Details for: CSTF1

Gene ID: 1477

Symbol: CSTF1

Ensembl ID: ENSG00000101138

Description: cleavage stimulation factor subunit 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 81.5840
    Cell Significance Index: -12.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.4037
    Cell Significance Index: -11.7700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.0529
    Cell Significance Index: -15.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.1225
    Cell Significance Index: -13.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.8467
    Cell Significance Index: -13.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.8982
    Cell Significance Index: -14.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.9125
    Cell Significance Index: -13.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8469
    Cell Significance Index: -15.1800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.5228
    Cell Significance Index: -10.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.7660
    Cell Significance Index: -3.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4188
    Cell Significance Index: 140.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0321
    Cell Significance Index: 61.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9315
    Cell Significance Index: 101.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7475
    Cell Significance Index: 121.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6963
    Cell Significance Index: 43.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5763
    Cell Significance Index: 20.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5413
    Cell Significance Index: 14.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.5308
    Cell Significance Index: 13.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4804
    Cell Significance Index: 33.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4084
    Cell Significance Index: 81.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3306
    Cell Significance Index: 9.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3115
    Cell Significance Index: 4.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2959
    Cell Significance Index: 8.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2662
    Cell Significance Index: 145.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2593
    Cell Significance Index: 114.6500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2502
    Cell Significance Index: 2.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2310
    Cell Significance Index: 10.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2308
    Cell Significance Index: 31.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2295
    Cell Significance Index: 16.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2188
    Cell Significance Index: 4.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2082
    Cell Significance Index: 4.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2041
    Cell Significance Index: 36.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2024
    Cell Significance Index: 40.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1937
    Cell Significance Index: 22.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1575
    Cell Significance Index: 19.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1422
    Cell Significance Index: 4.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1311
    Cell Significance Index: 6.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1267
    Cell Significance Index: 3.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1218
    Cell Significance Index: 15.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1217
    Cell Significance Index: 3.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0992
    Cell Significance Index: 1.6600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0923
    Cell Significance Index: 1.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0909
    Cell Significance Index: 2.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0790
    Cell Significance Index: 28.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0773
    Cell Significance Index: 3.6400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0663
    Cell Significance Index: 0.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0606
    Cell Significance Index: 1.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0543
    Cell Significance Index: 2.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0308
    Cell Significance Index: 5.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0275
    Cell Significance Index: 1.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0261
    Cell Significance Index: 18.0600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0167
    Cell Significance Index: 0.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0140
    Cell Significance Index: 1.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0091
    Cell Significance Index: 0.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0024
    Cell Significance Index: -0.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0034
    Cell Significance Index: -6.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0057
    Cell Significance Index: -0.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0064
    Cell Significance Index: -4.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0072
    Cell Significance Index: -5.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0075
    Cell Significance Index: -11.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0086
    Cell Significance Index: -11.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0123
    Cell Significance Index: -7.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0146
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0161
    Cell Significance Index: -11.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0184
    Cell Significance Index: -1.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0202
    Cell Significance Index: -0.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0206
    Cell Significance Index: -1.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0231
    Cell Significance Index: -10.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0231
    Cell Significance Index: -13.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0303
    Cell Significance Index: -18.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0330
    Cell Significance Index: -3.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0363
    Cell Significance Index: -10.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0442
    Cell Significance Index: -5.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0462
    Cell Significance Index: -6.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0523
    Cell Significance Index: -1.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0566
    Cell Significance Index: -4.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0611
    Cell Significance Index: -3.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0813
    Cell Significance Index: -17.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0969
    Cell Significance Index: -5.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1019
    Cell Significance Index: -6.8500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1067
    Cell Significance Index: -0.8700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1261
    Cell Significance Index: -1.3100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1265
    Cell Significance Index: -1.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1421
    Cell Significance Index: -14.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1430
    Cell Significance Index: -1.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1466
    Cell Significance Index: -1.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1531
    Cell Significance Index: -12.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1745
    Cell Significance Index: -2.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1788
    Cell Significance Index: -4.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1802
    Cell Significance Index: -7.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2060
    Cell Significance Index: -7.8000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2117
    Cell Significance Index: -3.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2420
    Cell Significance Index: -5.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2511
    Cell Significance Index: -15.4000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2663
    Cell Significance Index: -3.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2863
    Cell Significance Index: -7.3600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2887
    Cell Significance Index: -4.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2963
    Cell Significance Index: -8.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3113
    Cell Significance Index: -9.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CSTF1 is a single-copy gene located on human chromosome 2q32.3, and its expression is highly specific to certain cell types, including cerebral cortex GABAergic interneurons, forebrain radial glial cells, and intestinal epithelial cells. CSTF1 is a member of the CSTF complex, which is composed of CSTF1, CSTF2, and CSTF3 subunits. The CSTF complex is essential for the recognition and processing of pre-mRNAs, particularly those with introns. CSTF1 is a RNA-binding protein that interacts with other proteins and RNA molecules to regulate the cleavage and polyadenylation of pre-mRNAs. **Pathways and Functions:** CSTF1 plays a central role in the RNA processing pathways, particularly in the 3'-end processing of pre-mRNAs. The CSTF complex recognizes and binds to specific sequences within pre-mRNAs, facilitating the recruitment of the cleavage and polyadenylation machinery. CSTF1 is involved in the recognition and processing of both intron-containing and intronless pre-mRNAs, ensuring the accurate conversion of these transcripts into mature mRNA transcripts. CSTF1 also interacts with other RNA-binding proteins, such as the RNA-binding protein (RBP) family, to regulate the stability and translation of mRNAs. **Clinical Significance:** Abnormal expression or dysfunction of CSTF1 has been implicated in various human diseases, including cancers, neurological disorders, and developmental abnormalities. For example, mutations in CSTF1 have been associated with neurodevelopmental disorders, such as intellectual disability and autism spectrum disorder. Additionally, CSTF1 has been shown to be overexpressed in certain types of cancer, including colon cancer, and its dysregulation has been linked to tumorigenesis and metastasis. Furthermore, CSTF1 has been implicated in the regulation of RNA processing in the brain, and its dysregulation has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, CSTF1 is a critical gene involved in the regulation of RNA processing, particularly in the maturation of pre-mRNAs. Its dysregulation has significant implications for human health, and further research is needed to fully understand the mechanisms underlying CSTF1-mediated RNA processing and its role in disease.

