Details for: Lilrb4a

Gene ID: 14728

Symbol: Lilrb4a

Ensembl ID: ENSMUSG00000062593

Description: leukocyte immunoglobulin-like receptor, subfamily B, member 4A

Associated with

  • Apolipoprotein binding
    (GO:0034185)
  • Blood coagulation
    (GO:0007596)
  • Cd4-positive, alpha-beta t cell proliferation
    (GO:0035739)
  • Cd8-positive, alpha-beta t cell proliferation
    (GO:0035740)
  • Cell surface
    (GO:0009986)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Chemokine production
    (GO:0032602)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytokine production
    (GO:0001816)
  • External side of plasma membrane
    (GO:0009897)
  • Fc receptor mediated inhibitory signaling pathway
    (GO:0002774)
  • Fibronectin binding
    (GO:0001968)
  • Inflammatory response
    (GO:0006954)
  • Inflammatory response to antigenic stimulus
    (GO:0002437)
  • Inhibitory mhc class i receptor activity
    (GO:0032396)
  • Integrin binding
    (GO:0005178)
  • Negative regulation of activated t cell proliferation
    (GO:0046007)
  • Negative regulation of canonical nf-kappab signal transduction
    (GO:0043124)
  • Negative regulation of chemokine production
    (GO:0032682)
  • Negative regulation of cytokine production involved in inflammatory response
    (GO:1900016)
  • Negative regulation of cytotoxic t cell differentiation
    (GO:0045584)
  • Negative regulation of immunoglobulin production
    (GO:0002638)
  • Negative regulation of interleukin-1 beta production
    (GO:0032691)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of interleukin-5 production
    (GO:0032714)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of interleukin-10 production
    (GO:0032693)
  • Negative regulation of ip-10 production
    (GO:0071659)
  • Negative regulation of mapk cascade
    (GO:0043409)
  • Negative regulation of mast cell activation
    (GO:0033004)
  • Negative regulation of mast cell activation involved in immune response
    (GO:0033007)
  • Negative regulation of mirna transcription
    (GO:1902894)
  • Negative regulation of monocyte activation
    (GO:0150102)
  • Negative regulation of natural killer cell activation
    (GO:0032815)
  • Negative regulation of osteoclast differentiation
    (GO:0045671)
  • Negative regulation of plasma cell differentiation
    (GO:1900099)
  • Negative regulation of protein localization to nucleus
    (GO:1900181)
  • Negative regulation of protein tyrosine kinase activity
    (GO:0061099)
  • Negative regulation of signaling receptor activity
    (GO:2000272)
  • Negative regulation of t cell costimulation
    (GO:2000524)
  • Negative regulation of t cell cytokine production
    (GO:0002725)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Negative regulation of t cell receptor signaling pathway
    (GO:0050860)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Neutrophil homeostasis
    (GO:0001780)
  • Phosphatase binding
    (GO:0019902)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cd8-positive, alpha-beta t cell differentiation
    (GO:0043378)
  • Positive regulation of regulatory t cell differentiation
    (GO:0045591)
  • Positive regulation of t cell anergy
    (GO:0002669)
  • Protein phosphatase binding
    (GO:0019903)
  • Receptor internalization
    (GO:0031623)
  • Response to extracellular stimulus
    (GO:0009991)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Response to nematode
    (GO:0009624)
  • Response to other organism
    (GO:0051707)
  • Response to wounding
    (GO:0009611)
  • Signaling receptor inhibitor activity
    (GO:0030547)
  • Tolerance induction
    (GO:0002507)
  • Transmembrane receptor protein tyrosine kinase inhibitor activity
    (GO:0030293)
  • Type 2 immune response
    (GO:0042092)

Other Information

Genular Protein ID: 3180564765

Symbol: LRB4A_MOUSE

Name: Mast cell surface glycoprotein Gp49B

UniProtKB Accession Codes:

Q64281 Q64312

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 DIP 1 DNASU 1 EMBL 5 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 59 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MEROPS 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 2 VEuPathDB 2 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8132564

Title: Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49.

