Details for: Grb2
Associated with
Other Information
Genular Protein ID: 1387222941
Symbol: GRB2_MOUSE
Name: Growth factor receptor-bound protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7689150
Title: Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.
PubMed ID: 7689150
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7997267
Title: Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase.
PubMed ID: 7997267
DOI: 10.1038/372786a0
PubMed ID: 8943348
Title: Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.
PubMed ID: 8943348
PubMed ID: 9312046
Title: Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signaling.
PubMed ID: 9312046
PubMed ID: 9395447
Title: An eps homology (EH) domain protein that binds to the ral-GTPase target, RalBP1.
PubMed ID: 9395447
PubMed ID: 9722576
Title: Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules.
PubMed ID: 9722576
PubMed ID: 9569023
Title: Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2.
PubMed ID: 9569023
PubMed ID: 10377264
Title: Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.
PubMed ID: 10377264
DOI: 10.1042/bj3410211
PubMed ID: 10068651
Title: Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.
PubMed ID: 10068651
PubMed ID: 10521483
Title: Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.
PubMed ID: 10521483
PubMed ID: 10330178
Title: Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner.
PubMed ID: 10330178
PubMed ID: 11551227
Title: Mouse alpha1-syntrophin binding to Grb2: further evidence of a role for syntrophin in cell signaling.
PubMed ID: 11551227
DOI: 10.1021/bi010490n
PubMed ID: 11463797
Title: MIST functions through distinct domains in immunoreceptor signaling in the presence and absence of LAT.
PubMed ID: 11463797
PubMed ID: 11571277
Title: PrPC directly interacts with proteins involved in signaling pathways.
PubMed ID: 11571277
PubMed ID: 11113178
Title: Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling.
PubMed ID: 11113178
PubMed ID: 11711534
Title: 'Srcasm: a novel Src activating and signaling molecule.
PubMed ID: 11711534
PubMed ID: 12925710
Title: EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.
PubMed ID: 12925710
PubMed ID: 14610044
Title: LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation.
PubMed ID: 14610044
DOI: 10.1084/jem.20030232
PubMed ID: 15477350
Title: Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL.
PubMed ID: 15477350
DOI: 10.1084/jem.20041223
PubMed ID: 15477348
Title: Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.
PubMed ID: 15477348
DOI: 10.1084/jem.20041213
PubMed ID: 16249387
Title: LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.
PubMed ID: 16249387
PubMed ID: 16966330
Title: Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.
PubMed ID: 16966330
PubMed ID: 16582911
Title: NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.
PubMed ID: 16582911
DOI: 10.1038/ni1325
PubMed ID: 19597498
Title: Themis, a T cell-specific protein important for late thymocyte development.
PubMed ID: 19597498
DOI: 10.1038/ni.1768
PubMed ID: 19597497
Title: Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.
PubMed ID: 19597497
DOI: 10.1038/ni.1769
PubMed ID: 19805304
Title: Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes.
PubMed ID: 19805304
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 20398064
Title: Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn.
PubMed ID: 20398064
PubMed ID: 20644716
Title: Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production.
PubMed ID: 20644716
PubMed ID: 21543326
Title: Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis.
PubMed ID: 21543326
PubMed ID: 21930792
Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.
PubMed ID: 21930792
DOI: 10.1128/mcb.05817-11
PubMed ID: 22561606
Title: Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.
PubMed ID: 22561606
DOI: 10.1038/ni.2301
PubMed ID: 28290451
Title: Development of SH2 probes and pull-down assays to detect pathogen-induced, site-specific tyrosine phosphorylation of the TLR adaptor SCIMP.
PubMed ID: 28290451
DOI: 10.1038/icb.2017.10
PubMed ID: 28098138
Title: SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages.
PubMed ID: 28098138
DOI: 10.1038/ncomms14133
PubMed ID: 32930093
Title: SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism.
PubMed ID: 32930093
DOI: 10.7554/elife.58941
PubMed ID: 9135122
Title: Solution structure of the Grb2 N-terminal SH3 domain complexed with a ten-residue peptide derived from SOS: direct refinement against NOEs, J-couplings and 1H and 13C chemical shifts.
PubMed ID: 9135122
Sequence Information:
- Length: 217
- Mass: 25238
- Checksum: 97F4A4FE4B248DDF
- Sequence:
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQMPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV
Genular Protein ID: 2822893588
Symbol: Q3U1Q4_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10349636
Title: High-efficiency full-length cDNA cloning.
PubMed ID: 10349636
PubMed ID: 11042159
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
PubMed ID: 11042159
DOI: 10.1101/gr.145100
PubMed ID: 11076861
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
PubMed ID: 11076861
DOI: 10.1101/gr.152600
PubMed ID: 11217851
Title: Functional annotation of a full-length mouse cDNA collection.
PubMed ID: 11217851
DOI: 10.1038/35055500
PubMed ID: 12466851
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
PubMed ID: 12466851
DOI: 10.1038/nature01266
PubMed ID: 16141073
Title: Antisense Transcription in the Mammalian Transcriptome.
PubMed ID: 16141073
Sequence Information:
- Length: 217
- Mass: 25239
- Checksum: 97FA44FE4B248DDF
- Sequence:
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQMPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRDV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.