Genular: Defining Cellular Identity and Function

Details for: Gpc1

Gene ID: 14733

Symbol: Gpc1

Ensembl ID: ENSMUSG00000034220

Description: glypican 1

Associated with

A tetrasaccharide linker sequence is required for gag synthesis
(R-MMU-1971475)
Axon guidance
(R-MMU-422475)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Chondroitin sulfate/dermatan sulfate metabolism
(R-MMU-1793185)
Developmental biology
(R-MMU-1266738)
Glycosaminoglycan metabolism
(R-MMU-1630316)
Hemostasis
(R-MMU-109582)
Heparan sulfate/heparin (hs-gag) metabolism
(R-MMU-1638091)
Hs-gag biosynthesis
(R-MMU-2022928)
Hs-gag degradation
(R-MMU-2024096)
Metabolism
(R-MMU-1430728)
Metabolism of carbohydrates
(R-MMU-71387)
Metabolism of fat-soluble vitamins
(R-MMU-6806667)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Nervous system development
(R-MMU-9675108)
Retinoid metabolism and transport
(R-MMU-975634)
Sensory perception
(R-MMU-9709957)
Signaling by robo receptors
(R-MMU-376176)
Visual phototransduction
(R-MMU-2187338)
Cell migration
(GO:0016477)
Cell surface
(GO:0009986)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen v binding
(GO:0070052)
Copper ion binding
(GO:0005507)
Cytosol
(GO:0005829)
Endosome
(GO:0005768)
Extracellular matrix
(GO:0031012)
Extracellular region
(GO:0005576)
Fibroblast growth factor binding
(GO:0017134)
Golgi lumen
(GO:0005796)
Heparan sulfate proteoglycan catabolic process
(GO:0030200)
Laminin binding
(GO:0043236)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Myelin assembly
(GO:0032288)
Negative regulation of fibroblast growth factor receptor signaling pathway
(GO:0040037)
Neuronal cell body
(GO:0043025)
Nucleoplasm
(GO:0005654)
Plasma membrane
(GO:0005886)
Positive regulation of skeletal muscle cell differentiation
(GO:2001016)
Regulation of protein localization to membrane
(GO:1905475)
Regulation of signal transduction
(GO:0009966)
Schwann cell differentiation
(GO:0014037)
Side of membrane
(GO:0098552)
Synapse
(GO:0045202)

Other Information

Proteins

Glypican-1

Genular Protein ID: 3605267270

Symbol: GPC1_MOUSE

Name: Glypican-1

UniProtKB Accession Codes:

Q9QZF2

Database IDs:

Citations:

PubMed ID: 11474185

Title: Mapping of the rat glypican genes.

PubMed ID: 11474185

DOI: 10.1159/000056954

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12732622

Title: Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.

PubMed ID: 12732622

DOI: 10.1074/jbc.m300394200

PubMed ID: 15677459

Title: The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-nitric oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo.

PubMed ID: 15677459

DOI: 10.1074/jbc.m409179200

PubMed ID: 16971378

Title: Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes.

PubMed ID: 16971378

DOI: 10.1093/glycob/cwl045

PubMed ID: 16923158

Title: Copper-dependent co-internalization of the prion protein and glypican-1.

PubMed ID: 16923158

DOI: 10.1111/j.1471-4159.2006.03981.x

PubMed ID: 16452087

Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

PubMed ID: 16452087

DOI: 10.1074/mcp.t500041-mcp200

PubMed ID: 18717736

Title: Involvement of glypican-1 autoprocessing in scrapie infection.

PubMed ID: 18717736

DOI: 10.1111/j.1460-9568.2008.06386.x

PubMed ID: 19656770

Title: The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation.

PubMed ID: 19656770

DOI: 10.1074/mcp.m900195-mcp200

PubMed ID: 19732411

Title: Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis.

PubMed ID: 19732411

DOI: 10.1186/1749-8104-4-33

PubMed ID: 19936054

Title: Glypican-1 mediates both prion protein lipid raft association and disease isoform formation.

PubMed ID: 19936054

DOI: 10.1371/journal.ppat.1000666

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20100867

Title: A novel mechanism of sequestering fibroblast growth factor 2 by glypican in lipid rafts, allowing skeletal muscle differentiation.

PubMed ID: 20100867

DOI: 10.1128/mcb.01164-09

PubMed ID: 21996748

Title: A Kras(G12D)-driven genetic mouse model of pancreatic cancer requires glypican-1 for efficient proliferation and angiogenesis.

PubMed ID: 21996748

DOI: 10.1038/onc.2011.430

Sequence Information:

Length: 557
Mass: 61360
Checksum: 58A9A24955D16A0B
Sequence:

MELRTRGWWL LCAAAALVVC ARGDPASKSR SCSEVRQIYG AKGFSLSDVP QAEISGEHLR 
ICPQGYTCCT SEMEENLANH SRMELESALH DSSRALQATL ATQLHGIDDH FQRLLNDSER 
TLQEAFPGAF GDLYTQNTRA FRDLYAELRL YYRGANLHLE ETLAEFWARL LERLFKQLHP 
QLLPDDYLDC LGKQAEALRP FGDAPRELRL RATRAFVAAR SFVQGLGVAS DVVRKVAQVP 
LAPECSRAIM KLVYCAHCRG VPGARPCPDY CRNVLKGCLA NQADLDAEWR NLLDSMVLIT 
DKFWGPSGAE SVIGGVHVWL AEAINALQDN KDTLTAKVIQ ACGNPKVNPH GSGPEEKRRR 
GKLALQEKPS TGTLEKLVSE AKAQLRDIQD FWISLPGTLC SEKMAMSPAS DDRCWNGISK 
GRYLPEVMGD GLANQINNPE VEVDITKPDM TIRQQIMQLK IMTNRLRGAY GGNDVDFQDA 
SDDGSGSGSG GGCPDDTCGR RVSKKSSSSR TPLTHALPGL SEQEGQKTSA ATCPEPHSFF 
LLFLVTLVLA AARPRWR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gpc1

Associated with

Other Information

Mapping of the rat glypican genes. PubMed ID: 11474185

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate. PubMed ID: 12732622

The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-nitric oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo. PubMed ID: 15677459

Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes. PubMed ID: 16971378

Copper-dependent co-internalization of the prion protein and glypican-1. PubMed ID: 16923158

Comprehensive identification of phosphorylation sites in postsynaptic density preparations. PubMed ID: 16452087

Involvement of glypican-1 autoprocessing in scrapie infection. PubMed ID: 18717736

The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation. PubMed ID: 19656770

Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis. PubMed ID: 19732411

Glypican-1 mediates both prion protein lipid raft association and disease isoform formation. PubMed ID: 19936054

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

A novel mechanism of sequestering fibroblast growth factor 2 by glypican in lipid rafts, allowing skeletal muscle differentiation. PubMed ID: 20100867

A Kras(G12D)-driven genetic mouse model of pancreatic cancer requires glypican-1 for efficient proliferation and angiogenesis. PubMed ID: 21996748