Genular: Defining Cellular Identity and Function

Details for: Gria1

Gene ID: 14799

Symbol: Gria1

Ensembl ID: ENSMUSG00000020524

Description: glutamate receptor, ionotropic, AMPA1 (alpha 1)

Associated with

Activation of ampa receptors
(R-MMU-399710)
Activation of nmda receptors and postsynaptic events
(R-MMU-442755)
Asparagine n-linked glycosylation
(R-MMU-446203)
Cargo concentration in the er
(R-MMU-5694530)
Copii-mediated vesicle transport
(R-MMU-204005)
Er to golgi anterograde transport
(R-MMU-199977)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-MMU-399721)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Post-translational protein modification
(R-MMU-597592)
Protein-protein interactions at synapses
(R-MMU-6794362)
Synaptic adhesion-like molecules
(R-MMU-8849932)
Trafficking of ampa receptors
(R-MMU-399719)
Trafficking of glur2-containing ampa receptors
(R-MMU-416993)
Transmission across chemical synapses
(R-MMU-112315)
Transport to the golgi and subsequent modification
(R-MMU-948021)
Unblocking of nmda receptors, glutamate binding and activation
(R-MMU-438066)
Vesicle-mediated transport
(R-MMU-5653656)
Adenylate cyclase binding
(GO:0008179)
Ampa glutamate receptor activity
(GO:0004971)
Ampa glutamate receptor complex
(GO:0032281)
Amyloid-beta binding
(GO:0001540)
Asymmetric synapse
(GO:0032279)
Beta-2 adrenergic receptor binding
(GO:0031698)
Cell-cell junction
(GO:0005911)
Cell surface
(GO:0009986)
Cellular response to ammonium ion
(GO:0071242)
Cellular response to brain-derived neurotrophic factor stimulus
(GO:1990416)
Chemical synaptic transmission
(GO:0007268)
Dendrite
(GO:0030425)
Dendrite membrane
(GO:0032590)
Dendritic spine membrane
(GO:0032591)
Early endosome
(GO:0005769)
Early endosome membrane
(GO:0031901)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Endosome
(GO:0005768)
G-protein alpha-subunit binding
(GO:0001965)
G-protein beta-subunit binding
(GO:0031681)
Glutamate-gated receptor activity
(GO:0004970)
Glutamate receptor binding
(GO:0035254)
Identical protein binding
(GO:0042802)
Immunoglobulin binding
(GO:0019865)
Ionotropic glutamate receptor binding
(GO:0035255)
Ionotropic glutamate receptor complex
(GO:0008328)
Ligand-gated monoatomic ion channel activity
(GO:0015276)
Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
(GO:0099507)
Long-term memory
(GO:0007616)
Long-term synaptic depression
(GO:0060292)
Membrane
(GO:0016020)
Modulation of chemical synaptic transmission
(GO:0050804)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Myosin v binding
(GO:0031489)
Neuromuscular junction
(GO:0031594)
Neuronal action potential
(GO:0019228)
Neuronal cell body membrane
(GO:0032809)
Neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
(GO:0099583)
Pdz domain binding
(GO:0030165)
Plasma membrane
(GO:0005886)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of membrane potential
(GO:0045838)
Positive regulation of synaptic transmission
(GO:0050806)
Postsynaptic density
(GO:0014069)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase a binding
(GO:0051018)
Protein kinase binding
(GO:0019901)
Receptor internalization
(GO:0031623)
Regulation of postsynaptic membrane potential
(GO:0060078)
Regulation of receptor recycling
(GO:0001919)
Regulation of synaptic plasticity
(GO:0048167)
Response to toxic substance
(GO:0009636)
Scaffold protein binding
(GO:0097110)
Signaling receptor activity
(GO:0038023)
Small gtpase binding
(GO:0031267)
Synapse assembly
(GO:0007416)
Synaptic transmission, glutamatergic
(GO:0035249)
Synaptic vesicle
(GO:0008021)
Synaptic vesicle membrane
(GO:0030672)
Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
(GO:1904315)

Other Information

Proteins

Genular Protein ID: 649438577

Symbol: GRIA1_MOUSE

Name: Glutamate receptor 1

UniProtKB Accession Codes:

P23818

Database IDs:

Citations:

PubMed ID: 1699805

Title: Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate.

PubMed ID: 1699805

DOI: 10.1016/0014-5793(90)80452-o

PubMed ID: 12839988

Title: Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking.

PubMed ID: 12839988

DOI: 10.1093/emboj/cdg334

PubMed ID: 16129400

Title: Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites.

