Genular: Defining Cellular Identity and Function

Details for: Got2

Gene ID: 14719

Symbol: Got2

Ensembl ID: ENSMUSG00000031672

Description: glutamatic-oxaloacetic transaminase 2, mitochondrial

Associated with

Aspartate and asparagine metabolism
(R-MMU-8963693)
Gluconeogenesis
(R-MMU-70263)
Glucose metabolism
(R-MMU-70326)
Glutamate and glutamine metabolism
(R-MMU-8964539)
Glyoxylate metabolism and glycine degradation
(R-MMU-389661)
Metabolism
(R-MMU-1430728)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Metabolism of carbohydrates
(R-MMU-71387)
Amino acid binding
(GO:0016597)
Amino acid metabolic process
(GO:0006520)
Aspartate biosynthetic process
(GO:0006532)
Aspartate catabolic process
(GO:0006533)
Aspartate metabolic process
(GO:0006531)
Biosynthetic process
(GO:0009058)
Carboxylic acid binding
(GO:0031406)
Catalytic activity
(GO:0003824)
Cell surface
(GO:0009986)
Dicarboxylic acid metabolic process
(GO:0043648)
Enzyme binding
(GO:0019899)
Glutamate catabolic process to 2-oxoglutarate
(GO:0019551)
Glutamate catabolic process to aspartate
(GO:0019550)
Identical protein binding
(GO:0042802)
Kynurenine-oxoglutarate transaminase activity
(GO:0016212)
L-aspartate:2-oxoglutarate aminotransferase activity
(GO:0004069)
Lipid transport
(GO:0006869)
Membrane
(GO:0016020)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Myelin sheath
(GO:0043209)
Oxaloacetate metabolic process
(GO:0006107)
Perikaryon
(GO:0043204)
Phospholipid binding
(GO:0005543)
Plasma membrane
(GO:0005886)
Protein-containing complex
(GO:0032991)
Pyridoxal phosphate binding
(GO:0030170)
Response to ethanol
(GO:0045471)
Sarcolemma
(GO:0042383)
T-tubule
(GO:0030315)
Transaminase activity
(GO:0008483)
Transferase activity
(GO:0016740)

Other Information

Proteins

Aspartate aminotransferase, mitochondrial

Genular Protein ID: 2145237579

Symbol: AATM_MOUSE

Name: Aspartate aminotransferase, mitochondrial

UniProtKB Accession Codes:

P05202 O09188 Q3TIP6 Q3UD91 Q5HZH5

Database IDs:

Citations:

PubMed ID: 3782150

Title: Cloning and sequence analysis of mRNA for mouse aspartate aminotransferase isoenzymes.

PubMed ID: 3782150

DOI: 10.1016/s0021-9258(19)75987-0

PubMed ID: 2828632

Title: Structural organization of the mouse mitochondrial aspartate aminotransferase gene.

PubMed ID: 2828632

DOI: 10.1016/0022-2836(87)90454-2

PubMed ID: 10642497

Title: Mitochondrial aspartate aminotransferase: direction of a single protein with two distinct functions to two subcellular sites does not require alternative splicing of the mRNA.

PubMed ID: 10642497

DOI: 10.1042/bj3450423

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7878064

Title: Mitochondrial aspartate aminotransferase expressed on the surface of 3T3-L1 adipocytes mediates saturable fatty acid uptake.

PubMed ID: 7878064

DOI: 10.3181/00379727-208-43854

PubMed ID: 16800626

Title: Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease.

PubMed ID: 16800626

DOI: 10.1021/bi060474w

PubMed ID: 17442055

Title: Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain.

PubMed ID: 17442055

DOI: 10.1111/j.1471-4159.2007.04556.x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 31422819

Title: Bi-allelic GOT2 mutations cause a treatable malate-aspartate shuttle-related encephalopathy.

PubMed ID: 31422819

DOI: 10.1016/j.ajhg.2019.07.015

PubMed ID: 19826765

Title: Structure, expression, and function of kynurenine aminotransferases in human and rodent brains.

PubMed ID: 19826765

DOI: 10.1007/s00018-009-0166-4

PubMed ID: 20977429

Title: Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV.

PubMed ID: 20977429

DOI: 10.1042/bsr20100117

Sequence Information:

Length: 430
Mass: 47411
Checksum: D590524CA7FFB885
Sequence:

MALLHSSRIL SGMAAAFHPG LAAAASARAS SWWTHVEMGP PDPILGVTEA FKRDTNSKKM 
NLGVGAYRDD NGKPYVLPSV RKAEAQIAAK NLDKEYLPIG GLAEFCKASA ELALGENNEV 
LKSGRFVTVQ TISGTGALRV GASFLQRFFK FSRDVFLPKP SWGNHTPIFR DAGMQLQGYR 
YYDPKTCGFD FSGALEDISK IPEQSVLLLH ACAHNPTGVD PRPEQWKEIA SVVKKKNLFA 
FFDMAYQGFA SGDGDKDAWA VRHFIEQGIN VCLCQSYAKN MGLYGERVGA FTVVCKDAEE 
AKRVESQLKI LIRPLYSNPP LNGARIAATI LTSPDLRKQW LQEVKGMADR IISMRTQLVS 
NLKKEGSSHN WQHITDQIGM FCFTGLKPEQ VERLTKEFSV YMTKDGRISV AGVTSGNVGY 
LAHAIHQVTK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Got2

Associated with

Other Information

Cloning and sequence analysis of mRNA for mouse aspartate aminotransferase isoenzymes. PubMed ID: 3782150

Structural organization of the mouse mitochondrial aspartate aminotransferase gene. PubMed ID: 2828632

Mitochondrial aspartate aminotransferase: direction of a single protein with two distinct functions to two subcellular sites does not require alternative splicing of the mRNA. PubMed ID: 10642497

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mitochondrial aspartate aminotransferase expressed on the surface of 3T3-L1 adipocytes mediates saturable fatty acid uptake. PubMed ID: 7878064

Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease. PubMed ID: 16800626

Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain. PubMed ID: 17442055

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Bi-allelic GOT2 mutations cause a treatable malate-aspartate shuttle-related encephalopathy. PubMed ID: 31422819

Structure, expression, and function of kynurenine aminotransferases in human and rodent brains. PubMed ID: 19826765

Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV. PubMed ID: 20977429