PubMed ID: 8132564

DOI: 10.1016/s0021-9258(17)37207-1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8855262

Title: Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE.

PubMed ID: 8855262

DOI: 10.1073/pnas.93.20.10809

PubMed ID: 9338594

Title: gp49B1, an inhibitory signaling receptor gene of hematopoietic cells, is induced by leukemia inhibitory factor in the uterine endometrium just before implantation.

PubMed ID: 9338594

DOI: 10.1046/j.1440-169x.1997.t01-4-00006.x

PubMed ID: 8977169

Title: Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells.

PubMed ID: 8977169

PubMed ID: 8977170

Title: Mouse natural killer cells express gp49B1, a structural homologue of human killer inhibitory receptors.

PubMed ID: 8977170

PubMed ID: 9422771

Title: Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene.

PubMed ID: 9422771

DOI: 10.1074/jbc.273.2.1070

PubMed ID: 10026201

Title: gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization.

PubMed ID: 10026201

DOI: 10.1074/jbc.274.9.5791

PubMed ID: 9973385

Title: Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B.

PubMed ID: 9973385

PubMed ID: 10982834

Title: Natural killer cells and mast cells from gp49B null mutant mice are functional.

PubMed ID: 10982834

DOI: 10.1128/mcb.20.19.7178-7182.2000

PubMed ID: 11457897

Title: Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice.

PubMed ID: 11457897

DOI: 10.1084/jem.194.2.227

PubMed ID: 11323698

Title: gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation.

PubMed ID: 11323698

DOI: 10.1038/87749

PubMed ID: 12884301

Title: gp49B1 suppresses stem cell factor-induced mast cell activation-secretion and attendant inflammation in vivo.

PubMed ID: 12884301

DOI: 10.1002/eji.200323978

PubMed ID: 14557414

Title: Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils.

PubMed ID: 14557414

DOI: 10.1084/jem.20030906

PubMed ID: 12682239

Title: The gp49B1 inhibitory receptor regulates the IFN-gamma responses of T cells and NK cells.

PubMed ID: 12682239

DOI: 10.4049/jimmunol.170.8.4095

PubMed ID: 17761953

Title: Inhibitory receptor gp49B regulates eosinophil infiltration during allergic inflammation.

PubMed ID: 17761953

DOI: 10.1189/jlb.1106667

PubMed ID: 18792399

Title: A novel regulatory role of gp49B on dendritic cells in T-cell priming.

PubMed ID: 18792399

DOI: 10.1002/eji.200737550

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 24935931

Title: gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells.

PubMed ID: 24935931

DOI: 10.4049/jimmunol.1302772

PubMed ID: 34089617

Title: Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice.

PubMed ID: 34089617

DOI: 10.1093/intimm/dxab028

Sequence Information:

  • Length: 335
  • Mass: 37544
  • Checksum: 6005186D524E7876
  • Sequence:
    • MIAMLTVLLY LGLILEPRTA VQAGHLPKPI IWAEPGSVIA AYTSVITWCQ GSWEAQYYHL 
YKEKSVNPWD TQVPLETRNK AKFNIPSMTT SYAGIYKCYY ESAAGFSEHS DAMELVMTGA 
YENPSLSVYP SSNVTSGVSI SFSCSSSIVF GRFILIQEGK HGLSWTLDSQ HQANQPSYAT 
FVLDAVTPNH NGTFRCYGYF RNEPQVWSKP SNSLDLMISE TKDQSSTPTE DGLETYQKIL 
IGVLVSFLLL FFLLLFLILI GYQYGHKKKA NASVKNTQSE NNAELNSWNP QNEDPQGIVY 
AQVKPSRLQK DTACKETQDV TYAQLCIRTQ EQNNS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.