Genular: Defining Cellular Identity and Function

Details for: Gpr37

Gene ID: 14763

Symbol: Gpr37

Ensembl ID: ENSMUSG00000039904

Description: G protein-coupled receptor 37

Associated with

Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Cell surface
(GO:0009986)
Cellular response to reactive oxygen species
(GO:0034614)
Cytoplasm
(GO:0005737)
Dendrite development
(GO:0016358)
Dopamine biosynthetic process
(GO:0042416)
Endoplasmic reticulum
(GO:0005783)
G protein-coupled peptide receptor activity
(GO:0008528)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heat shock protein binding
(GO:0031072)
Hsp70 protein binding
(GO:0030544)
Locomotion involved in locomotory behavior
(GO:0031987)
Membrane
(GO:0016020)
Neuropeptide binding
(GO:0042923)
Neuropeptide receptor activity
(GO:0008188)
Neuropeptide signaling pathway
(GO:0007218)
Pdz domain binding
(GO:0030165)
Peptide binding
(GO:0042277)
Plasma membrane
(GO:0005886)
Positive regulation of dopamine metabolic process
(GO:0045964)
Positive regulation of mapk cascade
(GO:0043410)
Prosaposin receptor activity
(GO:0036505)
Receptor complex
(GO:0043235)
Signal transduction
(GO:0007165)
Synapse
(GO:0045202)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Prosaposin receptor GPR37

Genular Protein ID: 4025721769

Symbol: GPR37_MOUSE

Name: Prosaposin receptor GPR37

UniProtKB Accession Codes:

Q9QY42 Q8BKF8 Q8BXP9 Q8C022 Q9Z0G3

Database IDs:

Citations:

PubMed ID: 9799598

Title: Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis.

PubMed ID: 9799598

DOI: 10.1006/geno.1998.5433

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26961174

Title: G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination.

PubMed ID: 26961174

DOI: 10.1038/ncomms10884

PubMed ID: 28642167

Title: Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination.

PubMed ID: 28642167

DOI: 10.1016/j.neuroscience.2017.06.006

PubMed ID: 30010619

Title: GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain.

PubMed ID: 30010619

DOI: 10.1172/jci99888

PubMed ID: 33731716

Title: Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice.

PubMed ID: 33731716

DOI: 10.1038/s41467-021-21940-8

PubMed ID: 34678058

Title: Osteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 signaling in the mouse brain.

PubMed ID: 34678058

DOI: 10.1126/sciadv.abi5811

PubMed ID: 37436891

Title: Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling.

PubMed ID: 37436891

DOI: 10.1016/j.celrep.2023.112808

Sequence Information:

Length: 600
Mass: 66775
Checksum: 5F92E65984746B30
Sequence:

MPARGAPLSR TSRLLLLLLF KVSVSAALSF VPEPRNGTCL GESCSPLIQR RSRDARGPGN 
SAKDALRVHV PREKLEAEVR GATSWDLPPP RGGDTGVIEE AAAAGPLGPP TKPPSAWRWK 
SAQGKEPSGH LRRRDPTDPQ LFFPTSEGGE MSSKRDGIPQ SRQEHSVKTE PRDLFYWPRR 
TGQLQDSQHR PSAVHEGRTL APPGRALPQN GSADDWVPDQ GGPRRGNTTR RVRLKNPFYP 
LTQESYGAYA VMCLSVVIFG TGIIGNLAVM CIVCHNYYMR SISNSLLANL AFWDFLIIFF 
CLPLVIFHEL TKKWLLEDFS CKIVPYIEVA SLGVTTFTLC ALCIDRFRAA TNVQMYYEMI 
ENCSSTTAKL AVIWVGALLL ALPEVVLRQL SKEDLGFSGQ APAERCVIKI SPDLPDTIYV 
LALTYDGARL WWYFGCYFCL PTLFTITCSL VTARKIRKAE KASTRGNKRQ IHLESQMNCT 
VVALTILYGF CIIPENICNI VTAYMATGVS QQTMDLLNII SQFLLFFKSC VTPVLLFCLC 
RPFSRAFMEC CCCCCEECIQ KSSTVTSDDN DNEYTTELEL SPFSTIRREM STFASVGTHC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gpr37

Associated with

Other Information

Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis. PubMed ID: 9799598

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination. PubMed ID: 26961174

Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination. PubMed ID: 28642167

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. PubMed ID: 30010619

Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice. PubMed ID: 33731716

Osteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 signaling in the mouse brain. PubMed ID: 34678058

Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling. PubMed ID: 37436891