Details for: Lilrb4b

Gene ID: 14727

Symbol: Lilrb4b

Ensembl ID: ENSMUSG00000112023

Description: leukocyte immunoglobulin-like receptor, subfamily B, member 4B

Associated with

  • Apolipoprotein binding
    (GO:0034185)
  • Cell surface
    (GO:0009986)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Fc receptor mediated inhibitory signaling pathway
    (GO:0002774)
  • Fibronectin binding
    (GO:0001968)
  • Immune system process
    (GO:0002376)
  • Inhibitory mhc class i receptor activity
    (GO:0032396)
  • Mast cell activation
    (GO:0045576)
  • Membrane
    (GO:0016020)
  • Negative regulation of activated t cell proliferation
    (GO:0046007)
  • Negative regulation of canonical nf-kappab signal transduction
    (GO:0043124)
  • Negative regulation of chemokine production
    (GO:0032682)
  • Negative regulation of cytokine production involved in inflammatory response
    (GO:1900016)
  • Negative regulation of cytotoxic t cell differentiation
    (GO:0045584)
  • Negative regulation of interleukin-1 beta production
    (GO:0032691)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of interleukin-5 production
    (GO:0032714)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of interleukin-10 production
    (GO:0032693)
  • Negative regulation of ip-10 production
    (GO:0071659)
  • Negative regulation of mapk cascade
    (GO:0043409)
  • Negative regulation of mirna transcription
    (GO:1902894)
  • Negative regulation of monocyte activation
    (GO:0150102)
  • Negative regulation of osteoclast differentiation
    (GO:0045671)
  • Negative regulation of protein localization to nucleus
    (GO:1900181)
  • Negative regulation of protein tyrosine kinase activity
    (GO:0061099)
  • Negative regulation of signaling receptor activity
    (GO:2000272)
  • Negative regulation of t cell costimulation
    (GO:2000524)
  • Negative regulation of t cell cytokine production
    (GO:0002725)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Negative regulation of t cell receptor signaling pathway
    (GO:0050860)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cd8-positive, alpha-beta t cell differentiation
    (GO:0043378)
  • Positive regulation of regulatory t cell differentiation
    (GO:0045591)
  • Positive regulation of t cell anergy
    (GO:0002669)
  • Protein phosphatase binding
    (GO:0019903)
  • Receptor internalization
    (GO:0031623)
  • Signaling receptor inhibitor activity
    (GO:0030547)
  • Tolerance induction
    (GO:0002507)
  • Transmembrane receptor protein tyrosine kinase inhibitor activity
    (GO:0030293)

Other Information

Genular Protein ID: 3177257739

Symbol: LRB4B_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q61450 Q549E3

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CTD 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 38 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 3 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 1714901

Title: Molecular cloning of gp49, a cell-surface antigen that is preferentially expressed by mouse mast cell progenitors and is a new member of the immunoglobulin superfamily.

PubMed ID: 1714901

DOI: 10.1016/s0021-9258(18)98502-9

PubMed ID: 10630292

Title: The gp49A gene has extensive sequence conservation with the gp49B gene and provides gp49A protein, a unique member of a large family of activating and inhibitory receptors of the immunoglobulin superfamily.

PubMed ID: 10630292

DOI: 10.1007/s002510050604

PubMed ID: 11046024

Title: Stimulatory function of gp49A, a murine Ig-like receptor, in rat basophilic leukemia cells.

PubMed ID: 11046024

DOI: 10.4049/jimmunol.165.9.4970

PubMed ID: 10982834

Title: Natural killer cells and mast cells from gp49B null mutant mice are functional.

PubMed ID: 10982834

DOI: 10.1128/mcb.20.19.7178-7182.2000

Sequence Information:

  • Length: 303
  • Mass: 34194
  • Checksum: D165659BFAB9C40D
  • Sequence:
    • MIAMLTVLLY LALILEPRTA VQAGHLPKPI IWAEPGSVIA AYTSVIIWCW GSWEAQYYYL 
DKEKSVNPWD TEVPLENRNK TKFKIRFMTA SYAGIYNCYY KSAAGFSEHS DAMELVMTGA 
YENPSLSVYP SSNVTSGVSI SFKCSSSTLF GRFILIQEGK HGLSWTLDSQ HQANQPTHAT 
FVLDAVAPNH NGTFRCYGFF RNEPQVWSKP SNSLDLMISE TKEQSCTPTE DGLETYQKIL 
IGVLVSFLLL FFLLLFLILI GYQCRHKNKA NASVKNTQSE DNAELNSWNP QNEDPPRELC 
TPR

Genular Protein ID: 2011796619

Symbol: A0A1W2P7F3_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A1W2P7F3

Database IDs:

AGR 1 ARBA 1 AlphaFoldDB 1 Bgee 1 CTD 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 InterPro 3 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 3 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 208
  • Mass: 23245
  • Checksum: 139A76213FD9DD21
  • Sequence:
    • MIAMLTVLLY LALILEPRTA VQAGAYENPS LSVYPSSNVT SGVSISFKCS SSTLFGRFIL 
IQEGKHGLSW TLDSQHQANQ PTHATFVLDA VAPNHNGTFR CYGFFRNEPQ VWSKPSNSLD 
LMISETKEQS CTPTEDGLET YQKILIGVLV SFLLLFFLLL FLILIGYQCR HKNKANASVK 
NTQSEDNAEL NSWNPQNEDP PRELCTPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.