Details for: CST5

Gene ID: 1473

Symbol: CST5

Ensembl ID: ENSG00000170367

Description: cystatin D

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 6.8
    Marker Score: 3766.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.68
    Marker Score: 8264
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.71
    Marker Score: 2110
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3166
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.13
    Marker Score: 4859.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.97
    Marker Score: 2205
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.75
    Marker Score: 922
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.67
    Marker Score: 700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.36
    Marker Score: 902
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7469
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48042.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.98
    Marker Score: 1849
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 492
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.81
    Marker Score: 12651
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.76
    Marker Score: 721
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.73
    Marker Score: 1481
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.63
    Marker Score: 1011
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 489.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.57
    Marker Score: 341
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.55
    Marker Score: 258
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.52
    Marker Score: 3125
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.41
    Marker Score: 182
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.33
    Marker Score: 158
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.33
    Marker Score: 676.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.28
    Marker Score: 482
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.26
    Marker Score: 431
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.23
    Marker Score: 412.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.21
    Marker Score: 249
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.2
    Marker Score: 57
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 165
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.17
    Marker Score: 537
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.16
    Marker Score: 126
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.16
    Marker Score: 52
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.15
    Marker Score: 104
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.15
    Marker Score: 144
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.15
    Marker Score: 151
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.15
    Marker Score: 77
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.14
    Marker Score: 51
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.14
    Marker Score: 30
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.12
    Marker Score: 124
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.12
    Marker Score: 63
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.11
    Marker Score: 32
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.11
    Marker Score: 252
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.1
    Marker Score: 192.5
  • Cell Name: fibrocyte (CL0000135)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.09
    Marker Score: 312
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.09
    Marker Score: 460
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.08
    Marker Score: 32
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 86
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.08
    Marker Score: 178
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.07
    Marker Score: 54
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.07
    Marker Score: 184
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.07
    Marker Score: 38.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: regular cardiac myocyte (CL0002098)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.06
    Marker Score: 117
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.06
    Marker Score: 92
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.04
    Marker Score: 560
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.04
    Marker Score: 422.5

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Other Information

**Key characteristics**: - Cystatin D is a cysteine-type endopeptidase inhibitor. - It is a secreted protein that is produced by a variety of cell types. - It is expressed in high levels in erythrocytes, oligodendrocyte precursor cells, megakaryocytes, blood vessel endothelial cells, and acinar cells of the salivary gland. - It is expressed at lower levels in plasma cells, hematopoietic stem cells, megakaryocyte-erythroid progenitor cells, and goblet cells. **Pathways and functions**: Cystatin D inhibits the activity of cysteine-type endopeptidases, which are enzymes that break down proteins. By inhibiting these enzymes, cystatin D helps to maintain the integrity of cells and tissues. It also helps to regulate the inflammatory response by inhibiting the activation of inflammatory cytokines. **Clinical significance**: Cystatin D is a potential therapeutic target for a variety of diseases, including cancer and cardiovascular disease. Studies have shown that cystatin D can inhibit the growth of cancer cells and promote the regeneration of heart muscle cells. However, further research is needed to determine the optimal dosage and frequency of cystatin D therapy.

Genular Protein ID: 101515550

Symbol: CYTD_HUMAN

Name: Cystatin-D

UniProtKB Accession Codes:

P28325 Q5JRF5 Q9UCA0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1939105

Title: Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor.

PubMed ID: 1939105

DOI: 10.1016/s0021-9258(18)54958-9

PubMed ID: 8340398

Title: Human cystatin D. cDNA cloning, characterization of the Escherichia coli expressed inhibitor, and identification of the native protein in saliva.

PubMed ID: 8340398

DOI: 10.1016/s0021-9258(18)82317-1

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8083219

Title: Structural and functional characterization of two allelic variants of human cystatin D sharing a characteristic inhibition spectrum against mammalian cysteine proteinases.

PubMed ID: 8083219

DOI: 10.1016/s0021-9258(17)31633-2

PubMed ID: 20189825

Title: Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry.

PubMed ID: 20189825

DOI: 10.1016/j.jasms.2010.01.025

PubMed ID: 15728581

Title: Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile.

PubMed ID: 15728581

DOI: 10.1074/jbc.m411914200

PubMed ID: 8444475

Title: A sequence variation in the human cystatin D gene resulting in an amino acid (Cys/Arg) polymorphism at the protein level.

PubMed ID: 8444475

DOI: 10.1007/bf00202491

Sequence Information:

  • Length: 142
  • Mass: 16080
  • Checksum: CEFA89BA87A0DA68
  • Sequence:
    • MMWPMHTPLL LLTALMVAVA GSASAQSRTL AGGIHATDLN DKSVQCALDF AISEYNKVIN 
KDEYYSRPLQ VMAAYQQIVG GVNYYFNVKF GRTTCTKSQP NLDNCPFNDQ PKLKEEEFCS 
FQINEVPWED KISILNYKCR KV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.