Genular: Defining Cellular Identity and Function

Details for: Lrp2

Gene ID: 14725

Symbol: Lrp2

Ensembl ID: ENSMUSG00000027070

Description: low density lipoprotein receptor-related protein 2

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Cobalamin (cbl, vitamin b12) transport and metabolism
(R-MMU-196741)
Membrane trafficking
(R-MMU-199991)
Metabolism
(R-MMU-1430728)
Metabolism of fat-soluble vitamins
(R-MMU-6806667)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Metabolism of water-soluble vitamins and cofactors
(R-MMU-196849)
Retinoid metabolism and transport
(R-MMU-975634)
Sensory perception
(R-MMU-9709957)
Transport of rcbl within the body
(R-MMU-9758890)
Vesicle-mediated transport
(R-MMU-5653656)
Visual phototransduction
(R-MMU-2187338)
Amyloid-beta clearance
(GO:0097242)
Aorta development
(GO:0035904)
Apical part of cell
(GO:0045177)
Apical plasma membrane
(GO:0016324)
Axon
(GO:0030424)
Axonal growth cone
(GO:0044295)
Brush border
(GO:0005903)
Brush border membrane
(GO:0031526)
Calcium ion binding
(GO:0005509)
Cargo receptor activity
(GO:0038024)
Cell population proliferation
(GO:0008283)
Cell projection
(GO:0042995)
Cell surface
(GO:0009986)
Cellular response to growth factor stimulus
(GO:0071363)
Chemoattraction of axon
(GO:0061642)
Clathrin-coated pit
(GO:0005905)
Coronary artery morphogenesis
(GO:0060982)
Coronary vasculature development
(GO:0060976)
Dendrite
(GO:0030425)
Diol metabolic process
(GO:0034311)
Endocytic hemoglobin import into cell
(GO:0020028)
Endocytic vesicle
(GO:0030139)
Endocytosis
(GO:0006897)
Endoplasmic reticulum
(GO:0005783)
Endosomal transport
(GO:0016197)
Endosome
(GO:0005768)
External side of plasma membrane
(GO:0009897)
Extracellular space
(GO:0005615)
Folate import across plasma membrane
(GO:1904447)
Forebrain development
(GO:0030900)
Golgi apparatus
(GO:0005794)
Heart development
(GO:0007507)
Hemoglobin binding
(GO:0030492)
Hormone binding
(GO:0042562)
Insulin-like growth factor i binding
(GO:0031994)
Kidney development
(GO:0001822)
Low-density lipoprotein particle receptor binding
(GO:0050750)
Male gonad development
(GO:0008584)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Metal ion transport
(GO:0030001)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of bmp signaling pathway
(GO:0030514)
Nervous system development
(GO:0007399)
Neural tube closure
(GO:0001843)
Neuron projection arborization
(GO:0140058)
Nuclear receptor binding
(GO:0016922)
Outflow tract septum morphogenesis
(GO:0003148)
Pdz domain binding
(GO:0030165)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Plasma membrane
(GO:0005886)
Positive regulation of endocytosis
(GO:0045807)
Positive regulation of lipoprotein transport
(GO:0140077)
Positive regulation of neurogenesis
(GO:0050769)
Positive regulation of oligodendrocyte progenitor proliferation
(GO:0070447)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein import
(GO:0017038)
Protein transport
(GO:0015031)
Protein transporter activity
(GO:0140318)
Pulmonary artery morphogenesis
(GO:0061156)
Receptor-mediated endocytosis
(GO:0006898)
Receptor complex
(GO:0043235)
Response to leptin
(GO:0044321)
Response to x-ray
(GO:0010165)
Secondary heart field specification
(GO:0003139)
Sensory perception of sound
(GO:0007605)
Sh3 domain binding
(GO:0017124)
Signaling receptor activity
(GO:0038023)
Transcytosis
(GO:0045056)
Vagina development
(GO:0060068)
Ventricular compact myocardium morphogenesis
(GO:0003223)
Ventricular septum development
(GO:0003281)
Vitamin d metabolic process
(GO:0042359)

Other Information

Proteins

Low-density lipoprotein receptor-related protein 2

Genular Protein ID: 13150798

Symbol: LRP2_MOUSE

Name: Low-density lipoprotein receptor-related protein 2

UniProtKB Accession Codes:

A2ARV4 P70215 Q3TL35 Q9JLB3

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 10766831

Title: Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins.

