Genular: Defining Cellular Identity and Function

Details for: Grk5

Gene ID: 14773

Symbol: Grk5

Ensembl ID: ENSMUSG00000003228

Description: G protein-coupled receptor kinase 5

Associated with

G alpha (s) signalling events
(R-MMU-418555)
Gpcr downstream signalling
(R-MMU-388396)
Signaling by gpcr
(R-MMU-372790)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Beta-adrenergic receptor kinase activity
(GO:0047696)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Desensitization of g protein-coupled receptor signaling pathway
(GO:0002029)
Fat cell differentiation
(GO:0045444)
G protein-coupled receptor kinase activity
(GO:0004703)
Kinase activity
(GO:0016301)
Lipid binding
(GO:0008289)
Membrane
(GO:0016020)
Negative regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0106072)
Negative regulation of apoptotic process
(GO:0043066)
Nuclear membrane
(GO:0031965)
Nuclear speck
(GO:0016607)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of cell cycle
(GO:0051726)
Regulation of g protein-coupled receptor signaling pathway
(GO:0008277)
Regulation of signal transduction
(GO:0009966)
Signal transduction
(GO:0007165)
Tachykinin receptor signaling pathway
(GO:0007217)
Transferase activity
(GO:0016740)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

G protein-coupled receptor kinase 5

Genular Protein ID: 3763841464

Symbol: GRK5_MOUSE

Name: G protein-coupled receptor kinase 5

UniProtKB Accession Codes:

Q8VEB1 O70292 O70297

Database IDs:

Citations:

PubMed ID: 10506199

Title: The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation.

PubMed ID: 10506199

DOI: 10.1074/jbc.274.41.29381

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10624964

Title: Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice.

PubMed ID: 10624964

DOI: 10.1016/s0896-6273(00)81048-x

PubMed ID: 14565944

Title: G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation.

PubMed ID: 14565944

DOI: 10.1152/ajplung.00255.2003

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18711143

Title: Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes.

PubMed ID: 18711143

DOI: 10.1073/pnas.0803153105

PubMed ID: 19478075

Title: GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization.

PubMed ID: 19478075

DOI: 10.1074/jbc.m109.005959

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21041302

Title: GRK5 deficiency accelerates beta-amyloid accumulation in Tg2576 mice via impaired cholinergic activity.

PubMed ID: 21041302

DOI: 10.1074/jbc.m110.170894

Sequence Information:

Length: 590
Mass: 67732
Checksum: F47D87397B1A2399
Sequence:

MELENIVANT VLLKAREGGG GKRKGKSKKW KEILKFPHIS QCEDLRRTID RDYYSLCDKQ 
PIGRLLFRQF CETRPGLECY IQFLDLVAEY EITPDENLGA KGKEIMTKYL TPKSPVFIAQ 
VGQDLVSQTE KKLLQSPCKE LFSACAQSVH DYLKGDPFHE YLDSMYFDRF LQWKWLERQP 
VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKRLEKK RIKKRKGESM ALNEKQILEK 
VNSQFVVNLA YAYETKDALC LVLTIMNGGD LKFHIYNMGN PGFEEERALF YAAEILCGLE 
DLHRENTVYR DLKPENILLD DYGHIRISDL GLAVKIPEGD LIRGRVGTVG YMAPEVLNNQ 
RYGLSPDYWG LGCLIYEMIE GQSPFRGRKE KVKREEVDRR VLETEEVYSS KFSEEAKSIC 
NMLLTKDSKQ RLGCQEEGAA EVKRHPFFRN MNFKRLEAGM LDPPFVPDPR AVYCKDVLDI 
EQFSTVKGVN LDHTDDDFYS KFSTGSVPIP WQNEMIETEC FKELNVFGPN GTLSPDLNRS 
QPPEPPKKGL FHRLFRRQHQ SNSKSSPTPK TSCNHRINSN HINSNSTGSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Grk5

Associated with

Other Information

The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. PubMed ID: 10506199

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice. PubMed ID: 10624964

G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation. PubMed ID: 14565944

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes. PubMed ID: 18711143

GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization. PubMed ID: 19478075

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

GRK5 deficiency accelerates beta-amyloid accumulation in Tg2576 mice via impaired cholinergic activity. PubMed ID: 21041302