Details for: Nr3c1

Gene ID: 14815

Symbol: Nr3c1

Ensembl ID: ENSMUSG00000024431

Description: nuclear receptor subfamily 3, group C, member 1

Associated with

Other Information

Genular Protein ID: 2805810280

Symbol: GCR_MOUSE

Name: Glucocorticoid receptor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3780669

Title: The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins.

PubMed ID: 3780669

DOI: 10.1002/j.1460-2075.1986.tb04529.x

PubMed ID: 17012242

Title: A polymorphic glucocorticoid receptor in a mouse population may explain inherited altered stress response and increased anxiety-type behaviors.

PubMed ID: 17012242

DOI: 10.1096/fj.06-5926fje

PubMed ID: 20660300

Title: Discovery of glucocorticoid receptor-beta in mice with a role in metabolism.

PubMed ID: 20660300

DOI: 10.1210/me.2009-0411

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2911477

Title: Novel cDNA sequence possibly generated by alternative splicing of a mouse glucocorticoid receptor gene transcript from Shionogi carcinoma 115.

PubMed ID: 2911477

DOI: 10.1093/nar/17.1.445

PubMed ID: 2702670

Title: Regulation of glucocorticoid receptor protein and mRNA levels.

PubMed ID: 2702670

PubMed ID: 2019585

Title: Identification of phosphorylated sites in the mouse glucocorticoid receptor.

PubMed ID: 2019585

DOI: 10.1016/s0021-9258(20)89482-4

PubMed ID: 9195923

Title: Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin.

PubMed ID: 9195923

DOI: 10.1074/jbc.272.26.16224

PubMed ID: 9528750

Title: Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells.

PubMed ID: 9528750

DOI: 10.1128/mcb.18.4.1783

PubMed ID: 9742105

Title: Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression.

PubMed ID: 9742105

DOI: 10.1128/mcb.18.10.5880

PubMed ID: 10848625

Title: Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix.

PubMed ID: 10848625

DOI: 10.1091/mbc.11.6.2007

PubMed ID: 10678832

Title: The glucocorticoid receptor: rapid exchange with regulatory sites in living cells.

PubMed ID: 10678832

DOI: 10.1126/science.287.5456.1262

PubMed ID: 11278753

Title: Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleus.

PubMed ID: 11278753

DOI: 10.1074/jbc.m010809200

PubMed ID: 11555652

Title: Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids.

PubMed ID: 11555652

DOI: 10.1074/jbc.m106033200

PubMed ID: 11435610

Title: Molecular identification and characterization of A and B forms of the glucocorticoid receptor.

PubMed ID: 11435610

DOI: 10.1210/mend.15.7.0667

PubMed ID: 11751894

Title: A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins.

PubMed ID: 11751894

DOI: 10.1074/jbc.c100531200

PubMed ID: 12949501

Title: T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation.

PubMed ID: 12949501

DOI: 10.1038/nm895

PubMed ID: 15037546

Title: Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth.

PubMed ID: 15037546

DOI: 10.1101/gad.284704

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21994940

Title: Protein phosphatase 5 mediates lipid metabolism through reciprocal control of glucocorticoid receptor and peroxisome proliferator-activated receptor-? (PPAR?).

PubMed ID: 21994940

DOI: 10.1074/jbc.m111.311662

PubMed ID: 22170608

Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

PubMed ID: 22170608

DOI: 10.1038/nature10700

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 24736997

Title: A novel protein, CHRONO, functions as a core component of the mammalian circadian clock.

PubMed ID: 24736997

DOI: 10.1371/journal.pbio.1001839

PubMed ID: 25847991

Title: Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.

PubMed ID: 25847991

DOI: 10.1073/pnas.1411356112

PubMed ID: 25676786

Title: A hotspot in the glucocorticoid receptor DNA-binding domain susceptible to loss of function mutation.

PubMed ID: 25676786

DOI: 10.1016/j.steroids.2015.01.022

PubMed ID: 28751364

Title: Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.

PubMed ID: 28751364

DOI: 10.1073/pnas.1704955114

PubMed ID: 27686098

Title: REV-ERBalpha influences the stability and nuclear localization of the glucocorticoid receptor.

PubMed ID: 27686098

DOI: 10.1242/jcs.190959

Sequence Information:

  • Length: 792
  • Mass: 87164
  • Checksum: 528730BD2C517554
  • Sequence:
  • MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA AASQADSKQQ 
    RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV SLSMGLYMGE TETKVMGNDL 
    GYPQQGQLGL SSGETDFRLL EESIANLNRS TSRPENPKSS TPAAGCATPT EKEFPQTHSD 
    PSSEQQNRKS QPGTNGGSVK LYTTDQSTFD ILQDLEFSAG SPGKETNESP WRSDLLIDEN 
    LLSPLAGEDD PFLLEGDVNE DCKPLILPDT KPKIQDTGDT ILSSPSSVAL PQVKTEKDDF 
    IELCTPGVIK QEKLGPVYCQ ASFSGTNIIG NKMSAISVHG VSTSGGQMYH YDMNTASLSQ 
    QQDQKPVFNV IPPIPVGSEN WNRCQGSGED NLTSLGAMNF AGRSVFSNGY SSPGMRPDVS 
    SPPSSSSTAT GPPPKLCLVC SDEASGCHYG VLTCGSCKVF FKRAVEGQHN YLCAGRNDCI 
    IDKIRRKNCP ACRYRKCLQA GMNLEARKTK KKIKGIQQAT AGVSQDTSEN ANKTIVPAAL 
    PQLTPTLVSL LEVIEPEVLY AGYDSSVPDS AWRIMTTLNM LGGRQVIAAV KWAKAIPGFR 
    NLHLDDQMTL LQYSWMFLMA FALGWRSYRQ ASGNLLCFAP DLIINEQRMT LPCMYDQCKH 
    MLFISTELQR LQVSYEEYLC MKTLLLLSSV PKEGLKSQEL FDEIRMTYIK ELGKAIVKRE 
    GNSSQNWQRF YQLTKLLDSM HDVVENLLSY CFQTFLDKSM SIEFPEMLAE IITNQIPKYS 
    NGNIKKLLFH QK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.