Details for: CSTB

Gene ID: 1476

Symbol: CSTB

Ensembl ID: ENSG00000160213

Description: cystatin B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 650.6146
    Cell Significance Index: -101.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 359.7374
    Cell Significance Index: -91.2500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 273.1294
    Cell Significance Index: -112.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 240.8081
    Cell Significance Index: -97.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 229.6225
    Cell Significance Index: -108.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 207.9764
    Cell Significance Index: -106.9800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 162.0066
    Cell Significance Index: -108.7100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 103.7740
    Cell Significance Index: -99.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 85.5424
    Cell Significance Index: -105.4700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 28.5532
    Cell Significance Index: -87.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.4249
    Cell Significance Index: -108.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.9916
    Cell Significance Index: -64.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.1937
    Cell Significance Index: -37.6300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 12.3647
    Cell Significance Index: 106.2500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 9.7001
    Cell Significance Index: 89.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 6.9162
    Cell Significance Index: 1246.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 6.2630
    Cell Significance Index: 770.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.6866
    Cell Significance Index: 295.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.0052
    Cell Significance Index: 92.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.9283
    Cell Significance Index: 231.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.3924
    Cell Significance Index: 2398.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.0727
    Cell Significance Index: 288.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.9409
    Cell Significance Index: 115.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.2288
    Cell Significance Index: 150.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.2059
    Cell Significance Index: 1417.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.8813
    Cell Significance Index: 395.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.4423
    Cell Significance Index: 182.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.3792
    Cell Significance Index: 280.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.3539
    Cell Significance Index: 304.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.1391
    Cell Significance Index: 49.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.0721
    Cell Significance Index: 23.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8981
    Cell Significance Index: 51.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.8912
    Cell Significance Index: 242.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.7963
    Cell Significance Index: 50.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6813
    Cell Significance Index: 44.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6302
    Cell Significance Index: 56.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5070
    Cell Significance Index: 43.2000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.3511
    Cell Significance Index: 8.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.2433
    Cell Significance Index: 941.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0057
    Cell Significance Index: 52.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5125
    Cell Significance Index: 26.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5011
    Cell Significance Index: 13.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4534
    Cell Significance Index: 89.9900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.4201
    Cell Significance Index: 2.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4049
    Cell Significance Index: 77.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3600
    Cell Significance Index: 35.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3216
    Cell Significance Index: 64.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2053
    Cell Significance Index: 35.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1041
    Cell Significance Index: 16.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0721
    Cell Significance Index: 1.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0704
    Cell Significance Index: 51.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0519
    Cell Significance Index: 97.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0380
    Cell Significance Index: 13.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0091
    Cell Significance Index: -0.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0224
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0361
    Cell Significance Index: -26.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0409
    Cell Significance Index: -75.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0570
    Cell Significance Index: -87.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0594
    Cell Significance Index: -37.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0877
    Cell Significance Index: -119.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1314
    Cell Significance Index: -83.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1326
    Cell Significance Index: -74.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1477
    Cell Significance Index: -3.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1949
    Cell Significance Index: -6.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2165
    Cell Significance Index: -98.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2291
    Cell Significance Index: -48.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2536
    Cell Significance Index: -72.9700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2705
    Cell Significance Index: -4.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2759
