Genular: Defining Cellular Identity and Function

Details for: Grid2

Gene ID: 14804

Symbol: Grid2

Ensembl ID: ENSMUSG00000071424

Description: glutamate receptor, ionotropic, delta 2

Associated with

Cerebellar granule cell differentiation
(GO:0021707)
Dendritic spine
(GO:0043197)
Excitatory postsynaptic potential
(GO:0060079)
Excitatory synapse assembly
(GO:1904861)
Glutamate-gated receptor activity
(GO:0004970)
Glutamate receptor activity
(GO:0008066)
Glutamatergic synapse
(GO:0098978)
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0007157)
Identical protein binding
(GO:0042802)
Ionotropic glutamate receptor complex
(GO:0008328)
Ligand-gated monoatomic ion channel activity
(GO:0015276)
Membrane
(GO:0016020)
Modulation of chemical synaptic transmission
(GO:0050804)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Parallel fiber to purkinje cell synapse
(GO:0098688)
Pdz domain binding
(GO:0030165)
Plasma membrane
(GO:0005886)
Positive regulation of long-term synaptic depression
(GO:1900454)
Positive regulation of synapse assembly
(GO:0051965)
Postsynaptic density membrane
(GO:0098839)
Postsynaptic membrane
(GO:0045211)
Prepulse inhibition
(GO:0060134)
Protein binding
(GO:0005515)
Protein localization
(GO:0008104)
Regulation of neuron apoptotic process
(GO:0043523)
Regulation of neuron projection development
(GO:0010975)
Regulation of postsynaptic density assembly
(GO:0099151)
Regulation of presynapse assembly
(GO:1905606)
Scaffold protein binding
(GO:0097110)
Signaling receptor activity
(GO:0038023)
Somatodendritic compartment
(GO:0036477)
Synapse
(GO:0045202)
Synaptic transmission, glutamatergic
(GO:0035249)
Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
(GO:1904315)

Other Information

Proteins

Glutamate receptor ionotropic, delta-2

Genular Protein ID: 4287174292

Symbol: GRID2_MOUSE

Name: Glutamate receptor ionotropic, delta-2

UniProtKB Accession Codes:

Q61625 A4QPG1

Database IDs:

Citations:

PubMed ID: 7506541

Title: Selective expression of the glutamate receptor channel delta 2 subunit in cerebellar Purkinje cells.

PubMed ID: 7506541

DOI: 10.1006/bbrc.1993.2614

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12372286

Title: A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice.

PubMed ID: 12372286

DOI: 10.1016/s0896-6273(02)00861-9

PubMed ID: 15207857

Title: Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells.

PubMed ID: 15207857

DOI: 10.1016/j.mcn.2004.02.007

PubMed ID: 17027646

Title: Binding of glutamate receptor delta2 to its scaffold protein, Delphilin, is regulated by PKA.

PubMed ID: 17027646

DOI: 10.1016/j.bbrc.2006.09.109

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20395510

Title: Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer.

PubMed ID: 20395510

DOI: 10.1126/science.1185152

PubMed ID: 21410790

Title: Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions.

PubMed ID: 21410790

DOI: 10.1111/j.1460-9568.2011.07638.x

PubMed ID: 22220752

Title: The Cbln family of proteins interact with multiple signaling pathways.

PubMed ID: 22220752

DOI: 10.1111/j.1471-4159.2012.07648.x

PubMed ID: 29782851

Title: Glycosylation of Cblns attenuates their receptor binding.

PubMed ID: 29782851

DOI: 10.1016/j.brainres.2018.05.022

PubMed ID: 9285588

Title: Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene.

PubMed ID: 9285588

DOI: 10.1038/42009

Sequence Information:

Length: 1007
Mass: 113082
Checksum: A456166CC782A44B
Sequence:

MEVFPLLLFL SFCWSRTWDL ATADSIIHIG AIFDESAKKD DEVFRTAVGD LNQNEEILQT 
EKITFSVTFV DGNNPFQAVQ EACELMNQGI LALVSSIGCT SAGSLQSLAD AMHIPHLFIQ 
RSTAGTPRSG CGLTRSNRND DYTLSVRPPV YLNEVILRVV TEYAWQKFII FYDSEYDIRG 
IQEFLDKVSQ QGMDVALQKV ENNINKMITT LFDTMRIEEL NRYRDTLRRA ILVMNPATAK 
SFISEVVETN LVAFDCHWII INEEINDVDV QELVRRSIGR LTIIRQTFPV PQNISQRCFR 
GNHRISSSLC DPKDPFAQNM EISNLYIYDT VLLLANAFHK KLEDRKWHSM ASLSCIRKNS 
KPWQGGRSML ETIKKGGVNG LTGDLEFGEN GGNPNVHFEI LGTNYGEELG RGVRKLGCWN 
PVTGLNGSLT DKKLENNMRG VVLRVVTVLE EPFVMVSENV LGKPKKYQGF SIDVLDALSN 
YLGFNYEIYV APDHKYGSPQ EDGTWNGLVG ELVFKRADIG ISALTITPDR ENVVDFTTRY 
MDYSVGVLLR RAEKTVDMFA CLAPFDLSLW ACIAGTVLLV GLLVYLLNWL NPPRLQMGSM 
TSTTLYNSMW FVYGSFVQQG GEVPYTTLAT RMMMGAWWLF ALIVISSYTA NLAAFLTITR 
IESSIQSLQD LSKQTDIPYG TVLDSAVYQH VRMKGLNPFE RDSMYSQMWR MINRSNGSEN 
NVLESQAGIQ KVKYGNYAFV WDAAVLEYVA INDPDCSFYT VGNTVADRGY GIALQHGSPY 
RDVFSQRILE LQQSGDMDIL KHKWWPKNGQ CDLYSSVDAK QKGGALDIKS LAGVFCILAA 
GIVLSCLIAV LETWWSRRKG SRVPSKEDDK EIDLEHLHRR VNSLCTDDDS PHKQFSTSSI 
DLTPLDIDTL PTRQALEQIS DFRNTHITTT TFIPEQIQTL SRTLSAKAAS GFAFGSVPEH 
RTGPFRHRAP NGGFFRSPIK TMSSIPYQPT PTLGLNLGND PDRGTSI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Grid2

Associated with

Other Information

Selective expression of the glutamate receptor channel delta 2 subunit in cerebellar Purkinje cells. PubMed ID: 7506541

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. PubMed ID: 12372286

Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells. PubMed ID: 15207857

Binding of glutamate receptor delta2 to its scaffold protein, Delphilin, is regulated by PKA. PubMed ID: 17027646

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer. PubMed ID: 20395510

Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions. PubMed ID: 21410790

The Cbln family of proteins interact with multiple signaling pathways. PubMed ID: 22220752

Glycosylation of Cblns attenuates their receptor binding. PubMed ID: 29782851

Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene. PubMed ID: 9285588