Details for: CSTF1

Gene ID: 1477

Symbol: CSTF1

Ensembl ID: ENSG00000101138

Description: cleavage stimulation factor subunit 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71738
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47962
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.97
    Marker Score: 280
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.91
    Marker Score: 1141
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2709
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4899
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.83
    Marker Score: 3273
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.8
    Marker Score: 546
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.76
    Marker Score: 1445
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 305
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.75
    Marker Score: 1083
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.75
    Marker Score: 11789
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 575
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.71
    Marker Score: 1495
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.7
    Marker Score: 1908
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.68
    Marker Score: 723
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.68
    Marker Score: 907
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2861
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.67
    Marker Score: 1584
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 607
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.65
    Marker Score: 1367.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.65
    Marker Score: 210
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.65
    Marker Score: 655
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.63
    Marker Score: 596
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.63
    Marker Score: 156
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.63
    Marker Score: 473
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.63
    Marker Score: 666
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.63
    Marker Score: 196
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.62
    Marker Score: 416
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.62
    Marker Score: 343
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.62
    Marker Score: 1055
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.62
    Marker Score: 568
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.61
    Marker Score: 638
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6
    Marker Score: 3840
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.6
    Marker Score: 639
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.59
    Marker Score: 2410
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.58
    Marker Score: 308
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.58
    Marker Score: 171.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.57
    Marker Score: 134
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.57
    Marker Score: 1552
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.55
    Marker Score: 5532
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.54
    Marker Score: 583
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 431
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.54
    Marker Score: 7126
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.53
    Marker Score: 265
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.52
    Marker Score: 355
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.52
    Marker Score: 1187
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.52
    Marker Score: 541
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.52
    Marker Score: 342.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5
    Marker Score: 301
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5
    Marker Score: 17254.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.5
    Marker Score: 1007
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.49
    Marker Score: 1163
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 206
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.49
    Marker Score: 147
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.49
    Marker Score: 236
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.49
    Marker Score: 180
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.46
    Marker Score: 189
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.46
    Marker Score: 334
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.46
    Marker Score: 408
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.46
    Marker Score: 132
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.46
    Marker Score: 287
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.46
    Marker Score: 210
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.46
    Marker Score: 1968
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.46
    Marker Score: 1351
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.45
    Marker Score: 2957
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.45
    Marker Score: 128
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.45
    Marker Score: 5252
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.45
    Marker Score: 302
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.45
    Marker Score: 1287
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.45
    Marker Score: 3346
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.45
    Marker Score: 877
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.44
    Marker Score: 217
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.44
    Marker Score: 109
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.44
    Marker Score: 413
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.44
    Marker Score: 281
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.44
    Marker Score: 3751
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.44
    Marker Score: 107
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.43
    Marker Score: 181
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.43
    Marker Score: 87
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.43
    Marker Score: 608
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.43
    Marker Score: 94
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.43
    Marker Score: 304
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.43
    Marker Score: 291
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.43
    Marker Score: 1581
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.43
    Marker Score: 446
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.42
    Marker Score: 751
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.42
    Marker Score: 134
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.42
    Marker Score: 175
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.42
    Marker Score: 396

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Other Information

**Key characteristics:** - The CSTF1 gene is located on chromosome 19q21.1. - It is a protein of 363 amino acids. - It is expressed in a variety of cell types, including neurons, glial cells, and epithelial cells. - It is a key regulator of gene expression, as it is required for the processing of intronless pre-mRNAs. **Pathways and functions:** - The CSTF1 protein is a key component of the Csf complex. - The Csf complex is responsible for the processing of intronless pre-mRNAs by cleaving them from the primary transcript. - The processed mRNAs are then able to be translated to produce proteins that are involved in neuronal development, growth, and differentiation. **Clinical significance:** - Mutations in the CSTF1 gene have been linked to a number of human diseases, including autism, schizophrenia, and epilepsy. - These mutations can lead to the formation of unstable or misfolded CSTF1 proteins, which can disrupt the Csf complex and lead to neuronal dysfunction. - Therefore, CSTF1 is a promising target for the treatment of these disorders. **Additional information:** - The CSTF1 gene is also known as CLEF1. - It is a member of the CLEF family of proteins, which are involved in the processing of intronless pre-mRNAs. - The Csf complex is a highly conserved protein, with similar proteins found in other mammals.

Genular Protein ID: 1939791410

Symbol: CSTF1_HUMAN

Name: Cleavage stimulation factor subunit 1

UniProtKB Accession Codes:

Q05048 Q5QPD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 4 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1358884

Title: A human polyadenylation factor is a G protein beta-subunit homologue.

PubMed ID: 1358884

DOI: 10.1016/s0021-9258(18)35861-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10477523

Title: Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50.

PubMed ID: 10477523

DOI: 10.1126/science.285.5433.1576

PubMed ID: 10669729

Title: Complex protein interactions within the human polyadenylation machinery identify a novel component.

PubMed ID: 10669729

DOI: 10.1128/mcb.20.5.1515-1525.2000

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

Sequence Information:

  • Length: 431
  • Mass: 48358
  • Checksum: 88A5BE53022AD9E3
  • Sequence:
    • MYRTKVGLKD RQQLYKLIIS QLLYDGYISI ANGLINEIKP QSVCAPSEQL LHLIKLGMEN 
DDTAVQYAIG RSDTVAPGTG IDLEFDADVQ TMSPEASEYE TCYVTSHKGP CRVATYSRDG 
QLIATGSADA SIKILDTERM LAKSAMPIEV MMNETAQQNM ENHPVIRTLY DHVDEVTCLA 
FHPTEQILAS GSRDYTLKLF DYSKPSAKRA FKYIQEAEML RSISFHPSGD FILVGTQHPT 
LRLYDINTFQ CFVSCNPQDQ HTDAICSVNY NSSANMYVTG SKDGCIKLWD GVSNRCITTF 
EKAHDGAEVC SAIFSKNSKY ILSSGKDSVA KLWEISTGRT LVRYTGAGLS GRQVHRTQAV 
FNHTEDYVLL PDERTISLCC WDSRTAERRN LLSLGHNNIV RCIVHSPTNP GFMTCSDDFR 
ARFWYRRSTT D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.