Details for: CSTB

Gene ID: 1476

Symbol: CSTB

Ensembl ID: ENSG00000160213

Description: cystatin B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.25
    Marker Score: 7,749
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.72
    Marker Score: 24,280
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.56
    Marker Score: 26,519
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.52
    Marker Score: 27,464
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.5
    Marker Score: 22,300
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.49
    Marker Score: 18,348
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.45
    Marker Score: 193,095
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.39
    Marker Score: 4,097
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.35
    Marker Score: 29,124
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.28
    Marker Score: 32,523
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.28
    Marker Score: 113,675
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.28
    Marker Score: 5,377
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.28
    Marker Score: 3,748
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.24
    Marker Score: 2,552
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.21
    Marker Score: 27,707
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.17
    Marker Score: 42,542
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.1
    Marker Score: 36,039
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 3.06
    Marker Score: 4,914
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.04
    Marker Score: 9,534
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.03
    Marker Score: 7,409
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.02
    Marker Score: 5,893
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.99
    Marker Score: 76,609
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.98
    Marker Score: 4,733
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.96
    Marker Score: 3,564
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.94
    Marker Score: 3,437
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.91
    Marker Score: 7,013
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.87
    Marker Score: 4,761
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.84
    Marker Score: 7,846
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.83
    Marker Score: 684
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.83
    Marker Score: 7,143
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.82
    Marker Score: 7,023
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.81
    Marker Score: 2,815
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.79
    Marker Score: 13,401
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.78
    Marker Score: 16,465
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.77
    Marker Score: 3,574
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.7
    Marker Score: 2,734
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.69
    Marker Score: 2,109
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.69
    Marker Score: 1,120
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.68
    Marker Score: 17,148
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.68
    Marker Score: 7,188
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.68
    Marker Score: 26,986
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.67
    Marker Score: 10,280
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.66
    Marker Score: 1,310
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.64
    Marker Score: 9,385
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.64
    Marker Score: 16,054
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.63
    Marker Score: 5,961
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.63
    Marker Score: 1,246
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.62
    Marker Score: 1,786
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.6
    Marker Score: 1,237
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.59
    Marker Score: 2,307
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.59
    Marker Score: 3,809
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.56
    Marker Score: 87,261
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.56
    Marker Score: 5,837
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.54
    Marker Score: 2,731
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.53
    Marker Score: 6,551
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.53
    Marker Score: 1,301
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.52
    Marker Score: 4,466
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.52
    Marker Score: 895
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.5
    Marker Score: 6,367
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.48
    Marker Score: 854
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.47
    Marker Score: 5,025
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.47
    Marker Score: 5,163
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.47
    Marker Score: 1,695
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.47
    Marker Score: 4,697
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.45
    Marker Score: 1,427
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.45
    Marker Score: 3,543
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.45
    Marker Score: 999
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.45
    Marker Score: 775
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.44
    Marker Score: 10,539
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.44
    Marker Score: 4,252
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.43
    Marker Score: 580
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.41
    Marker Score: 8,939
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.41
    Marker Score: 1,510
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.41
    Marker Score: 9,858
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.4
    Marker Score: 7,133
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4
    Marker Score: 27,034
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.38
    Marker Score: 6,226
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.38
    Marker Score: 1,080
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.37
    Marker Score: 2,235
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.37
    Marker Score: 685
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.37
    Marker Score: 1,105
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.34
    Marker Score: 6,362
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.32
    Marker Score: 1,238
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.32
    Marker Score: 3,944
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.32
    Marker Score: 2,519
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.31
    Marker Score: 2,075
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.31
    Marker Score: 1,138
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.3
    Marker Score: 1,527
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.3
    Marker Score: 30,295
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.3
    Marker Score: 1,346
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.29
    Marker Score: 1,028
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.29
    Marker Score: 1,145
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.29
    Marker Score: 1,797
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.28
    Marker Score: 1,647
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.28
    Marker Score: 3,221
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.27
    Marker Score: 7,815
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.27
    Marker Score: 1,249
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.26
    Marker Score: 1,513
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 2.26
    Marker Score: 1,378
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 2.25
    Marker Score: 1,384

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Protease Inhibitory Activity**: CSTB exhibits potent inhibitory activity against cysteine proteases, such as cathepsins and granzymes, which are involved in various cellular processes, including apoptosis, cell migration, and immune responses. 2. **Secretion and Expression**: CSTB is secreted by various cell types, including immune cells, epithelial cells, and myeloid leukocytes. Its expression is induced in response to inflammatory stimuli, such as lipopolysaccharides and interferons. 3. **Cellular Localization**: CSTB is primarily localized to the extracellular space, where it can exert its protease inhibitory activity. It is also found in the cytosol and nucleus of certain cells. **Pathways and Functions** 1. **Immune Response**: CSTB plays a crucial role in regulating immune responses, particularly in the context of inflammation. It inhibits the activity of cysteine proteases, which are involved in the production of pro-inflammatory cytokines and chemokines. 2. **Extracellular Matrix Stability**: CSTB helps maintain the stability of the extracellular matrix by inhibiting the activity of proteases that degrade collagen and other matrix components. 3. **Cell Signaling**: CSTB can modulate cell signaling pathways, including the NF-κB and MAPK pathways, which are involved in inflammation and immune responses. **Clinical Significance** 1. **Inflammatory Disorders**: CSTB has been implicated in various inflammatory disorders, including rheumatoid arthritis, lupus, and asthma. Its dysregulation has been associated with the development of these diseases. 2. **Cancer**: CSTB has been shown to inhibit the growth and migration of cancer cells, suggesting its potential as a tumor suppressor. 3. **Neurological Disorders**: CSTB has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, cystatin B is a critical regulator of immune response and extracellular matrix stability. Its dysregulation has been associated with various diseases, highlighting the need for further research into its role in human health and disease. As an immunologist, it is essential to recognize the significance of CSTB and explore its potential as a therapeutic target for the treatment of inflammatory disorders and other diseases.

Genular Protein ID: 400739665

Symbol: CYTB_HUMAN

Name: Cystatin-B

UniProtKB Accession Codes:

P04080

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3902020

Title: Amino acid sequence of the intracellular cysteine proteinase inhibitor cystatin B from human liver.

PubMed ID: 3902020

DOI: 10.1016/0006-291x(85)90216-5

PubMed ID: 8596935

Title: Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1).

PubMed ID: 8596935

DOI: 10.1126/science.271.5256.1731

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11139332

Title: Nuclear localization of cystatin B, the cathepsin inhibitor implicated in myoclonus epilepsy (EPM1).

PubMed ID: 11139332

DOI: 10.1006/excr.2000.5085

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 2347312

Title: The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction.

PubMed ID: 2347312

DOI: 10.1002/j.1460-2075.1990.tb08321.x

PubMed ID: 9012407

Title: Identification of mutations in cystatin B, the gene responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy (EPM1).

PubMed ID: 9012407

Sequence Information:

  • Length: 98
  • Mass: 11140
  • Checksum: B8076220E19D0483
  • Sequence:
    • MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG 
DEDFVHLRVF QSLPHENKPL TLSNYQTNKA KHDELTYF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.