PubMed ID: 10766831

DOI: 10.1074/jbc.275.16.12003

PubMed ID: 10052453

Title: An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3.

PubMed ID: 10052453

DOI: 10.1016/s0092-8674(00)80655-8

PubMed ID: 10772929

Title: LDL receptor-related protein as a component of the midkine receptor.

PubMed ID: 10772929

DOI: 10.1006/bbrc.2000.2549

PubMed ID: 11247302

Title: Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2.

PubMed ID: 11247302

DOI: 10.1034/j.1600-0854.2001.020206.x

PubMed ID: 11964399

Title: Megalin functions as an endocytic sonic hedgehog receptor.

PubMed ID: 11964399

DOI: 10.1074/jbc.m201933200

PubMed ID: 12724130

Title: Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin.

PubMed ID: 12724130

DOI: 10.1152/ajprenal.00062.2003

PubMed ID: 15467006

Title: Megalin binds and internalizes angiotensin II.

PubMed ID: 15467006

DOI: 10.1152/ajprenal.00243.2004

PubMed ID: 16143106

Title: Role of endocytosis in cellular uptake of sex steroids.

PubMed ID: 16143106

DOI: 10.1016/j.cell.2005.06.032

PubMed ID: 15623804

Title: LRP2/megalin is required for patterning of the ventral telencephalon.

PubMed ID: 15623804

DOI: 10.1242/dev.01580

PubMed ID: 16380466

Title: Megalin binds and internalizes angiotensin-(1-7).

PubMed ID: 16380466

DOI: 10.1152/ajprenal.00164.2005

PubMed ID: 16099815

Title: Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M.

PubMed ID: 16099815

DOI: 10.1210/me.2005-0209

PubMed ID: 17462596

Title: Megalin-mediated endocytosis of cystatin C in proximal tubule cells.

PubMed ID: 17462596

DOI: 10.1016/j.bbrc.2007.04.072

PubMed ID: 17846082

Title: Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss.

PubMed ID: 17846082

DOI: 10.1096/fj.07-9171com

PubMed ID: 18174160

Title: Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells.

PubMed ID: 18174160

DOI: 10.1074/jbc.m709945200

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20460439

Title: LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche.

PubMed ID: 20460439

DOI: 10.1242/jcs.065912

PubMed ID: 20637285

Title: Megalin interacts with APP and the intracellular adapter protein FE65 in neurons.

PubMed ID: 20637285

DOI: 10.1016/j.mcn.2010.07.005

PubMed ID: 22841573

Title: Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance.

PubMed ID: 22841573

DOI: 10.1016/j.cmet.2012.07.002

PubMed ID: 22340494

Title: LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.

PubMed ID: 22340494

DOI: 10.1016/j.devcel.2011.11.023

PubMed ID: 22354480

Title: Megalin mediates the influence of sonic hedgehog on oligodendrocyte precursor cell migration and proliferation during development.

PubMed ID: 22354480

DOI: 10.1002/glia.22316

PubMed ID: 23825075

Title: Renal uptake of the antiapoptotic protein survivin is mediated by megalin at the apical membrane of the proximal tubule.

PubMed ID: 23825075

DOI: 10.1152/ajprenal.00546.2012

PubMed ID: 24825475

Title: Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis.

PubMed ID: 24825475

DOI: 10.15252/embr.201338317

PubMed ID: 24639464

Title: LRP2 mediates folate uptake in the developing neural tube.

PubMed ID: 24639464

DOI: 10.1242/jcs.140145

PubMed ID: 26439398

Title: LRP2 acts as SHH clearance receptor to protect the retinal margin from mitogenic stimuli.

PubMed ID: 26439398

DOI: 10.1016/j.devcel.2015.09.001

PubMed ID: 26822476

Title: Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development.

PubMed ID: 26822476

DOI: 10.1242/dmm.022053

PubMed ID: 27773703

Title: N-glycoform-dependent interactions of megalin with its ligands.

PubMed ID: 27773703

DOI: 10.1016/j.bbagen.2016.10.015

PubMed ID: 28659595

Title: Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2.