PubMed ID: 16129400

DOI: 10.1016/j.neuron.2005.06.035

PubMed ID: 16407208

Title: Age-dependent participation of Ras-GRF proteins in coupling calcium-permeable AMPA glutamate receptors to Ras/Erk signaling in cortical neurons.

PubMed ID: 16407208

DOI: 10.1074/jbc.m512060200

PubMed ID: 16606358

Title: Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor.

PubMed ID: 16606358

DOI: 10.1111/j.1471-4159.2006.03831.x

PubMed ID: 18341993

Title: Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4.

PubMed ID: 18341993

DOI: 10.1016/j.neuron.2008.02.012

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20152115

Title: SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development.

PubMed ID: 20152115

DOI: 10.1016/j.neuron.2009.12.021

PubMed ID: 21172611

Title: Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.

PubMed ID: 21172611

DOI: 10.1016/j.neuron.2010.11.026

PubMed ID: 23676497

Title: Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.

PubMed ID: 23676497

DOI: 10.1172/jci65401

PubMed ID: 23524343

Title: Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.

PubMed ID: 23524343

DOI: 10.1038/nm.3117

PubMed ID: 28334377

Title: LRIT3 Differentially Affects Connectivity and Synaptic Transmission of Cones to ON- and OFF-Bipolar Cells.

PubMed ID: 28334377

DOI: 10.1167/iovs.16-20745

PubMed ID: 28642476

Title: Prevention of long-term memory loss after retrieval by an endogenous CaMKII inhibitor.

PubMed ID: 28642476

DOI: 10.1038/s41598-017-04355-8

PubMed ID: 31651360

Title: Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels.

PubMed ID: 31651360

DOI: 10.1186/s40478-019-0812-5

Sequence Information:

Length: 907
Mass: 101569
Checksum: F0FF7031DADD7CEB
Sequence:

MPYIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT EPPKLLPQID 
IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF CGALHVCFIT PSFPVDTSNQ 
FVLQLRPELQ EALISIIDHY KWQTFVYIYD ADRGLSVLQR VLDTAAEKNW QVTAVNILTT 
TEEGYRMLFQ DLEKKKERLV VVDCESERLN AILGQIVKLE KNGIGYHYIL ANLGFMDIDL 
NKFKESGANV TGFQLVNYTD TIPARIMQQW RTSDARDHTR VDWKRPKYTS ALTYDGVKVM 
AEAFQSLRRQ RIDISRRGNA GDCLANPAVP WGQGIDIQRA LQQVRFEGLT GNVQFNEKGR 
RTNYTLHVIE MKHDGIRKIG YWNEDDKFVP AATDAQAGGD NSSVQNRTYI VTTILEDPYV 
MLKKNANQFE GNDRYEGYCV ELAAEIAKHV GYSYRLEIVS DGKYGARDPD TKAWNGMVGE 
LVYGRADVAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW 
MCIVFAYIGV SVVLFLVSRF SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ 
QGCDISPRSL SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA EDLAKQTEIA 
YGTLEAGSTK EFFRRSKIAV FEKMWTYMKS AEPSVFVRTT EEGMIRVRKS KGKYAYLLES 
TMNEYIEQRK PCDTMKVGGN LDSKGYGIAT PKGSALRGPV NLAVLKLSEQ GVLDKLKSKW 
WYDKGECGSK DSGSKDKTSA LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK 
GFCLIPQQSI NEAIRTSTLP RNSGAGASGG SGSGENGRVV SQDFPKSMQS IPCMSHSSGM 
PLGATGL

Genular Protein ID: 1645755883

Symbol: Q7TNB5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q7TNB5

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 907
Mass: 101593
Checksum: 8210835C034EEEB8
Sequence:

MPYIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT EPPKLLPQID 
IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF CGALHVCFIT PSFPVDTSNQ 
FVLQLRPELQ EALISIIDHY KWQTFVYIYD ADRGLSVLQR VLDTAAEKNW QVTAVNILTT 
TEEGYRMLFQ DLEKKKERLV VVDCESERLN AILGQIVKLE KNGIGYHYIL ANLGFMDIDL 
NKFKESGANV TGFQLVNYTD TIPARIMQQW RTSDARDHTR VDWKRPKYTS ALTYDGVKVM 
AEAFQSLRRQ RIDISRRGNA GDCLANPAVP WGQGIDIQRA LQQVRFEGLT GNVQFNEKGR 
RTNYTLHVIE MKHDGIRKIG YWNEDDKFVP AATDAQAGGD NSSVQNRTYI VTTILEDPYV 
MLKKNANQFE GNDRYEGYCV ELAAEIAKHV GYSYRLEIVS DGKYGARDPD TKAWNGMVGE 
LVYGRADVAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW 
MCIVFAYIGV SVVLFLVSRF SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ 
QGCDISPRSL SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA EDLAKQTEIA 
YGTLEAGSTK EFFRRSKIAV FEKMWTYMKS AEPSVFVRTT EEGMIRVRKS KGKYAYLLES 
TMNEYIEQRK PCDTMKVGGN LDSKGYGIAT PKGSALRNPV NLAVLKLNEQ GLLDKLKNKW 
WYDKGECGSG GGDSKDKTSA LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK 
GFCLIPQQSI NEAIRTSTLP RNSGAGASGG SGSGENGRVV SQDFPKSMQS IPCMSHSSGM 
PLGATGL

