Details for: ADRA1A

Gene ID: 148

Symbol: ADRA1A

Ensembl ID: ENSG00000120907

Description: adrenoceptor alpha 1A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 5.67
    Marker Score: 75401
  • Cell Name: interneuron (CL0000099)
    Fold Change: 4.4
    Marker Score: 2008
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 4.38
    Marker Score: 2125
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.85
    Marker Score: 8118
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.64
    Marker Score: 20256
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.49
    Marker Score: 1394
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.44
    Marker Score: 2111
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.38
    Marker Score: 869
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.35
    Marker Score: 35176
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.29
    Marker Score: 51110
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.25
    Marker Score: 48047
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.96
    Marker Score: 500
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.96
    Marker Score: 74552
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.77
    Marker Score: 983
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.76
    Marker Score: 9488
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.74
    Marker Score: 3297
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.65
    Marker Score: 10622
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.65
    Marker Score: 361
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.63
    Marker Score: 2011
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.61
    Marker Score: 2488
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.6
    Marker Score: 6712
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.51
    Marker Score: 6529
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167086
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.37
    Marker Score: 50423
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.31
    Marker Score: 692
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.31
    Marker Score: 20427
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.26
    Marker Score: 332
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.25
    Marker Score: 4838
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.18
    Marker Score: 2396
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.16
    Marker Score: 760
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.13
    Marker Score: 5248
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.1
    Marker Score: 752
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.08
    Marker Score: 1203
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.05
    Marker Score: 332
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.03
    Marker Score: 1099
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.02
    Marker Score: 2912
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48028
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5315
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.8
    Marker Score: 478
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.79
    Marker Score: 3269
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.78
    Marker Score: 3186
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.73
    Marker Score: 14559
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1170
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.73
    Marker Score: 692
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.71
    Marker Score: 395
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.71
    Marker Score: 266
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.71
    Marker Score: 4713
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.69
    Marker Score: 2869
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.68
    Marker Score: 5872
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.68
    Marker Score: 385
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.67
    Marker Score: 1383
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 434
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.61
    Marker Score: 289
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 483
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.57
    Marker Score: 284
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.57
    Marker Score: 1339
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.53
    Marker Score: 221
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.53
    Marker Score: 305
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.5
    Marker Score: 205
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.49
    Marker Score: 219
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.49
    Marker Score: 127
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.49
    Marker Score: 183
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.45
    Marker Score: 527
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.44
    Marker Score: 1253
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.38
    Marker Score: 152
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.37
    Marker Score: 613
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.36
    Marker Score: 347
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.35
    Marker Score: 641
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.34
    Marker Score: 154
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.34
    Marker Score: 197
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.34
    Marker Score: 200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.32
    Marker Score: 3333
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.32
    Marker Score: 99
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.32
    Marker Score: 108
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.3
    Marker Score: 83
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.29
    Marker Score: 92
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.28
    Marker Score: 2672
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.28
    Marker Score: 312
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.27
    Marker Score: 80
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.27
    Marker Score: 181
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.27
    Marker Score: 955
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.26
    Marker Score: 77
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.26
    Marker Score: 141
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.26
    Marker Score: 259
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.25
    Marker Score: 245
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.25
    Marker Score: 77
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.24
    Marker Score: 122
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.24
    Marker Score: 464
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.24
    Marker Score: 216
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.23
    Marker Score: 3773
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.23
    Marker Score: 280

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * The ADRA1A gene is located on chromosome 17q21.1. * It is a single-exon gene that is approximately 2.5 kb long. * The protein encoded by ADRA1A is a transmembrane protein that is expressed in the plasma membrane of cardiac muscle cells, interneurons, epicardial adipocytes, cerebral cortex neurons, and other cell types. * The ADRA1A protein is a member of the alpha-1A adrenoceptor family of receptors. * It is a ligand-gated ion channel that is expressed in high density in cardiac muscle cells, where it is thought to play a role in regulating heart rate. **Pathways and functions:** * The ADRA1A gene is involved in the regulation of heart rate by binding to epinephrine and norepinephrine receptors and triggering the activation of the G alpha (12/13) signalling cascade. * The G alpha (12/13) cascade is a second messenger pathway that is involved in regulating a variety of physiological processes, including heart rate, blood pressure, and metabolism. * In the heart, the G alpha (12/13) cascade is involved in the regulation of cardiac contractility and relaxation. * The ADRA1A gene is also involved in the regulation of blood pressure by binding to epinephrine and norepinephrine receptors and triggering the activation of the positive regulation of heart rate by epinephrine-norepinephrine. * The ADRA1A gene is also involved in the regulation of the force of heart contraction by epinephrine-norepinephrine. **Clinical significance:** Mutations in the ADRA1A gene have been linked to a variety of cardiovascular diseases, including hypertension, heart failure, and angina pectoris. These mutations can lead to the overactivation of the alpha-1A adrenoceptor, which can result in chronic hypertension and heart failure.

