Details for: CSTF3

Gene ID: 1479

Symbol: CSTF3

Ensembl ID: ENSG00000176102

Description: cleavage stimulation factor subunit 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 245.6520
    Cell Significance Index: -38.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 133.3762
    Cell Significance Index: -33.8300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 98.7504
    Cell Significance Index: -40.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.4047
    Cell Significance Index: -42.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 84.7493
    Cell Significance Index: -34.4300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 76.4213
    Cell Significance Index: -39.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.1144
    Cell Significance Index: -34.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.9777
    Cell Significance Index: -40.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.6401
    Cell Significance Index: -36.5400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.0078
    Cell Significance Index: -33.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.6182
    Cell Significance Index: -41.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.3335
    Cell Significance Index: -16.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.0353
    Cell Significance Index: 114.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0007
    Cell Significance Index: 401.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4314
    Cell Significance Index: 284.0600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.4162
    Cell Significance Index: 17.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4012
    Cell Significance Index: 39.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1672
    Cell Significance Index: 31.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1585
    Cell Significance Index: 415.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0337
    Cell Significance Index: 63.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9602
    Cell Significance Index: 36.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8925
    Cell Significance Index: 60.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8854
    Cell Significance Index: 39.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.8612
    Cell Significance Index: 20.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6961
    Cell Significance Index: 481.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6946
    Cell Significance Index: 36.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5844
    Cell Significance Index: 40.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.5648
    Cell Significance Index: 14.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5629
    Cell Significance Index: 91.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5393
    Cell Significance Index: 14.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5182
    Cell Significance Index: 14.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4944
    Cell Significance Index: 25.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4727
    Cell Significance Index: 258.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4561
    Cell Significance Index: 82.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4443
    Cell Significance Index: 15.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4263
    Cell Significance Index: 52.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3763
    Cell Significance Index: 28.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2930
    Cell Significance Index: 28.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2722
    Cell Significance Index: 12.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2716
    Cell Significance Index: 35.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2670
    Cell Significance Index: 7.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2668
    Cell Significance Index: 50.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2443
    Cell Significance Index: 108.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2434
    Cell Significance Index: 33.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2046
    Cell Significance Index: 9.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1936
    Cell Significance Index: 12.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1839
    Cell Significance Index: 166.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1527
    Cell Significance Index: 1.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1033
    Cell Significance Index: 3.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0935
    Cell Significance Index: 176.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0780
    Cell Significance Index: 5.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0760
    Cell Significance Index: 3.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0743
    Cell Significance Index: 114.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0654
    Cell Significance Index: 1.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0612
    Cell Significance Index: 112.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0508
    Cell Significance Index: 32.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0508
    Cell Significance Index: 69.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0271
    Cell Significance Index: 1.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0209
    Cell Significance Index: 9.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0179
    Cell Significance Index: 3.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0108
    Cell Significance Index: 1.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0081
    Cell Significance Index: -5.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0231
    Cell Significance Index: -3.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0256
    Cell Significance Index: -18.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0262
    Cell Significance Index: -19.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0378
    Cell Significance Index: -23.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0441
    Cell Significance Index: -5.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0461
    Cell Significance Index: -1.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0471
    Cell Significance Index: -26.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1066
    Cell Significance Index: -22.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1120
    Cell Significance Index: -1.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1209
    Cell Significance Index: -34.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1253
    Cell Significance Index: -3.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1269
    Cell Significance Index: -12.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1588
    Cell Significance Index: -18.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1652
    Cell Significance Index: -10.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2373
    Cell Significance Index: -5.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2425
    Cell Significance Index: -27.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2446
    Cell Significance Index: -28.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2517
    Cell Significance Index: -4.9100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2533
    Cell Significance Index: -5.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2573
    Cell Significance Index: -3.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3272
    Cell Significance Index: -34.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3465
    Cell Significance Index: -7.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3563
    Cell Significance Index: -9.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4335
    Cell Significance Index: -34.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5072
    Cell Significance Index: -13.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5226
    Cell Significance Index: -17.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5234
    Cell Significance Index: -16.6700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5267
    Cell Significance Index: -10.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5308
    Cell Significance Index: -27.6500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5970
    Cell Significance Index: -12.6700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6575
    Cell Significance Index: -13.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6674
    Cell Significance Index: -40.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6823
    Cell Significance Index: -18.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7018
    Cell Significance Index: -7.2700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7177
    Cell Significance Index: -12.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7191
    Cell Significance Index: -21.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7379
    Cell Significance Index: -23.6400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7547
    Cell Significance Index: -11.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CSTF3 is a small, non-coding RNA-binding protein that forms a complex with other proteins to regulate pre-mRNA processing. It is highly expressed in germ cells, neurons, and certain types of interneurons, indicating its crucial role in these cell types. CSTF3 is involved in the cleavage and polyadenylation of pre-mRNAs, which is essential for the production of mature mRNA molecules. The gene is also implicated in the regulation of gene expression, particularly in response to environmental cues, such as stress and inflammation. **Pathways and Functions:** CSTF3 is involved in several key pathways, including: 1. **Co-transcriptional mRNA 3'-end processing**: CSTF3 plays a critical role in the cleavage and polyadenylation of pre-mRNAs, which is a crucial step in the maturation of mRNA molecules. 2. **Gene expression (transcription)**: CSTF3 regulates gene expression by controlling the levels of mature mRNA molecules, which in turn affects the production of proteins. 3. **Metabolism of RNA**: CSTF3 is involved in the degradation of pre-mRNAs and the regulation of RNA metabolism. 4. **RNA binding**: CSTF3 interacts with other RNA-binding proteins to regulate pre-mRNA processing and translation. **Clinical Significance:** Dysregulation of CSTF3 has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: CSTF3 has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Neurodevelopmental disorders**: CSTF3 is also involved in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Cancer**: CSTF3 has been implicated in certain types of cancer, including glioblastoma and ovarian cancer. In conclusion, CSTF3 is a critical gene involved in RNA processing, transcription, and metabolism. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of this gene in human health and disease. Further research is needed to fully understand the mechanisms by which CSTF3 regulates gene expression and to identify potential therapeutic targets for the treatment of CSTF3-related disorders.

