Details for: CSTP1

Gene ID: 1480

Symbol: CSTP1

Ensembl ID: ENSG00000228476

Description: cystatin pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.1695
    Cell Significance Index: 101.1500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.4142
    Cell Significance Index: 4.2300
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.2025
    Cell Significance Index: 2.4100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0861
    Cell Significance Index: 0.9100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.0315
    Cell Significance Index: 0.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0292
    Cell Significance Index: 3.3500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0101
    Cell Significance Index: 0.1300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0095
    Cell Significance Index: 0.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0006
    Cell Significance Index: -0.2800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0054
    Cell Significance Index: -0.0600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0055
    Cell Significance Index: -0.0700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0114
    Cell Significance Index: -0.1400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0157
    Cell Significance Index: -0.1700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0212
    Cell Significance Index: -0.2200
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0219
    Cell Significance Index: -0.2500
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0416
    Cell Significance Index: -0.4400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0454
    Cell Significance Index: -0.4100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0536
    Cell Significance Index: -0.5800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0536
    Cell Significance Index: -0.3500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0556
    Cell Significance Index: -0.3300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0648
    Cell Significance Index: -0.6100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0717
    Cell Significance Index: -0.6800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0737
    Cell Significance Index: -0.8000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0749
    Cell Significance Index: -0.8300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0749
    Cell Significance Index: -0.7100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0851
    Cell Significance Index: -0.9900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0996
    Cell Significance Index: -1.0200
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1032
    Cell Significance Index: -1.1700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1033
    Cell Significance Index: -1.1600
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1293
    Cell Significance Index: -1.3500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1298
    Cell Significance Index: -1.0700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1333
    Cell Significance Index: -1.6600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1388
    Cell Significance Index: -1.6400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1607
    Cell Significance Index: -1.0100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1711
    Cell Significance Index: -1.8800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2379
    Cell Significance Index: -1.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding RNA**: CSTP1 is classified as a pseudogene, meaning it does not encode a functional protein. However, it shares a high degree of sequence similarity with the cystatin gene family, which suggests that CSTP1 may have evolved from a functional gene. 2. **Widespread tissue expression**: CSTP1 is expressed in a diverse range of cell types, including those from the salivary gland, immune system, nervous system, and epithelial tissues. 3. **Regulatory potential**: Despite its pseudogenic nature, CSTP1 may play a regulatory role in cellular processes, such as cell growth, differentiation, and survival. **Pathways and Functions:** 1. **Cell signaling pathways**: CSTP1 may be involved in regulating cell signaling pathways, such as the NF-κB pathway, which plays a crucial role in immune responses and inflammation. 2. **Apoptosis regulation**: CSTP1 may also regulate apoptosis (programmed cell death), which is essential for maintaining tissue homeostasis and preventing cancer. 3. **Gene expression regulation**: CSTP1 may act as a non-coding RNA regulatory element, influencing the expression of nearby genes and thereby modulating cellular processes. **Clinical Significance:** 1. **Cancer association**: CSTP1 has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer. This suggests that CSTP1 may play a role in tumorigenesis and cancer progression. 2. **Neurological disorders**: CSTP1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may contribute to neuroinflammation and neuronal damage. 3. **Immunological implications**: CSTP1 is expressed in immune cells, suggesting that it may play a role in regulating immune responses and inflammation. In conclusion, CSTP1 is a pseudogene with widespread tissue expression that may have regulatory functions in cellular processes. Further research is needed to elucidate the functional significance of CSTP1 and its potential role in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.