Genular Protein ID: 3604890831

Symbol: ADA1A_HUMAN

Name: Alpha-1A adrenergic receptor

UniProtKB Accession Codes:

P35348 A8K0I3 B0ZBD1 B0ZBD2 B0ZBD4 B0ZBD5 B0ZBD6 B0ZBD8 B0ZBD9 O60451 Q13675 Q13729 Q4VBM7 Q6RUJ4 Q6RUJ5 Q6RUJ7 Q6RUJ8 Q6RUJ9 Q96RE8 Q9UD63 Q9UD67

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CORUM 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EMBL 27 EMDB 3 Ensembl 8 ExpressionAtlas 1 GO 43 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 3 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8396931

Title: Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor.

PubMed ID: 8396931

DOI: 10.1006/bbrc.1993.2130

PubMed ID: 8024574

Title: Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.

PubMed ID: 8024574

DOI: 10.1006/bbrc.1994.1845

PubMed ID: 8183249

Title: The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.

PubMed ID: 8183249

PubMed ID: 8564208

Title: The alpha 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types.

PubMed ID: 8564208

DOI: 10.1111/j.1476-5381.1995.tb16640.x

PubMed ID: 7737411

Title: Cloning, functional expression and tissue distribution of human alpha 1c-adrenoceptor splice variants.

PubMed ID: 7737411

DOI: 10.1016/0014-5793(95)00330-c

PubMed ID: 7815325

Title: Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.

PubMed ID: 7815325

PubMed ID: 9490024

Title: Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms.

PubMed ID: 9490024

DOI: 10.1016/s0014-5793(98)00024-6

PubMed ID: 10493934

Title: Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors.

PubMed ID: 10493934

DOI: 10.1042/bj3430231

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8196478

Title: Identification of alpha 1-adrenoceptor subtypes present in the human prostate.

PubMed ID: 8196478

DOI: 10.1016/0024-3205(94)90031-0

PubMed ID: 18802028

Title: Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes.

PubMed ID: 18802028

DOI: 10.1161/circresaha.108.176024

PubMed ID: 22120526

Title: Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes.

PubMed ID: 22120526

DOI: 10.1016/j.cellsig.2011.11.014

PubMed ID: 24567387

Title: MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors.

PubMed ID: 24567387

DOI: 10.1073/pnas.1315359111

PubMed ID: 8832064

Title: Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy.

PubMed ID: 8832064

DOI: 10.1111/j.1476-5381.1996.tb15552.x

PubMed ID: 15179408

Title: Alpha 1A-adrenergic receptor polymorphism and vascular response.

PubMed ID: 15179408

DOI: 10.1016/j.clpt.2004.02.006

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 466
  • Mass: 51487
  • Checksum: 1A50487531DECDF0
  • Sequence:
    • MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 
THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 
SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 
EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 
APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 
FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL 
HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT 
TARVRSKSFL QVCCCVGPST PSLDKNHQVP TIKVHTISLS ENGEEV

Genular Protein ID: 2888964645

Symbol: B0ZBD3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0ZBD3

Database IDs:

ARBA 18 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 8 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 Pfam 1 PharmGKB 1 PhylomeDB 1 RefSeq 4 RuleBase 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 475
  • Mass: 52205
  • Checksum: DE3CEEDD1AB3E56D
  • Sequence:
    • MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 
THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 
SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 
EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 
APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 
FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL 
HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT 
TARTKSRSVT RLECSGMILA HCNLRLPGSR DSPASASQAA GTTGMCHQAD ATRPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.