Gene CSTB - ENSG00000160213 | NCBI Gene ID: 1476

Details for: CSTB

Gene ID: 1476

Symbol: CSTB

Ensembl ID: ENSG00000160213

Description: cystatin B

Associated with

Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Adult locomotory behavior
(GO:0008344)
Collagen-containing extracellular matrix
(GO:0062023)
Cysteine-type endopeptidase inhibitor activity
(GO:0004869)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endopeptidase inhibitor activity
(GO:0004866)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Ficolin-1-rich granule lumen
(GO:1904813)
Negative regulation of peptidase activity
(GO:0010466)
Negative regulation of proteolysis
(GO:0045861)
Nucleolus
(GO:0005730)
Nucleus
(GO:0005634)
Protease binding
(GO:0002020)
Rna binding
(GO:0003723)
Secretory granule lumen
(GO:0034774)
Tertiary granule lumen
(GO:1904724)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: secretory cell (CL0000151)
Fold Change: 4.25
Marker Score: 7749
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.72
Marker Score: 24280
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.56
Marker Score: 26519
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.52
Marker Score: 27464
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.5
Marker Score: 22300
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 3.49
Marker Score: 18348
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.45
Marker Score: 193095
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 3.39
Marker Score: 4096.5
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 3.35
Marker Score: 29123.5
Cell Name: mature T cell (CL0002419)
Fold Change: 3.28
Marker Score: 32523
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.28
Marker Score: 113674.5
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.28
Marker Score: 5377
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.28
Marker Score: 3747.5
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.24
Marker Score: 2552
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 3.21
Marker Score: 27707
Cell Name: malignant cell (CL0001064)
Fold Change: 3.17
Marker Score: 42542
Cell Name: blood cell (CL0000081)
Fold Change: 3.1
Marker Score: 36039
Cell Name: pneumocyte (CL0000322)
Fold Change: 3.06
Marker Score: 4914
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 3.04
Marker Score: 9534
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.03
Marker Score: 7409
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.02
Marker Score: 5893
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.99
Marker Score: 76609
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.98
Marker Score: 4733
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 2.96
Marker Score: 3564
Cell Name: club cell (CL0000158)
Fold Change: 2.94
Marker Score: 3437
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.91
Marker Score: 7013
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.87
Marker Score: 4761
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.84
Marker Score: 7846
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 2.83
Marker Score: 684
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.83
Marker Score: 7143
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.82
Marker Score: 7023
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.81
Marker Score: 2815
Cell Name: enterocyte (CL0000584)
Fold Change: 2.79
Marker Score: 13400.5
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.78
Marker Score: 16464.5
Cell Name: basal cell (CL0000646)
Fold Change: 2.77
Marker Score: 3574
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.7
Marker Score: 2734
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 2.69
Marker Score: 2109
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 2.69
Marker Score: 1120
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.68
Marker Score: 17148
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.68
Marker Score: 7188
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.68
Marker Score: 26986
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.67
Marker Score: 10280
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.66
Marker Score: 1310
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.64
Marker Score: 9385
Cell Name: elicited macrophage (CL0000861)
Fold Change: 2.64
Marker Score: 16054
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.63
Marker Score: 5961
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.63
Marker Score: 1246
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.62
Marker Score: 1786
Cell Name: basophil (CL0000767)
Fold Change: 2.6
Marker Score: 1237
Cell Name: lung secretory cell (CL1000272)
Fold Change: 2.59
Marker Score: 2307
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.59
Marker Score: 3809
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.56
Marker Score: 87261
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.56
Marker Score: 5837
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.54
Marker Score: 2731
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 2.53
Marker Score: 6550.5
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.53
Marker Score: 1301
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.52
Marker Score: 4466
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.52
Marker Score: 895
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.5
Marker Score: 6367
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.48
Marker Score: 854
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.47
Marker Score: 5025
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.47
Marker Score: 5163
Cell Name: dendritic cell (CL0000451)
Fold Change: 2.47
Marker Score: 1695
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 2.47
Marker Score: 4697
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.45
Marker Score: 1427
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.45
Marker Score: 3543
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.45
Marker Score: 999
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.45
Marker Score: 775
Cell Name: decidual cell (CL2000002)
Fold Change: 2.44
Marker Score: 10539
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.44
Marker Score: 4252
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.43
Marker Score: 580
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.41
Marker Score: 8939
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 2.41
Marker Score: 1510
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.41
Marker Score: 9858
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.4
Marker Score: 7133
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.4
Marker Score: 27034
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.38
Marker Score: 6226
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 2.38
Marker Score: 1080
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.37
Marker Score: 2235
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.37
Marker Score: 685
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.37
Marker Score: 1105
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.34
Marker Score: 6362
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 2.32
Marker Score: 1238
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.32
Marker Score: 3944
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.32
Marker Score: 2519
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.31
Marker Score: 2075
Cell Name: centroblast (CL0009112)
Fold Change: 2.31
Marker Score: 1138
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 2.3
Marker Score: 1527
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.3
Marker Score: 30295
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 2.3
Marker Score: 1346
Cell Name: granulocyte (CL0000094)
Fold Change: 2.29
Marker Score: 1028
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.29
Marker Score: 1145
Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.29
Marker Score: 1797
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 2.28
Marker Score: 1647
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.28
Marker Score: 3221
Cell Name: ciliated cell (CL0000064)
Fold Change: 2.27
Marker Score: 7815
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.27
Marker Score: 1249
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 2.26
Marker Score: 1513
Cell Name: neutrophil (CL0000775)
Fold Change: 2.26
Marker Score: 1378
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 2.25
Marker Score: 1384

