Details for: CST6

Gene ID: 1474

Symbol: CST6

Ensembl ID: ENSG00000175315

Description: cystatin E/M

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.0850
    Cell Significance Index: -9.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 9.1688
    Cell Significance Index: 229.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 5.6680
    Cell Significance Index: 347.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 2.6094
    Cell Significance Index: 54.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4480
    Cell Significance Index: -9.6600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.2191
    Cell Significance Index: 5.0000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.0957
    Cell Significance Index: 26.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.0752
    Cell Significance Index: 94.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9469
    Cell Significance Index: 42.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4534
    Cell Significance Index: 276.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3292
    Cell Significance Index: 12.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3113
    Cell Significance Index: 42.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1313
    Cell Significance Index: 111.9100
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 1.0337
    Cell Significance Index: 1.1900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.0118
    Cell Significance Index: 10.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9316
    Cell Significance Index: 841.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.7399
    Cell Significance Index: 11.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5297
    Cell Significance Index: 86.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4474
    Cell Significance Index: 48.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4408
    Cell Significance Index: 22.9000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.4406
    Cell Significance Index: 2.9300
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.3964
    Cell Significance Index: 3.9300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.2999
    Cell Significance Index: 3.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2944
    Cell Significance Index: 160.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2690
    Cell Significance Index: 118.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2257
    Cell Significance Index: 15.6100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0982
    Cell Significance Index: 1.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0909
    Cell Significance Index: 2.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0833
    Cell Significance Index: 1.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0620
    Cell Significance Index: 3.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0136
    Cell Significance Index: 0.2900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0113
    Cell Significance Index: 0.0700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0104
    Cell Significance Index: 0.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0090
    Cell Significance Index: 1.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0082
    Cell Significance Index: 6.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0065
    Cell Significance Index: 4.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0041
    Cell Significance Index: 0.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0014
    Cell Significance Index: -0.2600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0033
    Cell Significance Index: -0.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0037
    Cell Significance Index: -0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0048
    Cell Significance Index: -8.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0055
    Cell Significance Index: -0.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0115
    Cell Significance Index: -8.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0136
    Cell Significance Index: -8.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0163
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0164
    Cell Significance Index: -12.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0182
    Cell Significance Index: -11.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0189
    Cell Significance Index: -2.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0205
    Cell Significance Index: -11.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0238
    Cell Significance Index: -10.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0249
    Cell Significance Index: -8.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0252
    Cell Significance Index: -1.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0335
    Cell Significance Index: -3.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0343
    Cell Significance Index: -1.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0368
    Cell Significance Index: -10.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0390
    Cell Significance Index: -1.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0465
    Cell Significance Index: -9.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0510
    Cell Significance Index: -10.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0563
    Cell Significance Index: -6.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0584
    Cell Significance Index: -8.4900
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0624
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0676
    Cell Significance Index: -11.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0697
    Cell Significance Index: -14.6800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0731
    Cell Significance Index: -0.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0745
    Cell Significance Index: -8.6800
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0751
    Cell Significance Index: -0.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0805
    Cell Significance Index: -11.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0904
    Cell Significance Index: -10.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1027
    Cell Significance Index: -6.4700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1200
    Cell Significance Index: -1.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1249
    Cell Significance Index: -9.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1437
    Cell Significance Index: -9.6600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1478
    Cell Significance Index: -2.1000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1661
    Cell Significance Index: -1.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1694
    Cell Significance Index: -4.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1762
    Cell Significance Index: -4.5300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1968
    Cell Significance Index: -2.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2179
    Cell Significance Index: -8.0000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2209
    Cell Significance Index: -3.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2322
    Cell Significance Index: -12.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2590
    Cell Significance Index: -9.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2724
    Cell Significance Index: -7.4200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2783
    Cell Significance Index: -4.0400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2830
    Cell Significance Index: -7.5700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2917
    Cell Significance Index: -3.7800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2952
    Cell Significance Index: -6.1800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2959
    Cell Significance Index: -7.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2963
    Cell Significance Index: -10.3800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.3048
    Cell Significance Index: -4.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3140
    Cell Significance Index: -10.2800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3226
    Cell Significance Index: -7.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3226
    Cell Significance Index: -10.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3262
    Cell Significance Index: -8.7400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.3278
    Cell Significance Index: -4.3700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3352
    Cell Significance Index: -8.3600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3353
    Cell Significance Index: -5.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3367
    Cell Significance Index: -9.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3385
    Cell Significance Index: -9.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3522
    Cell Significance Index: -9.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CST6 is a small, secreted protein that belongs to the cystatin family, which comprises a group of cysteine protease inhibitors. Its primary function is to inhibit cysteine proteases, such as cathepsins, which are involved in protein degradation, cell signaling, and apoptosis. CST6 is highly expressed in various tissues, including the pancreas, lungs, intestines, and skin, where it plays a crucial role in maintaining tissue homeostasis and development. **Pathways and Functions:** CST6 is involved in various cellular pathways, including: 1. **Anatomical structure morphogenesis**: CST6 is essential for the development and maintenance of epithelial tissues, including the skin, lungs, and intestines. 2. **Epidermis development**: CST6 is highly expressed in the epidermis and plays a crucial role in the development and maintenance of the skin barrier. 3. **Cysteine-type endopeptidase inhibitor activity**: CST6 inhibits cysteine proteases, which are involved in protein degradation, cell signaling, and apoptosis. 4. **Extracellular exosome**: CST6 is secreted into the extracellular environment, where it can interact with other proteins and cells. **Clinical Significance:** CST6 has been implicated in various diseases, including: 1. **Pancreatitis**: CST6 has been shown to be downregulated in pancreatitis, suggesting its potential role in the development of this disease. 2. **Cystic fibrosis**: CST6 is highly expressed in the lungs of patients with cystic fibrosis, suggesting its potential role in the development of this disease. 3. **Skin diseases**: CST6 has been implicated in various skin diseases, including psoriasis and atopic dermatitis, suggesting its potential role in the development of these diseases. **Conclusion:** In conclusion, CST6 is a critical regulator of cellular homeostasis and tissue development. Its ability to inhibit cysteine proteases makes it a potential therapeutic target for various diseases. Further research is needed to fully understand the functions and significance of CST6 in human disease. **Future Directions:** 1. **Investigate the role of CST6 in disease**: Further studies are needed to investigate the role of CST6 in various diseases, including pancreatitis, cystic fibrosis, and skin diseases. 2. **Develop therapeutic strategies**: CST6 could be a potential therapeutic target for various diseases, and further research is needed to develop effective therapeutic strategies. 3. **Characterize the expression and function of CST6**: Further studies are needed to characterize the expression and function of CST6 in various tissues and cells.

