Details for: CSTF2

Gene ID: 1478

Symbol: CSTF2

Ensembl ID: ENSG00000101811

Description: cleavage stimulation factor subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 53.8107
    Cell Significance Index: -8.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.5617
    Cell Significance Index: -9.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.4488
    Cell Significance Index: -9.1200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 21.7105
    Cell Significance Index: -10.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.8673
    Cell Significance Index: -9.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.2477
    Cell Significance Index: -8.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.5354
    Cell Significance Index: -10.0100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.6091
    Cell Significance Index: 12.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9030
    Cell Significance Index: 89.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6281
    Cell Significance Index: 68.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6196
    Cell Significance Index: 559.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5217
    Cell Significance Index: 27.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4941
    Cell Significance Index: 80.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3047
    Cell Significance Index: 21.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2978
    Cell Significance Index: 35.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2609
    Cell Significance Index: 7.2900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.2489
    Cell Significance Index: 1.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2396
    Cell Significance Index: 48.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2375
    Cell Significance Index: 14.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2359
    Cell Significance Index: 5.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2091
    Cell Significance Index: 6.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1791
    Cell Significance Index: 34.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1551
    Cell Significance Index: 7.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1448
    Cell Significance Index: 28.7300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1434
    Cell Significance Index: 2.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1264
    Cell Significance Index: 4.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1135
    Cell Significance Index: 3.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1129
    Cell Significance Index: 13.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1098
    Cell Significance Index: 48.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1056
    Cell Significance Index: 37.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0992
    Cell Significance Index: 17.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0984
    Cell Significance Index: 2.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0984
    Cell Significance Index: 53.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0944
    Cell Significance Index: 5.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0595
    Cell Significance Index: 41.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0564
    Cell Significance Index: 1.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0488
    Cell Significance Index: 2.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0449
    Cell Significance Index: 3.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0314
    Cell Significance Index: 1.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0308
    Cell Significance Index: 2.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0276
    Cell Significance Index: 3.7900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0274
    Cell Significance Index: 0.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0271
    Cell Significance Index: 3.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0033
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0030
    Cell Significance Index: 4.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0011
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0007
    Cell Significance Index: 1.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0010
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0038
    Cell Significance Index: -5.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0042
    Cell Significance Index: -0.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0056
    Cell Significance Index: -3.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0075
    Cell Significance Index: -0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0090
    Cell Significance Index: -6.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0096
    Cell Significance Index: -7.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0097
    Cell Significance Index: -0.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0129
    Cell Significance Index: -9.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0131
    Cell Significance Index: -5.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0148
    Cell Significance Index: -0.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0169
    Cell Significance Index: -0.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0172
    Cell Significance Index: -0.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0176
    Cell Significance Index: -9.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0179
    Cell Significance Index: -2.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0190
    Cell Significance Index: -11.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0195
    Cell Significance Index: -1.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0228
    Cell Significance Index: -2.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0276
    Cell Significance Index: -0.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0281
    Cell Significance Index: -8.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0288
    Cell Significance Index: -4.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0293
    Cell Significance Index: -2.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0310
    Cell Significance Index: -4.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0366
    Cell Significance Index: -0.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0418
    Cell Significance Index: -1.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0420
    Cell Significance Index: -4.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0458
    Cell Significance Index: -1.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0521
    Cell Significance Index: -10.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0587
    Cell Significance Index: -6.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0674
    Cell Significance Index: -5.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0717
    Cell Significance Index: -1.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0736
    Cell Significance Index: -3.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0905
    Cell Significance Index: -9.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0938
    Cell Significance Index: -5.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1018
    Cell Significance Index: -5.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1045
    Cell Significance Index: -5.4900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1059
    Cell Significance Index: -0.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1070
    Cell Significance Index: -2.5700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1086
    Cell Significance Index: -1.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1179
    Cell Significance Index: -1.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1207
    Cell Significance Index: -9.5600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1416
    Cell Significance Index: -2.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1601
    Cell Significance Index: -2.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1693
    Cell Significance Index: -4.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1701
    Cell Significance Index: -3.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1725
    Cell Significance Index: -5.0800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1828
    Cell Significance Index: -2.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1832
    Cell Significance Index: -4.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1947
    Cell Significance Index: -6.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2036
    Cell Significance Index: -1.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2116
    Cell Significance Index: -2.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Function:** CSTF2 is a subunit of the CSTF complex, which is involved in the 3'-end processing of pre-mRNA. 2. **Expression:** CSTF2 is significantly expressed in various cell types, including oogonial cells, extravillous trophoblasts, and GABAergic interneurons. 3. **Pathways:** CSTF2 is involved in several cellular pathways, including cellular response to nerve growth factor stimulus, cleavage body, gene expression (transcription), metabolism of RNA, and mRNA 3'-end processing. 4. **Proteins:** CSTF2 interacts with other proteins, including CSTF1, UAP56, and TRF1, to form the CSTF complex. **Pathways and Functions:** 1. **mRNA 3'-end processing:** CSTF2 is essential for the 3'-end processing of pre-mRNA, which involves the removal of introns and the addition of a poly(A) tail. 2. **Gene expression (transcription):** CSTF2 is involved in the regulation of gene expression by controlling the processing of pre-mRNA. 3. **Cellular response to nerve growth factor stimulus:** CSTF2 is involved in the cellular response to nerve growth factor stimulus, which is essential for the development and maintenance of the nervous system. 4. **Metabolism of RNA:** CSTF2 is involved in the metabolism of RNA, including the processing of capped intron-containing pre-mRNA and the processing of intronless pre-mRNAs. **Clinical Significance:** 1. **Cancer:** Alterations in CSTF2 expression have been associated with various cancers, including breast cancer, lung cancer, and colon cancer. 2. **Neurological disorders:** CSTF2 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and amyotrophic lateral sclerosis (ALS). 3. **Regenerative medicine:** CSTF2 has been identified as a potential target for regenerative medicine, particularly in the context of tissue engineering and stem cell therapy. 4. **Gene therapy:** CSTF2 has been identified as a potential target for gene therapy, particularly in the context of treating genetic disorders. In conclusion, CSTF2 plays a crucial role in RNA processing and has implications in various diseases, including cancer, neurological disorders, and regenerative medicine. Further research is needed to fully understand the role of CSTF2 in human health and disease.