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**Key characteristics:** - Cystatin B is a secreted protein with a molecular weight of approximately 50-55 kDa. - It is expressed in a variety of cell types, including secretory cells, epithelial cells, and immune cells. - It is a potent inhibitor of cysteine proteases, which are enzymes that cleave peptide bonds in proteins. - Cystatin B works by binding to cysteine proteases and preventing them from cleaving proteins. **Pathways and functions:** - Cystatin B inhibits the activity of cysteine proteases, which are involved in a variety of cellular processes, including cell migration, cell cycle regulation, and apoptosis. - It also regulates the production of other proteins that are involved in immune responses. - In the immune system, cystatin B is expressed on the surface of immune cells, including macrophages and dendritic cells. - It plays a role in the regulation of inflammation and immune responses. - It is also involved in the regulation of cell migration and proliferation. **Clinical significance:** - Mutations in the CSTB gene have been linked to several human diseases, including cancer and autoimmune disorders. - In cancer, cystatin B mutations can lead to the activation of oncogenes and the development of tumors. - Cystatin B inhibitors are currently being investigated as potential treatments for cancer and other diseases that are characterized by excessive inflammation and cell growth.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cystatin-B

Genular Protein ID: 400739665

Symbol: CYTB_HUMAN

Name: Cystatin-B

UniProtKB Accession Codes:

P04080

Database IDs:

Citations:

PubMed ID: 3902020

Title: Amino acid sequence of the intracellular cysteine proteinase inhibitor cystatin B from human liver.

PubMed ID: 3902020

DOI: 10.1016/0006-291x(85)90216-5

PubMed ID: 8596935

Title: Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1).

PubMed ID: 8596935

DOI: 10.1126/science.271.5256.1731

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11139332

Title: Nuclear localization of cystatin B, the cathepsin inhibitor implicated in myoclonus epilepsy (EPM1).

PubMed ID: 11139332

DOI: 10.1006/excr.2000.5085

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 2347312

Title: The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction.

PubMed ID: 2347312

DOI: 10.1002/j.1460-2075.1990.tb08321.x

PubMed ID: 9012407

Title: Identification of mutations in cystatin B, the gene responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy (EPM1).

PubMed ID: 9012407

Sequence Information:

Length: 98
Mass: 11140
Checksum: B8076220E19D0483
Sequence:

MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG 
DEDFVHLRVF QSLPHENKPL TLSNYQTNKA KHDELTYF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CSTB

Associated with

Cells (max top 100)

Other Information

Amino acid sequence of the intracellular cysteine proteinase inhibitor cystatin B from human liver. PubMed ID: 3902020

Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1). PubMed ID: 8596935

The DNA sequence of human chromosome 21. PubMed ID: 10830953

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nuclear localization of cystatin B, the cathepsin inhibitor implicated in myoclonus epilepsy (EPM1). PubMed ID: 11139332

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction. PubMed ID: 2347312

Identification of mutations in cystatin B, the gene responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy (EPM1). PubMed ID: 9012407