Details for: CST6

Gene ID: 1474

Symbol: CST6

Ensembl ID: ENSG00000175315

Description: cystatin E/M

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 2.98
    Marker Score: 2959
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.81
    Marker Score: 3388
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1990
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1166
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.52
    Marker Score: 1035.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.26
    Marker Score: 10832
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.25
    Marker Score: 2186
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.24
    Marker Score: 10809
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 484
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4812
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.96
    Marker Score: 432
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5342
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.89
    Marker Score: 468
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.87
    Marker Score: 776
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 640
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.76
    Marker Score: 347
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.75
    Marker Score: 354
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.74
    Marker Score: 1928
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 460
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.7
    Marker Score: 5470
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.65
    Marker Score: 270
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.59
    Marker Score: 601
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 384
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.57
    Marker Score: 480
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 453
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.57
    Marker Score: 2974
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.55
    Marker Score: 685
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.49
    Marker Score: 272
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 472
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.48
    Marker Score: 1663
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.47
    Marker Score: 747
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.46
    Marker Score: 664
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.46
    Marker Score: 148
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.43
    Marker Score: 421.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.41
    Marker Score: 118
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.41
    Marker Score: 319
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.41
    Marker Score: 100
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.41
    Marker Score: 144
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.4
    Marker Score: 253
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.39
    Marker Score: 741
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.38
    Marker Score: 154
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.38
    Marker Score: 13074
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.37
    Marker Score: 519
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.34
    Marker Score: 5512
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.32
    Marker Score: 181
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.31
    Marker Score: 4926
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.31
    Marker Score: 107
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.3
    Marker Score: 603
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.28
    Marker Score: 122
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.28
    Marker Score: 85
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.27
    Marker Score: 491
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.27
    Marker Score: 395
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.26
    Marker Score: 265
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.25
    Marker Score: 294
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.25
    Marker Score: 1528
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.25
    Marker Score: 661
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.23
    Marker Score: 444
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.23
    Marker Score: 1140
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.23
    Marker Score: 520
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.23
    Marker Score: 810
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.22
    Marker Score: 197
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.22
    Marker Score: 234
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.2
    Marker Score: 328
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.2
    Marker Score: 225
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.19
    Marker Score: 250
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.19
    Marker Score: 335
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.19
    Marker Score: 307
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.18
    Marker Score: 151
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.17
    Marker Score: 439
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.16
    Marker Score: 127
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.16
    Marker Score: 2208
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.16
    Marker Score: 78
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.16
    Marker Score: 59
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.16
    Marker Score: 143

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Other Information

**Key characteristics:** - Cystatin E/M is a secreted protein that is expressed in high levels in epithelial cells. - It is a cysteine endopeptidase that is involved in the regulation of epithelial cell growth, differentiation, and migration. - Cystatin E/M is also involved in the regulation of the integrity of the epithelial barrier. **Pathways and functions:** - Cystatin E/M is a key regulator of epithelial cell growth and differentiation. - It is expressed in high levels in epithelial cells during embryonic development and in adult tissues where epithelial integrity is important. - Cystatin E/M inhibits the activity of cysteine proteases, which are enzymes that are involved in the degradation of proteins. - By inhibiting cysteine proteases, cystatin E/M allows epithelial cells to maintain their integrity and to form tight seals between cells. - Cystatin E/M also plays a role in the regulation of the epithelial barrier. It helps to maintain the integrity of the epithelial barrier by inhibiting the migration of harmful substances across the epithelial layer. **Clinical significance:** - Mutations in the CST6 gene have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. - In some cases, mutations in CST6 can lead to the development of epithelial tumors. - Cystatin E/M is a potential target for the treatment of cancer and other diseases that are characterized by epithelial cancer.

Genular Protein ID: 1532071121

Symbol: CYTM_HUMAN

Name: Cystatin-M

UniProtKB Accession Codes:

Q15828 Q540N7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8995380

Title: Identification, cloning, and characterization of cystatin M, a novel cysteine proteinase inhibitor, down-regulated in breast cancer.

PubMed ID: 8995380

DOI: 10.1074/jbc.272.2.903

PubMed ID: 9099741

Title: Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins.

PubMed ID: 9099741

DOI: 10.1074/jbc.272.16.10853

PubMed ID: 12839564

Title: The human cystatin M/E gene (CST6): exclusion candidate gene for harlequin ichthyosis.

PubMed ID: 12839564

DOI: 10.1046/j.1523-1747.2003.12312.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11348457

Title: Cystatin M/E expression is restricted to differentiated epidermal keratinocytes and sweat glands: a new skin-specific proteinase inhibitor that is a target for cross-linking by transglutaminase.

PubMed ID: 11348457

DOI: 10.1046/j.1523-1747.2001.01309.x

PubMed ID: 30425301

Title: Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin.

PubMed ID: 30425301

DOI: 10.1038/s41436-018-0355-3

Sequence Information:

  • Length: 149
  • Mass: 16511
  • Checksum: 2076A78BFC9FAC8C
  • Sequence:
    • MARSNLPLAL GLALVAFCLL ALPRDARARP QERMVGELRD LSPDDPQVQK AAQAAVASYN 
MGSNSIYYFR DTHIIKAQSQ LVAGIKYFLT MEMGSTDCRK TRVTGDHVDL TTCPLAAGAQ 
QEKLRCDFEV LVVPWQNSSQ LLKHNCVQM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.