Genular: Defining Cellular Identity and Function

Details for: Lpcat3

Gene ID: 14792

Symbol: Lpcat3

Ensembl ID: ENSMUSG00000004270

Description: lysophosphatidylcholine acyltransferase 3

Associated with

Acyl chain remodelling of pc
(R-MMU-1482788)
Acyl chain remodelling of pe
(R-MMU-1482839)
Acyl chain remodelling of ps
(R-MMU-1482801)
Glycerophospholipid biosynthesis
(R-MMU-1483206)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Phospholipid metabolism
(R-MMU-1483257)
1-acylglycerophosphocholine o-acyltransferase activity
(GO:0047184)
1-acylglycerophosphoethanolamine o-acyltransferase activity
(GO:0106262)
1-acylglycerophosphoserine o-acyltransferase activity
(GO:0106263)
Acyltransferase activity
(GO:0016746)
Chylomicron assembly
(GO:0034378)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Endoplasmic reticulum membrane organization
(GO:0090158)
Intestinal stem cell homeostasis
(GO:0036335)
Lipid metabolic process
(GO:0006629)
Lipid modification
(GO:0030258)
Lysophospholipid acyltransferase activity
(GO:0071617)
Membrane
(GO:0016020)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of response to endoplasmic reticulum stress
(GO:1903573)
Phosphatidylcholine acyl-chain remodeling
(GO:0036151)
Phosphatidylcholine biosynthetic process
(GO:0006656)
Phosphatidylethanolamine acyl-chain remodeling
(GO:0036152)
Phosphatidylserine acyl-chain remodeling
(GO:0036150)
Phospholipid biosynthetic process
(GO:0008654)
Positive regulation of intestinal cholesterol absorption
(GO:0045797)
Positive regulation of triglyceride transport
(GO:1905885)
Regulation of cholesterol biosynthetic process
(GO:0045540)
Regulation of plasma lipoprotein particle levels
(GO:0097006)
Transferase activity
(GO:0016740)
Very-low-density lipoprotein particle assembly
(GO:0034379)

Other Information

Proteins

Lysophospholipid acyltransferase 5

Genular Protein ID: 1410421988

Symbol: MBOA5_MOUSE

Name: Lysophospholipid acyltransferase 5

UniProtKB Accession Codes:

Q91V01 B1B362 O35131 Q8BNH6

Database IDs:

Citations:

PubMed ID: 18287005

Title: Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity.

PubMed ID: 18287005

DOI: 10.1073/pnas.0712245105

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9445485

Title: Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6.

PubMed ID: 9445485

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24206663

Title: LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition.

PubMed ID: 24206663

DOI: 10.1016/j.cmet.2013.10.002

PubMed ID: 25898003

Title: Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport.

PubMed ID: 25898003

DOI: 10.7554/elife.06328

PubMed ID: 25806685

Title: Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion.

PubMed ID: 25806685

DOI: 10.7554/elife.06557

PubMed ID: 26833026

Title: Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet.

PubMed ID: 26833026

DOI: 10.1016/j.cmet.2016.01.001

PubMed ID: 28846071

Title: ER phospholipid composition modulates lipogenesis during feeding and in obesity.

PubMed ID: 28846071

DOI: 10.1172/jci93616

PubMed ID: 29395055

Title: Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis.

PubMed ID: 29395055

DOI: 10.1016/j.stem.2017.12.017

Sequence Information:

Length: 487
Mass: 56147
Checksum: EBC51DB3734B17C7
Sequence:

MASTADGDMG ETLEQMRGLW PGVEDLSLNK LATSLGASEQ ALRLIFSIFL GYPLALFYRH 
YLFYKDSYLI HLFHTFTGLS IAYFNFGHQF YHSLLCVVLQ FLILRLMGRT VTAVITTLCF 
QMAYLLAGYY YTATGDYDIK WTMPHCVLTL KLIGLCIDYY DGGKDGNSLT SEQQKYAIRG 
VPSLLEVAGF SYFYGAFLVG PQFSMNHYMK LVRGQLTDIP GKMPNSTIPA LKRLSLGLVY 
LVGYTLLSPH ITDDYLLTED YDNRPFWFRC MYMLIWGKFV LYKYVTCWLV TEGVCILSGL 
GFNGFDENGT VRWDACANMK VWLFETTPRF NGTIASFNIN TNAWVARYIF KRLKFLGNKE 
LSQGLSLLFL ALWHGLHSGY LICFQMEFLI VIVEKQVSSL IRDSPALSSL ASITALQPFY 
YLVQQTIHWL FMGYSMTAFC LFTWDKWLKV YRSIYFLGHV FFLSLLFILP YIHKAMVPRK 
EKLKKRE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lpcat3

Associated with

Other Information

Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. PubMed ID: 18287005

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. PubMed ID: 9445485

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. PubMed ID: 24206663

Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport. PubMed ID: 25898003

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. PubMed ID: 25806685

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet. PubMed ID: 26833026

ER phospholipid composition modulates lipogenesis during feeding and in obesity. PubMed ID: 28846071

Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis. PubMed ID: 29395055