Genular: Defining Cellular Identity and Function

Details for: Grb10

Gene ID: 14783

Symbol: Grb10

Ensembl ID: ENSMUSG00000020176

Description: growth factor receptor bound protein 10

Associated with

Axon guidance
(R-MMU-422475)
Cytokine signaling in immune system
(R-MMU-1280215)
Developmental biology
(R-MMU-1266738)
Flt3 signaling
(R-MMU-9607240)
Immune system
(R-MMU-168256)
Insulin receptor signalling cascade
(R-MMU-74751)
Irs activation
(R-MMU-74713)
Nervous system development
(R-MMU-9675108)
Ret signaling
(R-MMU-8853659)
Signal attenuation
(R-MMU-74749)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by scf-kit
(R-MMU-1433557)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Erk1 and erk2 cascade
(GO:0070371)
Gene expression
(GO:0010467)
Identical protein binding
(GO:0042802)
Insulin-like growth factor receptor signaling pathway
(GO:0048009)
Insulin receptor binding
(GO:0005158)
Insulin receptor signaling pathway
(GO:0008286)
Negative regulation of glucose import
(GO:0046325)
Negative regulation of glycogen biosynthetic process
(GO:0045719)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of phosphorylation
(GO:0042326)
Negative regulation of wnt signaling pathway
(GO:0030178)
Phosphotyrosine residue binding
(GO:0001784)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030949)
Protein-containing complex
(GO:0032991)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Response to insulin
(GO:0032868)
Signaling receptor complex adaptor activity
(GO:0030159)
Signal transduction
(GO:0007165)
Vascular associated smooth muscle cell migration
(GO:1904738)

Other Information

Proteins

Growth factor receptor-bound protein 10

Genular Protein ID: 452566782

Symbol: GRB10_MOUSE

Name: Growth factor receptor-bound protein 10

UniProtKB Accession Codes:

Q60760 O35352 Q3TQ71 Q7TSA4 Q8BSH4 Q8BSS5 Q91WC5

Database IDs:

Citations:

PubMed ID: 7731717

Title: The cloning of Grb10 reveals a new family of SH2 domain proteins.

PubMed ID: 7731717

PubMed ID: 9062339

Title: The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.

PubMed ID: 9062339

DOI: 10.1172/jci119246

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9448292

Title: Identification of the Meg1/Grb10 imprinted gene on mouse proximal chromosome 11, a candidate for the Silver-Russell syndrome gene.

PubMed ID: 9448292

DOI: 10.1073/pnas.95.3.1102

PubMed ID: 10454568

Title: Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis.

PubMed ID: 10454568

DOI: 10.1128/mcb.19.9.6217

PubMed ID: 10861285

Title: Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion.

PubMed ID: 10861285

DOI: 10.1093/hmg/9.11.1587

PubMed ID: 12771153

Title: Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling.

PubMed ID: 12771153

DOI: 10.1074/jbc.m211572200

PubMed ID: 12697834

Title: The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor.

PubMed ID: 12697834

DOI: 10.1128/mcb.23.9.3363-3372.2003

PubMed ID: 12829789

Title: Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism.

PubMed ID: 12829789

DOI: 10.1073/pnas.1532175100

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 15722337

Title: Phosphorylation of grb10 regulates its interaction with 14-3-3.

PubMed ID: 15722337

DOI: 10.1074/jbc.m501477200

PubMed ID: 15664450

Title: Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling.

PubMed ID: 15664450

DOI: 10.1016/j.mce.2004.11.004

PubMed ID: 17376403

Title: GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway.

PubMed ID: 17376403

DOI: 10.1016/j.bbrc.2007.03.019

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18286479

Title: Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization.

PubMed ID: 18286479

DOI: 10.1002/jcp.21405

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 621
Mass: 70585
Checksum: 6FC737E8F35468BB
Sequence:

MNNDINSSVE SLNSACNMQS DTDTAPLLED GQHASNQGAA SSSRGQPQAS PRQKMQRSQP 
VHILRRLQEE DQQLRTASLP AIPNPFPELT GAAPGSPPSV APSSLPPPPS QPPAKHCGRC 
EKWIPGENTR GNGKRKIWRW QFPPGFQLSK LTRPGLWTKT TARFSKKQPK NQCPTDTVNP 
VARMPTSQME KLRLRKDVKV FSEDGTSKVV EILTDMTARD LCQLLVYKSH CVDDNSWTLV 
EHHPQLGLER CLEDHEIVVQ VESTMPSESK FLFRKNYAKY EFFKNPVNFF PDQMVNWCQQ 
SNGGQAQLLQ NFLNTSSCPE IQGFLQVKEV GRKSWKKLYV CLRRSGLYYS TKGTSKEPRH 
LQLLADLEES SIFYLIAGKK QYNAPNEHGM CIKPNKAKTE MKELRLLCAE DEQIRTCWMT 
AFRLLKYGML LYQNYRIPQR KGLPPPFNAP MRSVSENSLV AMDFSGQIGR VIDNPAEAQS 
AALEEGHAWR KRSTRMNILS SQSPLHPSTL NAVIHRTQHW FHGRISREES HRIIKQQGLV 
DGLFLLRDSQ SNPKAFVLTL CHHQKIKNFQ ILPCEDDGQT FFTLDDGNTK FSDLIQLVDF 
YQLNKGVLPC KLKHHCIRVA L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Grb10

Associated with

Other Information

The cloning of Grb10 reveals a new family of SH2 domain proteins. PubMed ID: 7731717

The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts. PubMed ID: 9062339

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of the Meg1/Grb10 imprinted gene on mouse proximal chromosome 11, a candidate for the Silver-Russell syndrome gene. PubMed ID: 9448292

Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis. PubMed ID: 10454568

Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion. PubMed ID: 10861285

Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. PubMed ID: 12771153

The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. PubMed ID: 12697834

Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism. PubMed ID: 12829789

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

Phosphorylation of grb10 regulates its interaction with 14-3-3. PubMed ID: 15722337

Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling. PubMed ID: 15664450

GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway. PubMed ID: 17376403

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization. PubMed ID: 18286479

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079