Genular: Defining Cellular Identity and Function

Details for: Hspa5

Gene ID: 14828

Symbol: Hspa5

Ensembl ID: ENSMUSG00000026864

Description: heat shock protein 5

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen presentation: folding, assembly and peptide loading of class i mhc
(R-MMU-983170)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to heat stress
(R-MMU-3371556)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Immune system
(R-MMU-168256)
Regulation of hsf1-mediated heat shock response
(R-MMU-3371453)
Atp-dependent protein folding chaperone
(GO:0140662)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cell surface
(GO:0009986)
Cellular response to glucose starvation
(GO:0042149)
Cellular response to interleukin-4
(GO:0071353)
Cerebellar purkinje cell layer development
(GO:0021680)
Cerebellum structural organization
(GO:0021589)
Chaperone cofactor-dependent protein refolding
(GO:0051085)
Cop9 signalosome
(GO:0008180)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum-golgi intermediate compartment
(GO:0005793)
Endoplasmic reticulum chaperone complex
(GO:0034663)
Endoplasmic reticulum lumen
(GO:0005788)
Endoplasmic reticulum membrane
(GO:0005789)
Endoplasmic reticulum unfolded protein response
(GO:0030968)
Enzyme binding
(GO:0019899)
Erad pathway
(GO:0036503)
Er overload response
(GO:0006983)
Extracellular region
(GO:0005576)
Heat shock protein binding
(GO:0031072)
Hydrolase activity
(GO:0016787)
Intracellular membrane-bounded organelle
(GO:0043231)
Ire1-mediated unfolded protein response
(GO:0036498)
Maintenance of protein localization in endoplasmic reticulum
(GO:0035437)
Membrane
(GO:0016020)
Midbody
(GO:0030496)
Misfolded protein binding
(GO:0051787)
Mitochondrion
(GO:0005739)
Myelin sheath
(GO:0043209)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of embryonic development
(GO:0040019)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of protein ubiquitination
(GO:0031398)
Post-translational protein targeting to membrane, translocation
(GO:0031204)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein folding chaperone
(GO:0044183)
Protein refolding
(GO:0042026)
Proteolysis involved in protein catabolic process
(GO:0051603)
Response to endoplasmic reticulum stress
(GO:0034976)
Ribosome binding
(GO:0043022)
Smooth endoplasmic reticulum
(GO:0005790)
Ubiquitin protein ligase binding
(GO:0031625)
Unfolded protein binding
(GO:0051082)

Other Information

Proteins

BIP_MOUSE
Q3U7T8_MOUSE

Genular Protein ID: 1016752910

Symbol: BIP_MOUSE

Name: N/A

UniProtKB Accession Codes:

P20029 O35642 Q3UFF2 Q61630

Database IDs:

Citations:

PubMed ID: 2895472

Title: cDNA cloning of the immunoglobulin heavy chain binding protein.

PubMed ID: 2895472

DOI: 10.1073/pnas.85.7.2250

PubMed ID: 2559088

Title: Identification of immunoglobulin heavy chain binding protein as glucose-regulated protein 78 on the basis of amino acid sequence, immunological cross-reactivity, and functional activity.

PubMed ID: 2559088

DOI: 10.1242/jcs.1989.supplement_11.10

PubMed ID: 8645260

Title: Molecular characterization of seizure-related genes isolated by differential screening.

PubMed ID: 8645260

DOI: 10.1006/bbrc.1996.0313

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7607546

Title: Structure and regulation of the mouse GRP78 (BiP) promoter by glucose and calcium ionophore.

PubMed ID: 7607546

DOI: 10.1016/0378-1119(95)00083-i

PubMed ID: 7523108

Title: Separation and sequencing of familiar and novel murine proteins using preparative two-dimensional gel electrophoresis.

PubMed ID: 7523108

DOI: 10.1002/elps.11501501101

PubMed ID: 2583523

Title: Differential screening of a cDNA library with cDNA probes amplified in a heterologous host: isolation of murine GRP78 (BiP) and other serum-regulated low-abundance mRNAs.

PubMed ID: 2583523

DOI: 10.1016/0378-1119(89)90054-1

PubMed ID: 12475965

Title: A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.

PubMed ID: 12475965

DOI: 10.1091/mbc.e02-05-0311

PubMed ID: 12065409

Title: A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes.

PubMed ID: 12065409

DOI: 10.1093/emboj/cdf315

PubMed ID: 11836248

Title: Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress.

PubMed ID: 11836248

DOI: 10.1074/jbc.m112214200

PubMed ID: 12411443

Title: ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress.

PubMed ID: 12411443

DOI: 10.1074/jbc.m206995200

PubMed ID: 16800626

Title: Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease.

PubMed ID: 16800626

DOI: 10.1021/bi060474w

PubMed ID: 16931514

Title: Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver.

PubMed ID: 16931514

DOI: 10.1074/jbc.m605701200

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20484814

Title: The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice.

PubMed ID: 20484814

DOI: 10.1172/jci42164

PubMed ID: 20945367

Title: Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm.

PubMed ID: 20945367

DOI: 10.1002/jcp.22444

PubMed ID: 21992152

Title: Interferon-inducible antiviral protein MxA enhances cell death triggered by endoplasmic reticulum stress.

PubMed ID: 21992152

DOI: 10.1089/jir.2010.0132

PubMed ID: 23921388

Title: Identification and characterization of a novel human methyltransferase modulating Hsp70 function through lysine methylation.

PubMed ID: 23921388

DOI: 10.1074/jbc.m113.483248

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 25009997

Title: Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity.

