Genular: Defining Cellular Identity and Function

Details for: Lpar1

Gene ID: 14745

Symbol: Lpar1

Ensembl ID: ENSMUSG00000038668

Description: lysophosphatidic acid receptor 1

Associated with

Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (i) signalling events
(R-MMU-418594)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Lysosphingolipid and lpa receptors
(R-MMU-419408)
Signaling by gpcr
(R-MMU-372790)
Activation of phospholipase c activity
(GO:0007202)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Bleb assembly
(GO:0032060)
Calmodulin dependent kinase signaling pathway
(GO:0099004)
Cell chemotaxis
(GO:0060326)
Cell surface
(GO:0009986)
Cellular response to 1-oleoyl-sn-glycerol 3-phosphate
(GO:1904566)
Cytoplasm
(GO:0005737)
Dendritic shaft
(GO:0043198)
Dendritic spine
(GO:0043197)
Endocytic vesicle
(GO:0030139)
Endosome
(GO:0005768)
G-protein alpha-subunit binding
(GO:0001965)
Gaba-ergic synapse
(GO:0098982)
Glutamatergic synapse
(GO:0098978)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Lysophosphatidic acid binding
(GO:0035727)
Lysophosphatidic acid receptor activity
(GO:0070915)
Membrane
(GO:0016020)
Negative regulation of camp-mediated signaling
(GO:0043951)
Negative regulation of cilium assembly
(GO:1902018)
Negative regulation of neuron projection development
(GO:0010977)
Neurogenesis
(GO:0022008)
Neuronal cell body
(GO:0043025)
Pdz domain binding
(GO:0030165)
Phospholipid binding
(GO:0005543)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dendritic spine development
(GO:0060999)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of rho protein signal transduction
(GO:0035025)
Positive regulation of smooth muscle cell chemotaxis
(GO:0071673)
Positive regulation of stress fiber assembly
(GO:0051496)
Postsynaptic membrane
(GO:0045211)
Presynaptic membrane
(GO:0042734)
Protein binding
(GO:0005515)
Regulation of cell shape
(GO:0008360)
Regulation of metabolic process
(GO:0019222)
Regulation of postsynaptic neurotransmitter receptor internalization
(GO:0099149)
Regulation of synaptic vesicle cycle
(GO:0098693)
Signal transduction
(GO:0007165)

Other Information

Proteins

LPAR1_MOUSE

Genular Protein ID: 3462126355

Symbol: LPAR1_MOUSE

Name: N/A

UniProtKB Accession Codes:

P61793 A2AMJ2 O88584 P56487 P70420 Q61130

Database IDs:

Citations:

PubMed ID: 8922387

Title: Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

PubMed ID: 8922387

DOI: 10.1083/jcb.135.4.1071

PubMed ID: 9013780

Title: Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain.

PubMed ID: 9013780

DOI: 10.1016/s0169-328x(96)00128-3

PubMed ID: 9721207

Title: Complete cDNA sequence, genomic structure, and chromosomal localization of the LPA receptor gene, lpA1/vzg-1/Gpcr26.

PubMed ID: 9721207

DOI: 10.1006/geno.1998.5400

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9600933

Title: A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid.

PubMed ID: 9600933

DOI: 10.1073/pnas.95.11.6151

PubMed ID: 11040035

Title: Functional comparisons of the lysophosphatidic acid receptors, LP(A1)/VZG-1/EDG-2, LP(A2)/EDG-4, and LP(A3)/EDG-7 in neuronal cell lines using a retrovirus expression system.

PubMed ID: 11040035

DOI: 10.1124/mol.58.5.895

PubMed ID: 11093753

Title: Lysophosphatidic acid receptors.

PubMed ID: 11093753

DOI: 10.1124/mol.58.6.1188

PubMed ID: 11087877

Title: Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior.

PubMed ID: 11087877

DOI: 10.1073/pnas.97.24.13384

PubMed ID: 12181339

Title: Dual regulation of actin rearrangement through lysophosphatidic acid receptor in neuroblast cell lines: actin depolymerization by Ca(2+)-alpha-actinin and polymerization by rho.

PubMed ID: 12181339

DOI: 10.1091/mbc.01-09-0465

PubMed ID: 12215548

Title: Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2).

PubMed ID: 12215548

DOI: 10.1128/mcb.22.19.6921-6929.2002

PubMed ID: 15195086

Title: Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling.

PubMed ID: 15195086

DOI: 10.1038/nm1060

PubMed ID: 18157949

Title: A lysophosphatidic acid receptor lacking the PDZ-binding domain is constitutively active and stimulates cell proliferation.