Genular Protein ID: 1532071121

Symbol: CYTM_HUMAN

Name: Cystatin-M

UniProtKB Accession Codes:

Q15828 Q540N7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8995380

Title: Identification, cloning, and characterization of cystatin M, a novel cysteine proteinase inhibitor, down-regulated in breast cancer.

PubMed ID: 8995380

DOI: 10.1074/jbc.272.2.903

PubMed ID: 9099741

Title: Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins.

PubMed ID: 9099741

DOI: 10.1074/jbc.272.16.10853

PubMed ID: 12839564

Title: The human cystatin M/E gene (CST6): exclusion candidate gene for harlequin ichthyosis.

PubMed ID: 12839564

DOI: 10.1046/j.1523-1747.2003.12312.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11348457

Title: Cystatin M/E expression is restricted to differentiated epidermal keratinocytes and sweat glands: a new skin-specific proteinase inhibitor that is a target for cross-linking by transglutaminase.

PubMed ID: 11348457

DOI: 10.1046/j.1523-1747.2001.01309.x

PubMed ID: 30425301

Title: Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin.

PubMed ID: 30425301

DOI: 10.1038/s41436-018-0355-3

Sequence Information:

  • Length: 149
  • Mass: 16511
  • Checksum: 2076A78BFC9FAC8C
  • Sequence:
    • MARSNLPLAL GLALVAFCLL ALPRDARARP QERMVGELRD LSPDDPQVQK AAQAAVASYN 
MGSNSIYYFR DTHIIKAQSQ LVAGIKYFLT MEMGSTDCRK TRVTGDHVDL TTCPLAAGAQ 
QEKLRCDFEV LVVPWQNSSQ LLKHNCVQM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.