Genular: Defining Cellular Identity and Function

Details for: Grin2c

Gene ID: 14813

Symbol: Grin2c

Ensembl ID: ENSMUSG00000020734

Description: glutamate receptor, ionotropic, NMDA2C (epsilon 3)

Associated with

Activation of nmda receptors and postsynaptic events
(R-MMU-442755)
Assembly and cell surface presentation of nmda receptors
(R-MMU-9609736)
Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Protein-protein interactions at synapses
(R-MMU-6794362)
Synaptic adhesion-like molecules
(R-MMU-8849932)
Transmission across chemical synapses
(R-MMU-112315)
Unblocking of nmda receptors, glutamate binding and activation
(R-MMU-438066)
Calcium ion transmembrane import into cytosol
(GO:0097553)
Directional locomotion
(GO:0033058)
Excitatory postsynaptic potential
(GO:0060079)
Glutamate-gated calcium ion channel activity
(GO:0022849)
Glutamate-gated receptor activity
(GO:0004970)
Glutamatergic synapse
(GO:0098978)
Ionotropic glutamate receptor signaling pathway
(GO:0035235)
Ligand-gated monoatomic ion channel activity
(GO:0015276)
Long-term synaptic potentiation
(GO:0060291)
Membrane
(GO:0016020)
Monoatomic cation channel activity
(GO:0005261)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Negative regulation of protein catabolic process
(GO:0042177)
Neuromuscular process controlling balance
(GO:0050885)
Nmda glutamate receptor activity
(GO:0004972)
Nmda selective glutamate receptor complex
(GO:0017146)
Pdz domain binding
(GO:0030165)
Plasma membrane
(GO:0005886)
Positive regulation of excitatory postsynaptic potential
(GO:2000463)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Postsynaptic density membrane
(GO:0098839)
Postsynaptic membrane
(GO:0045211)
Protein binding
(GO:0005515)
Protein localization to postsynaptic membrane
(GO:1903539)
Regulation of membrane potential
(GO:0042391)
Regulation of monoatomic cation transmembrane transport
(GO:1904062)
Regulation of neuronal synaptic plasticity
(GO:0048168)
Response to wounding
(GO:0009611)
Signaling receptor activity
(GO:0038023)
Startle response
(GO:0001964)
Synapse
(GO:0045202)
Synaptic transmission, glutamatergic
(GO:0035249)
Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
(GO:1904315)

Other Information

Proteins

Glutamate receptor ionotropic, NMDA 2C

Genular Protein ID: 1093255499

Symbol: NMDE3_MOUSE

Name: Glutamate receptor ionotropic, NMDA 2C

UniProtKB Accession Codes:

Q01098

Database IDs:

Citations:

PubMed ID: 1377365

Title: Molecular diversity of the NMDA receptor channel.

PubMed ID: 1377365

DOI: 10.1038/358036a0

PubMed ID: 8987814

Title: Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit.

PubMed ID: 8987814

DOI: 10.1523/jneurosci.16-24-07859.1996

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 27922130

Title: The NMDA receptor GluN2C subunit controls cortical excitatory-inhibitory balance, neuronal oscillations and cognitive function.

PubMed ID: 27922130

DOI: 10.1038/srep38321

Sequence Information:

Length: 1239
Mass: 135420
Checksum: 793E8E731E20C3C9
Sequence:

MGGALGPALL LTSLLGAWAG LGAGQGEQAV TVAVVFGSSG PLQAQARTRL TPQNFLDLPL 
EIQPLTIGVN NTNPSSILTQ ICGLLGAARV HGIVFEDNVD TEAVAQLLDF VSSQTHVPIL 
SISGGSAVVL TPKEPGSAFL QLGVSLEQQL QVLFKVLEEY DWSAFAVITS LHPGHALFLE 
GVRAVADASY LSWRLLDVLT LELGPGGPRA RTQRLLRQVD APVLVAYCSR EEAEVLFAEA 
AQAGLVGPGH VWLVPNLALG STDAPPAAFP VGLISVVTES WRLSLRQKVR DGVAILALGA 
HSYRRQYGTL PAPAGDCRSH PGPVSPAREA FYRHLLNVTW EGRDFSFSPG GYLVQPTMVV 
IALNRHRLWE MVGRWDHGVL YMKYPVWPRY STSLQPVVDS RHLTVATLEE RPFVIVESPD 
PGTGGCVPNT VPCRRQSNHT FSSGDITPYT KLCCKGFCID ILKKLAKVVK FSYDLYLVTN 
GKHGKRVRGV WNGMIGEVYY KRADMAIGSL TINEERSEII DFSVPFVETG ISVMVARSNG 
TVSPSAFLEP YSPAVWVMMF VMCLTVVAIT VFMFEYFSPV SYNQNLTKGK KSGGPSFTIG 
KSVWLLWALV FNNSVPIENP RGTTSKIMVL VWAFFAVIFL ASYTANLAAF MIQEQYIDTV 
SGLSDKKFQR PQDQYPPFRF GTVPNGSTER NIRSNYRDMH THMVKFNQRS VEDALTSLKM 
GKLDAFIYDA AVLNYMAGKD EGCKLVTIGS GKVFATTGYG IAMQKDSHWK RAIDLALLQF 
LGDGETQKLE TVWLSGICHN EKNEVMSSKL DIDNMAGVFY MLLVAMGLAL LVFAWEHLVY 
WKLRHSVPSS SQLDFLLAFS RGIYSCFNGV QSLPSPARPP SPDLTAGSAQ ANVLKMLQAA 
RDMVSTADVS GSLDRATRTI ENWGNNRRAP APTTSGPRSC TPGPPGQPSP SGWRPPGGGR 
TPLARRAPQP PARPATCAGS PQPDVSRASC RHAWDARWPV RVGHQGSHLS ASERRALPER 
SLLHAHCHYS SFPRAERSGR PFLPLFPEPP EPDDLPLLGP EQLARREALL RAAWARGPRP 
RHASLPSSVA EAFTRSNPLP ARCTGHACAC PCPQSRPSCR HVAQTQSLRL PSYREACVEG 
VPAGVAATWQ PRQHVCLHTH THLPFCWGTV CRHPPPCSSH SPWLIGTWEP PSHRGRTLGL 
GTGYRDSGVL EEVSREACGT QGFPRSCTWR RISSLESEV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Grin2c

Associated with

Other Information

Molecular diversity of the NMDA receptor channel. PubMed ID: 1377365

Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. PubMed ID: 8987814

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The NMDA receptor GluN2C subunit controls cortical excitatory-inhibitory balance, neuronal oscillations and cognitive function. PubMed ID: 27922130

Database document:

PubMed ID: 1377365

PubMed ID: 8987814

PubMed ID: 21183079

PubMed ID: 27922130