ADRA1A | ENSG00000120907 | NCBI 148

Details for: ADRA1A

Gene ID: 148

Symbol: ADRA1A

Ensembl ID: ENSG00000120907

Description: adrenoceptor alpha 1A

Associated with

Adrenoceptors
(R-HSA-390696)
Amine ligand-binding receptors
(R-HSA-375280)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (12/13) signalling events
(R-HSA-416482)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Signaling by gpcr
(R-HSA-372790)
Activation of phospholipase c activity
(GO:0007202)
Adenylate cyclase-activating adrenergic receptor signaling pathway
(GO:0071880)
Adult heart development
(GO:0007512)
Alpha1-adrenergic receptor activity
(GO:0004937)
Apoptotic process
(GO:0006915)
Calcium ion transport into cytosol
(GO:0060402)
Caveola
(GO:0005901)
Cell-cell signaling
(GO:0007267)
Cell growth involved in cardiac muscle cell development
(GO:0061049)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
G protein-coupled receptor signaling pathway
(GO:0007186)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular signal transduction
(GO:0035556)
Mapk cascade
(GO:0000165)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
(GO:0001985)
Neuron-glial cell signaling
(GO:0150099)
Norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
(GO:0001994)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Pilomotor reflex
(GO:0097195)
Plasma membrane
(GO:0005886)
Positive regulation of action potential
(GO:0045760)
Positive regulation of cardiac muscle contraction
(GO:0060452)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of heart rate by epinephrine-norepinephrine
(GO:0001996)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of protein kinase c signaling
(GO:0090037)
Positive regulation of smooth muscle contraction
(GO:0045987)
Positive regulation of synaptic transmission, gabaergic
(GO:0032230)
Positive regulation of the force of heart contraction by epinephrine-norepinephrine
(GO:0001997)
Positive regulation of vasoconstriction
(GO:0045907)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Response to hormone
(GO:0009725)
Response to xenobiotic stimulus
(GO:0009410)
Signal transduction
(GO:0007165)
Smooth muscle contraction
(GO:0006939)

Other Information

Proteins

Alpha-1A adrenergic receptor
B0ZBD3_HUMAN

Genular Protein ID: 3604890831

Symbol: ADA1A_HUMAN

Name: Alpha-1A adrenergic receptor

UniProtKB Accession Codes:

P35348 A8K0I3 B0ZBD1 B0ZBD2 B0ZBD4 B0ZBD5 B0ZBD6 B0ZBD8 B0ZBD9 O60451 Q13675 Q13729 Q4VBM7 Q6RUJ4 Q6RUJ5 Q6RUJ7 Q6RUJ8 Q6RUJ9 Q96RE8 Q9UD63 Q9UD67

Database IDs:

Citations:

PubMed ID: 8396931

Title: Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor.

PubMed ID: 8396931

DOI: 10.1006/bbrc.1993.2130

PubMed ID: 8024574

Title: Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.

PubMed ID: 8024574

DOI: 10.1006/bbrc.1994.1845

PubMed ID: 8183249

Title: The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.

PubMed ID: 8183249

PubMed ID: 8564208

Title: The alpha 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types.

PubMed ID: 8564208

DOI: 10.1111/j.1476-5381.1995.tb16640.x

PubMed ID: 7737411

Title: Cloning, functional expression and tissue distribution of human alpha 1c-adrenoceptor splice variants.

PubMed ID: 7737411

DOI: 10.1016/0014-5793(95)00330-c

PubMed ID: 7815325

Title: Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.

PubMed ID: 7815325

PubMed ID: 9490024

Title: Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms.

PubMed ID: 9490024

DOI: 10.1016/s0014-5793(98)00024-6

PubMed ID: 10493934

Title: Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors.

PubMed ID: 10493934

DOI: 10.1042/bj3430231

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8196478

Title: Identification of alpha 1-adrenoceptor subtypes present in the human prostate.

PubMed ID: 8196478

DOI: 10.1016/0024-3205(94)90031-0

PubMed ID: 18802028

Title: Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes.

PubMed ID: 18802028

DOI: 10.1161/circresaha.108.176024

PubMed ID: 22120526

Title: Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes.

PubMed ID: 22120526

DOI: 10.1016/j.cellsig.2011.11.014

PubMed ID: 24567387

Title: MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors.

PubMed ID: 24567387

DOI: 10.1073/pnas.1315359111

PubMed ID: 8832064

Title: Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy.

PubMed ID: 8832064

DOI: 10.1111/j.1476-5381.1996.tb15552.x

PubMed ID: 15179408

Title: Alpha 1A-adrenergic receptor polymorphism and vascular response.

PubMed ID: 15179408

DOI: 10.1016/j.clpt.2004.02.006

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 466
Mass: 51487
Checksum: 1A50487531DECDF0
Sequence:

MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 
THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 
SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 
EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 
APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 
FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL 
HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT 
TARVRSKSFL QVCCCVGPST PSLDKNHQVP TIKVHTISLS ENGEEV

Genular Protein ID: 2888964645

Symbol: B0ZBD3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0ZBD3

Database IDs:

Sequence Information:

Length: 475
Mass: 52205
Checksum: DE3CEEDD1AB3E56D
Sequence:

MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 
THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 
SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 
EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 
APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 
FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL 
HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT 
TARTKSRSVT RLECSGMILA HCNLRLPGSR DSPASASQAA GTTGMCHQAD ATRPS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADRA1A

Associated with

Other Information

Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor. PubMed ID: 8396931

Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c. PubMed ID: 8024574

The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. PubMed ID: 8183249

The alpha 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types. PubMed ID: 8564208

Cloning, functional expression and tissue distribution of human alpha 1c-adrenoceptor splice variants. PubMed ID: 7737411

Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. PubMed ID: 7815325

Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms. PubMed ID: 9490024

Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors. PubMed ID: 10493934

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of alpha 1-adrenoceptor subtypes present in the human prostate. PubMed ID: 8196478

Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes. PubMed ID: 18802028

Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes. PubMed ID: 22120526

MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors. PubMed ID: 24567387

Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy. PubMed ID: 8832064

Alpha 1A-adrenergic receptor polymorphism and vascular response. PubMed ID: 15179408

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974