Genular Protein ID: 2243120076

Symbol: CSTF3_HUMAN

Name: Cleavage stimulation factor subunit 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7984242

Title: A subunit of the polyadenylation factor CstF is the human homologue of the Drosophila suppressor of forked protein.

PubMed ID: 7984242

DOI: 10.1038/372471a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10669729

Title: Complex protein interactions within the human polyadenylation machinery identify a novel component.

PubMed ID: 10669729

DOI: 10.1128/mcb.20.5.1515-1525.2000

PubMed ID: 14749727

Title: Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.

PubMed ID: 14749727

DOI: 10.1038/sj.emboj.7600070

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 717
  • Mass: 82922
  • Checksum: 9ADE7AC86FBB3E93
  • Sequence:
  • MSGDGATEQA AEYVPEKVKK AEKKLEENPY DLDAWSILIR EAQNQPIDKA RKTYERLVAQ 
    FPSSGRFWKL YIEAEIKAKN YDKVEKLFQR CLMKVLHIDL WKCYLSYVRE TKGKLPSYKE 
    KMAQAYDFAL DKIGMEIMSY QIWVDYINFL KGVEAVGSYA ENQRITAVRR VYQRGCVNPM 
    INIEQLWRDY NKYEEGINIH LAKKMIEDRS RDYMNARRVA KEYETVMKGL DRNAPSVPPQ 
    NTPQEAQQVD MWKKYIQWEK SNPLRTEDQT LITKRVMFAY EQCLLVLGHH PDIWYEAAQY 
    LEQSSKLLAE KGDMNNAKLF SDEAANIYER AISTLLKKNM LLYFAYADYE ESRMKYEKVH 
    SIYNRLLAIE DIDPTLVYIQ YMKFARRAEG IKSGRMIFKK AREDTRTRHH VYVTAALMEY 
    YCSKDKSVAF KIFELGLKKY GDIPEYVLAY IDYLSHLNED NNTRVLFERV LTSGSLPPEK 
    SGEIWARFLA FESNIGDLAS ILKVEKRRFT AFKEEYEGKE TALLVDRYKF MDLYPCSASE 
    LKALGYKDVS RAKLAAIIPD PVVAPSIVPV LKDEVDRKPE YPKPDTQQMI PFQPRHLAPP 
    GLHPVPGGVF PVPPAAVVLM KLLPPPICFQ GPFVQVDELM EIFRRCKIPN TVEEAVRIIT 
    GGAPELAVEG NGPVESNAVL TKAVKRPNED SDEDEEKGAV VPPVHDIYRA RQQKRIR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.