    Cell Significance Index: -31.6100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3359
    Cell Significance Index: -38.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4712
    Cell Significance Index: -7.0600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5010
    Cell Significance Index: -4.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5320
    Cell Significance Index: -13.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6073
    Cell Significance Index: -70.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6576
    Cell Significance Index: -42.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6655
    Cell Significance Index: -96.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6766
    Cell Significance Index: -53.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6934
    Cell Significance Index: -22.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7276
    Cell Significance Index: -20.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7335
    Cell Significance Index: -33.2500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.8177
    Cell Significance Index: -11.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8209
    Cell Significance Index: -11.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9551
    Cell Significance Index: -60.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9638
    Cell Significance Index: -20.8800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9947
    Cell Significance Index: -6.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0211
    Cell Significance Index: -106.3200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -1.0710
    Cell Significance Index: -18.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1986
    Cell Significance Index: -73.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.3263
    Cell Significance Index: -101.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.4262
    Cell Significance Index: -95.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.6258
    Cell Significance Index: -91.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.6542
    Cell Significance Index: -44.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.6928
    Cell Significance Index: -69.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.7346
    Cell Significance Index: -51.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7519
    Cell Significance Index: -107.4100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.8219
    Cell Significance Index: -18.8600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.0326
    Cell Significance Index: -24.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.0486
    Cell Significance Index: -51.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -2.2681
    Cell Significance Index: -114.6200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -2.2754
    Cell Significance Index: -29.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Protease Inhibitory Activity**: CSTB exhibits potent inhibitory activity against cysteine proteases, such as cathepsins and granzymes, which are involved in various cellular processes, including apoptosis, cell migration, and immune responses. 2. **Secretion and Expression**: CSTB is secreted by various cell types, including immune cells, epithelial cells, and myeloid leukocytes. Its expression is induced in response to inflammatory stimuli, such as lipopolysaccharides and interferons. 3. **Cellular Localization**: CSTB is primarily localized to the extracellular space, where it can exert its protease inhibitory activity. It is also found in the cytosol and nucleus of certain cells. **Pathways and Functions** 1. **Immune Response**: CSTB plays a crucial role in regulating immune responses, particularly in the context of inflammation. It inhibits the activity of cysteine proteases, which are involved in the production of pro-inflammatory cytokines and chemokines. 2. **Extracellular Matrix Stability**: CSTB helps maintain the stability of the extracellular matrix by inhibiting the activity of proteases that degrade collagen and other matrix components. 3. **Cell Signaling**: CSTB can modulate cell signaling pathways, including the NF-κB and MAPK pathways, which are involved in inflammation and immune responses. **Clinical Significance** 1. **Inflammatory Disorders**: CSTB has been implicated in various inflammatory disorders, including rheumatoid arthritis, lupus, and asthma. Its dysregulation has been associated with the development of these diseases. 2. **Cancer**: CSTB has been shown to inhibit the growth and migration of cancer cells, suggesting its potential as a tumor suppressor. 3. **Neurological Disorders**: CSTB has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, cystatin B is a critical regulator of immune response and extracellular matrix stability. Its dysregulation has been associated with various diseases, highlighting the need for further research into its role in human health and disease. As an immunologist, it is essential to recognize the significance of CSTB and explore its potential as a therapeutic target for the treatment of inflammatory disorders and other diseases.

Genular Protein ID: 400739665

Symbol: CYTB_HUMAN

Name: Cystatin-B

UniProtKB Accession Codes:

P04080

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3902020

Title: Amino acid sequence of the intracellular cysteine proteinase inhibitor cystatin B from human liver.

PubMed ID: 3902020

DOI: 10.1016/0006-291x(85)90216-5

PubMed ID: 8596935

Title: Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1).

PubMed ID: 8596935

DOI: 10.1126/science.271.5256.1731

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11139332

Title: Nuclear localization of cystatin B, the cathepsin inhibitor implicated in myoclonus epilepsy (EPM1).

PubMed ID: 11139332

DOI: 10.1006/excr.2000.5085

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 2347312

Title: The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction.

PubMed ID: 2347312

DOI: 10.1002/j.1460-2075.1990.tb08321.x

PubMed ID: 9012407

Title: Identification of mutations in cystatin B, the gene responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy (EPM1).

PubMed ID: 9012407

Sequence Information:

  • Length: 98
  • Mass: 11140
  • Checksum: B8076220E19D0483
  • Sequence:
    • MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG 
DEDFVHLRVF QSLPHENKPL TLSNYQTNKA KHDELTYF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.