Genular: Defining Cellular Identity and Function

Details for: Adgrg1

Gene ID: 14766

Symbol: Adgrg1

Ensembl ID: ENSMUSG00000031785

Description: adhesion G protein-coupled receptor G1

Associated with

Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Angiogenesis
(GO:0001525)
Brain development
(GO:0007420)
Cell adhesion
(GO:0007155)
Cell differentiation
(GO:0030154)
Cell migration
(GO:0016477)
Cell surface receptor signaling pathway
(GO:0007166)
Cerebral cortex radial glia-guided migration
(GO:0021801)
Cerebral cortex regionalization
(GO:0021796)
Collagen binding
(GO:0005518)
Extracellular matrix binding
(GO:0050840)
Extracellular region
(GO:0005576)
Glial limiting end-foot
(GO:0097451)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Hematopoietic stem cell homeostasis
(GO:0061484)
Heparin binding
(GO:0008201)
Layer formation in cerebral cortex
(GO:0021819)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of neuron migration
(GO:2001223)
Nervous system development
(GO:0007399)
Neural precursor cell proliferation
(GO:0061351)
Plasma membrane
(GO:0005886)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of neural precursor cell proliferation
(GO:2000179)
Positive regulation of rho protein signal transduction
(GO:0035025)
Protein binding
(GO:0005515)
Protein kinase c signaling
(GO:0070528)
Rho protein signal transduction
(GO:0007266)
Seminiferous tubule development
(GO:0072520)
Signal transduction
(GO:0007165)
Transmembrane signaling receptor activity
(GO:0004888)
Vascular endothelial growth factor production
(GO:0010573)

Other Information

Proteins

Adhesion G-protein coupled receptor G1

Genular Protein ID: 1131344502

Symbol: AGRG1_MOUSE

Name: Adhesion G-protein coupled receptor G1

UniProtKB Accession Codes:

Q8K209 Q3UR17 Q9QZT2

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17576745

Title: Disease-associated mutations affect GPR56 protein trafficking and cell surface expression.

PubMed ID: 17576745

DOI: 10.1093/hmg/ddm144

PubMed ID: 18509043

Title: GPR56 regulates pial basement membrane integrity and cortical lamination.

PubMed ID: 18509043

DOI: 10.1523/jneurosci.0853-08.2008

PubMed ID: 18378689

Title: Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a G alpha 12/13 and Rho pathway.

PubMed ID: 18378689

DOI: 10.1074/jbc.m708919200

PubMed ID: 19515912

Title: GPR56-regulated granule cell adhesion is essential for rostral cerebellar development.

PubMed ID: 19515912

DOI: 10.1523/jneurosci.1182-09.2009

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20981830

Title: GPR56 is essential for testis development and male fertility in mice.

PubMed ID: 20981830

DOI: 10.1002/dvdy.22468

PubMed ID: 21768377

Title: G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination.

PubMed ID: 21768377

DOI: 10.1073/pnas.1104821108

PubMed ID: 22238662

Title: Disease-associated mutations prevent GPR56-collagen III interaction.

PubMed ID: 22238662

DOI: 10.1371/journal.pone.0029818

PubMed ID: 23478665

Title: Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56.

PubMed ID: 23478665

DOI: 10.1038/leu.2013.75

PubMed ID: 24531968

Title: Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning.

PubMed ID: 24531968

DOI: 10.1126/science.1244392

PubMed ID: 27068534

Title: Heparin interacts with adhesion-GPCR GPR56/ADGRG1, reduces receptor shedding, and promotes cell adhesion and motility.

PubMed ID: 27068534

DOI: 10.1242/jcs.174458

Sequence Information:

Length: 687
Mass: 77255
Checksum: B5315D70B66C9A9A
Sequence:

MAVQVLRQMV YFLLSLFSLV QGAHSGSPRE DFRFCGQRNQ TQQSTLHYDQ SSEPHIFVWN 
TEETLTIRAP FLAAPDIPRF FPEPRGLYHF CLYWSRHTGR LHLRYGKHDY LLSSQASRLL 
CFQKQEQSLK QGAPLIATSV SSWQIPQNTS LPGAPSFIFS FHNAPHKVSH NASVDMCDLK 
KELQQLSRYL QHPQKAAKRP TAAFISQQLQ SLESKLTSVS FLGDTLSFEE DRVNATVWKL 
PPTAGLEDLH IHSQKEEEQS EVQAYSLLLP RAVFQQTRGR RRDDAKRLLV VDFSSQALFQ 
DKNSSQVLGE KVLGIVVQNT KVTNLSDPVV LTFQHQPQPK NVTLQCVFWV EDPASSSTGS 
WSSAGCETVS RDTQTSCLCN HLTYFAVLMV SSTEVEATHK HYLTLLSYVG CVISALACVF 
TIAAYLCSRR KSRDYTIKVH MNLLSAVFLL DVSFLLSEPV ALTGSEAACR TSAMFLHFSL 
LACLSWMGLE GYNLYRLVVE VFGTYVPGYL LKLSIVGWGF PVFLVTLVAL VDVNNYGPII 
LAVRRTPERV TYPSMCWIRD SLVSYVTNLG LFSLVFLFNL AMLATMVVQI LRLRPHSQNW 
PHVLTLLGLS LVLGLPWALV FFSFASGTFQ LVILYLFSII TSFQGFLIFL WYWSMRFQAQ 
GGPSPLKNNS DSAKLPISSG STSSSRI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Adgrg1

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Disease-associated mutations affect GPR56 protein trafficking and cell surface expression. PubMed ID: 17576745

GPR56 regulates pial basement membrane integrity and cortical lamination. PubMed ID: 18509043

Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a G alpha 12/13 and Rho pathway. PubMed ID: 18378689

GPR56-regulated granule cell adhesion is essential for rostral cerebellar development. PubMed ID: 19515912

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

GPR56 is essential for testis development and male fertility in mice. PubMed ID: 20981830

G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination. PubMed ID: 21768377

Disease-associated mutations prevent GPR56-collagen III interaction. PubMed ID: 22238662

Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56. PubMed ID: 23478665

Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. PubMed ID: 24531968

Heparin interacts with adhesion-GPCR GPR56/ADGRG1, reduces receptor shedding, and promotes cell adhesion and motility. PubMed ID: 27068534