Details for: Grn

Gene ID: 14824

Symbol: Grn

Ensembl ID: ENSMUSG00000034708

Description: granulin

Associated with

Other Information

Genular Protein ID: 1761867540

Symbol: GRN_MOUSE

Name: Paragranulin

UniProtKB Accession Codes:

P28798

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CPTAC 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 61 Gene3D 1 GeneTree 1 GlyCosmos 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 8482392

Title: Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin).

PubMed ID: 8482392

DOI: 10.1016/0014-5793(93)81544-a

PubMed ID: 1618805

Title: The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth.

PubMed ID: 1618805

DOI: 10.1016/s0021-9258(18)42382-4

PubMed ID: 8471244

Title: Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor of the growth-modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells.

PubMed ID: 8471244

DOI: 10.1002/mrd.1080340302

PubMed ID: 8496151

Title: Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line.

PubMed ID: 8496151

DOI: 10.1016/s0021-9258(18)82064-6

PubMed ID: 12526812

Title: Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair.

PubMed ID: 12526812

DOI: 10.1016/s0092-8674(02)01141-8

PubMed ID: 12524533

Title: Progranulin is a mediator of the wound response.

PubMed ID: 12524533

DOI: 10.1038/nm816

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20026663

Title: Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice.

PubMed ID: 20026663

DOI: 10.1084/jem.20091568

PubMed ID: 21092856

Title: Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

PubMed ID: 21092856

DOI: 10.1016/j.neuron.2010.09.034

PubMed ID: 23041626

Title: Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.

PubMed ID: 23041626

DOI: 10.1172/jci63113

PubMed ID: 26370502

Title: Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.

PubMed ID: 26370502

DOI: 10.1083/jcb.201502029

PubMed ID: 27789271

Title: Progranulin Recruits HSP70 to beta-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.

PubMed ID: 27789271

DOI: 10.1016/j.ebiom.2016.10.010

PubMed ID: 28073925

Title: Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.

PubMed ID: 28073925

DOI: 10.1093/hmg/ddx011

PubMed ID: 28453791

Title: Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.

PubMed ID: 28453791

DOI: 10.1093/hmg/ddx162

PubMed ID: 28835281

Title: Lysosomal processing of progranulin.

PubMed ID: 28835281

DOI: 10.1186/s13024-017-0205-9

PubMed ID: 28541286

Title: Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.

PubMed ID: 28541286

DOI: 10.1038/ncomms15277

PubMed ID: 28728022

Title: Loss of TMEM106B ameliorates lysosomal and frontotemporal dementia-related phenotypes in progranulin-deficient mice.

PubMed ID: 28728022

DOI: 10.1016/j.neuron.2017.06.026

PubMed ID: 32761777

Title: Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice.

PubMed ID: 32761777

DOI: 10.15252/embr.202050197

PubMed ID: 32852886

Title: Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice.

PubMed ID: 32852886

DOI: 10.15252/embr.202050219

PubMed ID: 32929860

Title: Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.

PubMed ID: 32929860

DOI: 10.15252/embr.202050241

Sequence Information:

  • Length: 589
  • Mass: 63458
  • Checksum: 1DE8229C413CB787
  • Sequence:
    • MWVLMSWLAF AAGLVAGTQC PDGQFCPVAC CLDQGGANYS CCNPLLDTWP RITSHHLDGS 
CQTHGHCPAG YSCLLTVSGT SSCCPFSKGV SCGDGYHCCP QGFHCSADGK SCFQMSDNPL 
GAVQCPGSQF ECPDSATCCI MVDGSWGCCP MPQASCCEDR VHCCPHGASC DLVHTRCVSP 
TGTHTLLKKF PAQKTNRAVS LPFSVVCPDA KTQCPDDSTC CELPTGKYGC CPMPNAICCS 
DHLHCCPQDT VCDLIQSKCL SKNYTTDLLT KLPGYPVKEV KCDMEVSCPE GYTCCRLNTG 
AWGCCPFAKA VCCEDHIHCC PAGFQCHTEK GTCEMGILQV PWMKKVIAPL RLPDPQILKS 
DTPCDDFTRC PTNNTCCKLN SGDWGCCPIP EAVCCSDNQH CCPQGFTCLA QGYCQKGDTM 
VAGLEKIPAR QTTPLQIGDI GCDQHTSCPV GQTCCPSLKG SWACCQLPHA VCCEDRQHCC 
PAGYTCNVKA RTCEKDVDFI QPPVLLTLGP KVGNVECGEG HFCHDNQTCC KDSAGVWACC 
PYLKGVCCRD GRHCCPGGFH CSARGTKCLR KKIPRWDMFL RDPVPRPLL

