubMed ID: 16635487

DOI: 10.1016/j.exer.2006.01.030

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 20189825

Title: Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry.

PubMed ID: 20189825

DOI: 10.1016/j.jasms.2010.01.025

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11276250

Title: Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping.

PubMed ID: 11276250

DOI: 10.1038/86188

PubMed ID: 16170782

Title: 3D domain-swapped human cystatin C with amyloid-like intermolecular beta-sheets.

PubMed ID: 16170782

DOI: 10.1002/prot.20633

PubMed ID: 1352269

Title: Hereditary cystatin C amyloid angiopathy: identification of the disease-causing mutation and specific diagnosis by polymerase chain reaction based analysis.

PubMed ID: 1352269

DOI: 10.1007/bf00194306

PubMed ID: 11815350

Title: CST3 genotype associated with exudative age related macular degeneration.

PubMed ID: 11815350

DOI: 10.1136/bjo.86.2.214

Sequence Information:

Length: 146
Mass: 15799
Checksum: 75EF049CAE2E8B2B
Sequence:

MAGPLRAPLL LLAILAVALA VSPAAGSSPG KPPRLVGGPM DASVEEEGVR RALDFAVGEY 
NKASNDMYHS RALQVVRARK QIVAGVNYFL DVELGRTTCT KTQPNLDNCP FHDQPHLKRK 
AFCSFQIYAV PWQGTMTLSK STCQDA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CST3

Associated with

Other Information

Molecular cloning and sequence analysis of cDNA coding for the precursor of the human cysteine proteinase inhibitor cystatin C. PubMed ID: 3495457

The human cystatin C gene (CST3) is a member of the cystatin gene family which is localized on chromosome 20. PubMed ID: 2764935

Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases. PubMed ID: 2541223

Structure and expression of the human cystatin C gene. PubMed ID: 2363674

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis. PubMed ID: 6283552

Human cystatin, a new protein inhibitor of cysteine proteinases. PubMed ID: 6365094

Protein inhibitors of cysteine proteinases. III. Amino-acid sequence of cystatin from chicken egg white. PubMed ID: 6662498

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Cystatin C as a potential cerebrospinal fluid marker for the diagnosis of Creutzfeldt-Jakob disease. PubMed ID: 15274116

A dual Golgi- and mitochondria-localised Ala25Ser precursor cystatin C: an additional tool for characterising intracellular mis-localisation leading to increased AMD susceptibility. PubMed ID: 16635487

Enrichment of glycopeptides for glycan structure and attachment site identification. PubMed ID: 19838169

Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry. PubMed ID: 20189825

Initial characterization of the human central proteome. PubMed ID: 21269460

Resveratrol-induced changes of the human adipocyte secretion profile. PubMed ID: 22905912

A single kinase generates the majority of the secreted phosphoproteome. PubMed ID: 26091039

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping. PubMed ID: 11276250

3D domain-swapped human cystatin C with amyloid-like intermolecular beta-sheets. PubMed ID: 16170782

Hereditary cystatin C amyloid angiopathy: identification of the disease-causing mutation and specific diagnosis by polymerase chain reaction based analysis. PubMed ID: 1352269

CST3 genotype associated with exudative age related macular degeneration. PubMed ID: 11815350