Details for: CSTF3

Gene ID: 1479

Symbol: CSTF3

Ensembl ID: ENSG00000176102

Description: cleavage stimulation factor subunit 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.74
    Marker Score: 3039
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.72
    Marker Score: 105924
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.71
    Marker Score: 16097
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.68
    Marker Score: 15951
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.67
    Marker Score: 33297
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.66
    Marker Score: 63028
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.65
    Marker Score: 14132
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.63
    Marker Score: 6292
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.59
    Marker Score: 12150
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.56
    Marker Score: 16099
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.53
    Marker Score: 56388
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.52
    Marker Score: 22710
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.51
    Marker Score: 6252
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.51
    Marker Score: 787
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.46
    Marker Score: 853
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.45
    Marker Score: 2239
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.41
    Marker Score: 5748
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.38
    Marker Score: 2807
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.37
    Marker Score: 29258
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.35
    Marker Score: 1518
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.32
    Marker Score: 1497
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.31
    Marker Score: 1507
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.29
    Marker Score: 2684
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.28
    Marker Score: 5040
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.25
    Marker Score: 571
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.25
    Marker Score: 5762
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.25
    Marker Score: 1507
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.23
    Marker Score: 5138
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.18
    Marker Score: 2004.5
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.17
    Marker Score: 1568
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.16
    Marker Score: 676
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.15
    Marker Score: 645
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.14
    Marker Score: 1264
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.14
    Marker Score: 561
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.13
    Marker Score: 1198
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.07
    Marker Score: 2523
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.07
    Marker Score: 36168
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.07
    Marker Score: 9285
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.06
    Marker Score: 355
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.05
    Marker Score: 935
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.05
    Marker Score: 1509
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.05
    Marker Score: 699.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.04
    Marker Score: 4274
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.04
    Marker Score: 6714
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.03
    Marker Score: 1070
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.02
    Marker Score: 2922
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.02
    Marker Score: 2236
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.01
    Marker Score: 4375
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.01
    Marker Score: 1246
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71678
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47903
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.99
    Marker Score: 1072
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.99
    Marker Score: 1882
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.99
    Marker Score: 289
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30388
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.98
    Marker Score: 310
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.98
    Marker Score: 1219
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.97
    Marker Score: 1434
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.97
    Marker Score: 3765
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.97
    Marker Score: 674
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.97
    Marker Score: 910
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.96
    Marker Score: 2309
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.96
    Marker Score: 402
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.96
    Marker Score: 650
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2395
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.94
    Marker Score: 456
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.94
    Marker Score: 1211
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.92
    Marker Score: 1768.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.92
    Marker Score: 982
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.91
    Marker Score: 985.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5190
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.91
    Marker Score: 727
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.91
    Marker Score: 953
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2695
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.9
    Marker Score: 7737
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.89
    Marker Score: 1079
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.89
    Marker Score: 443
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.89
    Marker Score: 4770
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1430
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.88
    Marker Score: 829
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.87
    Marker Score: 3228
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.86
    Marker Score: 516
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.86
    Marker Score: 1573
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.86
    Marker Score: 430
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.86
    Marker Score: 29871
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.85
    Marker Score: 319
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.85
    Marker Score: 200
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.85
    Marker Score: 494
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.85
    Marker Score: 731
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.85
    Marker Score: 18906
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13223
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.84
    Marker Score: 1398
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.84
    Marker Score: 1988
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.83
    Marker Score: 657
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.83
    Marker Score: 465
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.83
    Marker Score: 319

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Other Information

**Key characteristics:** * The CSTF3 gene is located on chromosome 17q21.1. * It is a large gene, encoding a protein of 1,441 amino acids. * The protein is a member of the CSTF family of proteins, which are involved in RNA processing and cleavage. * CSTF3 is expressed in high levels in the developing brain. **Pathways and functions:** * CSTF3 is a key regulator of gene expression in the developing brain. * It is involved in the co-transcriptional mrna 3'-end processing pathway, which is responsible for generating the mature mRNA transcripts that are subsequently translated into proteins. * CSTF3 also plays a role in the cleavage and polyadenylation pathway, which is responsible for adding a polyadenylation signal to the 3' ends of mRNA transcripts. * In addition, CSTF3 is involved in the regulation of mRNA binding, mRNA cleavage, and protein binding. **Clinical significance:** * Mutations in the CSTF3 gene have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. * These disorders are characterized by a variety of developmental abnormalities, including intellectual disability, autism, and epilepsy. * CSTF3 is a promising target for the treatment of these disorders.

Genular Protein ID: 2243120076

Symbol: CSTF3_HUMAN

Name: Cleavage stimulation factor subunit 3

UniProtKB Accession Codes:

Q12996 A8K471 D3DR04 E9PB40 Q32P22 Q96FQ8 Q96QD6 Q96QK4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 1 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7984242

Title: A subunit of the polyadenylation factor CstF is the human homologue of the Drosophila suppressor of forked protein.

PubMed ID: 7984242

DOI: 10.1038/372471a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10669729

Title: Complex protein interactions within the human polyadenylation machinery identify a novel component.

PubMed ID: 10669729

DOI: 10.1128/mcb.20.5.1515-1525.2000

PubMed ID: 14749727

Title: Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.

PubMed ID: 14749727

DOI: 10.1038/sj.emboj.7600070

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 717
  • Mass: 82922
  • Checksum: 9ADE7AC86FBB3E93
  • Sequence:
    • MSGDGATEQA AEYVPEKVKK AEKKLEENPY DLDAWSILIR EAQNQPIDKA RKTYERLVAQ 
FPSSGRFWKL YIEAEIKAKN YDKVEKLFQR CLMKVLHIDL WKCYLSYVRE TKGKLPSYKE 
KMAQAYDFAL DKIGMEIMSY QIWVDYINFL KGVEAVGSYA ENQRITAVRR VYQRGCVNPM 
INIEQLWRDY NKYEEGINIH LAKKMIEDRS RDYMNARRVA KEYETVMKGL DRNAPSVPPQ 
NTPQEAQQVD MWKKYIQWEK SNPLRTEDQT LITKRVMFAY EQCLLVLGHH PDIWYEAAQY 
LEQSSKLLAE KGDMNNAKLF SDEAANIYER AISTLLKKNM LLYFAYADYE ESRMKYEKVH 
SIYNRLLAIE DIDPTLVYIQ YMKFARRAEG IKSGRMIFKK AREDTRTRHH VYVTAALMEY 
YCSKDKSVAF KIFELGLKKY GDIPEYVLAY IDYLSHLNED NNTRVLFERV LTSGSLPPEK 
SGEIWARFLA FESNIGDLAS ILKVEKRRFT AFKEEYEGKE TALLVDRYKF MDLYPCSASE 
LKALGYKDVS RAKLAAIIPD PVVAPSIVPV LKDEVDRKPE YPKPDTQQMI PFQPRHLAPP 
GLHPVPGGVF PVPPAAVVLM KLLPPPICFQ GPFVQVDELM EIFRRCKIPN TVEEAVRIIT 
GGAPELAVEG NGPVESNAVL TKAVKRPNED SDEDEEKGAV VPPVHDIYRA RQQKRIR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.