Genular Protein ID: 2021892309

Symbol: Q3U9N4_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3U9N4

Database IDs:

AGR 1 ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 11 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneTree 1 HOGENOM 1 InterPro 3 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSR 1 PROSITE 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 602
  • Mass: 65018
  • Checksum: BF84F121CDCB6ECE
  • Sequence:
    • MPPREPGPRR RQTMWVLMSW LAFAAGLVAG TQCPDGQFCP VACCLDQGGA NYSCCNPLLD 
TWPRITSHHL DGSCQTHGHC PAGYSCLLTV SGTSSCCPFS KGVSCGDGYH CCPQGFHCSA 
DGKSCFQMSD NPLGAVQCPG SQFECPDSAT CCIMVDGSWG CCPMPQASCC EDRVHCCPHG 
ASCDLVHTRC VSPTGTHTLL KKFPAQKTNR AVSLPFSVVC PDAKTQCPDD STCCELPTGK 
YGCCPMPNAI CCSDHLHCCP QDTVCDLIQS KCLSKNYTTD LLTKLPGYPV KEVKCDMEVS 
CPEGYTCCRL NTGAWGCCPF AKAVCCEDHI HCCPAGFQCH TEKGTCEMGI LQVPWMKKVI 
APLRLPDPQI LKSDTPCDDF TRCPTNNTCC KLNSGDWGCC PIPEAVCCSD NQHCCPQGFT 
CLAQGYCQKG DTMVAGLEKI PARQTTPLQI GDIGCDQHTS CPVGQTCCPS LKGSWACCQL 
PHAVCCEDRQ HCCPAGYTCN VKARTCEKDV DFIQPPVLLT LGPKVGNVEC GEGHFCHDNQ 
TCCKDSAGVW ACCPYLKGVC CRDGRHCCPG GFHCSARGTK CLRKKIPRWD MFLRDPVPRP 
LL

Genular Protein ID: 2233228357

Symbol: Q9D2V3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9D2V3

Database IDs:

AGR 1 ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 InterPro 3 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 602
  • Mass: 64965
  • Checksum: BF84F121CDCB7BDB
  • Sequence:
    • MPPREPGPRR RQTMWVLMSW LAFAAGLVAG TQCPDGQFCP VACCLDQGGA NYSCCNPLLD 
TWPRITSHHL DGSCQTHGHC PAGYSCLLTV SGTSSCCPFS KGVSCGDGYH CCPQGFHCSA 
DGKSCFQMSD NPLGAVQCPG SQFECPDSAT CCIMVDGSWG CCPMPQASCC EDRVHCCPHG 
ASCDLVHTRC VSPTGTHTLL KKFPAQKTNR AVSLPFSVVC PDAKTQCPDD STCCELPTGK 
YGCCPMPNAI CCSDHLHCCP QDTVCDLIQS KCLSKNYTTD LLTKLPGYPV KEVKCDMEVS 
CPEGYTCCRL NTGAWGCCPF AKAVCCEDHI HCCPAGFQCH TEKGTCEMGI LQVPWMKKVI 
APLRLPDPQI LKSDTPCDDF TRCPTNNTCC KLNSGDWGCC PIPEAVCCSD NQHCCPQGFT 
CLAQGYCQKG DTMVAGLEKI PARQTTPLQI GDIGCDQHTS CPVGQTCCPS LKGSWACCQL 
PHAVCCEDRQ HCCPAGYTCN VKARTCEKDV DFIQPPVLLT LGPKVGNVEC GEGHFCHDNQ 
TCCKDSAGVW ACCPYLKGVC CRDGRHCCPG GFHCSARGTK CLRKKIPCWD MFLRDPVPRP 
LL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.