PubMed ID: 28659595

DOI: 10.1038/s41598-017-04648-y

Sequence Information:

Length: 4660
Mass: 519208
Checksum: 4CF399C24DF2FAA4
Sequence:

MERGAAAAAW MLLLAIAACL APVSGQECGS GNFRCDNGYC IPASWRCDGT RDCLDDTDEI 
GCPPRSCGSG FFLCPAEGTC IPSSWVCDQD KDCSDGADEQ QNCPGTTCSS QQLTCSNGQC 
VPIEYRCDHV SDCPDGSDER NCYYPTCDQL TCANGACYNT SQKCDHKVDC RDSSDEANCT 
TLCSQKEFQC GSGECILRAY VCDHDNDCED NSDEHNCNYD TCGGHQFTCS NGQCINQNWV 
CDGDDDCQDS GDEDGCESNQ RHHTCYPREW ACPGSGRCIS MDKVCDGVPD CPEGEDENNA 
TSGRYCGTGL CSILNCEYQC HQTPYGGECF CPPGHIINSN DSRTCIDFDD CQIWGICDQK 
CESRQGRHQC LCEEGYILER GQHCKSNDSF SAASIIFSNG RDLLVGDLHG RNFRILAESK 
NRGIVMGVDF HYQKHRVFWT DPMQAKVFST DINGLNTQEI LNVSIDAPEN LAVDWINNKL 
YLVETRVNRI DVVNLEGNQR VTLITENLGH PRGIALDPTV GYLFFSDWGS LSGQPKVERA 
FMDGSNRKDL VTTKLGWPAG ITLDLVSKRV YWVDSRYDYI ETVTYDGIQR KTVARGGSLV 
PHPFGISLFE EHVFFTDWTK MAVMKANKFT DTNPQVYHQS SLTPFGVTVY HALRQPNATN 
PCGNNNGGCA QICVLSHRTD NGGLGYRCKC EFGFELDADE HHCVAVKNFL LFSSQTAVRG 
IPFTLSTQED VMVPVTGSPS FFVGIDFDAQ HSTIFYSDLS KNIIYQQKID GTGKEVITAN 
RLQNVECLSF DWISRNLYWT DGGSKSVTVM KLADKSRRQI ISNLNNPRSI VVHPAAGYMF 
LSDWFRPAKI MRAWSDGSHL MPIVNTSLGW PNGLAIDWST SRLYWVDAFF DKIEHSNLDG 
LDRKRLGHVD QMTHPFGLTV FKDNVFLTDW RLGAIIRVRK SDGGDMTVVR RGISSIMHVK 
AYDADLQTGT NYCSQTTHPN GDCSHFCFPV PNFQRVCGCP YGMKLQRDQM TCEGDPAREP 
PTQQCGSSSF PCNNGKCVPS IFRCDGVDDC HDNSDEHQCG ALNNTCSSSA FTCVHGGQCI 
PGQWRCDKQN DCLDGSDEQN CPTRSPSSTC PPTSFTCDNH MCIPKEWVCD TDNDCSDGSD 
EKNCQASGTC HPTQFRCPDH RCISPLYVCD GDKDCVDGSD EAGCVLNCTS SQFKCADGSS 
CINSRYRCDG VYDCKDNSDE AGCPTRPPGM CHPDEFQCQG DGTCIPNTWE CDGHPDCIQG 
SDEHNGCVPK TCSPSHFLCD NGNCIYNSWV CDGDNDCRDM SDEKDCPTQP FHCPSSQWQC 
PGYSICVNLS ALCDGVFDCP NGTDESPLCN QDSCLHFNGG CTHRCIQGPF GATCVCPIGY 
QLANDTKTCE DVNECDIPGF CSQHCVNMRG SFRCACDPEY TLESDGRTCK VTASENLLLV 
VASRDKIIMD NITAHTHNIY SLVQDVSFVV ALDFDSVTGR VFWSDLLEGK TWSAFQNGTD 
KRVVHDSGLS LTEMIAVDWI GRNIYWTDYT LETIEVSKID GSHRTVLISK NVTKPRGLAL 
DPRMGDNVMF WSDWGHHPRI ERASMDGTMR TVIVQEKIYW PCGLSIDYPN RLIYFMDAYL 
DYIEFCDYDG QNRRQVIASD LVLHHPHALT LFEDSVFWTD RGTHQVMQAN KWHGRNQSVV 
MYSVPQPLGI IAIHPSRQPS SPNPCASATC SHLCLLSAQE PRHYSCACPS GWNLSDDSVN 
CVRGDQPFLI SVRENVIFGI SLDPEVKSND AMVPISGIQH GYDVEFDDSE QFIYWVENPG 
EIHRVKTDGS NRTAFAPLSL LGSSLGLALD WVSRNIYYTT PASRSIEVLT LRGDTRYGKT 
LITNDGTPLG VGFPVGIAVD PARGKLYWSD HGTDSGVPAK IASANMDGTS LKILFTGNME 
HLEVVTLDIQ EQKLYWAVTS RGVIERGNVD GTERMILVHH LAHPWGLVVH GSFLYYSDEQ 
YEVIERVDKS SGSNKVVFRD NIPYLRGLRV YHHRNAADSS NGCSNNPNAC QQICLPVPGG 
MFSCACASGF KLSPDGRSCS PYNSFIVVSM LPAVRGFSLE LSDHSEAMVP VAGQGRNVLH 
ADVDVANGFI YWCDFSSSVR SSNGIRRIKP NGSNFTNIVT YGIGANGIRG VAVDWVAGNL 
YFTNAFVYET LIEVIRINTT YRRVLLKVSV DMPRHIVVDP KHRYLFWADY GQKPKIERSF 
LDCTNRTVLV SEGIVTPRGL AVDHDTGYIY WVDDSLDIIA RIHRDGGESQ VVRYGSRYPT 
