Genular: Defining Cellular Identity and Function

Details for: Gpc3

Gene ID: 14734

Symbol: Gpc3

Ensembl ID: ENSMUSG00000055653

Description: glypican 3

Associated with

A tetrasaccharide linker sequence is required for gag synthesis
(R-MMU-1971475)
Chondroitin sulfate/dermatan sulfate metabolism
(R-MMU-1793185)
Glycosaminoglycan metabolism
(R-MMU-1630316)
Heparan sulfate/heparin (hs-gag) metabolism
(R-MMU-1638091)
Hs-gag biosynthesis
(R-MMU-2022928)
Hs-gag degradation
(R-MMU-2024096)
Metabolism
(R-MMU-1430728)
Metabolism of carbohydrates
(R-MMU-71387)
Metabolism of fat-soluble vitamins
(R-MMU-6806667)
Metabolism of proteins
(R-MMU-392499)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Post-translational protein modification
(R-MMU-597592)
Post-translational protein phosphorylation
(R-MMU-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-MMU-381426)
Retinoid metabolism and transport
(R-MMU-975634)
Sensory perception
(R-MMU-9709957)
Visual phototransduction
(R-MMU-2187338)
Animal organ morphogenesis
(GO:0009887)
Anterior/posterior axis specification
(GO:0009948)
Body morphogenesis
(GO:0010171)
Bone mineralization
(GO:0030282)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Canonical wnt signaling pathway
(GO:0060070)
Cell migration
(GO:0016477)
Cell proliferation involved in kidney development
(GO:0072111)
Cell proliferation involved in metanephros development
(GO:0072203)
Cell surface
(GO:0009986)
Collagen-containing extracellular matrix
(GO:0062023)
Coronary vasculature development
(GO:0060976)
Embryonic hindlimb morphogenesis
(GO:0035116)
Epithelial cell proliferation
(GO:0050673)
Golgi lumen
(GO:0005796)
Growth
(GO:0040007)
Kidney development
(GO:0001822)
Lung development
(GO:0030324)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Mesenchymal cell proliferation involved in ureteric bud development
(GO:0072138)
Mesonephric duct morphogenesis
(GO:0072180)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of growth
(GO:0045926)
Negative regulation of peptidase activity
(GO:0010466)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Osteoclast differentiation
(GO:0030316)
Peptidase inhibitor activity
(GO:0030414)
Peptidyl-dipeptidase inhibitor activity
(GO:0060422)
Plasma membrane
(GO:0005886)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of endocytosis
(GO:0045807)
Positive regulation of glucose import
(GO:0046326)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of smoothened signaling pathway
(GO:0045880)
Positive regulation of wnt signaling pathway, planar cell polarity pathway
(GO:2000096)
Protein binding
(GO:0005515)
Regulation of canonical wnt signaling pathway
(GO:0060828)
Regulation of growth
(GO:0040008)
Regulation of non-canonical wnt signaling pathway
(GO:2000050)
Regulation of protein localization to membrane
(GO:1905475)
Regulation of signal transduction
(GO:0009966)
Response to bacterium
(GO:0009617)
Side of membrane
(GO:0098552)
Smoothened signaling pathway
(GO:0007224)
Wnt signaling pathway, planar cell polarity pathway
(GO:0060071)

Other Information

Proteins

Glypican-3

Genular Protein ID: 2991911484

Symbol: GPC3_MOUSE

Name: Glypican-3

UniProtKB Accession Codes:

Q8CFZ4

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10402475

Title: Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome.

PubMed ID: 10402475

DOI: 10.1083/jcb.146.1.255

PubMed ID: 10964473

Title: glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development.

PubMed ID: 10964473

DOI: 10.1006/dbio.2000.9831

PubMed ID: 11180950

Title: Glypican-3 modulates BMP- and FGF-mediated effects during renal branching morphogenesis.

PubMed ID: 11180950

DOI: 10.1006/dbio.2000.0127

PubMed ID: 15537637

Title: The loss of glypican-3 induces alterations in Wnt signaling.

PubMed ID: 15537637

DOI: 10.1074/jbc.m410090200

PubMed ID: 18477453

Title: Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding.

PubMed ID: 18477453

DOI: 10.1016/j.devcel.2008.03.006

PubMed ID: 19733558

Title: Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development.

PubMed ID: 19733558

DOI: 10.1016/j.ydbio.2009.08.029

PubMed ID: 23665349

Title: Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex.

PubMed ID: 23665349

DOI: 10.1016/j.ajpath.2013.03.013

Sequence Information:

Length: 579
Mass: 65332
Checksum: 066C23B3493A9346
Sequence:

MAGTVRTACL LVAMLLGLGC LGQAQPPPPP DATCHQVRSF FQRLQPGLKW VPETPVPGSD 
LQVCLPKGPT CCSRKMEEKY QLTARLNMEQ LLQSASMELK FLIIQNAAVF QEAFEIVVRH 
AKNYTNAMFK NNYPSLTPQA FEFVGEFFTD VSLYILGSDI NVDDMVNELF DSLFPVIYTQ 
MMNPGLPESV LDINECLRGA RRDLKVFGSF PKLIMTQVSK SLQVTRIFLQ ALNLGIEVIN 
TTDHLKFSKD CGRMLTRMWY CSYCQGLMMV KPCGGYCNVV MQGCMAGVVE IDKYWREYIL 
SLEELVNGMY RIYDMENVLL GLFSTIHDSI QYVQKNGGKL TTTIGKLCAH SQQRQYRSAY 
YPEDLFIDKK ILKVAHVEHE ETLSSRRREL IQKLKSFINF YSALPGYICS HSPVAENDTL 
CWNGQELVER YSQKAARNGM KNQFNLHELK MKGPEPVVSQ IIDKLKHINQ LLRTMSVPKG 
KVLDKSLDEE GLESGDCGDD EDECIGSSGD GMVKVKNQLR FLAELAYDLD VDDAPGNKQH 
GNQKDNEITT SHSVGNMPSP LKILISVAIY VACFFFLVH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gpc3

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome. PubMed ID: 10402475

glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development. PubMed ID: 10964473

Glypican-3 modulates BMP- and FGF-mediated effects during renal branching morphogenesis. PubMed ID: 11180950

The loss of glypican-3 induces alterations in Wnt signaling. PubMed ID: 15537637

Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. PubMed ID: 18477453

Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development. PubMed ID: 19733558

Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex. PubMed ID: 23665349