PubMed ID: 25009997

DOI: 10.1016/j.ydbio.2014.06.024

PubMed ID: 27159390

Title: Bicarbonate correction of ketoacidosis alters host-pathogen interactions and alleviates mucormycosis.

PubMed ID: 27159390

DOI: 10.1172/jci82744

PubMed ID: 33863978

Title: ILDR2 stabilization is regulated by its interaction with GRP78.

PubMed ID: 33863978

DOI: 10.1038/s41598-021-87884-7

Sequence Information:

Length: 655
Mass: 72422
Checksum: AFB795D15E20FAC2
Sequence:

MMKFTVVAAA LLLLGAVRAE EEDKKEDVGT VVGIDLGTTY SCVGVFKNGR VEIIANDQGN 
RITPSYVAFT PEGERLIGDA AKNQLTSNPE NTVFDAKRLI GRTWNDPSVQ QDIKFLPFKV 
VEKKTKPYIQ VDIGGGQTKT FAPEEISAMV LTKMKETAEA YLGKKVTHAV VTVPAYFNDA 
QRQATKDAGT IAGLNVMRII NEPTAAAIAY GLDKREGEKN ILVFDLGGGT FDVSLLTIDN 
GVFEVVATNG DTHLGGEDFD QRVMEHFIKL YKKKTGKDVR KDNRAVQKLR REVEKAKRAL 
SSQHQARIEI ESFFEGEDFS ETLTRAKFEE LNMDLFRSTM KPVQKVLEDS DLKKSDIDEI 
VLVGGSTRIP KIQQLVKEFF NGKEPSRGIN PDEAVAYGAA VQAGVLSGDQ DTGDLVLLDV 
CPLTLGIETV GGVMTKLIPR NTVVPTKKSQ IFSTASDNQP TVTIKVYEGE RPLTKDNHLL 
GTFDLTGIPP APRGVPQIEV TFEIDVNGIL RVTAEDKGTG NKNKITITND QNRLTPEEIE 
RMVNDAEKFA EEDKKLKERI DTRNELESYA YSLKNQIGDK EKLGGKLSSE DKETMEKAVE 
EKIEWLESHQ DADIEDFKAK KKELEEIVQP IISKLYGSGG PPPTGEEDTS EKDEL

Genular Protein ID: 1966921881

Symbol: Q3U7T8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3U7T8

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 619
Mass: 68498
Checksum: 9F4639F3C41F0EAA
Sequence:

MMKFTVVAAA LLLLGAVRAE EEDKKEDVGT VVGIDLGTTY SCVGVFKNGR VEIIANDQGN 
RITPSYVAFT PEGERLIGDA AKNQLTSNPE NTVFDAKRLI GRTWNDPSVQ QDIKFLPFKV 
VEKKTKPYIQ VDIGGGQTKT FAPEEISAMV LTKMKETAEA YLGKKVTHAV VTVPAYFNDA 
QRQATKDAGT IAGLNVMRII NEPTAAAIAY GLDKREGEKN ILVFDLGGGT FDVSLLTIDN 
GVFEVVATNG DTHLGGEDFD QRVMEHFIKL YKKKTGKDVR KDNRAVQKLR REVEKAKRAL 
SSQHQARIEI ESFFEGEDFS ETLTRAKFEE LNMDLFRSTM KPVQKVLEDS DLKKSDIDEI 
VLVGGSTRIP KIQQLVKEFF NGKEPSRGIN PDEAVAYGAA VQAGVLSGDQ DTGDLVLLDV 
CPLTLGIETV GGVMTKLIPR NTVVPTKKSQ IFSTASDNQP TVTIKVYEGE RPLTKDNHLL 
GTFDLTGIPP APRGVPQIEV TFEIDVNGIL RVTAEDKGTG NKNKITITND QNRLTPEEIE 
RMVNDAEKFA EEDKKLKERI DTRNELESYA YSLKNQIGDK EKLGGKLSSE DKETMEKAVE 
EKIEWLESHQ DADIEDFKA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hspa5

Associated with

Other Information

cDNA cloning of the immunoglobulin heavy chain binding protein. PubMed ID: 2895472

Identification of immunoglobulin heavy chain binding protein as glucose-regulated protein 78 on the basis of amino acid sequence, immunological cross-reactivity, and functional activity. PubMed ID: 2559088

Molecular characterization of seizure-related genes isolated by differential screening. PubMed ID: 8645260

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure and regulation of the mouse GRP78 (BiP) promoter by glucose and calcium ionophore. PubMed ID: 7607546

Separation and sequencing of familiar and novel murine proteins using preparative two-dimensional gel electrophoresis. PubMed ID: 7523108

Differential screening of a cDNA library with cDNA probes amplified in a heterologous host: isolation of murine GRP78 (BiP) and other serum-regulated low-abundance mRNAs. PubMed ID: 2583523

A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins. PubMed ID: 12475965

A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes. PubMed ID: 12065409

Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress. PubMed ID: 11836248

ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress. PubMed ID: 12411443

Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease. PubMed ID: 16800626

Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver. PubMed ID: 16931514

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice. PubMed ID: 20484814

Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm. PubMed ID: 20945367

Interferon-inducible antiviral protein MxA enhances cell death triggered by endoplasmic reticulum stress. PubMed ID: 21992152

Identification and characterization of a novel human methyltransferase modulating Hsp70 function through lysine methylation. PubMed ID: 23921388

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity. PubMed ID: 25009997

Bicarbonate correction of ketoacidosis alters host-pathogen interactions and alleviates mucormycosis. PubMed ID: 27159390

ILDR2 stabilization is regulated by its interaction with GRP78. PubMed ID: 33863978

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073