PYGITVFGES IIWVDRNLRK VFQASKQPGN TDPPTVIRDS INLLRDVTIF DEHVQPLSPA 
ELNNNPCLQS NGGCSHFCFA LPELPTPKCG CAFGTLEDDG KNCATSREDF LIYSLNNSLR 
SLHFDPQDHN LPFQAISVEG MAIALDYDRR NNRIFFTQKL NPIRGQISYV NLYSGASSPT 
ILLSNIGVTD GIAFDWINRR IYYSDFSNQT INSMAEDGSN RAVIARVSKP RAIVLDPCRG 
YMYWTDWGTN AKIERATLGG NFRVPIVNTS LVWPNGLTLD LETDLLYWAD ASLQKIERST 
LTGSNREVVI STAFHSFGLT VYGQYIYWTD FYTKKIYRAN KYDGSDLIAM TTRLPTQPSG 
ISTVVKTQQQ QCSNPCDQFN GGCSHICAPG PNGAECQCPH EGSWYLANDN KYCVVDTGAR 
CNQFQFTCLN GRCISQDWKC DNDNDCGDGS DELPTVCAFH TCRSTAFTCA NGRCVPYHYR 
CDFYNDCGDN SDEAGCLFRS CNSTTEFTCS NGRCIPLSYV CNGINNCHDN DTSDEKNCPP 
ITCQPDFAKC QTTNICVPRA FLCDGDNDCG DGSDENPIYC ASHTCRSNEF QCVSPHRCIP 
SYWFCDGEAD CVDSSDEPDT CGHSLNSCSA NQFHCDNGRC ISSSWVCDGD NDCGDMSDED 
QRHHCELQNC SSTEFTCINS RPPNRRCIPQ HWVCDGDADC ADALDELQNC TMRACSTGEF 
SCANGRCIRQ SFRCDRRNDC GDYSDERGCS YPPCRDDQFT CQNGQCITKL YVCDEDNDCG 
DGSDEQEHLC HTPEPTCPPH QFRCDNGHCI EMGTVCNHVD DCSDNSDEKG CGINECQDSS 
ISHCDHNCTD TITSFYCSCL PGYKLMSDKR TCVDIDECKE TPQLCSQKCE NVIGSYICKC 
APGYIREPDG KSCRQNSNIE PYLVFSNRYY IRNLTIDGTS YSLILQGLGN VVALDFDRVE 
ERLYWIDAEK QIIERMFLNK TNQETIISHR LRRAESLAVD WVSRKLYWLD AILDCLFVSD 
LEGRQRKMLA QHCVDANNTF CFENPRGIVL HPQRGYVYWA DWGDHAYIAR IGMDGTNKTV 
IISTKIEWPN AITIDYTNDL LYWADAHLGY IEFSDLEGHH RHTVYDGTLP HPFALTIFED 
TVFWTDWNTR TVEKGNKYDG SGRVVLVNTT HKPFDIHVLH PYRQPIMSNP CATNNGGCSH 
LCLIKAGGRG FTCECPDDFQ TVQLRDRTLC MPMCSSTQFL CGNNEKCIPI WWKCDGQKDC 
SDGSDESDLC PHRFCRLGQF QCRDGNCTSP QALCNARQDC ADGSDEDRVL CEHHRCEANE 
WQCANKRCIP EYWQCDSVDD CLDNSDEDPS HCASRTCRPG QFKCNNGRCI PQSWKCDVDN 
DCGDYSDEPI HECMTAAYNC DNHTEFSCKT NYRCIPQWAV CNGFDDCRDN SDEQGCESVP 
CHPSGDFRCG NHHCIPLRWK CDGIDDCGDN SDEESCVPRE CTESEFRCAD QQCIPSRWVC 
DQENDCGDNS DERDCEMKTC HPEHFQCTSG HCVPKALACD GRADCLDASD ESACPTRFPN 
GTYCPAAMFE CKNHVCIQSF WICDGENDCV DGSDEEIHLC FNVPCESPQR FRCDNSRCIY 
GHQLCNGVDD CGDGSDEKEE HCRKPTHKPC TDTEYKCSNG NCVSQHYVCD NVDDCGDLSD 
ETGCNLGENR TCAEKICEQN CTQLSNGGFI CSCRPGFKPS TLDKNSCQDI NECEEFGICP 
QSCRNSKGSY ECFCVDGFKS MSTHYGERCA ADGSPPLLLL PENVRIRKYN ISSEKFSEYL 
EEEEHIQAID YDWDPEGIGL SVVYYTVLSQ GSQFGAIKRA YLPDFESGSN NPVREVDLGL 
KYLMQPDGLA VDWVGRHIYW SDAKSQRIEV ATLDGRYRKW LITTQLDQPA AIAVNPKLGL 
MFWTDQGKQP KIESAWMNGE HRSVLASANL GWPNGLSIDY LNGDRIYWSD SKEDVIESIK 
YDGTDRRLII NDAMKPFSLD IFEDQLYWVA KEKGEVWRQN KFGKGNKEKL LVVNPWLTQV 
RIFHQLRYNQ SVSNPCKQVC SHLCLLRPGG YSCACPQGSD FVTGSTVECD AASELPITMP 
SPCRCMHGGS CYFDENDLPK CKCSSGYSGE YCEIGLSRGI PPGTTMALLL TFAMVIIVGA 
LVLVGFFHYR KTGSLLPSLP KLPSLSSLAK PSENGNGVTF RSGADVNMDI GVSPFGPETI 
IDRSMAMNEQ FVMEVGKQPV IFENPMYAAK DSTSKVGLAV QGPSVSSQVT VPENVENQNY 
GRSIDPSEIV PEPKPASPGA DETQGTKWNI FKRKPKQTTN FENPIYAEMD TEQKEAVAVA 
PPPSPSLPAK ASKRSSTPGY TATEDTFKDT ANLVKEDSDV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lrp2