Genular Protein ID: 1738021224

Symbol: CSTF2_HUMAN

Name: Cleavage stimulation factor subunit 2

UniProtKB Accession Codes:

P33240 Q5H951 Q6LA74 Q8N502

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1741396

Title: The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs.

PubMed ID: 1741396

DOI: 10.1073/pnas.89.4.1403

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9199325

Title: RNA recognition by the human polyadenylation factor CstF.

PubMed ID: 9199325

DOI: 10.1128/mcb.17.7.3907

PubMed ID: 9736695

Title: Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition.

PubMed ID: 9736695

DOI: 10.1073/pnas.95.19.11095

PubMed ID: 10669729

Title: Complex protein interactions within the human polyadenylation machinery identify a novel component.

PubMed ID: 10669729

DOI: 10.1128/mcb.20.5.1515-1525.2000

PubMed ID: 11389848

Title: Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination.

PubMed ID: 11389848

DOI: 10.1016/s1097-2765(01)00236-2

PubMed ID: 11598190

Title: Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA.

PubMed ID: 11598190

DOI: 10.1091/mbc.12.10.3046

PubMed ID: 14749727

Title: Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.

PubMed ID: 14749727

DOI: 10.1038/sj.emboj.7600070

PubMed ID: 14707147

Title: HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin.

PubMed ID: 14707147

DOI: 10.1074/jbc.m311719200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18688255

Title: Conserved motifs in both CPSF73 and CPSF100 are required to assemble the active endonuclease for histone mRNA 3'-end maturation.

PubMed ID: 18688255

DOI: 10.1038/embor.2008.146

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21102410

Title: The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA.

PubMed ID: 21102410

DOI: 10.1038/emboj.2010.287

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 32816001

Title: A missense mutation in the CSTF2 gene that impairs the function of the RNA recognition motif and causes defects in 3' end processing is associated with intellectual disability in humans.

PubMed ID: 32816001

DOI: 10.1093/nar/gkaa689

PubMed ID: 12773396

Title: Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein.

PubMed ID: 12773396

DOI: 10.1093/emboj/cdg259

PubMed ID: 17116658

Title: The C-terminal domains of vertebrate CstF-64 and its yeast orthologue Rna15 form a new structure critical for mRNA 3'-end processing.

PubMed ID: 17116658

DOI: 10.1074/jbc.m609981200

Sequence Information:

  • Length: 577
  • Mass: 60959
  • Checksum: B76595E9BF8FABBD
  • Sequence:
    • MAGLTVRDPA VDRSLRSVFV GNIPYEATEE QLKDIFSEVG PVVSFRLVYD RETGKPKGYG 
FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE LKSLGTGAPV IESPYGETIS 
PEDAPESISK AVASLPPEQM FELMKQMKLC VQNSPQEARN MLLQNPQLAY ALLQAQVVMR 
IVDPEIALKI LHRQTNIPTL IAGNPQPVHG AGPGSGSNVS MNQQNPQAPQ AQSLGGMHVN 
GAPPLMQASM QGGVPAPGQM PAAVTGPGPG SLAPGGGMQA QVGMPGSGPV SMERGQVPMQ 
DPRAAMQRGS LPANVPTPRG LLGDAPNDPR GGTLLSVTGE VEPRGYLGPP HQGPPMHHVP 
GHESRGPPPH ELRGGPLPEP RPLMAEPRGP MLDQRGPPLD GRGGRDPRGI DARGMEARAM 
EARGLDARGL EARAMEARAM EARAMEARAM EARAMEVRGM EARGMDTRGP VPGPRGPIPS 
GMQGPSPINM GAVVPQGSRQ VPVMQGTGMQ GASIQGGSQP GGFSPGQNQV TPQDHEKAAL 
IMQVLQLTAD QIAMLPPEQR QSILILKEQI QKSTGAP