Genular Protein ID: 1939791410

Symbol: CSTF1_HUMAN

Name: Cleavage stimulation factor subunit 1

UniProtKB Accession Codes:

Q05048 Q5QPD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 4 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1358884

Title: A human polyadenylation factor is a G protein beta-subunit homologue.

PubMed ID: 1358884

DOI: 10.1016/s0021-9258(18)35861-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10477523

Title: Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50.

PubMed ID: 10477523

DOI: 10.1126/science.285.5433.1576

PubMed ID: 10669729

Title: Complex protein interactions within the human polyadenylation machinery identify a novel component.

PubMed ID: 10669729

DOI: 10.1128/mcb.20.5.1515-1525.2000

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

Sequence Information:

  • Length: 431
  • Mass: 48358
  • Checksum: 88A5BE53022AD9E3
  • Sequence:
    • MYRTKVGLKD RQQLYKLIIS QLLYDGYISI ANGLINEIKP QSVCAPSEQL LHLIKLGMEN 
DDTAVQYAIG RSDTVAPGTG IDLEFDADVQ TMSPEASEYE TCYVTSHKGP CRVATYSRDG 
QLIATGSADA SIKILDTERM LAKSAMPIEV MMNETAQQNM ENHPVIRTLY DHVDEVTCLA 
FHPTEQILAS GSRDYTLKLF DYSKPSAKRA FKYIQEAEML RSISFHPSGD FILVGTQHPT 
LRLYDINTFQ CFVSCNPQDQ HTDAICSVNY NSSANMYVTG SKDGCIKLWD GVSNRCITTF 
EKAHDGAEVC SAIFSKNSKY ILSSGKDSVA KLWEISTGRT LVRYTGAGLS GRQVHRTQAV 
FNHTEDYVLL PDERTISLCC WDSRTAERRN LLSLGHNNIV RCIVHSPTNP GFMTCSDDFR 
ARFWYRRSTT D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.