Genular: Defining Cellular Identity and Function

Details for: Grb7

Gene ID: 14786

Symbol: Grb7

Ensembl ID: ENSMUSG00000019312

Description: growth factor receptor bound protein 7

Associated with

Axon guidance
(R-MMU-422475)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Developmental biology
(R-MMU-1266738)
Downstream signal transduction
(R-MMU-186763)
Grb7 events in erbb2 signaling
(R-MMU-1306955)
Hemostasis
(R-MMU-109582)
Nervous system development
(R-MMU-9675108)
Ret signaling
(R-MMU-8853659)
Rho gtpase cycle
(R-MMU-9012999)
Rnd1 gtpase cycle
(R-MMU-9696273)
Signaling by erbb2
(R-MMU-1227986)
Signaling by pdgf
(R-MMU-186797)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by scf-kit
(R-MMU-1433557)
Tie2 signaling
(R-MMU-210993)
Anchoring junction
(GO:0070161)
Cell projection
(GO:0042995)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Focal adhesion
(GO:0005925)
Identical protein binding
(GO:0042802)
Insulin receptor signaling pathway
(GO:0008286)
Lipid binding
(GO:0008289)
Membrane
(GO:0016020)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of translation
(GO:0017148)
Phosphatidylinositol binding
(GO:0035091)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration
(GO:0030335)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Rna binding
(GO:0003723)
Signal transduction
(GO:0007165)
Stress granule assembly
(GO:0034063)

Other Information

Proteins

Growth factor receptor-bound protein 7

Genular Protein ID: 965468916

Symbol: GRB7_MOUSE

Name: Growth factor receptor-bound protein 7

UniProtKB Accession Codes:

Q03160 Q3TH55

Database IDs:

Citations:

PubMed ID: 1409582

Title: High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.

PubMed ID: 1409582

DOI: 10.1073/pnas.89.19.8894

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8631863

Title: Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7.

PubMed ID: 8631863

DOI: 10.1074/jbc.271.18.10607

PubMed ID: 8940081

Title: Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors.

PubMed ID: 8940081

DOI: 10.1074/jbc.271.48.30942

PubMed ID: 10377264

Title: Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.

PubMed ID: 10377264

DOI: 10.1042/bj3410211

PubMed ID: 10521483

Title: Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.

PubMed ID: 10521483

DOI: 10.1074/jbc.274.43.30896

PubMed ID: 17318180

Title: The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation.

PubMed ID: 17318180

DOI: 10.1038/sj.emboj.7601598

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18273060

Title: Regulation of stress granule dynamics by Grb7 and FAK signalling pathway.

PubMed ID: 18273060

DOI: 10.1038/emboj.2008.19

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 535
Mass: 59959
Checksum: CD8C307864703645
Sequence:

MELDLSPTHL SSSPEDVCPT PATPPETPPP PDNPPPGDVK RSQPLPIPSS RKLREEEFQA 
TSLPSIPNPF PELCSPPSQK PILGGSSGAR GLLPRDSSRL CVVKVYSEDG ACRSVEVAAG 
ATARHVCEML VQRAHALSDE SWGLVESHPY LALERGLEDH EFVVEVQEAW PVGGDSRFIF 
RKNFAKYELF KSPPHTLFPE KMVSSCLDAQ TGISHEDLIQ NFLNAGSFPE IQGFLQLRGS 
GRGSGRKLWK RFFCFLRRSG LYYSTKGTSK DPRHLQYVAD VNESNVYVVT QGRKLYGMPT 
DFGFCVKPNK LRNGHKGLHI FCSEDEQSRT CWLAAFRLFK YGVQLYKNYQ QAQSRHLRLS 
YLGSPPLRSV SDNTLVAMDF SGHAGRVIDN PREALSAAME EAQAWRKKTN HRLSLPTTCS 
GSSLSAAIHR TQPWFHGRIS REESQRLIGQ QGLVDGVFLV RESQRNPQGF VLSLCHLQKV 
KHYLILPSED EGCLYFSMDE GQTRFTDLLQ LVEFHQLNRG ILPCLLRHCC ARVAL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Grb7

Associated with

Other Information

High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. PubMed ID: 1409582

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7. PubMed ID: 8631863

Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors. PubMed ID: 8940081

Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor. PubMed ID: 10377264

Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. PubMed ID: 10521483

The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation. PubMed ID: 17318180

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Regulation of stress granule dynamics by Grb7 and FAK signalling pathway. PubMed ID: 18273060

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079