Genular Protein ID: 1498334623

Symbol: E7EWR4_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EWR4

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 597
  • Mass: 62943
  • Checksum: 26FC51420F354C66
  • Sequence:
    • MAGLTVRDPA VDRSLRSVFV GNIPYEATEE QLKDIFSEVG PVVSFRLVYD RETGKPKGYG 
FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE LKSLGTGAPV IESPYGETIS 
PEDAPESISK AVASLPPEQM FELMKQMKLC VQNSPQEARN MLLQNPQLAY ALLQAQVVMR 
IVDPEIALKI LHRQTNIPTL IAGNPQPVHG AGPGSGSNVS MNQQNPQAPQ AQSLGGMHVN 
GAPPLMQASM QGGVPAPGQM PAAVTGPGPG SLAPGGGMQA QVGMPGSGPV SMERGQGTLQ 
HSPVGPAGPA SIERVQVPMQ DPRAAMQRGS LPANVPTPRG LLGDAPNDPR GGTLLSVTGE 
VEPRGYLGPP HQGPPMHHVP GHESRGPPPH ELRGGPLPEP RPLMAEPRGP MLDQRGPPLD 
GRGGRDPRGI DARGMEARAM EARGLDARGL EARAMEARAM EARAMEARAM EARAMEVRGM 
EARGMDTRGP VPGPRGPIPS GMQGPSPINM GAVVPQGSRQ VPVMQGTGMQ GASIQGGSQP 
GGFSPGQNQV TPQDHEKAAL IMQVLQLTAD QIAMLPPEQR QSILILKEQI QKSTGAP

Genular Protein ID: 2536657045

Symbol: B3V096_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3V096

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 3 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 19284619

Title: A family of splice variants of CstF-64 expressed in vertebrate nervous systems.

PubMed ID: 19284619

DOI: 10.1186/1471-2199-10-22

Sequence Information:

  • Length: 597
  • Mass: 62929
  • Checksum: E5FB880F9C3805B2
  • Sequence:
    • MAGLTVRDPA VDRSLRSVFV GNIPYEATEE QLKDIFSEVG PVVSFRLVYD RETGKPKGYG 
FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE LKSLGTGAPV IESPYGETIS 
PEDAPESISK AVASLPPEQM FELMKQMKLC VQNSPQEARN MLLQNPQLAY ALLQAQVVMR 
IVDPEIALKI LHRQTNIPTL IAGNPQPVHG AGPGSGSNVS MNQQNPQAPQ AQSLGGMHVN 
GAPPLMQASM QGGVPAPGQM PAAVTGPGPG SLAPGGGMQA QVGMPGSGPV SMERGQGTLQ 
HSPVGPAGPA SIERVNVPMQ DPRAAMQRGS LPANVPTPRG LLGDAPNDPR GGTLLSVTGE 
VEPRGYLGPP HQGPPMHHVP GHESRGPPPH ELRGGPLPEP RPLMAEPRGP MLDQRGPPLD 
GRGGRDPRGI DARGMEARAM EARGLDARGL EARAMEARAM EARAMEARAM EARAMEVRGM 
EARGMDTRGP VPGPRGPIPS GMQGPSPINM GAVVPQGSRQ VPVMQGTGMQ GASIQGGSQP 
GGFSPGQNQV TPQDHEKAAL IMQVLQLTAD QIAMLPPEQR QSILILKEQI QKSTGAP

Genular Protein ID: 980341482

Symbol: B4DUD5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DUD5

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 3 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 ProteomicsDB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 553
  • Mass: 58618
  • Checksum: BCB98CDD080A96ED
  • Sequence:
    • MAGLTVRDPA VDRSLRSVFV GNIPYEATEE QLKDIFSEVG PVVSFRLVYD RETGKPKGYG 
FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE LKSLGTGAPV IESPYGETIS 
PEDAPESISK AVASLPPEQM FELMKQMKLC VQNSPQEARN MLLQNPQLAY ALLQAQVVMR 
IVDPEIALKI LHRQTNIPTL IAGNPQAQSL GGMHVNGAPP LMQASMQGGV PAPGQMPAAV 
TGPGPGSLAP GGGMQAQVGM PGSGPVSMER GQVPMQDPRA AMQRGSLPAN VPTPRGLLGD 
APNDPRGGTL LSVTGEVEPR GYLGPPHQGP PMHHVPGHES RGPPPHELRG GPLPEPRPLM 
AEPRGPMLDQ RGPPLDGRGG RDPRGIDARG MEARAMEARG LDARGLEARA MEARAMEARA 
MEARAMEARA MEVRGMEARG MDTRGPVPGP RGPIPSGMQG PSPINMGAVV PQGSRQVPVM 
QGTGMQGASI QGGSQPGGFS PGQNQVTPQD HEKAALIMQV LQLTADQIAM LPPEQRQSIL 
ILKEQIQKST GAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.