Associated with

Other Information

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins. PubMed ID: 10766831

An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. PubMed ID: 10052453

LDL receptor-related protein as a component of the midkine receptor. PubMed ID: 10772929

Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. PubMed ID: 11247302

Megalin functions as an endocytic sonic hedgehog receptor. PubMed ID: 11964399

Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin. PubMed ID: 12724130

Megalin binds and internalizes angiotensin II. PubMed ID: 15467006

Role of endocytosis in cellular uptake of sex steroids. PubMed ID: 16143106

LRP2/megalin is required for patterning of the ventral telencephalon. PubMed ID: 15623804

Megalin binds and internalizes angiotensin-(1-7). PubMed ID: 16380466

Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M. PubMed ID: 16099815

Megalin-mediated endocytosis of cystatin C in proximal tubule cells. PubMed ID: 17462596

Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss. PubMed ID: 17846082

Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells. PubMed ID: 18174160

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche. PubMed ID: 20460439

Megalin interacts with APP and the intracellular adapter protein FE65 in neurons. PubMed ID: 20637285

Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance. PubMed ID: 22841573

LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals. PubMed ID: 22340494

Megalin mediates the influence of sonic hedgehog on oligodendrocyte precursor cell migration and proliferation during development. PubMed ID: 22354480

Renal uptake of the antiapoptotic protein survivin is mediated by megalin at the apical membrane of the proximal tubule. PubMed ID: 23825075

Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis. PubMed ID: 24825475

LRP2 mediates folate uptake in the developing neural tube. PubMed ID: 24639464

LRP2 acts as SHH clearance receptor to protect the retinal margin from mitogenic stimuli. PubMed ID: 26439398

Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development. PubMed ID: 26822476

N-glycoform-dependent interactions of megalin with its ligands. PubMed ID: 27773703

Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2. PubMed ID: 28659595