PubMed ID: 18157949

DOI: 10.1016/j.bbamcr.2007.11.013

PubMed ID: 17656621

Title: Absence of LPA1 signaling results in defective cortical development.

PubMed ID: 17656621

DOI: 10.1093/cercor/bhm132

PubMed ID: 17692995

Title: Lysophosphatidic acid stimulates astrocyte proliferation through LPA1.

PubMed ID: 17692995

DOI: 10.1016/j.neuint.2007.07.004

PubMed ID: 18708146

Title: Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus.

PubMed ID: 18708146

DOI: 10.1016/j.mcn.2008.07.014

PubMed ID: 18066075

Title: The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak.

PubMed ID: 18066075

DOI: 10.1038/nm1685

PubMed ID: 19689455

Title: Behavioral phenotype of maLPA1-null mice: increased anxiety-like behavior and spatial memory deficits.

PubMed ID: 19689455

DOI: 10.1111/j.1601-183x.2009.00524.x

PubMed ID: 20358347

Title: Altered food consumption in mice lacking lysophosphatidic acid receptor-1.

PubMed ID: 20358347

DOI: 10.1007/bf03185929

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21821728

Title: Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs.

PubMed ID: 21821728

DOI: 10.1152/ajplung.00058.2011

PubMed ID: 21569876

Title: Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass.

PubMed ID: 21569876

DOI: 10.1016/j.bone.2011.04.018

PubMed ID: 23478264

Title: Distinct phospholipase C-beta isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure.

PubMed ID: 23478264

DOI: 10.1128/mcb.00038-13

PubMed ID: 25226845

Title: Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex.

PubMed ID: 25226845

DOI: 10.1007/s00429-014-0885-7

PubMed ID: 25732591

Title: Comparative analyses of lysophosphatidic acid receptor-mediated signaling.

PubMed ID: 25732591

DOI: 10.1007/s00018-015-1872-8

Sequence Information:

Length: 364
Mass: 41119
Checksum: B0FA6265AA6688B7
Sequence:

MAAASTSSPV ISQPQFTAMN EQQCFYNESI AFFYNRSGKY LATEWNTVSK LVMGLGITVC 
VFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL AYFYLMFNTG PNTRRLTVST 
WLLRQGLIDT SLTASVANLL AIAIERHITV FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA 
IPSVGWNCIC DIDHCSNMAP LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS 
RHSSGPRRNR DTMMSLLKTV VIVLGAFIVC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA 
EFNSAMNPII YSYRDKEMSA TFRQILCCQR NENPNGPTEG SDRSASSLNH TILAGVHSND 
HSVV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lpar1

Associated with

Other Information

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. PubMed ID: 8922387

Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain. PubMed ID: 9013780

Complete cDNA sequence, genomic structure, and chromosomal localization of the LPA receptor gene, lpA1/vzg-1/Gpcr26. PubMed ID: 9721207

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. PubMed ID: 9600933

Functional comparisons of the lysophosphatidic acid receptors, LP(A1)/VZG-1/EDG-2, LP(A2)/EDG-4, and LP(A3)/EDG-7 in neuronal cell lines using a retrovirus expression system. PubMed ID: 11040035

Lysophosphatidic acid receptors. PubMed ID: 11093753

Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. PubMed ID: 11087877

Dual regulation of actin rearrangement through lysophosphatidic acid receptor in neuroblast cell lines: actin depolymerization by Ca(2+)-alpha-actinin and polymerization by rho. PubMed ID: 12181339

Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). PubMed ID: 12215548

Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. PubMed ID: 15195086

A lysophosphatidic acid receptor lacking the PDZ-binding domain is constitutively active and stimulates cell proliferation. PubMed ID: 18157949

Absence of LPA1 signaling results in defective cortical development. PubMed ID: 17656621

Lysophosphatidic acid stimulates astrocyte proliferation through LPA1. PubMed ID: 17692995

Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus. PubMed ID: 18708146

The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. PubMed ID: 18066075

Behavioral phenotype of maLPA1-null mice: increased anxiety-like behavior and spatial memory deficits. PubMed ID: 19689455

Altered food consumption in mice lacking lysophosphatidic acid receptor-1. PubMed ID: 20358347

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs. PubMed ID: 21821728

Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass. PubMed ID: 21569876

Distinct phospholipase C-beta isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure. PubMed ID: 23478264

Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex. PubMed ID: 25226845

Comparative analyses of lysophosphatidic acid receptor-mediated signaling. PubMed ID: 25732591