Genular Protein ID: 120514213

Symbol: F6YNQ1_MOUSE

Name: N/A

UniProtKB Accession Codes:

F6YNQ1

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 838
Mass: 93968
Checksum: DF63B4852EA6879A
Sequence:

MTYRFCSQFS KGVYAIFGFY ERRTVNMLTS FCGALHVCFI TPSFPVDTSN QFVLQLRPEL 
QEALISIIDH YKWQTFVYIY DADRGLSVLQ RVLDTAAEKN WQVTAVNILT TTEEGYRMLF 
QDLEKKKERL VVVDCESERL NAILGQIVKL EKNGIGYHYI LANLGFMDID LNKFKESGAN 
VTGFQLVNYT DTIPARIMQQ WRTSDARDHT RVDWKRPKYT SALTYDGVKV MAEAFQSLRR 
QRIDISRRGN AGDCLANPAV PWGQGIDIQR ALQQVRFEGL TGNVQFNEKG RRTNYTLHVI 
EMKHDGIRKI GYWNEDDKFV PAATDAQAGG DNSSVQNRTY IVTTILEDPY VMLKKNANQF 
EGNDRYEGYC VELAAEIAKH VGYSYRLEIV SDGKYGARDP DTKAWNGMVG ELVYGRADVA 
VAPLTITLVR EEVIDFSKPF MSLGISIMIK KPQKSKPGVF SFLDPLAYEI WMCIVFAYIG 
VSVVLFLVSR FSPYEWHSEE FEEGRDQTTS DQSNEFGIFN SLWFSLGAFM QQGCDISPRS 
LSGRIVGGVW WFFTLIIISS YTANLAAFLT VERMVSPIES AEDLAKQTEI AYGTLEAGST 
KEFFRRSKIA VFEKMWTYMK SAEPSVFVRT TEEGMIRVRK SKGKYAYLLE STMNEYIEQR 
KPCDTMKVGG NLDSKGYGIA TPKGSALRGP VNLAVLKLSE QGVLDKLKSK WWYDKGECGS 
KDSGSKDKTS ALSLSNVAGV FYILIGGLGL AMLVALIEFC YKSRSESKRM KGFCLIPQQS 
INEAIRTSTL PRNSGAGASG GSGSGENGRV VSQDFPKSMQ SIPCMSHSSG MPLGATGL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gria1

Associated with

Other Information

Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate. PubMed ID: 1699805

Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking. PubMed ID: 12839988

Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites. PubMed ID: 16129400

Age-dependent participation of Ras-GRF proteins in coupling calcium-permeable AMPA glutamate receptors to Ras/Erk signaling in cortical neurons. PubMed ID: 16407208

Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. PubMed ID: 16606358

Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4. PubMed ID: 18341993

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development. PubMed ID: 20152115

Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. PubMed ID: 21172611

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. PubMed ID: 23676497

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. PubMed ID: 23524343

LRIT3 Differentially Affects Connectivity and Synaptic Transmission of Cones to ON- and OFF-Bipolar Cells. PubMed ID: 28334377

Prevention of long-term memory loss after retrieval by an endogenous CaMKII inhibitor. PubMed ID: 28642476

Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels. PubMed ID: 31651360

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 1699805

PubMed ID: 12839988

PubMed ID: 16129400

PubMed ID: 16407208

PubMed ID: 16606358

PubMed ID: 18341993

PubMed ID: 21183079

PubMed ID: 20152115

PubMed ID: 21172611

PubMed ID: 23676497

PubMed ID: 23524343

PubMed ID: 28334377

PubMed ID: 28642476

PubMed ID: 31651360

PubMed ID: 15489334

PubMed ID: 19468303

PubMed ID: 21183079

PubMed ID: 19468303

PubMed ID: 21183079